RGD Reference Report - Carbonic anhydrase enzymes II, VII, IX and XII in colorectal carcinomas. - Rat Genome Database

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Carbonic anhydrase enzymes II, VII, IX and XII in colorectal carcinomas.

Authors: Viikilä, Pia  Kivelä, Antti J  Mustonen, Harri  Koskensalo, Selja  Waheed, Abdul  Sly, William S  Pastorek, Jaromir  Pastorekova, Silvia  Parkkila, Seppo  Haglund, Caj 
Citation: Viikilä P, etal., World J Gastroenterol. 2016 Sep 28;22(36):8168-77. doi: 10.3748/wjg.v22.i36.8168.
RGD ID: 155226860
Pubmed: PMID:27688658   (View Abstract at PubMed)
PMCID: PMC5037085   (View Article at PubMed Central)
DOI: DOI:10.3748/wjg.v22.i36.8168   (Journal Full-text)


AIM: To investigate expression of four alpha-carbonic anhydrases (CAs) in colorectal carcinomas (CRC) and compare the results with patients' survival.
METHODS: Colorectal carcinoma samples from 539 CRC patients and control tissues were arranged as tissue microarrays and analyzed with antibodies against CA II, CA VII, CA IX, and CA XII. Intensity and extent of staining were both scored from 0 to 3 in each sample. These enzyme expression levels were then correlated to patients' survival and clinicopathological parameters, which were tumor differentiation grade and stage, site of tumor, patients' age, and gender. Kaplan-Meier analysis and Cox regression hazard ratio model were used to analyze survival data.
RESULTS: CA II and CA XII staining intensities correlated with patients' survival in that higher expression indicated poorer prognosis. In Cox regression analysis one unit increase in the CA II intensity increased the hazard ratio to 1.19 fold (CI: 1.04-1.37, P = 0.009). A significant correlation was also found when comparing CA XII staining intensity with survival of CRC patients (HR = 1.18, 95%CI: 1.01-1.38, P = 0.036). The extent of CA XII immunostaining did not correlate to the patients' survival (P = 0.242, Kaplan-Meier analysis). A significant interaction between age group and extent of the CA II staining was found. Increased extent of CA II had a significant hazard ratio among patients 65 years and older (1.42, 95%CI: 1.16-1.73, P = 0.0006). No correlations were found between CA VII (intensity P = 0.566, extent P = 0.495, Kaplan-Meier analysis), or CA IX (intensity P = 0.879, extent P = 0.315, Kaplan-Meier analysis) immunostaining results and survival, or the other parameters.
CONCLUSION: The present findings indicate that CA II and CA XII could be useful in predicting survival in CRC.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
colorectal carcinoma disease_progressionIEP 155226860; 155226860 RGD 
colorectal carcinoma disease_progressionISOCA12 (Homo sapiens)155226860; 155226860 RGD 
colorectal carcinoma disease_progressionISOCA2 (Homo sapiens)155226860; 155226860 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Car12  (carbonic anhydrase 12)
Car2  (carbonic anhydrase 2)

Genes (Mus musculus)
Car12  (carbonic anhydrase 12)
Car2  (carbonic anhydrase 2)

Genes (Homo sapiens)
CA12  (carbonic anhydrase 12)
CA2  (carbonic anhydrase 2)


Additional Information