Ca12 (carbonic anhydrase 12) - Rat Genome Database

Name: Ca12
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Ca12 (carbonic anhydrase 12) Chinchilla lanigera

Analyze

Symbol:

Ca12

Name:

carbonic anhydrase 12

RGD ID:

8704192

Description:

ENCODES a protein that exhibits carbonate dehydratase activity (ortholog); INVOLVED IN chloride ion homeostasis (ortholog); estrous cycle (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); colon adenocarcinoma (ortholog); colorectal adenocarcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

carbonic anhydrase XII

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CA12 (carbonic anhydrase 12)	NCBI	Ortholog
Mus musculus (house mouse):	Car12 (carbonic anhydrase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Car12 (carbonic anhydrase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CA12 (carbonic anhydrase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CA12 (carbonic anhydrase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ca12 (carbonic anhydrase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CA12 (carbonic anhydrase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CA12 (carbonic anhydrase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ca12 (carbonic anhydrase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	11,943,340 - 11,975,928 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	11,927,730 - 11,975,553 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colon adenocarcinoma (ISO)

colorectal adenocarcinoma (ISO)

colorectal cancer (ISO)

colorectal carcinoma (ISO)

Colorectal Neoplasms (ISO)

esophagus squamous cell carcinoma (ISO)

fibrolamellar carcinoma (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

hypertrophic cardiomyopathy (ISO)

isolated hyperchlorhidrosis (ISO)

lung cancer (ISO)

lung metastasis (ISO)

Lung Neoplasms (ISO)

lung non-small cell carcinoma (ISO)

Lynch syndrome (ISO)

nemaline myopathy 6 (ISO)

oral squamous cell carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chloride ion homeostasis (ISO)

estrous cycle (ISO)

Cellular Component

apical plasma membrane (ISO)

basolateral plasma membrane (ISO)

Molecular Function

carbonate dehydratase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Ca12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	11,943,340 - 11,975,928 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	11,927,730 - 11,975,553 (+)	NCBI	ChiLan1.0	ChiLan1.0

CA12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	63,321,378 - 63,381,846 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	63,321,378 - 63,381,846 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	63,613,577 - 63,674,045 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	61,402,783 - 61,461,128 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	15	40,494,364 - 40,552,718 (-)	NCBI		Celera
Cytogenetic Map	15	q22.2	NCBI
HuRef	15	40,438,444 - 40,496,766 (-)	NCBI		HuRef
CHM1_1	15	63,734,781 - 63,793,114 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	61,126,049 - 61,186,532 (-)	NCBI		T2T-CHM13v2.0

Car12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	66,619,026 - 66,674,127 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	66,620,968 - 66,674,127 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	66,712,296 - 66,766,845 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	66,713,686 - 66,766,845 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	66,561,493 - 66,614,652 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	66,512,886 - 66,565,989 (+)	NCBI		MGSCv36	mm8
Celera	9	63,948,029 - 64,000,964 (+)	NCBI		Celera
Cytogenetic Map	9	C	NCBI
cM Map	9	36.09	NCBI

Car12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	76,169,723 - 76,225,465 (+)	NCBI		GRCr8
mRatBN7.2	8	67,274,739 - 67,330,428 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	67,274,359 - 67,330,440 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	72,787,939 - 72,840,890 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	71,060,751 - 71,113,710 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	68,930,478 - 68,983,460 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	72,405,770 - 72,461,425 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	72,405,748 - 72,460,240 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	72,071,988 - 72,127,646 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	71,017,732 - 71,070,729 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	8	66,660,144 - 66,713,076 (+)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

CA12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	52,571,690 - 52,630,424 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	56,747,752 - 56,806,529 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	42,270,188 - 42,328,952 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	60,565,592 - 60,624,008 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	60,565,592 - 60,624,008 (-)	Ensembl	panpan1.1		panPan2

CA12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	27,903,460 - 27,957,162 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	27,905,837 - 27,957,742 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	27,822,431 - 27,876,096 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	28,075,321 - 28,129,041 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	28,077,699 - 28,129,047 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	28,012,749 - 28,066,343 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	28,074,625 - 28,128,260 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	28,311,867 - 28,365,995 (-)	NCBI		UU_Cfam_GSD_1.0

Ca12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	106,028,826 - 106,081,389 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	23,876,812 - 23,929,987 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	23,876,889 - 23,929,720 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CA12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	108,649,271 - 108,710,651 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	108,649,277 - 108,710,658 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	119,822,275 - 119,904,112 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CA12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	20,162,706 - 20,221,680 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	20,162,926 - 20,224,502 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	121,178,247 - 121,238,609 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ca12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624781	9,140,837 - 9,196,400 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624781	9,140,753 - 9,195,651 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013518981	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01042685	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01177179	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000014378 ⟹ ENSCLAP00000014220

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955450	11,943,340 - 11,975,928 (+)	Ensembl

RefSeq Acc Id:

XM_013518981 ⟹ XP_013374435

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955450	11,927,730 - 11,975,553 (+)	NCBI

Sequence:

show sequence

GCCGCCGCCGCCGCCGCCGCCCTCCTGCTGCTGGTCCTGCCGGCGCCGCCTTGCAGCGCGGCCG
CCCGCAACGGCACCAAGTGGACCTATATTGGCCCTAATGGGGAGAAGAACTGGTCCAAGAAGTA
CCCATCCTGTGGGGGCCTGCTGCAGTCTCCGATAGACCTGCATGGTGACATCCTTCAGTATAAC
GCCAGCCTTGGACCCCTCGAGTTCCAAGGTTACAATGTGTCTTCCAGCGAACTGCTGAACCTGA
CTAATAATGGCCATTCAGTGAAGCTGTGCCTGCACCCAGCCATGCACATCCAGGGCCTCGGCTC
CCACCGGTACCGGGCCACACAGCTGCACCTGCACTGGGGGGACAGCCAGGAGCCCTTCGGCTCT
GAGCACACCGTCAGCGGGAAGCACTTCGCTGCTGAGCTGCATATTGTCCACTATAACTCAGACC
AGTACCCTAACATCAGCGCTGCCAGTAACCAGTCAGGAGGCCTCGCCGTCCTCGCTGTTCTCCT
GGAGAGAGGCTCCTTCAATCCATCATATGACAAGATCTTCAGTCACCTTCAACACGTGAGGTTC
AAAGGTCAACAAGTGCGCATCCCGGGCTTCAACATTGAAGAGCTGCTTCCGGAGAAGACTGCCG
AGTACTACCGCTACGAGGGGTCCCTGACCACCCCACCTTGCAACCCCACCGTGCTCTGGACGGT
TTTCCGTAACACTGTGCAAGTTTCCCAGGAGCAGCTGCTGGCTTTAGAGACAGCTCTGTTCTGC
ACAGATGTGAGTGACCCTGCCCCCATAGAAATGGTCAACAACTTCCGGCAAGTCCAAAAGTTTG
AAGAGAGGCTGGTGTACATCTCCTTCCAACAAGGACTTACCGACGCAGAACTGAGTATGGGCAT
CGTCCTGTCCGTGGCCCTGGCTGGTATTCTTGGCATCTGCATTGTCCTGGGAGTGTCCATTTGG
CTCTTCAGAAGGAAAAAGAGCGCTGTGGCCGAAACAGCAGTGCCCGCTTCACAGGATGATCACC
ATGGGAAGGTCACCGTGCTCAGACTTGAAGGTGTGTCAGCCCTGCTGCCATGGCTAATTATCCA
TGTGACTATGGACAAGTCTCTTGGTTCGGGGTTTGCACCTGAACACAGTCAGCAAGGCTATCTT
CTTGCTAAGATCTTCACATCTGGTTTTTCTTCTATGAATCCAGGGAGAAAAACGAGGGAAAACC
TGCACTCTCACATTAGCTATTAATTCCCTTGGCCCGTGGTTTTATCGTCACTTTTGGGTTTTCC
TAAACATAATTACCTTTCCTGGTAAGAACATTAAAAATATTTTTGGAAATTATGAAACCAAAAG
TTTGAAGTACAGTCATAACGAGATCTTCAAAATGCAGGTCTAGTACTGTGAGGTATTAAAAGAA
CAGTTGCAAAATGAACAGGTTCCACTGTAGTTCATGAATGCCCTGCTTGGAGGGACTCCCTCCC
AACAGCAGAAGCGAGCAAGTCCCAAGGGGAAGAGTCTGACTTCAAAAAGCCCCTCAGTGCCGTA
TCTGAGTCAGGCTGCTGTCTGGTTATTCTCTCCACTTTGACTAACGAGACTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013374435	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000014220.1

RefSeq Acc Id:

XP_013374435 ⟸ XM_013518981

- Sequence:

show sequence

AAAAAAALLLLVLPAPPCSAAARNGTKWTYIGPNGEKNWSKKYPSCGGLLQSPIDLHGDILQYN
ASLGPLEFQGYNVSSSELLNLTNNGHSVKLCLHPAMHIQGLGSHRYRATQLHLHWGDSQEPFGS
EHTVSGKHFAAELHIVHYNSDQYPNISAASNQSGGLAVLAVLLERGSFNPSYDKIFSHLQHVRF
KGQQVRIPGFNIEELLPEKTAEYYRYEGSLTTPPCNPTVLWTVFRNTVQVSQEQLLALETALFC
TDVSDPAPIEMVNNFRQVQKFEERLVYISFQQGLTDAELSMGIVLSVALAGILGICIVLGVSIW
LFRRKKSAVAETAVPASQDDHHGKVTVLRLEGVSALLPWLIIHVTMDKSLGSGFAPEHSQQGYL
LAKIFTSGFSSMNPGRKTRENLHSHISY

hide sequence

RefSeq Acc Id:

ENSCLAP00000014220 ⟸ ENSCLAT00000014378

Protein Domains

Alpha-carbonic anhydrase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000009814	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000014378.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.200.10	UniProtKB/TrEMBL
InterPro	CA_dom	UniProtKB/TrEMBL
	CA_dom_sf	UniProtKB/TrEMBL
	Carbonic_anhydrase_a-class	UniProtKB/TrEMBL
	Carbonic_anhydrase_a-class_CS	UniProtKB/TrEMBL
NCBI Gene	Ca12	ENTREZGENE
PANTHER	PTHR18952	UniProtKB/TrEMBL
	PTHR18952:SF19	UniProtKB/TrEMBL
Pfam	Carb_anhydrase	UniProtKB/TrEMBL
PROSITE	ALPHA_CA_1	UniProtKB/TrEMBL
	ALPHA_CA_2	UniProtKB/TrEMBL
SMART	Carb_anhydrase	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51069	UniProtKB/TrEMBL
UniProt	A0A8C2VE25_CHILA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Ca12	carbonic anhydrase 12		carbonic anhydrase XII	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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