CA12 (carbonic anhydrase 12) - Rat Genome Database

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Gene: CA12 (carbonic anhydrase 12) Canis lupus familiaris
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Symbol: CA12
Name: carbonic anhydrase 12
RGD ID: 12291816
Description: ENCODES a protein that exhibits carbonate dehydratase activity (inferred); zinc ion binding (inferred); INVOLVED IN chloride ion homeostasis (inferred); ASSOCIATED WITH Bloom syndrome (ortholog); colon cancer (ortholog); hypertrophic cardiomyopathy (ortholog); FOUND IN integral component of membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13027,903,460 - 27,957,162 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3027,905,837 - 27,957,742 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3027,822,431 - 27,876,096 (-)NCBI
ROS_Cfam_1.03028,075,321 - 28,129,041 (-)NCBI
UMICH_Zoey_3.13028,012,749 - 28,066,343 (-)NCBI
UNSW_CanFamBas_1.03028,074,625 - 28,128,260 (-)NCBI
UU_Cfam_GSD_1.03028,311,867 - 28,365,995 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
CA12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13027,903,460 - 27,957,162 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3027,905,837 - 27,957,742 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3027,822,431 - 27,876,096 (-)NCBI
ROS_Cfam_1.03028,075,321 - 28,129,041 (-)NCBI
UMICH_Zoey_3.13028,012,749 - 28,066,343 (-)NCBI
UNSW_CanFamBas_1.03028,074,625 - 28,128,260 (-)NCBI
UU_Cfam_GSD_1.03028,311,867 - 28,365,995 (-)NCBI
CA12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1563,321,378 - 63,381,846 (-)EnsemblGRCh38hg38GRCh38
GRCh381563,321,378 - 63,381,846 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371563,613,577 - 63,674,045 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361561,402,783 - 61,461,128 (-)NCBINCBI36hg18NCBI36
Celera1540,494,364 - 40,552,718 (-)NCBI
Cytogenetic Map15q22.2NCBI
HuRef1540,438,444 - 40,496,766 (-)NCBIHuRef
CHM1_11563,732,628 - 63,793,404 (-)NCBICHM1_1
Car12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39966,619,026 - 66,674,127 (+)NCBIGRCm39mm39
GRCm39 Ensembl966,620,968 - 66,674,127 (+)Ensembl
GRCm38966,712,296 - 66,766,845 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl966,713,686 - 66,766,845 (+)EnsemblGRCm38mm10GRCm38
MGSCv37966,561,493 - 66,614,652 (+)NCBIGRCm37mm9NCBIm37
MGSCv36966,512,886 - 66,565,989 (+)NCBImm8
Celera963,948,029 - 64,000,964 (+)NCBICelera
Cytogenetic Map9CNCBI
Ca12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2867,274,739 - 67,330,428 (+)NCBI
Rnor_6.0 Ensembl872,405,748 - 72,460,240 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0872,405,770 - 72,461,425 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0872,071,988 - 72,127,646 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4871,017,732 - 71,070,729 (+)NCBIRGSC3.4rn4RGSC3.4
Celera866,660,144 - 66,713,076 (+)NCBICelera
Cytogenetic Map8q24NCBI
Ca12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545011,943,340 - 11,975,928 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545011,927,730 - 11,975,553 (+)NCBIChiLan1.0ChiLan1.0
CA12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11560,565,592 - 60,624,008 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1560,565,592 - 60,624,008 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01542,270,188 - 42,328,952 (-)NCBIMhudiblu_PPA_v0panPan3
Ca12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640106,028,826 - 106,081,389 (-)NCBI
SpeTri2.0NW_00493647123,876,889 - 23,929,720 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1108,649,271 - 108,710,651 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11108,649,277 - 108,710,658 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21119,822,275 - 119,904,112 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CA12
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12620,162,706 - 20,221,680 (+)NCBI
ChlSab1.1 Ensembl2620,162,926 - 20,224,502 (+)Ensembl
Ca12
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247819,140,753 - 9,195,651 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 10 4 6 4
Low 2 2 2 6 8 2 1
Below cutoff 5 10 6 6 6 4 4 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000026900   ⟹   ENSCAFP00000025003
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3027,916,836 - 27,957,742 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000026901   ⟹   ENSCAFP00000025004
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3027,905,837 - 27,939,553 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000066578   ⟹   ENSCAFP00000057765
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3027,905,837 - 27,957,742 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000073734   ⟹   ENSCAFP00000059017
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3027,905,837 - 27,957,742 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000078778   ⟹   ENSCAFP00000055172
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3027,914,955 - 27,957,742 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000081167   ⟹   ENSCAFP00000043814
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3027,905,837 - 27,957,156 (-)Ensembl
RefSeq Acc Id: XM_014109570   ⟹   XP_013965045
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13027,903,460 - 27,957,162 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022413036   ⟹   XP_022268744
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13027,903,460 - 27,939,573 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038442560   ⟹   XP_038298488
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03028,075,321 - 28,129,041 (-)NCBI
RefSeq Acc Id: XM_038517013   ⟹   XP_038372941
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13028,012,749 - 28,066,343 (-)NCBI
RefSeq Acc Id: XM_038580631   ⟹   XP_038436559
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03028,311,867 - 28,365,995 (-)NCBI
RefSeq Acc Id: XM_038644941   ⟹   XP_038500869
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03028,074,625 - 28,128,260 (-)NCBI
RefSeq Acc Id: XM_535507   ⟹   XP_535507
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13027,903,460 - 27,957,162 (-)NCBI
Dog10K_Boxer_Tasha3027,822,431 - 27,876,096 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038298488 (Get FASTA)   NCBI Sequence Viewer  
  XP_038372941 (Get FASTA)   NCBI Sequence Viewer  
  XP_038436559 (Get FASTA)   NCBI Sequence Viewer  
  XP_038500869 (Get FASTA)   NCBI Sequence Viewer  
  XP_535507 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013965045   ⟸   XM_014109570
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_535507   ⟸   XM_535507
- Sequence:
RefSeq Acc Id: XP_022268744   ⟸   XM_022413036
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCAFP00000055172   ⟸   ENSCAFT00000078778
RefSeq Acc Id: ENSCAFP00000059017   ⟸   ENSCAFT00000073734
RefSeq Acc Id: ENSCAFP00000057765   ⟸   ENSCAFT00000066578
RefSeq Acc Id: ENSCAFP00000025003   ⟸   ENSCAFT00000026900
RefSeq Acc Id: ENSCAFP00000025004   ⟸   ENSCAFT00000026901
RefSeq Acc Id: ENSCAFP00000043814   ⟸   ENSCAFT00000081167
RefSeq Acc Id: XP_038372941   ⟸   XM_038517013
RefSeq Acc Id: XP_038500869   ⟸   XM_038644941
RefSeq Acc Id: XP_038298488   ⟸   XM_038442560
RefSeq Acc Id: XP_038436559   ⟸   XM_038580631
Protein Domains
Alpha-carbonic anhydrase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016990 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000025003 UniProtKB/TrEMBL
  ENSCAFP00000025004 UniProtKB/TrEMBL
  ENSCAFP00000043814 UniProtKB/TrEMBL
  ENSCAFP00000055172 UniProtKB/TrEMBL
  ENSCAFP00000057765 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000059017 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000026900 UniProtKB/TrEMBL
  ENSCAFT00000026901 UniProtKB/TrEMBL
  ENSCAFT00000066578 UniProtKB/TrEMBL
  ENSCAFT00000073734 UniProtKB/TrEMBL
  ENSCAFT00000078778 UniProtKB/TrEMBL
  ENSCAFT00000081167 UniProtKB/TrEMBL
Gene3D-CATH 3.10.200.10 UniProtKB/TrEMBL
InterPro CA_dom UniProtKB/TrEMBL
  CA_dom_sf UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class_CS UniProtKB/TrEMBL
  Carbonic_anhydrase_CA12 UniProtKB/TrEMBL
NCBI Gene CA12 ENTREZGENE
PANTHER PTHR18952 UniProtKB/TrEMBL
  PTHR18952:SF19 UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/TrEMBL
PROSITE ALPHA_CA_1 UniProtKB/TrEMBL
  ALPHA_CA_2 UniProtKB/TrEMBL
SMART Carb_anhydrase UniProtKB/TrEMBL
Superfamily-SCOP SSF51069 UniProtKB/TrEMBL
UniProt A0A5F4BPV8_CANLF UniProtKB/TrEMBL
  A0A5F4CP29_CANLF UniProtKB/TrEMBL
  A0A5F4CXG0_CANLF UniProtKB/TrEMBL
  A0A5F4CYI0_CANLF UniProtKB/TrEMBL
  F1Q440_CANLF UniProtKB/TrEMBL
  F1Q441_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:38607 ENTREZGENE