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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306612
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Car12
Name: carbonic anhydrase 12
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Car12affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of CAR12 mRNAPMID:22298810
Car12decreases expressionISOCar12 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CAR12 mRNAPMID:33956508
Car12increases expressionISOCA12 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of CA12 mRNAPMID:19619570 PMID:20106945 PMID:21632981 PMID:21802500
Car12multiple interactionsISOCA12 (Homo sapiens)6480464CTD[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of CA12 mRNA; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CA12 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CA12 gene]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CA12 gene]PMID:19574409 PMID:19619570 PMID:26159488
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