Adm (adrenomedullin) - Rat Genome Database

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Gene: Adm (adrenomedullin) Rattus norvegicus
Analyze
Symbol: Adm
Name: adrenomedullin
RGD ID: 2047
Description: Enables adrenomedullin receptor binding activity. Involved in several processes, including androgen metabolic process; regulation of heart contraction; and response to insulin. Located in extracellular space. Used to study congestive heart failure and toxic shock syndrome. Biomarker of glomerulonephritis; hypertension; hypertrophic cardiomyopathy; obstructive jaundice; and ureteral obstruction. Human ortholog(s) of this gene implicated in brain infarction; breast cancer; pancreatic cancer; and pulmonary hypertension. Orthologous to human ADM (adrenomedullin); PARTICIPATES IN p38 MAPK signaling pathway; hypoxia inducible factor pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-hydroxy-5alpha-androstan-3-one.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adrenomedullin precursor; Ap; H39316; pro-adrenomedullin; RATAP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81174,164,178 - 174,182,372 (+)NCBIGRCr8
mRatBN7.21164,745,484 - 164,747,655 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,745,466 - 164,747,654 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1173,083,288 - 173,085,466 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01180,269,319 - 180,271,497 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01172,954,068 - 172,956,245 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01175,443,189 - 175,447,260 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1175,445,088 - 175,447,259 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01182,433,109 - 182,435,280 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41168,380,255 - 168,382,426 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11168,490,917 - 168,493,089 (+)NCBI
Celera1162,637,077 - 162,639,248 (+)NCBICelera
Cytogenetic Map1q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
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Original Reference(s)
AdmRatabdominal aortic aneurysm  ISOADM (Homo sapiens)1625299protein:increased expression:mast cell and abdominal aortaRGD 
AdmRatAcidoses  IDA 1625312associated with HemorrhageRGD 
AdmRatAlbuminuria  ISOADM (Homo sapiens)2313311associated with HypertensionRGD 
AdmRatbrain infarction treatmentISOADM (Homo sapiens)5508764 RGD 
AdmRatbreast cancer  ISOADM (Homo sapiens)2325318 RGD 
AdmRatCardiac Arrhythmias  IDA 1625318associated with Myocardial IschemiaRGD 
AdmRatcolorectal cancer  ISOADM (Homo sapiens)152985531mRNA and protein:increased expression:colorectum (human)RGD 
AdmRatcongestive heart failure  IDA 704370 RGD 
AdmRatCOVID-19  ISOADM (Homo sapiens)9068941mRNA:increased expression:bronchoalveolar lavage (human)RGDPMID:32407669 and REF_RGD_ID:30296672
AdmRatdiabetic retinopathy  ISOADM (Homo sapiens)2313312associated with Diabetes Mellitus more ...RGD 
AdmRatExperimental Diabetes Mellitus  IEP 1625296protein:increased expression:pigmented epithelial cell and retinaRGD 
AdmRatExperimental Liver Cirrhosis  IEP 1625319protein:increased expression:plasmaRGD 
AdmRatglomerulonephritis  IEP 1625317associated with Anti-Glomerular Basement Membrane DiseaseRGD 
AdmRatglomerulonephritis  IEP 2325320 RGD 
AdmRatHemorrhagic Shock  IEP 7364990 RGD 
AdmRatHemorrhagic Shock treatmentISOADM (Homo sapiens)7364987 RGD 
AdmRatHyperalgesia  IDA 1625316 RGD 
AdmRathyperinsulinism  ISOADM (Homo sapiens)1625301associated with Obesity and protein:increased expression:plasmaRGD 
AdmRathypertension  IEP 1625300mRNA more ...RGD 
AdmRathypertension  ISOADM (Homo sapiens)1625298protein:increased expression:plasmaRGD 
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Original Reference(s)
AdmRatautistic disorder  ISOADM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12579522
AdmRatExperimental Liver Cirrhosis  ISOADM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15370692 and PMID:16610064
AdmRatgastric ulcer  ISOADM (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:9845272
AdmRatglomerulonephritis  ISOADM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15063164 and PMID:15680492
AdmRatHyperalgesia  ISOADM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17043245
AdmRathyperglycemia  ISOADM (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:33491863
AdmRatInsulin Resistance  ISOADM (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:33491863
AdmRatPain  ISOADM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17043245
AdmRatpolycystic ovary syndrome  ISOADM (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:33491863
AdmRatSepsis  ISOADM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14766677
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1 to 20 of 334 rows

  
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Original Reference(s)
AdmRat(-)-epigallocatechin 3-gallate decreases secretionISOADM (Homo sapiens)6480464epigallocatechin gallate results in decreased secretion of ADM proteinCTDPMID:22178239
AdmRat1,2-dimethylhydrazine decreases expressionISOAdm (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of ADM mRNACTDPMID:22206623
AdmRat1-chloro-2,4-dinitrobenzene increases expressionISOADM (Homo sapiens)6480464Dinitrochlorobenzene results in increased expression of ADM mRNACTDPMID:25236440
AdmRat1-fluoro-2,4-dinitrobenzene increases expressionISOADM (Homo sapiens)6480464Dinitrofluorobenzene results in increased expression of ADM mRNACTDPMID:23999411
AdmRat17alpha-ethynylestradiol affects expressionISOAdm (Mus musculus)6480464Ethinyl Estradiol affects the expression of ADM mRNACTDPMID:17555576
AdmRat17alpha-ethynylestradiol multiple interactionsISOAdm (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADM mRNACTDPMID:17942748
AdmRat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of ADM mRNACTDPMID:12655037 and PMID:15834898
AdmRat17alpha-ethynylestradiol increases expressionISOAdm (Mus musculus)6480464Ethinyl Estradiol results in increased expression of ADM mRNACTDPMID:17942748
AdmRat17beta-estradiol affects expressionISOAdm (Mus musculus)6480464Estradiol affects the expression of ADM mRNACTDPMID:15598610
AdmRat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of ADM mRNACTDPMID:32145629
AdmRat17beta-estradiol decreases expressionISOADM (Homo sapiens)6480464Estradiol results in decreased expression of ADM mRNACTDPMID:17121429
AdmRat17beta-estradiol increases abundanceEXP 6480464ADM protein results in increased abundance of EstradiolCTDPMID:21824440
AdmRat17beta-estradiol multiple interactionsEXP 6480464[Testosterone co-treated with Estradiol] results in increased expression of ADM mRNA and ADM protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]CTDPMID:18401014 and PMID:32741896
AdmRat17beta-estradiol multiple interactionsISOADM (Homo sapiens)6480464[Estradiol binds to ESR2 protein] which results in decreased expression of ADM mRNA more ...CTDPMID:18401014 more ...
AdmRat17beta-estradiol affects expressionISOADM (Homo sapiens)6480464Estradiol affects the expression of ADM mRNACTDPMID:22574217
AdmRat17beta-hydroxy-5alpha-androstan-3-one multiple interactionsEXP 6480464VEGFA protein affects the reaction [Dihydrotestosterone results in increased expression of ADM mRNA]CTDPMID:17113911
AdmRat17beta-hydroxy-5alpha-androstan-3-one increases expressionEXP 6480464Dihydrotestosterone results in increased expression of ADM mRNACTDPMID:17113911
AdmRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOADM (Homo sapiens)6480464pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ADM mRNA]CTDPMID:20064835
AdmRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of ADM mRNACTDPMID:33387578
AdmRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of ADM mRNACTDPMID:34747641

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Biological Process
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Original Reference(s)
AdmRatadenylate cyclase-activating G protein-coupled receptor signaling pathway involved_inISOADM (Homo sapiens)1624291 PMID:10882736 more ...RGDPMID:10882736 more ...
AdmRatadenylate cyclase-activating G protein-coupled receptor signaling pathway involved_inIBAPANTHER:PTN000602075 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
AdmRatadrenomedullin receptor signaling pathway involved_inISOADM (Homo sapiens)1624291 PMID:10882736 more ...RGDPMID:10882736 more ...
AdmRatadrenomedullin receptor signaling pathway involved_inIBAPANTHER:PTN002764933 and UniProtKB:P353181600115GO_REF:0000033GO_CentralGO_REF:0000033
AdmRatandrogen metabolic process  IDA 2325639 RGD 
AdmRatanimal organ regeneration  IEP 1625331 RGD 
AdmRatantimicrobial humoral immune response mediated by antimicrobial peptide involved_inISOADM (Homo sapiens) and UniProtKB:P35318-PRO_00000009631624291 PMID:10225288RGDPMID:10225288
AdmRatbranching involved in labyrinthine layer morphogenesis acts_upstream_of_or_withinISOAdm (Mus musculus)1624291MGI:2176598 PMID:16981008RGDPMID:16981008
AdmRatcell population proliferation acts_upstream_ofISOAdm (Mus musculus)1624291MGI:2176598 PMID:16537897RGDPMID:16537897
AdmRatcellular response to xenobiotic stimulus  IEP 628358 RGD 
AdmRatdevelopmental growth acts_upstream_of_or_withinISOAdm (Mus musculus)1624291MGI:2176598 PMID:16981008RGDPMID:16981008
AdmRatfemale pregnancy  IEP 1625327 RGD 
AdmRatG protein-coupled receptor internalization involved_inISOADM (Homo sapiens)1624291 PMID:10882736RGDPMID:10882736
AdmRatheart development involved_inISOAdm (Mus musculus)1624291 PMID:18097473RGDPMID:18097473
AdmRatheart development acts_upstream_of_or_withinISOAdm (Mus musculus)1624291MGI:2176598 PMID:16537897 and PMID:16981008RGDPMID:16537897 and PMID:16981008
AdmRatnegative regulation of cell population proliferation  IMP 1625329 RGD 
AdmRatnegative regulation of vascular permeability involved_inISOAdm (Mus musculus)1624291 PMID:18097473RGDPMID:18097473
AdmRatnegative regulation of vasoconstriction involved_inISOADM (Homo sapiens)1624291 PMID:11410113RGDPMID:11410113
AdmRatneural tube closure acts_upstream_of_or_withinISOAdm (Mus musculus)1624291MGI:2176598 PMID:16981008RGDPMID:16981008
AdmRatneuron projection regeneration  IMP 1625313 RGD 
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Cellular Component

  
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Original Reference(s)
AdmRatcytoplasm located_inISOADM (Homo sapiens)1624291 PMID:12379507RGDPMID:12379507
AdmRatextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
AdmRatextracellular region located_inIEAInterPro:IPR001710 and InterPro:IPR0211161600115GO_REF:0000002InterProGO_REF:0000002
AdmRatextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
AdmRatextracellular space  IDA 1625328 RGD 
AdmRatextracellular space is_active_inIBAPANTHER:PTN002764933 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
AdmRatextracellular space located_inISOADM (Homo sapiens)1624291 PMID:12379507RGDPMID:12379507
AdmRatextracellular space located_inISOADM (Homo sapiens) and UniProtKB:P35318-PRO_00000009631624291 PMID:10225288RGDPMID:10225288

Molecular Function

  

RGD Manual Annotations


  
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Original Reference(s)
AdmRatp38 MAPK signaling pathway   IMP 1625329 RGD 

Imported Annotations - PID (archival)

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Original Reference(s)
AdmRathypoxia inducible factor pathway   ISOADM (Homo sapiens)6484113 PIDPID:200202

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#
Reference Title
Reference Citation
1. The effect of vitamin E, L-arginine, N-nitro L-arginine methyl ester and forskolin on endocrine and metabolic changes of rats exposed to acute cold stress. Al-Ayadhi LY, etal., Saudi Med J. 2006 Jan;27(1):17-22.
2. Mid-regional pro-adrenomedullin is associated with pulse pressure, left ventricular mass, and albuminuria in African Americans with hypertension. Al-Omari MA, etal., Am J Hypertens. 2009 Aug;22(8):860-6. Epub 2009 May 7.
3. Adrenomedullin and vascular endothelium growth factor genes are overexpressed in the regenerating rat adrenal cortex, and AM and VEGF reciprocally enhance their mRNA expression in cultured rat adrenocortical cells. Albertin G, etal., Int J Mol Med. 2005 Sep;16(3):431-5.
4. ZD6474 inhibits tumor growth and intraperitoneal dissemination in a highly metastatic orthotopic gastric cancer model. Arao T, etal., Int J Cancer. 2006 Jan 15;118(2):483-9. doi: 10.1002/ijc.21340.
5. Vasodilator mRNA levels are increased in the livers of portal hypertensive NO-synthase 3-deficient mice. Biecker E, etal., Eur J Clin Invest. 2004 Apr;34(4):283-9.
6. Plasma adrenomedullin concentrations in patients with renovascular or malignant hypertension. Caliumi C, etal., Minerva Cardioangiol. 2004 Aug;52(4):313-22.
7. Plasma levels of adrenomedullin, a vasoactive peptide, in type 2 diabetic patients with and without retinopathy. Caliumi C, etal., Minerva Endocrinol. 2007 Jun;32(2):73-8.
8. Adrenomedullin and adrenomedullin-binding protein-1 downregulate inflammatory cytokines and attenuate tissue injury after gut ischemia-reperfusion. Carrizo GJ, etal., Surgery. 2007 Feb;141(2):245-53. Epub 2006 Sep 14.
9. Adrenomedullin in the rat testis. I: Its production, actions on testosterone secretion, regulation by human chorionic gonadotropin, and its interaction with endothelin 1 in the leydig cell. Chan YF, etal., Biol Reprod. 2008 Apr;78(4):773-9. Epub 2007 Dec 19.
10. Peripheral administration of human adrenomedullin and its binding protein attenuates stroke-induced apoptosis and brain injury in rats. Chaung WW, etal., Mol Med. 2011;17(9-10):1075-83. doi: 10.2119/molmed.2010.00104. Epub 2011 Jun 17.
11. Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure. Cueille C, etal., Biochem Biophys Res Commun 2002 Jun 7;294(2):340-6.
12. Hypoxic induction of receptor activity-modifying protein 2 alters regulation of pulmonary endothelin-1 by adrenomedullin: induction under normoxia versus inhibition under hypoxia. Dschietzig T, etal., J Pharmacol Exp Ther. 2007 Apr;321(1):409-19. Epub 2007 Jan 24.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Effects of Adrenomedullin on the Glomerular Adrenomedullin System in a Rat Model of Anti-Thy1 Glomerulonephritis. Geissler B, etal., Nephron Exp Nephrol. 2010 Apr 30;115(3):e80-e88.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Adrenomedullin inhibits adipogenesis under transcriptional control of insulin. Harmancey R, etal., Diabetes. 2007 Mar;56(3):553-63.
17. Changes in expression of adrenomedullin in the myocardium of streptozotocin-induced diabetic rats. He RX, etal., Chin Med J (Engl). 2007 Feb 5;120(3):187-91.
18. Adrenomedullin production is increased in colorectal adenocarcinomas; its relation to matrix metalloproteinase-9. Hikosaka T, etal., Peptides. 2011 Sep;32(9):1825-31. doi: 10.1016/j.peptides.2011.07.012. Epub 2011 Aug 3.
19. Adrenomedullin facilitates reinnervation of phenol-injured perivascular nerves in the rat mesenteric resistance artery. Hobara N, etal., Neuroscience. 2007 Jan 19;144(2):721-30. Epub 2006 Nov 13.
20. Possible involvement of adrenomedullin in lipopolysaccharide-induced small-intestinal motility changes in conscious rats. Hussain S, etal., J Gastroenterol. 2005 Dec;40(12):1123-9.
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PMID:7690563   PMID:10225288   PMID:10882736   PMID:11410113   PMID:11556887   PMID:11927154   PMID:11954957   PMID:11963825   PMID:12060855   PMID:12126744   PMID:12165411   PMID:12379507  
PMID:12419522   PMID:12491794   PMID:12573799   PMID:12574099   PMID:12606469   PMID:12630816   PMID:12732346   PMID:12906842   PMID:12913064   PMID:14715486   PMID:14715505   PMID:14717924  
PMID:14766677   PMID:15005274   PMID:15070851   PMID:15192039   PMID:15256273   PMID:15271873   PMID:15315911   PMID:15489334   PMID:15511634   PMID:15576460   PMID:15579624   PMID:15613468  
PMID:15619030   PMID:15623431   PMID:15680493   PMID:15752540   PMID:15913808   PMID:15949644   PMID:15962372   PMID:16040721   PMID:16337713   PMID:16389603   PMID:16537897   PMID:16596251  
PMID:16672720   PMID:16821090   PMID:16964401   PMID:16981008   PMID:17645630   PMID:17786287   PMID:17898545   PMID:17932560   PMID:18094364   PMID:18097473   PMID:18401014   PMID:18434369  
PMID:18685068   PMID:19636336   PMID:19681873   PMID:19738161   PMID:19823891   PMID:20074556   PMID:20802507   PMID:20844145   PMID:21034462   PMID:21173072   PMID:21595896   PMID:21664393  
PMID:21824440   PMID:21958875   PMID:22021555   PMID:22042486   PMID:22365702   PMID:22500019   PMID:22956308   PMID:23939287   PMID:24177018   PMID:24505304   PMID:25061099   PMID:25781901  
PMID:25990643   PMID:26259851   PMID:27184601   PMID:27737007   PMID:30366012   PMID:31489964   PMID:34978596  



Adm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81174,164,178 - 174,182,372 (+)NCBIGRCr8
mRatBN7.21164,745,484 - 164,747,655 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,745,466 - 164,747,654 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1173,083,288 - 173,085,466 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01180,269,319 - 180,271,497 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01172,954,068 - 172,956,245 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01175,443,189 - 175,447,260 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1175,445,088 - 175,447,259 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01182,433,109 - 182,435,280 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41168,380,255 - 168,382,426 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11168,490,917 - 168,493,089 (+)NCBI
Celera1162,637,077 - 162,639,248 (+)NCBICelera
Cytogenetic Map1q33NCBI
ADM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381110,305,073 - 10,307,397 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1110,305,073 - 10,307,397 (+)EnsemblGRCh38hg38GRCh38
GRCh371110,326,620 - 10,328,944 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,283,218 - 10,285,499 (+)NCBINCBI36Build 36hg18NCBI36
Build 341110,283,217 - 10,285,499NCBI
Celera1110,448,490 - 10,450,771 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef119,999,508 - 10,001,789 (+)NCBIHuRef
CHM1_11110,324,758 - 10,327,040 (+)NCBICHM1_1
T2T-CHM13v2.01110,389,576 - 10,391,900 (+)NCBIT2T-CHM13v2.0
Adm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397110,226,864 - 110,229,027 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7110,226,868 - 110,229,027 (+)EnsemblGRCm39 Ensembl
GRCm387110,627,657 - 110,629,820 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7110,627,661 - 110,629,820 (+)EnsemblGRCm38mm10GRCm38
MGSCv377117,771,183 - 117,773,333 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367110,418,846 - 110,420,996 (+)NCBIMGSCv36mm8
Celera7110,600,687 - 110,602,837 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map757.7NCBI
Adm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541425,951,349 - 25,953,645 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541425,951,473 - 25,953,593 (+)NCBIChiLan1.0ChiLan1.0
ADM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2912,745,404 - 12,748,234 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11112,705,550 - 12,710,554 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01110,437,712 - 10,440,053 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11110,165,423 - 10,167,842 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1110,165,418 - 10,167,842 (+)Ensemblpanpan1.1panPan2
ADM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12133,472,197 - 33,474,472 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2133,471,623 - 33,474,495 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2133,038,463 - 33,040,738 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02134,350,243 - 34,352,518 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2134,350,217 - 34,352,540 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12133,612,009 - 33,614,284 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02133,781,446 - 33,783,719 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02134,074,331 - 34,076,606 (+)NCBIUU_Cfam_GSD_1.0
Adm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494751,971,243 - 51,973,608 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365288,005,189 - 8,007,643 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365288,005,223 - 8,007,586 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl249,229,223 - 49,231,866 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1249,229,223 - 49,231,521 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2252,576,219 - 52,578,518 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1154,518,359 - 54,520,683 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl154,518,358 - 54,520,686 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038152,185,898 - 152,188,305 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247662,401,769 - 2,404,446 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247662,402,152 - 2,404,343 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Adm
4 total Variants

Predicted Target Of
Summary Value
Count of predictions:165
Count of miRNA genes:118
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000036718
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 77 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat

1 to 10 of 77 rows
D1Wox34  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81174,182,140 - 174,182,274 (+)Marker Load Pipeline
mRatBN7.21164,747,424 - 164,747,558 (+)MAPPERmRatBN7.2
Rnor_6.01175,447,029 - 175,447,162NCBIRnor6.0
Rnor_5.01182,435,050 - 182,435,183UniSTSRnor5.0
RGSC_v3.41168,382,195 - 168,382,329RGDRGSC3.4
RGSC_v3.41168,382,196 - 168,382,329UniSTSRGSC3.4
RGSC_v3.11168,492,858 - 168,492,992RGD
Celera1162,639,018 - 162,639,151UniSTS
RH 3.4 Map11338.3RGD
RH 3.4 Map11338.3UniSTS
RH 2.0 Map1910.1RGD
Cytogenetic Map1q33UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000036718   ⟹   ENSRNOP00000035811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1164,745,466 - 164,747,654 (+)Ensembl
Rnor_6.0 Ensembl1175,445,088 - 175,447,259 (+)Ensembl
RefSeq Acc Id: NM_012715   ⟹   NP_036847
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81174,180,200 - 174,182,371 (+)NCBI
mRatBN7.21164,745,484 - 164,747,655 (+)NCBI
Rnor_6.01175,445,088 - 175,447,259 (+)NCBI
Rnor_5.01182,433,109 - 182,435,280 (+)NCBI
RGSC_v3.41168,380,255 - 168,382,426 (+)RGD
Celera1162,637,077 - 162,639,248 (+)RGD
Sequence:
RefSeq Acc Id: XM_063281152   ⟹   XP_063137222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81174,164,178 - 174,182,372 (+)NCBI
RefSeq Acc Id: XM_063281156   ⟹   XP_063137226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81174,178,258 - 174,182,372 (+)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_036847 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137222 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137226 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB60519 (Get FASTA)   NCBI Sequence Viewer  
  AAH61775 (Get FASTA)   NCBI Sequence Viewer  
  BAA03665 (Get FASTA)   NCBI Sequence Viewer  
  EDM17863 (Get FASTA)   NCBI Sequence Viewer  
  EDM17864 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000035811.1
GenBank Protein P43145 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_036847   ⟸   NM_012715
- Peptide Label: precursor
- UniProtKB: P43145 (UniProtKB/Swiss-Prot),   A6I816 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035811   ⟸   ENSRNOT00000036718
RefSeq Acc Id: XP_063137222   ⟸   XM_063281152
- Peptide Label: isoform X1
- UniProtKB: P43145 (UniProtKB/Swiss-Prot),   A6I816 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137226   ⟸   XM_063281156
- Peptide Label: isoform X1
- UniProtKB: P43145 (UniProtKB/Swiss-Prot),   A6I816 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-P43145-F1-model_v2 AlphaFold P43145 1-185 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690314
Promoter ID:EPDNEW_R839
Type:single initiation site
Name:Adm_1
Description:adrenomedullin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01175,445,070 - 175,445,130EPDNEW


1 to 21 of 21 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-57834 BioCyc
Ensembl Genes ENSRNOG00000027030 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000036718.2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5621783 IMAGE-MGC_LOAD
InterPro Adrenomedullin UniProtKB/Swiss-Prot
  Adrenomedullin-reg_peptide UniProtKB/Swiss-Prot
  Calcitonin/adrenomedullin UniProtKB/Swiss-Prot
KEGG Report rno:25026 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72547 IMAGE-MGC_LOAD
NCBI Gene 25026 ENTREZGENE
PANTHER ADRENOMEDULLIN, ADM UniProtKB/Swiss-Prot
  PRO-ADRENOMEDULLIN UniProtKB/Swiss-Prot
Pfam Calc_CGRP_IAPP UniProtKB/Swiss-Prot
PharmGKB ADM RGD
PhenoGen Adm PhenoGen
PRINTS ADRENOMEDULN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000027030 RatGTEx
TIGR TC234620
UniProt A6I816 ENTREZGENE, UniProtKB/TrEMBL
  A6I817_RAT UniProtKB/TrEMBL
  ADML_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 21 of 21 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Adm  adrenomedullin      Symbol and Name status set to approved 70586 APPROVED
2001-04-19 Ap  Adrenomedullin precursor      Symbol withdrawn, duplicate entry of Adm (RGD:2047) 61478 WITHDRAWN

Note Type Note Reference
gene_disease may be involved in the progression of ischemic brain damage in a model for stroke 69742
gene_expression expressed in atria and ventricles of the heart 625420
gene_expression expressed in brain cortex 69742
gene_expression expressed in the adrenal zona glomerulosa 631805
gene_function has vasodilator activity 632209
gene_process required for embryonic growth and development 632209
gene_process involved in regulation of adrenal development 631805
gene_process inhibits the apoptotic effects of doxorubicin on cardiomyocytes and suppresses the doxorubicin-induced effects of DNA fragmentation and caspase-3 activation in cardiomyocytes 628358
gene_process capable of acting as a hormone 628358
gene_process has a protective role against cardiomyocyte injury through a cAMP-dependent mechanism 628358
gene_product member of the calcitonin gene-related peptide family 69742
gene_protein 52 amino acids 628358