RGD Reference Report - RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. - Rat Genome Database

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RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor.

Authors: McLatchie, LM  Fraser, NJ  Main, MJ  Wise, A  Brown, J  Thompson, N  Solari, R  Lee, MG  Foord, SM 
Citation: McLatchie LM, etal., Nature. 1998 May 28;393(6683):333-9.
RGD ID: 8553905
Pubmed: PMID:9620797   (View Abstract at PubMed)
DOI: DOI:10.1038/30666   (Journal Full-text)

Calcitonin-gene-related peptide (CGRP) and adrenomedullin are related peptides with distinct pharmacological profiles. Here we show that a receptor with seven transmembrane domains, the calcitonin-receptor-like receptor (CRLR), can function as either a CGRP receptor or an adrenomedullin receptor, depending on which members of a new family of single-transmembrane-domain proteins, which we have called receptor-activity-modifying proteins or RAMPs, are expressed. RAMPs are required to transport CRLR to the plasma membrane. RAMP1 presents the receptor at the cell surface as a mature glycoprotein and a CGRP receptor. RAMP2-transported receptors are core-glycosylated and are adrenomedullin receptors.




Molecular Function

  
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Original Reference(s)
AdmRatprotein binding enablesIPIUniProtKB:O60895PMID:9620797UniProt 


Genes (Rattus norvegicus)
Adm  (adrenomedullin)