ADM (adrenomedullin) - Rat Genome Database

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Gene: ADM (adrenomedullin) Canis lupus familiaris
Analyze
Symbol: ADM
Name: adrenomedullin
RGD ID: 12298314
Description: ENCODES a protein that exhibits adrenomedullin receptor binding (ortholog); INVOLVED IN aging (ortholog); androgen metabolic process (ortholog); animal organ regeneration (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; p38 MAPK signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acidoses (ortholog); Albuminuria (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: pro-adrenomedullin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12133,472,197 - 33,474,472 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2133,471,623 - 33,474,495 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2133,038,463 - 33,040,738 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02134,350,243 - 34,352,518 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2134,350,217 - 34,352,540 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12133,612,009 - 33,614,284 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02133,781,446 - 33,783,719 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02134,074,331 - 34,076,606 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA)
adrenomedullin receptor signaling pathway  (IEA)
aging  (ISO)
amylin receptor signaling pathway  (IEA)
androgen metabolic process  (ISO)
animal organ regeneration  (ISO)
antibacterial humoral response  (ISO)
antifungal humoral response  (ISO)
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
branching involved in labyrinthine layer morphogenesis  (IEA,ISO)
calcium ion homeostasis  (ISO)
cAMP-mediated signaling  (ISO)
cell population proliferation  (ISO)
defense response to Gram-negative bacterium  (ISO)
defense response to Gram-positive bacterium  (ISO)
developmental growth  (IEA,ISO)
female pregnancy  (ISO)
G protein-coupled receptor internalization  (IEA)
heart development  (IEA,ISO)
hormone secretion  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of vascular permeability  (IEA)
negative regulation of vasoconstriction  (IEA)
neural tube closure  (IEA,ISO)
neuron projection regeneration  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
positive regulation of angiogenesis  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of heart rate  (IEA,ISO)
positive regulation of vasculogenesis  (IEA)
receptor internalization  (ISO)
regulation of systemic arterial blood pressure  (IEA)
regulation of the force of heart contraction  (ISO)
regulation of urine volume  (IEA)
response to cold  (ISO)
response to glucocorticoid  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to organic substance  (ISO)
response to starvation  (ISO)
response to wounding  (ISO)
response to yeast  (ISO)
signal transduction  (IEA)
spongiotrophoblast layer development  (IEA,ISO)
vascular associated smooth muscle cell development  (IEA)
vasculogenesis  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:9788655   PMID:9822453  


Genomics

Comparative Map Data
ADM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12133,472,197 - 33,474,472 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2133,471,623 - 33,474,495 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2133,038,463 - 33,040,738 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02134,350,243 - 34,352,518 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2134,350,217 - 34,352,540 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12133,612,009 - 33,614,284 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02133,781,446 - 33,783,719 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02134,074,331 - 34,076,606 (+)NCBIUU_Cfam_GSD_1.0
ADM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381110,305,073 - 10,307,397 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1110,305,073 - 10,307,397 (+)EnsemblGRCh38hg38GRCh38
GRCh371110,326,620 - 10,328,944 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,283,218 - 10,285,499 (+)NCBINCBI36Build 36hg18NCBI36
Build 341110,283,217 - 10,285,499NCBI
Celera1110,448,490 - 10,450,771 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef119,999,508 - 10,001,789 (+)NCBIHuRef
CHM1_11110,324,758 - 10,327,040 (+)NCBICHM1_1
T2T-CHM13v2.01110,389,576 - 10,391,900 (+)NCBIT2T-CHM13v2.0
Adm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397110,226,864 - 110,229,027 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7110,226,868 - 110,229,027 (+)EnsemblGRCm39 Ensembl
GRCm387110,627,657 - 110,629,820 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7110,627,661 - 110,629,820 (+)EnsemblGRCm38mm10GRCm38
MGSCv377117,771,183 - 117,773,333 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367110,418,846 - 110,420,996 (+)NCBIMGSCv36mm8
Celera7110,600,687 - 110,602,837 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map757.7NCBI
Adm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21164,745,484 - 164,747,655 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,745,466 - 164,747,654 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1173,083,288 - 173,085,466 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01180,269,319 - 180,271,497 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01172,954,068 - 172,956,245 (+)NCBIRnor_WKY
Rnor_6.01175,443,189 - 175,447,260 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1175,445,088 - 175,447,259 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01182,433,109 - 182,435,280 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41168,380,255 - 168,382,426 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11168,490,917 - 168,493,089 (+)NCBI
Celera1162,637,077 - 162,639,248 (+)NCBICelera
Cytogenetic Map1q33NCBI
Adm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541425,951,349 - 25,953,645 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541425,951,473 - 25,953,593 (+)NCBIChiLan1.0ChiLan1.0
ADM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11110,165,423 - 10,167,842 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1110,165,418 - 10,167,842 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01110,437,712 - 10,440,053 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Adm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494751,971,243 - 51,973,608 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365288,005,223 - 8,007,586 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl249,229,223 - 49,231,866 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1249,229,223 - 49,231,521 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2252,576,219 - 52,578,518 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1154,518,359 - 54,520,683 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl154,518,358 - 54,520,686 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038152,185,898 - 152,188,305 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247662,401,769 - 2,404,446 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247662,402,152 - 2,404,343 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 4 7 6 4 6
Low 1 1 15 6 6 6 6 12 6
Below cutoff 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000012064   ⟹   ENSCAFP00000011183
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2133,471,623 - 33,474,495 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845025906   ⟹   ENSCAFP00845020421
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2134,350,217 - 34,352,540 (+)Ensembl
RefSeq Acc Id: NM_001003183   ⟹   NP_001003183
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12133,472,197 - 33,474,472 (+)NCBI
Dog10K_Boxer_Tasha2133,038,463 - 33,040,738 (+)NCBI
ROS_Cfam_1.02134,350,243 - 34,352,518 (+)NCBI
UMICH_Zoey_3.12133,612,009 - 33,614,284 (+)NCBI
UNSW_CanFamBas_1.02133,781,446 - 33,783,719 (+)NCBI
UU_Cfam_GSD_1.02134,074,331 - 34,076,606 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001003183 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD05423 (Get FASTA)   NCBI Sequence Viewer  
  AAD09957 (Get FASTA)   NCBI Sequence Viewer  
  BAD52304 (Get FASTA)   NCBI Sequence Viewer  
  O77559 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001003183   ⟸   NM_001003183
- Peptide Label: precursor
- UniProtKB: Q9TVC9 (UniProtKB/Swiss-Prot),   O77559 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000011183   ⟸   ENSCAFT00000012064
RefSeq Acc Id: ENSCAFP00845020421   ⟸   ENSCAFT00845025906

Promoters
RGD ID:13687244
Promoter ID:EPDNEW_C5313
Type:single initiation site
Name:ADM_1
Description:adrenomedullin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12133,472,171 - 33,472,231EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007539 Ensembl
  ENSCAFG00030005052 UniProtKB/TrEMBL
  ENSCAFG00040012387 UniProtKB/TrEMBL
  ENSCAFG00845014478 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030008172.1 UniProtKB/TrEMBL
  ENSCAFP00040019820 UniProtKB/TrEMBL
  ENSCAFP00845020421 ENTREZGENE
  ENSCAFP00845020421.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030009324.1 UniProtKB/TrEMBL
  ENSCAFT00040022874 UniProtKB/TrEMBL
  ENSCAFT00845025906 ENTREZGENE
  ENSCAFT00845025906.1 UniProtKB/TrEMBL
InterPro Calcitonin/adrenomedullin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pro-ADM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403817 UniProtKB/Swiss-Prot
NCBI Gene ADM ENTREZGENE
Pfam Calc_CGRP_IAPP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ADRENOMEDULN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0RCZ9_CANLF UniProtKB/TrEMBL
  A0A8I3RY48_CANLF UniProtKB/TrEMBL
  ADML_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
  Q9TVC9 ENTREZGENE
UniProt Secondary Q9TVC9 UniProtKB/Swiss-Prot
VGNC ID VGNC:37660 ENTREZGENE