RGD Reference Report - Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist. - Rat Genome Database

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Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist.

Authors: Miseki, T  Kawakami, H  Natsuizaka, M  Darmanin, S  Cui, HY  Chen, J  Fu, Q  Okada, F  Shindo, M  Higashino, F  Asaka, M  Hamuro, J  Kobayashi, M 
Citation: Miseki T, etal., Cancer Gene Ther. 2007 Jan;14(1):39-44. Epub 2006 Jul 14.
RGD ID: 2325318
Pubmed: PMID:16841081   (View Abstract at PubMed)
DOI: DOI:10.1038/sj.cgt.7700979   (Journal Full-text)

We have recently reported that the intra-tumoral injection of adrenomedullin (AM) antagonist (AMA; AM (22-52)) peptides significantly reduced the in vivo growth of a pancreatic cancer cell line in severely combined immunodeficient (SCID) mice. In the present study, we examined the effects of intra-tumoral and intra-muscular transfers of naked DNA encoding AMA on the in vivo growth of cancer cell lines. We demonstrate that these treatments induce the regression of a pancreatic cancer cell line and a breast cancer cell line inoculated in SCID mice. Furthermore, CD31-positive cells disappear completely from tumor tissues, following treatment, indicating that neo-vascularization is entirely inhibited. These results suggest that the intra-tumoral or intra-muscular transfer of naked DNA encoding AMA might be a promising alternative modality for treating human cancers.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
breast cancer  IMP 2325318 RGD 
breast cancer  ISOADM (Homo sapiens)2325318; 2325318 RGD 
pancreatic cancer  IMP 2325318 RGD 
pancreatic cancer  ISOADM (Homo sapiens)2325318; 2325318 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adm  (adrenomedullin)

Genes (Mus musculus)
Adm  (adrenomedullin)

Genes (Homo sapiens)
ADM  (adrenomedullin)


Additional Information