ADM (adrenomedullin) - Rat Genome Database

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Gene: ADM (adrenomedullin) Homo sapiens
Analyze
Symbol: ADM
Name: adrenomedullin
RGD ID: 730917
HGNC Page HGNC
Description: Enables adrenomedullin receptor binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; defense response to bacterium; and regulation of blood circulation. Located in cytoplasm and extracellular space. Implicated in brain infarction; breast cancer; pancreatic cancer; and pulmonary hypertension. Biomarker of several diseases, including artery disease (multiple); diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and obesity.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AM; PAMP; preproadrenomedullin; pro-adrenomedullin; proadrenomedullin N-20 terminal peptide
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1110,305,073 - 10,307,397 (+)EnsemblGRCh38hg38GRCh38
GRCh381110,305,073 - 10,307,397 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371110,326,620 - 10,328,944 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,283,218 - 10,285,499 (+)NCBINCBI36hg18NCBI36
Build 341110,283,217 - 10,285,499NCBI
Celera1110,448,490 - 10,450,771 (+)NCBI
Cytogenetic Map11p15.4NCBI
HuRef119,999,508 - 10,001,789 (+)NCBIHuRef
CHM1_11110,324,758 - 10,327,040 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-fluoro-2,4-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (EXP)
2-butoxyethanol  (ISO)
2-hydroxyethyl methacrylate  (EXP)
2-hydroxypropanoic acid  (EXP)
2-methylcholine  (EXP)
3',5'-cyclic AMP  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
acrolein  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (EXP)
alpha-Sanshool  (ISO)
ammonium chloride  (ISO)
antimony(0)  (EXP)
antimycin A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
azathioprine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
bortezomib  (EXP)
bucladesine  (EXP)
buta-1,3-diene  (ISO)
Butylparaben  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbamazepine  (EXP)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
chloropicrin  (EXP)
chloroprene  (ISO)
chromium atom  (EXP)
chrysene  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
Deguelin  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (ISO)
diethyl maleate  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
diphenylcyclopropenone  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
diquat  (EXP)
disulfiram  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
ethanol  (EXP)
ferric oxide  (ISO)
fingolimod hydrochloride  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (EXP)
furan  (ISO)
hydrogen peroxide  (EXP)
ionomycin  (EXP,ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
leflunomide  (EXP)
letrozole  (ISO)
Licochalcone B  (EXP)
lipopolysaccharide  (EXP,ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP,ISO)
mercaptopurine  (ISO)
mercury atom  (EXP)
mercury dibromide  (EXP)
mercury dichloride  (ISO)
mercury(0)  (EXP)
metacetamol  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (EXP)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
mycophenolic acid  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP)
nitrates  (EXP)
nitric oxide  (ISO)
nitrofen  (ISO)
nitroprusside  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phenobarbital  (EXP)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (EXP)
piroxicam  (EXP)
potassium chromate  (EXP)
potassium dichromate  (EXP)
progesterone  (EXP,ISO)
propranolol  (ISO)
prostaglandin E2  (EXP)
purine-6-thiol  (ISO)
quercetin  (EXP)
quinapril hydrochloride  (ISO)
quinolin-8-ol  (EXP)
rac-lactic acid  (EXP)
resveratrol  (EXP)
riddelliine  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
SB 431542  (EXP)
SCH772984  (ISO)
serpentine asbestos  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
Soman  (ISO)
staurosporine  (EXP)
succimer  (ISO)
sulforaphane  (EXP)
sulindac sulfide  (EXP)
sunitinib  (EXP)
tamoxifen  (ISO)
tebufenpyrad  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (EXP)
thimerosal  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (ISO)
tributyl phosphate  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP)
tunicamycin  (EXP)
urethane  (EXP)
valproic acid  (EXP,ISO)
vandetanib  (EXP)
vorinostat  (EXP)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IDA,IGI)
adrenomedullin receptor signaling pathway  (IDA)
aging  (IEA,ISO)
amylin receptor signaling pathway  (IGI)
androgen metabolic process  (IEA,ISO)
animal organ regeneration  (IEA,ISO)
antibacterial humoral response  (IDA)
antifungal humoral response  (IDA)
antimicrobial humoral immune response mediated by antimicrobial peptide  (IDA)
branching involved in labyrinthine layer morphogenesis  (IEA,ISO)
calcium ion homeostasis  (ISO)
cAMP-mediated signaling  (IEA,ISO)
defense response to Gram-negative bacterium  (IDA)
defense response to Gram-positive bacterium  (IDA)
developmental growth  (IEA,ISO)
female pregnancy  (IEA,ISO)
G protein-coupled receptor internalization  (IDA)
heart development  (IEA,ISO)
hormone secretion  (IEA,ISO)
inflammatory response  (TAS)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of vascular permeability  (IEA)
negative regulation of vasoconstriction  (IDA)
neural tube closure  (IEA,ISO)
neuron projection regeneration  (IEA,ISO)
odontogenesis of dentin-containing tooth  (IEA,ISO)
positive regulation of angiogenesis  (IEA)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO)
positive regulation of heart rate  (IDA,ISO)
positive regulation of progesterone biosynthetic process  (TAS)
positive regulation of vasculogenesis  (IEA)
receptor internalization  (IDA)
regulation of systemic arterial blood pressure  (IDA)
regulation of the force of heart contraction  (IEA,ISO)
regulation of urine volume  (IDA)
response to cold  (IEA,ISO)
response to glucocorticoid  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to insulin  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to organic substance  (ISO)
response to starvation  (IEA,ISO)
response to wounding  (IEA,ISO)
response to yeast  (IDA)
signal transduction  (IEA,TAS)
spongiotrophoblast layer development  (IEA,ISO)
vascular associated smooth muscle cell development  (IEA)
vasculogenesis  (IDA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
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4. Caliumi C, etal., Minerva Endocrinol. 2007 Jun;32(2):73-8.
5. Carrizo GJ, etal., Surgery. 2007 Feb;141(2):245-53. Epub 2006 Sep 14.
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8. GOA_HUMAN data from the GO Consortium
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14. Letizia C, etal., Exp Clin Endocrinol Diabetes. 2005 Mar;113(3):171-5.
15. Looi YH, etal., Br J Pharmacol. 2006 Jul;148(5):599-609. Epub 2006 May 22.
16. Ma W, etal., Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):16027-32. Epub 2006 Oct 16.
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19. Nagaya N, etal., Circulation. 2004 Jan 27;109(3):351-6. Epub 2004 Jan 12.
20. Nishikimi T, etal., Hypertension 2003 Mar;41(3):512-8.
21. Norregaard R, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Jan;296(1):R185-92. Epub 2008 Oct 22.
22. Pan ChS, etal., Basic Res Cardiol. 2006 May;101(3):193-203. Epub 2006 Feb 6.
23. Paulmyer-Lacroix O, etal., Eur J Endocrinol. 2006 Jul;155(1):177-85.
24. Petkeviciene J, etal., PLoS One. 2014 Oct 14;9(10):e109974. doi: 10.1371/journal.pone.0109974. eCollection 2014.
25. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. Ramachandran V, etal., Cancer Res. 2007 Mar 15;67(6):2666-75.
27. RGD automated import pipeline for gene-chemical interactions
28. Shah KG, etal., J Surg Res. 2010 Sep;163(1):110-7. doi: 10.1016/j.jss.2010.03.064. Epub 2010 Apr 24.
29. Suzuki Y, etal., Peptides. 2004 Aug;25(8):1321-6.
30. Temmesfeld-Wollbruck B, etal., Intensive Care Med. 2007 Apr;33(4):703-10. Epub 2007 Feb 22.
31. Tsuruda T, etal., Cardiovasc Res. 2006 Apr 1;70(1):158-64. Epub 2006 Mar 9.
32. Weng Y, etal., Fen Zi Xi Bao Sheng Wu Xue Bao. 2006 Aug;39(4):373-7.
33. Wu R, etal., Ann Surg. 2005 Jul;242(1):115-23.
34. Wu R, etal., Crit Care Med. 2007 Mar;35(3):912-8.
35. Wu R, etal., Mol Med. 2009 Jan-Feb;15(1-2):28-33. doi: 10.2119/molmed.2008.00092. Epub 2008 Oct 10.
36. Wu R, etal., Peptides. 2008 Jul;29(7):1223-30. doi: 10.1016/j.peptides.2008.02.021. Epub 2008 Mar 8.
37. Yang J, etal., Ann Surg. 2009 Feb;249(2):310-7. doi: 10.1097/SLA.0b013e3181961d43.
38. Yang J, etal., Peptides. 2010 May;31(5):872-7. doi: 10.1016/j.peptides.2010.01.010. Epub 2010 Feb 2.
39. Zakareia FA, etal., J Diabetes Complications. 2009 Feb 11.
40. Zee RY, etal., Stroke. 2006 Jul;37(7):1686-90. Epub 2006 May 25.
41. Zhang XH, etal., Am J Physiol Heart Circ Physiol. 2007 Aug 31;.
42. Zhou Z, etal., Cell Host Microbe. 2020 Jun 10;27(6):883-890.e2. doi: 10.1016/j.chom.2020.04.017. Epub 2020 May 4.
Additional References at PubMed
PMID:7688224   PMID:7745031   PMID:8074714   PMID:8076689   PMID:8137955   PMID:8387282   PMID:8524787   PMID:8687431   PMID:8742029   PMID:8774254   PMID:8885746   PMID:9145435  
PMID:9357065   PMID:9535752   PMID:9578982   PMID:9620797   PMID:9768331   PMID:9916958   PMID:10225288   PMID:10588445   PMID:10822232   PMID:10855685   PMID:10867102   PMID:10882736  
PMID:10899511   PMID:10956553   PMID:11116141   PMID:11150646   PMID:11387328   PMID:11410113   PMID:11463574   PMID:11463752   PMID:11502838   PMID:11511315   PMID:11562782   PMID:11571480  
PMID:11712085   PMID:11744163   PMID:11774814   PMID:11879669   PMID:11905404   PMID:11921362   PMID:11921363   PMID:11956648   PMID:11972292   PMID:12036966   PMID:12137974   PMID:12189226  
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PMID:12566732   PMID:12579522   PMID:12601625   PMID:12630817   PMID:12630823   PMID:12630824   PMID:12643861   PMID:12646214   PMID:12660258   PMID:12667630   PMID:12684703   PMID:12687457  
PMID:12716843   PMID:12720100   PMID:12753312   PMID:12763641   PMID:12782295   PMID:12805025   PMID:12835224   PMID:12853384   PMID:12903912   PMID:12907107   PMID:12920627   PMID:12969589  
PMID:14517225   PMID:14534081   PMID:14612905   PMID:14671210   PMID:14714580   PMID:14715486   PMID:14720432   PMID:14725946   PMID:14759562   PMID:15016771   PMID:15044509   PMID:15192039  
PMID:15194870   PMID:15242974   PMID:15300632   PMID:15336545   PMID:15361766   PMID:15489334   PMID:15527794   PMID:15531734   PMID:15544858   PMID:15613468   PMID:15665526   PMID:15677761  
PMID:15684700   PMID:15702240   PMID:15711093   PMID:15758554   PMID:15761041   PMID:15788445   PMID:15866060   PMID:15902095   PMID:15908101   PMID:15917349   PMID:15974887   PMID:15976103  
PMID:16097366   PMID:16115629   PMID:16154664   PMID:16221100   PMID:16256216   PMID:16270874   PMID:16322067   PMID:16356592   PMID:16416151   PMID:16517613   PMID:16596251   PMID:16609682  
PMID:16622024   PMID:16797107   PMID:16815566   PMID:16821090   PMID:16854513   PMID:16963041   PMID:16964401   PMID:17022943   PMID:17053041   PMID:17290391   PMID:17307261   PMID:17327422  
PMID:17384335   PMID:17388661   PMID:17584073   PMID:17719138   PMID:17766467   PMID:17922433   PMID:17941085   PMID:17952853   PMID:18000597   PMID:18080871   PMID:18081029   PMID:18240029  
PMID:18371176   PMID:18401334   PMID:18434369   PMID:18463805   PMID:18615773   PMID:18657357   PMID:18692535   PMID:18705285   PMID:18708640   PMID:18929609   PMID:19010904   PMID:19126117  
PMID:19166930   PMID:19210874   PMID:19212702   PMID:19247278   PMID:19253104   PMID:19306911   PMID:19323987   PMID:19346663   PMID:19564455   PMID:19610056   PMID:19616043   PMID:19623513  
PMID:19627536   PMID:19636336   PMID:19706311   PMID:19738161   PMID:19823891   PMID:19847298   PMID:19913121   PMID:19932100   PMID:20016189   PMID:20074556   PMID:20151808   PMID:20216319  
PMID:20467777   PMID:20534761   PMID:20628086   PMID:20686565   PMID:20691218   PMID:20713499   PMID:20798523   PMID:20854881   PMID:20942979   PMID:20954838   PMID:21050876   PMID:21075100  
PMID:21094578   PMID:21350119   PMID:21408188   PMID:21458987   PMID:21558311   PMID:21558971   PMID:21721459   PMID:21725669   PMID:21791966   PMID:21798961   PMID:21830197   PMID:21839130  
PMID:21889828   PMID:21909110   PMID:21909115   PMID:21957602   PMID:21994414   PMID:22070520   PMID:22087514   PMID:22102369   PMID:22178239   PMID:22400488   PMID:22406979   PMID:22456622  
PMID:22500019   PMID:22608560   PMID:22628306   PMID:22801438   PMID:22818355   PMID:22859951   PMID:22880472   PMID:22881718   PMID:22885414   PMID:22932875   PMID:22960655   PMID:22971508  
PMID:23002189   PMID:23017815   PMID:23088295   PMID:23199555   PMID:23258247   PMID:23269582   PMID:23356193   PMID:23381795   PMID:23445133   PMID:23450059   PMID:23478664   PMID:23562132  
PMID:23564381   PMID:23583388   PMID:23634287   PMID:23638647   PMID:23653390   PMID:23663996   PMID:23688561   PMID:23711352   PMID:23722054   PMID:23793138   PMID:23797962   PMID:23880804  
PMID:23894342   PMID:23936408   PMID:23954711   PMID:23968191   PMID:23969937   PMID:23984422   PMID:24037526   PMID:24060192   PMID:24100627   PMID:24147025   PMID:24169318   PMID:24333654  
PMID:24457114   PMID:24457964   PMID:24505304   PMID:24506434   PMID:24519534   PMID:24523299   PMID:24531032   PMID:24623968   PMID:24831942   PMID:24853905   PMID:24874704   PMID:24927229  
PMID:25009125   PMID:25043691   PMID:25053723   PMID:25287126   PMID:25433141   PMID:25439669   PMID:25475159   PMID:25528198   PMID:25948679   PMID:26035796   PMID:26043778   PMID:26186194  
PMID:26196743   PMID:26271020   PMID:26286191   PMID:26342564   PMID:26461449   PMID:26597206   PMID:26662217   PMID:26748496   PMID:26762744   PMID:26847772   PMID:26972419   PMID:27153479  
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PMID:30020508   PMID:30166452   PMID:30383252   PMID:30536342   PMID:30540625   PMID:30690080   PMID:30890367   PMID:30987836   PMID:31048758   PMID:31537150   PMID:31594258   PMID:31852972  
PMID:31974673   PMID:32203061   PMID:32393512   PMID:32412065   PMID:32462910   PMID:32569606   PMID:32649233   PMID:32702064   PMID:32736707   PMID:32819314   PMID:33066783   PMID:33160126  
PMID:33413127   PMID:33431996   PMID:33462236   PMID:33556140   PMID:33664308   PMID:33736553   PMID:33754916   PMID:33928380   PMID:34163006  


Genomics

Comparative Map Data
ADM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1110,305,073 - 10,307,397 (+)EnsemblGRCh38hg38GRCh38
GRCh381110,305,073 - 10,307,397 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371110,326,620 - 10,328,944 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,283,218 - 10,285,499 (+)NCBINCBI36hg18NCBI36
Build 341110,283,217 - 10,285,499NCBI
Celera1110,448,490 - 10,450,771 (+)NCBI
Cytogenetic Map11p15.4NCBI
HuRef119,999,508 - 10,001,789 (+)NCBIHuRef
CHM1_11110,324,758 - 10,327,040 (+)NCBICHM1_1
Adm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397110,226,864 - 110,229,027 (+)NCBIGRCm39mm39
GRCm39 Ensembl7110,226,868 - 110,229,027 (+)Ensembl
GRCm387110,627,657 - 110,629,820 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7110,627,661 - 110,629,820 (+)EnsemblGRCm38mm10GRCm38
MGSCv377117,771,183 - 117,773,333 (+)NCBIGRCm37mm9NCBIm37
MGSCv367110,418,846 - 110,420,996 (+)NCBImm8
Celera7110,600,687 - 110,602,837 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map757.7NCBI
Adm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21164,745,484 - 164,747,655 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1164,745,466 - 164,747,654 (+)Ensembl
Rnor_6.01175,443,189 - 175,447,260 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1175,445,088 - 175,447,259 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01182,433,109 - 182,435,280 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41168,380,255 - 168,382,426 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11168,490,917 - 168,493,089 (+)NCBI
Celera1162,637,077 - 162,639,248 (+)NCBICelera
Cytogenetic Map1q33NCBI
Adm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541425,951,349 - 25,953,645 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541425,951,473 - 25,953,593 (+)NCBIChiLan1.0ChiLan1.0
ADM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11110,165,423 - 10,167,842 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1110,165,418 - 10,167,842 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01110,437,712 - 10,440,053 (+)NCBIMhudiblu_PPA_v0panPan3
ADM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12133,472,197 - 33,474,472 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2133,471,623 - 33,474,495 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2133,038,463 - 33,040,738 (+)NCBI
ROS_Cfam_1.02134,350,243 - 34,352,518 (+)NCBI
UMICH_Zoey_3.12133,612,009 - 33,614,284 (+)NCBI
UNSW_CanFamBas_1.02133,781,446 - 33,783,719 (+)NCBI
UU_Cfam_GSD_1.02134,074,331 - 34,076,606 (+)NCBI
Adm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494751,971,243 - 51,973,608 (-)NCBI
SpeTri2.0NW_0049365288,005,223 - 8,007,586 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl249,229,223 - 49,231,866 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1249,229,223 - 49,231,521 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2252,576,219 - 52,578,518 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1154,518,359 - 54,520,683 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl154,518,358 - 54,520,686 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038152,185,898 - 152,188,305 (-)NCBIVero_WHO_p1.0
Adm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247662,402,152 - 2,404,343 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
WI-9301  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371110,328,759 - 10,328,872UniSTSGRCh37
Build 361110,285,335 - 10,285,448RGDNCBI36
Celera1110,450,607 - 10,450,720RGD
Cytogenetic Map11p15.4UniSTS
HuRef1110,001,625 - 10,001,738UniSTS
GeneMap99-GB4 RH Map1148.79UniSTS
Whitehead-RH Map1148.8UniSTS
Whitehead-YAC Contig Map11 UniSTS
RH17382  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371110,328,555 - 10,328,798UniSTSGRCh37
Build 361110,285,131 - 10,285,374RGDNCBI36
Celera1110,450,403 - 10,450,646RGD
Cytogenetic Map11p15.4UniSTS
HuRef1110,001,421 - 10,001,664UniSTS
GeneMap99-GB4 RH Map1150.28UniSTS
NCBI RH Map1131.5UniSTS
ADM-1  
Human AssemblyChrPosition (strand)SourceJBrowse
HuRef1110,000,139 - 10,000,452UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3286
Count of miRNA genes:845
Interacting mature miRNAs:1029
Transcripts:ENST00000278175, ENST00000524948, ENST00000525063, ENST00000526492, ENST00000528544, ENST00000528655, ENST00000530439, ENST00000534464
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 1 10 2 44 4 2 48 4
Medium 2251 2619 1316 416 1486 274 4106 1742 1659 377 895 1440 154 1156 2613 4
Low 174 352 403 206 342 191 197 448 2046 41 551 149 16 1 171 2
Below cutoff 9 2 5 84 9 5 21 1 8 20 3

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000278175   ⟹   ENSP00000278175
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1110,305,073 - 10,307,397 (+)Ensembl
RefSeq Acc Id: ENST00000524948   ⟹   ENSP00000433062
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1110,305,077 - 10,306,260 (+)Ensembl
RefSeq Acc Id: ENST00000525063   ⟹   ENSP00000435124
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1110,305,088 - 10,306,908 (+)Ensembl
RefSeq Acc Id: ENST00000526492   ⟹   ENSP00000434354
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1110,305,088 - 10,306,530 (+)Ensembl
RefSeq Acc Id: ENST00000528544   ⟹   ENSP00000434749
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1110,305,377 - 10,306,112 (+)Ensembl
RefSeq Acc Id: ENST00000528655   ⟹   ENSP00000436607
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1110,305,084 - 10,307,355 (+)Ensembl
RefSeq Acc Id: ENST00000530439   ⟹   ENSP00000436837
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1110,305,074 - 10,307,362 (+)Ensembl
RefSeq Acc Id: ENST00000534464   ⟹   ENSP00000431438
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1110,305,073 - 10,307,395 (+)Ensembl
RefSeq Acc Id: NM_001124   ⟹   NP_001115
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381110,305,073 - 10,307,397 (+)NCBI
GRCh371110,326,642 - 10,328,923 (+)ENTREZGENE
Build 361110,283,218 - 10,285,499 (+)NCBI Archive
HuRef119,999,508 - 10,001,789 (+)ENTREZGENE
CHM1_11110,324,643 - 10,327,066 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001115   ⟸   NM_001124
- Peptide Label: precursor
- UniProtKB: P35318 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000436837   ⟸   ENST00000530439
RefSeq Acc Id: ENSP00000431438   ⟸   ENST00000534464
RefSeq Acc Id: ENSP00000433062   ⟸   ENST00000524948
RefSeq Acc Id: ENSP00000435124   ⟸   ENST00000525063
RefSeq Acc Id: ENSP00000434354   ⟸   ENST00000526492
RefSeq Acc Id: ENSP00000436607   ⟸   ENST00000528655
RefSeq Acc Id: ENSP00000434749   ⟸   ENST00000528544
RefSeq Acc Id: ENSP00000278175   ⟸   ENST00000278175

Promoters
RGD ID:6788430
Promoter ID:HG_KWN:12316
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000278175,   UC001MIK.1,   UC001MIM.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361110,283,089 - 10,283,589 (+)MPROMDB
RGD ID:6851662
Promoter ID:EP73633
Type:single initiation site
Name:HS_ADM
Description:Adrenomedullin.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361110,283,196 - 10,283,256EPD
RGD ID:7219629
Promoter ID:EPDNEW_H15560
Type:multiple initiation site
Name:ADM_2
Description:adrenomedullin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15561  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381110,304,893 - 10,304,953EPDNEW
RGD ID:7219631
Promoter ID:EPDNEW_H15561
Type:multiple initiation site
Name:ADM_1
Description:adrenomedullin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15560  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381110,305,073 - 10,305,133EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11p15.5-13(chr11:202758-31726224)x3 copy number gain See cases [RCV000053613] Chr11:202758..31726224 [GRCh38]
Chr11:202758..31747772 [GRCh37]
Chr11:192758..31704348 [NCBI36]
Chr11:11p15.5-13
pathogenic
GRCh38/hg38 11p15.5-15.1(chr11:446754-18904742)x3 copy number gain See cases [RCV000133997] Chr11:446754..18904742 [GRCh38]
Chr11:446754..18926289 [GRCh37]
Chr11:436754..18882865 [NCBI36]
Chr11:11p15.5-15.1
pathogenic
GRCh38/hg38 11p15.4-15.2(chr11:9989516-16825806)x1 copy number loss See cases [RCV000136773] Chr11:9989516..16825806 [GRCh38]
Chr11:10011063..16847353 [GRCh37]
Chr11:9967639..16803929 [NCBI36]
Chr11:11p15.4-15.2
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:61793-10727969)x3 copy number gain See cases [RCV000139987] Chr11:61793..10727969 [GRCh38]
Chr11:61793..10749516 [GRCh37]
Chr11:51793..10706092 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.4(chr11:7995676-10437205)x3 copy number gain See cases [RCV000143490] Chr11:7995676..10437205 [GRCh38]
Chr11:8017223..10458752 [GRCh37]
Chr11:7973799..10415328 [NCBI36]
Chr11:11p15.4
uncertain significance
GRCh37/hg19 11p15.5-12(chr11:230615-37698540)x3 copy number gain See cases [RCV000511561] Chr11:230615..37698540 [GRCh37]
Chr11:11p15.5-12
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-14.3(chr11:230615-25584362)x3 copy number gain See cases [RCV000512225] Chr11:230615..25584362 [GRCh37]
Chr11:11p15.5-14.3
pathogenic
GRCh37/hg19 11p15.5-13(chr11:230615-31995219)x3 copy number gain See cases [RCV000512477] Chr11:230615..31995219 [GRCh37]
Chr11:11p15.5-13
pathogenic
GRCh37/hg19 11p15.5-15.1(chr11:230615-17099213)x3 copy number gain not provided [RCV000683372] Chr11:230615..17099213 [GRCh37]
Chr11:11p15.5-15.1
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.4(chr11:9991402-10353745)x3 copy number gain not provided [RCV000749947] Chr11:9991402..10353745 [GRCh37]
Chr11:11p15.4
benign
NM_001124.3(ADM):c.9G>A (p.Leu3=) single nucleotide variant not provided [RCV000925916] Chr11:10305709 [GRCh38]
Chr11:10327256 [GRCh37]
Chr11:11p15.4
likely benign
NM_001124.3(ADM):c.477G>T (p.Pro159=) single nucleotide variant not provided [RCV000937228] Chr11:10306560 [GRCh38]
Chr11:10328107 [GRCh37]
Chr11:11p15.4
likely benign
GRCh37/hg19 11p15.5-15.3(chr11:193146-12643136) copy number gain Russell-Silver syndrome [RCV000767567] Chr11:193146..12643136 [GRCh37]
Chr11:11p15.5-15.3
pathogenic
NM_001124.3(ADM):c.150C>G (p.Ser50Arg) single nucleotide variant not provided [RCV000959901] Chr11:10306000 [GRCh38]
Chr11:10327547 [GRCh37]
Chr11:11p15.4
benign
NM_001124.3(ADM):c.254C>G (p.Pro85Arg) single nucleotide variant not provided [RCV000956909] Chr11:10306337 [GRCh38]
Chr11:10327884 [GRCh37]
Chr11:11p15.4
benign
GRCh37/hg19 11p15.5-13(chr11:235934-33826995)x3 copy number gain not provided [RCV001006372] Chr11:235934..33826995 [GRCh37]
Chr11:11p15.5-13
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:259 AgrOrtholog
COSMIC ADM COSMIC
Ensembl Genes ENSG00000148926 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000278175 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000431438 UniProtKB/TrEMBL
  ENSP00000433062 UniProtKB/TrEMBL
  ENSP00000434354 UniProtKB/TrEMBL
  ENSP00000434749 UniProtKB/TrEMBL
  ENSP00000435124 UniProtKB/Swiss-Prot
  ENSP00000436607 UniProtKB/Swiss-Prot
  ENSP00000436837 UniProtKB/TrEMBL
Ensembl Transcript ENST00000278175 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000524948 UniProtKB/TrEMBL
  ENST00000525063 UniProtKB/Swiss-Prot
  ENST00000526492 UniProtKB/TrEMBL
  ENST00000528544 UniProtKB/TrEMBL
  ENST00000528655 UniProtKB/Swiss-Prot
  ENST00000530439 UniProtKB/TrEMBL
  ENST00000534464 UniProtKB/TrEMBL
GTEx ENSG00000148926 GTEx
HGNC ID HGNC:259 ENTREZGENE
Human Proteome Map ADM Human Proteome Map
InterPro Adrenomedullin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calcitonin/adrenomedullin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:133 UniProtKB/Swiss-Prot
NCBI Gene 133 ENTREZGENE
OMIM 103275 OMIM
Pfam Calc_CGRP_IAPP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ADM RGD, PharmGKB
PRINTS ADRENOMEDULN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ADML_HUMAN UniProtKB/Swiss-Prot
  E9PL83_HUMAN UniProtKB/TrEMBL
  E9PML4_HUMAN UniProtKB/TrEMBL
  E9PQE6_HUMAN UniProtKB/TrEMBL
  E9PQT2_HUMAN UniProtKB/TrEMBL
  P35318 ENTREZGENE
UniProt Secondary B2R793 UniProtKB/Swiss-Prot
  D3DQV3 UniProtKB/Swiss-Prot
  Q6FGW2 UniProtKB/Swiss-Prot