Adm (adrenomedullin) - Rat Genome Database

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Gene: Adm (adrenomedullin) Mus musculus
Symbol: Adm
Name: adrenomedullin
RGD ID: 730918
Description: Predicted to enable adrenomedullin receptor binding activity. Involved in several processes, including circulatory system development; negative regulation of vascular permeability; and positive regulation of vasculogenesis. Acts upstream of or within chordate embryonic development; developmental growth; and positive regulation of cell population proliferation. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; extraembryonic component; gut; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in brain infarction; breast cancer; pancreatic cancer; and pulmonary hypertension. Orthologous to human ADM (adrenomedullin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A; AM; pro-adrenomedullin
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm397110,226,864 - 110,229,027 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7110,226,868 - 110,229,027 (+)EnsemblGRCm39 Ensembl
GRCm387110,627,657 - 110,629,820 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7110,627,661 - 110,629,820 (+)EnsemblGRCm38mm10GRCm38
MGSCv377117,771,183 - 117,773,333 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367110,418,846 - 110,420,996 (+)NCBIMGSCv36mm8
Celera7110,600,687 - 110,602,837 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map757.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-butoxyethanol  (EXP)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Sanshool  (ISO)
ammonium chloride  (ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
bucladesine  (ISO)
buta-1,3-diene  (EXP)
Butylparaben  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
chromium atom  (ISO)
chrysene  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
diethyl maleate  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
diphenylcyclopropenone  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (EXP,ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
ferric oxide  (EXP)
fingolimod hydrochloride  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (ISO)
gentamycin  (ISO)
hydrogen peroxide  (ISO)
ionomycin  (ISO)
isoprenaline  (ISO)
ivermectin  (EXP)
kenpaullone  (ISO)
leflunomide  (ISO)
letrozole  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
malathion  (ISO)
maneb  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercaptopurine  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
metacetamol  (EXP)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methylarsonic acid  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
Muraglitazar  (ISO)
mycophenolic acid  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitrates  (ISO)
nitric oxide  (ISO)
nitrofen  (ISO)
nitroprusside  (ISO)
ochratoxin A  (ISO)
Octicizer  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (EXP)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
purine-6-thiol  (ISO)
quercetin  (ISO)
quinapril hydrochloride  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
rotenone  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
SCH772984  (ISO)
serpentine asbestos  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
Soman  (ISO)
staurosporine  (ISO)
succimer  (EXP)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
topotecan  (ISO)
tributyl phosphate  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (EXP)
tris(2-chloroethyl) phosphate  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vandetanib  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
adrenomedullin receptor signaling pathway  (ISO)
androgen metabolic process  (ISO)
animal organ regeneration  (ISO)
antibacterial humoral response  (ISO)
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
branching involved in labyrinthine layer morphogenesis  (IMP)
cAMP-mediated signaling  (ISO)
cell population proliferation  (IMP)
defense response to Gram-negative bacterium  (ISO)
defense response to Gram-positive bacterium  (ISO)
developmental growth  (IMP)
female pregnancy  (ISO)
G protein-coupled receptor internalization  (ISO)
heart development  (IMP)
negative regulation of cell population proliferation  (ISO)
negative regulation of vascular permeability  (IMP)
negative regulation of vasoconstriction  (ISO)
neural tube closure  (IMP)
neuron projection regeneration  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
positive regulation of angiogenesis  (IMP)
positive regulation of apoptotic process  (ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of vasculogenesis  (IMP)
receptor internalization  (ISO)
regulation of systemic arterial blood pressure  (ISO)
regulation of the force of heart contraction  (ISO)
regulation of urine volume  (ISO)
response to glucocorticoid  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to organic substance  (ISO)
response to starvation  (ISO)
spongiotrophoblast layer development  (IMP)
vascular associated smooth muscle cell development  (IMP)
vasculogenesis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal artery morphology  (IAGP)
abnormal coronary artery morphology  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal liver vasculature morphology  (IAGP)
abnormal lymph organ development  (IAGP)
abnormal myocardial trabeculae morphology  (IAGP)
abnormal placenta fetal blood space morphology  (IAGP)
abnormal placenta intervillous maternal lacunae morphology  (IAGP)
abnormal placenta labyrinth morphology  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal uterine spiral artery remodeling  (IAGP)
abnormal vascular endothelial cell morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
blood vessel inflammation  (IAGP)
cardiac hypertrophy  (IAGP)
decreased creatinine clearance  (IAGP)
decreased fluid intake  (IAGP)
decreased placenta weight  (IAGP)
decreased uterine NK cell number  (IAGP)
decreased ventricle muscle contractility  (IAGP)
disorganized myocardium  (IAGP)
edema  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged myocardial fiber  (IAGP)
glomerulosclerosis  (IAGP)
hemorrhage  (IAGP)
hydrops fetalis  (IAGP)
impaired basement membrane formation  (IAGP)
impaired coordination  (IAGP)
increased anxiety-related response  (IAGP)
increased cardiomyocyte apoptosis  (IAGP)
increased heart left ventricle wall thickness  (IAGP)
increased locomotor activity  (IAGP)
increased placenta apoptosis  (IAGP)
increased stereotypic behavior  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased systemic arterial blood pressure  (IAGP)
increased uterine NK cell number  (IAGP)
increased vertical activity  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
liver hemorrhage  (IAGP)
lung hemorrhage  (IAGP)
lymphedema  (IAGP)
oliguria  (IAGP)
oxidative stress  (IAGP)
pericardial effusion  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
renal cast  (IAGP)
renal fibrosis  (IAGP)
skin hemorrhage  (IAGP)
small heart  (IAGP)
umbilical artery stenosis  (IAGP)
umbilical vein stenosis  (IAGP)

References - curated
# Reference Title Reference Citation
1. Mid-regional pro-adrenomedullin is associated with pulse pressure, left ventricular mass, and albuminuria in African Americans with hypertension. Al-Omari MA, etal., Am J Hypertens. 2009 Aug;22(8):860-6. Epub 2009 May 7.
2. ZD6474 inhibits tumor growth and intraperitoneal dissemination in a highly metastatic orthotopic gastric cancer model. Arao T, etal., Int J Cancer. 2006 Jan 15;118(2):483-9. doi: 10.1002/ijc.21340.
3. Vasodilator mRNA levels are increased in the livers of portal hypertensive NO-synthase 3-deficient mice. Biecker E, etal., Eur J Clin Invest. 2004 Apr;34(4):283-9.
4. Plasma adrenomedullin concentrations in patients with renovascular or malignant hypertension. Caliumi C, etal., Minerva Cardioangiol. 2004 Aug;52(4):313-22.
5. Plasma levels of adrenomedullin, a vasoactive peptide, in type 2 diabetic patients with and without retinopathy. Caliumi C, etal., Minerva Endocrinol. 2007 Jun;32(2):73-8.
6. Adrenomedullin and adrenomedullin-binding protein-1 downregulate inflammatory cytokines and attenuate tissue injury after gut ischemia-reperfusion. Carrizo GJ, etal., Surgery. 2007 Feb;141(2):245-53. Epub 2006 Sep 14.
7. Peripheral administration of human adrenomedullin and its binding protein attenuates stroke-induced apoptosis and brain injury in rats. Chaung WW, etal., Mol Med. 2011;17(9-10):1075-83. doi: 10.2119/molmed.2010.00104. Epub 2011 Jun 17.
8. Effects of Adrenomedullin on the Glomerular Adrenomedullin System in a Rat Model of Anti-Thy1 Glomerulonephritis. Geissler B, etal., Nephron Exp Nephrol. 2010 Apr 30;115(3):e80-e88.
9. Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5. Glowacki G, etal., Gene 2001 Sep 19;275(2):267-77.
10. Changes in expression of adrenomedullin in the myocardium of streptozotocin-induced diabetic rats. He RX, etal., Chin Med J (Engl). 2007 Feb 5;120(3):187-91.
11. Adrenomedullin production is increased in colorectal adenocarcinomas; its relation to matrix metalloproteinase-9. Hikosaka T, etal., Peptides. 2011 Sep;32(9):1825-31. doi: 10.1016/j.peptides.2011.07.012. Epub 2011 Aug 3.
12. The gene expression of adrenomedullin, calcitonin-receptor-like receptor and receptor activity modifying proteins (RAMPs) in CCl4-induced rat liver cirrhosis. Hwang IS, etal., Regul Pept. 2006 Jul 15;135(1-2):69-77. Epub 2006 May 19.
13. Increased production of adrenomedullin in glomeruli from anti-glomerular basement membrane glomerulonephritis rats treated with methylprednisolone. Iwatsubo S, etal., Nephron Exp Nephrol. 2006;104(1):e41-7. Epub 2006 May 6.
14. Plasma adrenomedullin level and development of hypertension. Kato J, etal., J Hum Hypertens. 2006 Aug;20(8):566-70. Epub 2006 Apr 20.
15. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, etal., Hum Mol Genet 1998 Nov;7(12):1967-78.
16. Adrenomedullin, a new peptide, in patients with insulinoma. Letizia C, etal., Eur J Endocrinol. 2001 May;144(5):517-20.
17. Acute hyperinsulinemia is associated with increased plasma adrenomedullin concentrations in uncomplicated obesity. Letizia C, etal., Exp Clin Endocrinol Diabetes. 2005 Mar;113(3):171-5.
18. Adrenomedullin acts via nitric oxide and peroxynitrite to protect against myocardial ischaemia-induced arrhythmias in anaesthetized rats. Looi YH, etal., Br J Pharmacol. 2006 Jul;148(5):599-609. Epub 2006 May 22.
19. A role for adrenomedullin as a pain-related peptide in the rat. Ma W, etal., Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):16027-32. Epub 2006 Oct 16.
20. Differential regulation of adrenomedullin gene expression in the fundic and pyloric regions of the rat stomach during acute and chronic starvation. Man SY, etal., Neuropeptides. 2007 Jun;41(3):177-87. Epub 2007 Mar 1.
21. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
22. MGDs mouse GO annotations MGD data from the GO Consortium
24. Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist. Miseki T, etal., Cancer Gene Ther. 2007 Jan;14(1):39-44. Epub 2006 Jul 14.
25. Effects of adrenomedullin inhalation on hemodynamics and exercise capacity in patients with idiopathic pulmonary arterial hypertension. Nagaya N, etal., Circulation. 2004 Jan 27;109(3):351-6. Epub 2004 Jan 12.
26. Ventricular adrenomedullin system in the transition from LVH to heart failure in rats. Nishikimi T, etal., Hypertension 2003 Mar;41(3):512-8.
27. Increased renal adrenomedullin expression in rats with ureteral obstruction. Norregaard R, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Jan;296(1):R185-92. Epub 2008 Oct 22.
28. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
29. Potentiated response to adrenomedullin in myocardia and aortas in spontaneously hypertensive rat. Pan ChS, etal., Basic Res Cardiol. 2006 May;101(3):193-203. Epub 2006 Feb 6.
30. Expression of adrenomedullin in adipose tissue of lean and obese women. Paulmyer-Lacroix O, etal., Eur J Endocrinol. 2006 Jul;155(1):177-85.
31. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
32. Adrenomedullin is expressed in pancreatic cancer and stimulates cell proliferation and invasion in an autocrine manner via the adrenomedullin receptor, ADMR. Ramachandran V, etal., Cancer Res. 2007 Mar 15;67(6):2666-75.
33. Mouse MP Annotation Import Pipeline RGD automated import pipeline
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Attenuation of renal ischemia and reperfusion injury by human adrenomedullin and its binding protein. Shah KG, etal., J Surg Res. 2010 Sep;163(1):110-7. doi: 10.1016/j.jss.2010.03.064. Epub 2010 Apr 24.
36. Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene. Shindo T, etal., Circulation. 2001 Oct 16;104(16):1964-71.
37. Adrenomedullin as a sensitive marker for coronary and peripheral arterial complications in patients with atherosclerotic risks. Suzuki Y, etal., Peptides. 2004 Aug;25(8):1321-6.
38. Adrenomedullin reduces vascular hyperpermeability and improves survival in rat septic shock. Temmesfeld-Wollbruck B, etal., Intensive Care Med. 2007 Apr;33(4):703-10. Epub 2007 Feb 22.
39. Adrenomedullin in mast cells of abdominal aortic aneurysm. Tsuruda T, etal., Cardiovasc Res. 2006 Apr 1;70(1):158-64. Epub 2006 Mar 9.
40. Study on increasing expression of adrenomedullin in diabetic rats' retinal pigment epithelium cells. Weng Y, etal., Fen Zi Xi Bao Sheng Wu Xue Bao. 2006 Aug;39(4):373-7.
41. Mechanisms responsible for vascular hyporesponsiveness to adrenomedullin after hemorrhage: the central role of adrenomedullin binding protein-1. Wu R, etal., Ann Surg. 2005 Jul;242(1):115-23.
42. Adrenomedullin and adrenomedullin binding protein-1 prevent metabolic acidosis after uncontrolled hemorrhage in rats. Wu R, etal., Crit Care Med. 2007 Mar;35(3):912-8.
43. Reversing established sepsis in rats with human vasoactive hormone adrenomedullin and its binding protein. Wu R, etal., Mol Med. 2009 Jan-Feb;15(1-2):28-33. doi: 10.2119/molmed.2008.00092. Epub 2008 Oct 10.
44. Human vasoactive hormone adrenomedullin and its binding protein rescue experimental animals from shock. Wu R, etal., Peptides. 2008 Jul;29(7):1223-30. doi: 10.1016/j.peptides.2008.02.021. Epub 2008 Mar 8.
45. Human adrenomedullin and its binding protein attenuate organ injury and reduce mortality after hepatic ischemia-reperfusion. Yang J, etal., Ann Surg. 2009 Feb;249(2):310-7. doi: 10.1097/SLA.0b013e3181961d43.
46. Human adrenomedullin and its binding protein ameliorate sepsis-induced organ injury and mortality in jaundiced rats. Yang J, etal., Peptides. 2010 May;31(5):872-7. doi: 10.1016/j.peptides.2010.01.010. Epub 2010 Feb 2.
47. Correlation of electroretinography b-wave absolute latency, plasma levels of human basic fibroblast growth factor, vascular endothelial growth factor, soluble fatty acid synthase, and adrenomedullin in diabetic retinopathy. Zakareia FA, etal., J Diabetes Complications. 2009 Feb 11.
48. The effect of adrenomedullin on the L-type calcium current in myocytes from septic shock rats: Signaling pathway. Zhang XH, etal., Am J Physiol Heart Circ Physiol. 2007 Aug 31;.
Additional References at PubMed
PMID:1374388   PMID:8938454   PMID:8977434   PMID:9460649   PMID:9564831   PMID:9666083   PMID:9722956   PMID:9724050   PMID:9808778   PMID:10349636   PMID:10556422   PMID:10585447  
PMID:10725249   PMID:10777702   PMID:10873386   PMID:10885754   PMID:11042159   PMID:11076861   PMID:11130978   PMID:11149956   PMID:11217851   PMID:11772884   PMID:11921355   PMID:11934832  
PMID:12037382   PMID:12118100   PMID:12477932   PMID:12630810   PMID:12630815   PMID:12667641   PMID:12668590   PMID:12761846   PMID:12782295   PMID:12871842   PMID:14610273   PMID:14620929  
PMID:14769703   PMID:14967720   PMID:15005577   PMID:15096451   PMID:15105383   PMID:15242968   PMID:15242974   PMID:15735755   PMID:15781248   PMID:15867131   PMID:16141072   PMID:16141073  
PMID:16376459   PMID:16384868   PMID:16537897   PMID:16602821   PMID:16723707   PMID:16842816   PMID:16981008   PMID:17116754   PMID:17141159   PMID:17332272   PMID:17360661   PMID:17804806  
PMID:17889965   PMID:17947702   PMID:18097473   PMID:18097475   PMID:18340042   PMID:18469803   PMID:18498438   PMID:18583422   PMID:18708640   PMID:18716289   PMID:18723674   PMID:18929609  
PMID:19094967   PMID:19714395   PMID:19847298   PMID:20182890   PMID:20185832   PMID:20854881   PMID:20858768   PMID:20926767   PMID:21267068   PMID:21270129   PMID:21305474   PMID:21308776  
PMID:21558971   PMID:21677750   PMID:21826707   PMID:21873635   PMID:21994414   PMID:22079286   PMID:22275070   PMID:22326698   PMID:22690112   PMID:22841816   PMID:22960655   PMID:23099649  
PMID:23297372   PMID:23355623   PMID:23364478   PMID:23379656   PMID:23520487   PMID:23562442   PMID:23635772   PMID:23957015   PMID:24123312   PMID:24748541   PMID:24813793   PMID:24899577  
PMID:25203207   PMID:25252154   PMID:26582637   PMID:26661726   PMID:26687815   PMID:27445864   PMID:27553639   PMID:27640364   PMID:27965594   PMID:28204537   PMID:28299347   PMID:28324104  
PMID:28489004   PMID:28663440   PMID:29025060   PMID:29187812   PMID:29911998   PMID:30166452   PMID:30409884   PMID:30537525   PMID:30582443   PMID:30658846   PMID:30718289   PMID:31205027  
PMID:31754214   PMID:32093901   PMID:32457985   PMID:33268595   PMID:33385343   PMID:33535178   PMID:33955458   PMID:34279605   PMID:34508690   PMID:35297995   PMID:36374225   PMID:36575170  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm397110,226,864 - 110,229,027 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7110,226,868 - 110,229,027 (+)EnsemblGRCm39 Ensembl
GRCm387110,627,657 - 110,629,820 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7110,627,661 - 110,629,820 (+)EnsemblGRCm38mm10GRCm38
MGSCv377117,771,183 - 117,773,333 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367110,418,846 - 110,420,996 (+)NCBIMGSCv36mm8
Celera7110,600,687 - 110,602,837 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map757.7NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381110,305,073 - 10,307,397 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1110,305,073 - 10,307,397 (+)EnsemblGRCh38hg38GRCh38
GRCh371110,326,620 - 10,328,944 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,283,218 - 10,285,499 (+)NCBINCBI36Build 36hg18NCBI36
Build 341110,283,217 - 10,285,499NCBI
Celera1110,448,490 - 10,450,771 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef119,999,508 - 10,001,789 (+)NCBIHuRef
CHM1_11110,324,758 - 10,327,040 (+)NCBICHM1_1
T2T-CHM13v2.01110,389,576 - 10,391,900 (+)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21164,745,484 - 164,747,655 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,745,466 - 164,747,654 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1173,083,288 - 173,085,466 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01180,269,319 - 180,271,497 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01172,954,068 - 172,956,245 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01175,443,189 - 175,447,260 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1175,445,088 - 175,447,259 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01182,433,109 - 182,435,280 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41168,380,255 - 168,382,426 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11168,490,917 - 168,493,089 (+)NCBI
Celera1162,637,077 - 162,639,248 (+)NCBICelera
Cytogenetic Map1q33NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541425,951,349 - 25,953,645 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541425,951,473 - 25,953,593 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11112,705,550 - 12,710,554 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01110,437,712 - 10,440,053 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11110,165,423 - 10,167,842 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1110,165,418 - 10,167,842 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12133,472,197 - 33,474,472 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2133,471,623 - 33,474,495 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2133,038,463 - 33,040,738 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02134,350,243 - 34,352,518 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2134,350,217 - 34,352,540 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12133,612,009 - 33,614,284 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02133,781,446 - 33,783,719 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02134,074,331 - 34,076,606 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494751,971,243 - 51,973,608 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365288,005,189 - 8,007,643 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365288,005,223 - 8,007,586 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl249,229,223 - 49,231,866 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1249,229,223 - 49,231,521 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2252,576,219 - 52,578,518 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1154,518,359 - 54,520,683 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl154,518,358 - 54,520,686 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038152,185,898 - 152,188,305 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247662,401,769 - 2,404,446 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247662,402,152 - 2,404,343 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Adm
70 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:260
Count of miRNA genes:199
Interacting mature miRNAs:236
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)767849748119499223Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)769949748120499223Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)774849748122199223Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)774849748122199223Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
10412110Cctq1_mcentral corneal thickness QTL 1 (mouse)Not determined780551681114551791Mouse
4142500Morq1_mmodifier of Rs1 QTL 1 (mouse)Not determined80551681114551791Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)780849748126699172Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781249748124199223Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781449748126499172Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)781849748126499172Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785049208124199223Mouse
1301997Cia7_mcollagen induced arthritis QTL 7 (mouse)Not determined785365595112533819Mouse
1301647Elpt_melevated leptin (mouse)Not determined786500186120500329Mouse
1301188Heal6_mwound healing/regeneration 6 (mouse)Not determined787043932121044066Mouse
1302062Stheal6_msoft tissue heal 6 (mouse)Not determined787043932121044066Mouse
13463473Hbbcq4_mhemoglobin concentration QTL 4 (mouse)787043932121044066Mouse
1301781Capsq3_mcapsaicin sensitivity related QTL 3 (mouse)Not determined787143137119485380Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787249208126499172Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787249208126499172Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791482996125483156Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791482996125483156Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793391848127392041Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7100750722134750843Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7100993261134993342Mouse
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7101693381135693530Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7101693381135693530Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7101693381135693530Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102485219136485380Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105250663139250811Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105350008139350008Mouse
25394573Skmw62_mskeletal muscle weight 62, gastroc (mouse)7106893715110612309Mouse
13524524Bodwtq6_mbody wweight QTL 6 (mouse)7107245693113055693Mouse
4141056Lskcn2_mLSK cell number 2 (mouse)Not determined108482996118693530Mouse
35673311Ari6_mantibody response to influenza 6, day 15, IgG2b (mouse)7108699207115099235Mouse
25394557Skmw64_mskeletal muscle weight 64, soleus (mouse)7108715780114592736Mouse
25394559Skmw63_mskeletal muscle weight 63, TA (mouse)7108791458110612309Mouse
25394556Skmw65_mskeletal muscle weight 65, EDL (mouse)7109059337110612309Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387110,628,868 - 110,628,943UniSTSGRCm38
MGSCv377117,772,382 - 117,772,457UniSTSGRCm37
Celera7110,601,886 - 110,601,961UniSTS
Cytogenetic Map7F1UniSTS
cM Map750.5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv377117,773,136 - 117,773,237UniSTSGRCm37
Celera7110,602,640 - 110,602,741UniSTS
Cytogenetic Map7F1UniSTS
cM Map750.5UniSTS
cM Map750.5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387110,629,589 - 110,629,722UniSTSGRCm38
MGSCv377117,773,103 - 117,773,236UniSTSGRCm37
Celera7110,602,607 - 110,602,740UniSTS
Cytogenetic Map7F1UniSTS
cM Map750.5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387110,628,344 - 110,628,899UniSTSGRCm38
Celera7110,601,362 - 110,601,917UniSTS
Cytogenetic Map7F1UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387110,629,622 - 110,629,723UniSTSGRCm38
MGSCv377117,773,136 - 117,773,237UniSTSGRCm37
Celera7110,602,640 - 110,602,741UniSTS
Cytogenetic Map7F1UniSTS
cM Map750.5UniSTS



Nucleotide Sequences
RefSeq Transcripts NM_009627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC154911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D78349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U77630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000033054   ⟹   ENSMUSP00000033054
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7110,226,868 - 110,229,027 (+)Ensembl
GRCm38.p6 Ensembl7110,627,661 - 110,629,820 (+)Ensembl
RefSeq Acc Id: ENSMUST00000185766
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7110,227,235 - 110,227,758 (+)Ensembl
GRCm38.p6 Ensembl7110,628,028 - 110,628,551 (+)Ensembl
RefSeq Acc Id: NM_009627   ⟹   NP_033757
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm397110,226,864 - 110,229,027 (+)NCBI
GRCm387110,627,657 - 110,629,820 (+)NCBI
MGSCv377117,771,183 - 117,773,333 (+)RGD
Celera7110,600,687 - 110,602,837 (+)RGD
RefSeq Acc Id: NP_033757   ⟸   NM_009627
- Peptide Label: precursor
- UniProtKB: P97453 (UniProtKB/Swiss-Prot),   Q6GTK2 (UniProtKB/Swiss-Prot),   P97297 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000033054   ⟸   ENSMUST00000033054

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97297-F1-model_v2 AlphaFold P97297 1-184 view protein structure

RGD ID:8665223
Promoter ID:EPDNEW_M10643
Type:single initiation site
Description:Mus musculus adrenomedullin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm387110,627,657 - 110,627,717EPDNEW
RGD ID:6840501
Promoter ID:MM_KWN:52288
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Mouse AssemblyChrPosition (strand)Source
MGSCv367117,771,011 - 117,771,511 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108058 AgrOrtholog
Ensembl Genes ENSMUSG00000030790 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033054 ENTREZGENE
  ENSMUST00000033054.10 UniProtKB/Swiss-Prot
InterPro Adrenomedullin UniProtKB/Swiss-Prot
  Calcitonin/adrenomedullin UniProtKB/Swiss-Prot
KEGG Report mmu:11535 UniProtKB/Swiss-Prot
Pfam Calc_CGRP_IAPP UniProtKB/Swiss-Prot
PhenoGen Adm PhenoGen
UniProt Secondary P97453 UniProtKB/Swiss-Prot
  Q6GTK2 UniProtKB/Swiss-Prot