RGD Reference Report - The gene expression of adrenomedullin, calcitonin-receptor-like receptor and receptor activity modifying proteins (RAMPs) in CCl4-induced rat liver cirrhosis. - Rat Genome Database

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The gene expression of adrenomedullin, calcitonin-receptor-like receptor and receptor activity modifying proteins (RAMPs) in CCl4-induced rat liver cirrhosis.

Authors: Hwang, IS  Tang, F  Leung, PP  Li, YY  Fan, ST  Luk, JM 
Citation: Hwang IS, etal., Regul Pept. 2006 Jul 15;135(1-2):69-77. Epub 2006 May 19.
RGD ID: 1625319
Pubmed: PMID:16713642   (View Abstract at PubMed)
DOI: DOI:10.1016/j.regpep.2006.04.006   (Journal Full-text)

This study was undertaken to determine AM expression in carbon tetrachloride (CCl4)-induced liver cirrhosis developed with peritoneal ascites. Sprague-Dawley rats received subcutaneous injections of CCl4 twice weekly in olive oil (1:1, 0.3 ml per kg body weight) for 6 or 12 weeks until ascites developed, or saline in olive oil as control. At 6 weeks, fibrosis developed and at 12 weeks cirrhosis developed with ascites formation. At both 6 and 12 weeks, increases in plasma renin and AM were evident, as was the gene expression of AM. At 12 weeks after CCl4 injection, the gene expression of calcitonin-like-receptor (CRLR) and receptor activity modifying proteins (RAMP1, RAMP2 and RAMP3) were all elevated when compared to the control. The results suggest that liver cirrhosis increases mRNA expressions of AM, CRLR and RAMP1, RAMP2 and RAMP3 and that the increase in AM gene expression precedes the development of cirrhosis. The increase in AM synthesis as reflected by an increase in AM gene expression, together with a lack of increase in AM peptide at both 6 and 12 weeks may suggest an elevation of AM release. Given the potent vasodilatory action of AM, the increase in the synthesis and release of AM in the cirrhotic liver may also contribute to peripheral vasodilatation in liver cirrhosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Liver Cirrhosis  ISOAdm (Rattus norvegicus)1625319; 1625319protein:increased expression:plasmaRGD 
Experimental Liver Cirrhosis  IEP 1625319protein:increased expression:plasmaRGD 
Experimental Liver Cirrhosis  ISORamp2 (Rattus norvegicus)1625319; 1625319 RGD 
Experimental Liver Cirrhosis  IEP 1625319 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adm  (adrenomedullin)
Ramp2  (receptor activity modifying protein 2)

Genes (Mus musculus)
Adm  (adrenomedullin)
Ramp2  (receptor (calcitonin) activity modifying protein 2)

Genes (Homo sapiens)
ADM  (adrenomedullin)
RAMP2  (receptor activity modifying protein 2)


Additional Information