Atp6ap2 (ATPase H+ transporting accessory protein 2) - Rat Genome Database

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Gene: Atp6ap2 (ATPase H+ transporting accessory protein 2) Rattus norvegicus
Analyze
Symbol: Atp6ap2
Name: ATPase H+ transporting accessory protein 2 (Ensembl:ATPase, H+ transporting, lysosomal accessory protein 2)
RGD ID: 1561269
Description: Predicted to enable signaling receptor activity. Predicted to be involved in several processes, including angiotensin maturation; nervous system development; and regulation of signal transduction. Located in several cellular components, including apical plasma membrane; cell body; and extracellular space. Is active in synaptic vesicle membrane. Biomarker of hypertension. Human ortholog(s) of this gene implicated in X-linked parkinsonism-spasticity syndrome; congenital disorder of glycosylation type II; and syndromic X-linked intellectual disability Hedera type. Orthologous to human ATP6AP2 (ATPase H+ transporting accessory protein 2); PARTICIPATES IN renin-angiotensin cascade pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATPase H(+)-transporting lysosomal-interacting protein 2; ATPase, H(+)-transporting, lysosomal-interacting protein 2; ATPase, H+ transporting, lysosomal accessory protein 2; MGC94783; renin receptor; renin/prorenin receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X10,183,983 - 10,210,948 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX10,183,068 - 10,210,918 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX10,365,151 - 10,392,104 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X13,862,316 - 13,889,268 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X10,131,474 - 10,158,431 (-)NCBIRnor_WKY
Rnor_6.0X11,137,889 - 11,164,854 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX11,136,939 - 11,164,915 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X11,936,459 - 11,963,424 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X22,264,078 - 22,291,988 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX10,708,369 - 10,735,267 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
alpha-pinene  (ISO)
amiodarone  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
auramine O  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
D-glucose  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glucose  (EXP)
isoprenaline  (EXP)
L-ethionine  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (EXP)
methyl methanesulfonate  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
Nivalenol  (ISO)
NS-398  (EXP)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
rac-lactic acid  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vitamin E  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Structure of V-ATPase from the mammalian brain. Abbas YM, etal., Science. 2020 Mar 13;367(6483):1240-1246. doi: 10.1126/science.aaz2924.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Soluble form of the (pro)renin receptor is augmented in the collecting duct and urine of chronic angiotensin II-dependent hypertensive rats. Gonzalez AA, etal., Hypertension. 2011 Apr;57(4):859-64. Epub 2011 Feb 14.
4. Prorenin and (pro)renin receptor: a review of available data from in vitro studies and experimental models in rodents. Nguyen G and Danser AH, Exp Physiol. 2008 May;93(5):557-63. Epub 2008 Mar 30.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Characterization of a functional (pro)renin receptor in rat brain neurons. Shan Z, etal., Exp Physiol. 2008 May;93(5):701-8. Epub 2008 Mar 7.
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:12045255   PMID:15489334   PMID:15489960   PMID:15746149   PMID:16374430   PMID:18212268   PMID:18664599   PMID:18756297   PMID:19056867   PMID:19174157   PMID:19199708   PMID:19769609  
PMID:19861503   PMID:20093472   PMID:20689062   PMID:21068087   PMID:21483231   PMID:21803797   PMID:22203739   PMID:22684035   PMID:23376485   PMID:23533145   PMID:24817138   PMID:25143455  
PMID:25555681   PMID:25668351   PMID:25767135   PMID:25844689   PMID:26984496   PMID:27121029   PMID:27440776   PMID:29127204   PMID:29846109   PMID:30414975   PMID:30952701   PMID:31527264  
PMID:32469229   PMID:32757619   PMID:32799674   PMID:32830537   PMID:33547400   PMID:34087284   PMID:34228176  


Genomics

Comparative Map Data
Atp6ap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X10,183,983 - 10,210,948 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX10,183,068 - 10,210,918 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX10,365,151 - 10,392,104 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X13,862,316 - 13,889,268 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X10,131,474 - 10,158,431 (-)NCBIRnor_WKY
Rnor_6.0X11,137,889 - 11,164,854 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX11,136,939 - 11,164,915 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X11,936,459 - 11,963,424 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X22,264,078 - 22,291,988 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX10,708,369 - 10,735,267 (-)NCBICelera
Cytogenetic MapXq12NCBI
ATP6AP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X40,580,970 - 40,606,848 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX40,579,372 - 40,606,848 (+)EnsemblGRCh38hg38GRCh38
GRCh37X40,440,222 - 40,466,100 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X40,325,160 - 40,350,833 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X40,196,446 - 40,222,125NCBI
CeleraX44,580,390 - 44,606,072 (+)NCBICelera
Cytogenetic MapXp11.4NCBI
HuRefX38,171,318 - 38,196,989 (+)NCBIHuRef
CHM1_1X40,472,702 - 40,498,380 (+)NCBICHM1_1
T2T-CHM13v2.0X39,982,532 - 40,008,405 (+)NCBIT2T-CHM13v2.0
Atp6ap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X12,453,998 - 12,483,290 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX12,454,040 - 12,483,288 (+)EnsemblGRCm39 Ensembl
GRCm38X12,587,759 - 12,617,051 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX12,587,801 - 12,617,049 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X12,164,885 - 12,194,177 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X11,736,552 - 11,773,924 (+)NCBIMGSCv36mm8
CeleraX10,281,818 - 10,311,001 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
Atp6ap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555652,006,154 - 2,029,921 (-)NCBIChiLan1.0ChiLan1.0
ATP6AP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X40,730,677 - 40,756,209 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX40,730,677 - 40,756,209 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X33,026,525 - 33,052,252 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ATP6AP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X35,050,588 - 35,073,633 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX35,050,606 - 35,073,067 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX22,398,893 - 22,421,901 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X35,099,002 - 35,122,024 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX35,099,006 - 35,122,017 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X35,178,090 - 35,201,096 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X35,150,804 - 35,173,213 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X35,193,579 - 35,216,589 (+)NCBIUU_Cfam_GSD_1.0
Atp6ap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X27,365,515 - 27,392,087 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365027,206,172 - 7,233,912 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365027,206,226 - 7,232,798 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP6AP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX36,271,222 - 36,304,181 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X36,271,154 - 36,300,240 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X40,369,340 - 40,398,417 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP6AP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X37,742,550 - 37,769,022 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX37,742,545 - 37,769,062 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660762,940,061 - 2,966,802 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp6ap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476214,952,002 - 14,975,900 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476214,952,313 - 14,975,678 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atp6ap2
69 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:215
Count of miRNA genes:150
Interacting mature miRNAs:177
Transcripts:ENSRNOT00000005138
Prediction methods:Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
70166Bp65Blood pressure QTL 655.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144797211374346Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat

Markers in Region
BE102970  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X10,185,787 - 10,185,966 (+)MAPPERmRatBN7.2
Rnor_6.0X11,139,694 - 11,139,872NCBIRnor6.0
Rnor_5.0X11,938,264 - 11,938,442UniSTSRnor5.0
RGSC_v3.4X22,266,804 - 22,266,982UniSTSRGSC3.4
CeleraX10,710,174 - 10,710,352UniSTS
RH 3.4 MapX42.0UniSTS
Cytogenetic MapXq13UniSTS
BI276143  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X10,183,429 - 10,183,647 (+)MAPPERmRatBN7.2
Rnor_6.0X11,137,336 - 11,137,553NCBIRnor6.0
Rnor_5.0X11,935,906 - 11,936,123UniSTSRnor5.0
RGSC_v3.4X22,264,446 - 22,264,663UniSTSRGSC3.4
CeleraX10,707,816 - 10,708,033UniSTS
Cytogenetic MapXq13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 57 41 19 41 6 6 74 35 34 11 6
Low 2 2 5 7 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005138   ⟹   ENSRNOP00000005138
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX10,183,068 - 10,210,918 (-)Ensembl
Rnor_6.0 EnsemblX11,136,939 - 11,164,915 (-)Ensembl
RefSeq Acc Id: NM_001007091   ⟹   NP_001007092
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X10,183,983 - 10,210,948 (-)NCBI
Rnor_6.0X11,137,889 - 11,164,854 (-)NCBI
Rnor_5.0X11,936,459 - 11,963,424 (-)NCBI
CeleraX10,708,369 - 10,735,267 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001007092   ⟸   NM_001007091
- Peptide Label: precursor
- UniProtKB: Q6AXS4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005138   ⟸   ENSRNOT00000005138

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AXS4-F1-model_v2 AlphaFold Q6AXS4 1-350 view protein structure
PRR I-TASSER model Q6AXS4 18-350 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701713
Promoter ID:EPDNEW_R12237
Type:initiation region
Name:Atp6ap2_1
Description:ATPase H+ transporting accessory protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X11,164,841 - 11,164,901EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561269 AgrOrtholog
BioCyc Gene G2FUF-3063 BioCyc
Ensembl Genes ENSRNOG00000003858 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000005138 ENTREZGENE
  ENSRNOP00000005138.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005138 ENTREZGENE
  ENSRNOT00000005138.7 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7106562 IMAGE-MGC_LOAD
InterPro Renin_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:302526 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94783 IMAGE-MGC_LOAD
NCBI Gene 302526 ENTREZGENE
PANTHER PTHR13351 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Renin_r UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atp6ap2 PhenoGen
UniProt A0A8L2UHU2_RAT UniProtKB/TrEMBL
  Q6AXS4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp6ap2  ATPase H+ transporting accessory protein 2  Atp6ap2  ATPase, H+ transporting, lysosomal accessory protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Atp6ap2  ATPase, H+ transporting, lysosomal accessory protein 2      Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 Atp6ap2  ATPase, H+ transporting, lysosomal accessory protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL