LIN28B (lin-28 homolog B) - Rat Genome Database

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Gene: LIN28B (lin-28 homolog B) Homo sapiens
Analyze
Symbol: LIN28B
Name: lin-28 homolog B
RGD ID: 1604919
HGNC Page HGNC
Description: Enables RNA binding activity and sequence-specific double-stranded DNA binding activity. Involved in RNA metabolic process and regulation of RNA metabolic process. Located in cytosol; nucleolus; and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CSDD2; FLJ16517; Lin-28.2; lin-28B; protein lin-28 homolog B
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6104,936,616 - 105,083,332 (+)EnsemblGRCh38hg38GRCh38
GRCh386104,936,999 - 105,083,332 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376105,404,982 - 105,531,207 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366105,511,616 - 105,637,899 (+)NCBINCBI36hg18NCBI36
Celera6106,027,398 - 106,153,711 (+)NCBI
Cytogenetic Map6q16.3-q21NCBI
HuRef6102,848,044 - 102,974,520 (+)NCBIHuRef
CHM1_16105,666,790 - 105,793,230 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IDA)
nucleolus  (IDA,IEA)
nucleoplasm  (IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:16971064   PMID:18029348   PMID:18391950   PMID:18391951   PMID:18951094   PMID:19211792   PMID:19266077   PMID:19448620   PMID:19448621   PMID:19448622  
PMID:19448623   PMID:19483683   PMID:19495417   PMID:19615732   PMID:19703396   PMID:19745602   PMID:20303062   PMID:20350940   PMID:20398887   PMID:20525879   PMID:20546612   PMID:20827722  
PMID:20846217   PMID:20881960   PMID:20962026   PMID:21102462   PMID:21145461   PMID:21512136   PMID:21533284   PMID:21625210   PMID:22118463   PMID:22263265   PMID:22433967   PMID:22681889  
PMID:22822098   PMID:22941191   PMID:22964795   PMID:22976955   PMID:23042116   PMID:23052130   PMID:23063642   PMID:23152804   PMID:23318446   PMID:23378032   PMID:23449627   PMID:23482325  
PMID:23494474   PMID:23563607   PMID:23639551   PMID:23667675   PMID:23740805   PMID:23798711   PMID:24056962   PMID:24244607   PMID:24386298   PMID:24498170   PMID:24602972   PMID:24732380  
PMID:24770850   PMID:24778252   PMID:24780874   PMID:24885919   PMID:24942926   PMID:25010285   PMID:25117712   PMID:25197381   PMID:25200669   PMID:25201220   PMID:25231870   PMID:25301052  
PMID:25360631   PMID:25429064   PMID:25503985   PMID:25544563   PMID:25638158   PMID:25655194   PMID:25726847   PMID:25858147   PMID:25925570   PMID:26028027   PMID:26071398   PMID:26080928  
PMID:26123663   PMID:26158423   PMID:26186194   PMID:26481147   PMID:26712910   PMID:26743584   PMID:26751131   PMID:26787543   PMID:26898455   PMID:26969084   PMID:27021521   PMID:27180906  
PMID:27304100   PMID:27320042   PMID:27383785   PMID:27776272   PMID:27793004   PMID:28102845   PMID:28267418   PMID:28301057   PMID:28380382   PMID:28431233   PMID:28473536   PMID:28514442  
PMID:28525351   PMID:28533407   PMID:28536261   PMID:28693523   PMID:29099484   PMID:29222745   PMID:29298432   PMID:29301498   PMID:29330293   PMID:29336272   PMID:29503447   PMID:29568061  
PMID:29669301   PMID:29689270   PMID:29787985   PMID:29802200   PMID:29845934   PMID:29950144   PMID:29955894   PMID:29970131   PMID:30053798   PMID:30137214   PMID:30154460   PMID:30209976  
PMID:30307771   PMID:30353165   PMID:30527666   PMID:30742065   PMID:30958882   PMID:30997501   PMID:31079917   PMID:31147574   PMID:31215730   PMID:31379107   PMID:31415216   PMID:31537384  
PMID:31586073   PMID:31601998   PMID:31609010   PMID:31705593   PMID:31792362   PMID:31822558   PMID:31907362   PMID:31959994   PMID:31970774   PMID:32006618   PMID:32046465   PMID:32060556  
PMID:32072603   PMID:32176739   PMID:32234488   PMID:32524321   PMID:32571380   PMID:32601179   PMID:32620742   PMID:32634132   PMID:32640226   PMID:32678275   PMID:32694731   PMID:32807901  
PMID:32877691   PMID:33319653   PMID:33484878   PMID:33961781   PMID:34227673  


Genomics

Comparative Map Data
LIN28B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6104,936,616 - 105,083,332 (+)EnsemblGRCh38hg38GRCh38
GRCh386104,936,999 - 105,083,332 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376105,404,982 - 105,531,207 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366105,511,616 - 105,637,899 (+)NCBINCBI36hg18NCBI36
Celera6106,027,398 - 106,153,711 (+)NCBI
Cytogenetic Map6q16.3-q21NCBI
HuRef6102,848,044 - 102,974,520 (+)NCBIHuRef
CHM1_16105,666,790 - 105,793,230 (+)NCBICHM1_1
Lin28b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391045,252,713 - 45,362,410 (-)NCBIGRCm39mm39
GRCm39 Ensembl1045,252,716 - 45,362,491 (-)Ensembl
GRCm381045,376,617 - 45,486,314 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1045,376,620 - 45,486,395 (-)EnsemblGRCm38mm10GRCm38
MGSCv371045,096,425 - 45,190,007 (-)NCBIGRCm37mm9NCBIm37
MGSCv361045,065,048 - 45,158,616 (-)NCBImm8
Celera1046,249,152 - 46,342,378 (-)NCBICelera
Cytogenetic Map10B2NCBI
Lin28b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22048,865,329 - 48,964,769 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2048,869,485 - 48,955,077 (-)Ensembl
Rnor_6.02050,482,536 - 50,580,273 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2050,486,809 - 50,564,987 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02052,094,397 - 52,182,964 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42049,685,524 - 49,765,967 (-)NCBIRGSC3.4rn4RGSC3.4
Celera2051,065,112 - 51,157,124 (+)NCBICelera
Cytogenetic Map20q13NCBI
Lin28b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541130,381,208 - 30,499,678 (+)NCBIChiLan1.0ChiLan1.0
LIN28B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16106,646,991 - 106,772,374 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6106,640,448 - 106,772,374 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06102,755,256 - 102,897,739 (+)NCBIMhudiblu_PPA_v0panPan3
LIN28B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11262,403,831 - 62,529,435 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1262,403,333 - 62,524,838 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1262,192,981 - 62,315,060 (+)NCBI
ROS_Cfam_1.01263,254,885 - 63,380,812 (+)NCBI
UMICH_Zoey_3.11262,610,319 - 62,736,100 (+)NCBI
UNSW_CanFamBas_1.01262,451,489 - 62,577,218 (+)NCBI
UU_Cfam_GSD_1.01262,730,358 - 62,855,996 (+)NCBI
Lin28b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494697,371,614 - 97,497,852 (+)NCBI
SpeTri2.0NW_0049365641,646,469 - 1,768,879 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIN28B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl171,166,786 - 71,296,861 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1171,173,291 - 71,296,131 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2180,544,640 - 80,620,604 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LIN28B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11368,721,209 - 68,859,257 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1368,725,392 - 68,839,811 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604041,068,949 - 41,187,159 (-)NCBIVero_WHO_p1.0
Lin28b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624952193,395 - 309,102 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AL008739  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376105,508,534 - 105,508,688UniSTSGRCh37
Build 366105,615,227 - 105,615,381RGDNCBI36
Celera6106,131,011 - 106,131,165RGD
Cytogenetic Map6q21UniSTS
HuRef6102,951,805 - 102,951,959UniSTS
SHGC-80846  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376105,514,648 - 105,514,985UniSTSGRCh37
Build 366105,621,341 - 105,621,678RGDNCBI36
Celera6106,137,127 - 106,137,464RGD
Cytogenetic Map6q21UniSTS
HuRef6102,957,921 - 102,958,258UniSTS
TNG Radiation Hybrid Map650994.0UniSTS
RH121687  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376105,514,110 - 105,514,396UniSTSGRCh37
Build 366105,620,803 - 105,621,089RGDNCBI36
Celera6106,136,589 - 106,136,875RGD
Cytogenetic Map6q21UniSTS
HuRef6102,957,383 - 102,957,669UniSTS
TNG Radiation Hybrid Map650990.0UniSTS
D6S2097  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376105,437,027 - 105,437,158UniSTSGRCh37
Build 366105,543,720 - 105,543,851RGDNCBI36
Celera6106,059,498 - 106,059,629RGD
Cytogenetic Map6q21UniSTS
HuRef6102,880,239 - 102,880,370UniSTS
SHGC-58271  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376105,528,448 - 105,528,585UniSTSGRCh37
Build 366105,635,141 - 105,635,278RGDNCBI36
Celera6106,150,953 - 106,151,090RGD
Cytogenetic Map6q21UniSTS
HuRef6102,971,761 - 102,971,898UniSTS
TNG Radiation Hybrid Map651002.0UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIRLET7Bhsa-let-7b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI16971064
MIRLET7Dhsa-let-7d-5pTarbaseexternal_infoSequencingPOSITIVE
MIR125B1hsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20827722
MIR125B1hsa-miR-125b-5pOncomiRDBexternal_infoNANA20827722
MIR125B2hsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20827722
MIR125B2hsa-miR-125b-5pOncomiRDBexternal_infoNANA20827722

Predicted Target Of
Summary Value
Count of predictions:1660
Count of miRNA genes:857
Interacting mature miRNAs:1010
Transcripts:ENST00000345080
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 7 2 31 29 68 29 197 16 35 8 42 34 1 4
Low 10 4 157 27 54 28 32 19 350 12 449 70 1 1 3
Below cutoff 961 696 480 59 301 36 1075 870 2640 54 261 366 25 219 837

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_032815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001004317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006715477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011535818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK131411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL135911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL357315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW674597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC127712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC127713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC137526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC137527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC141959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC141960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC150537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC150538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ127228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JB830145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z95329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000345080   ⟹   ENSP00000344401
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6104,957,107 - 105,083,332 (+)Ensembl
RefSeq Acc Id: ENST00000635857   ⟹   ENSP00000489735
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6104,936,616 - 105,078,602 (+)Ensembl
RefSeq Acc Id: ENST00000637759   ⟹   ENSP00000490468
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6104,940,866 - 105,080,479 (+)Ensembl
RefSeq Acc Id: NM_001004317   ⟹   NP_001004317
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386104,957,107 - 105,083,332 (+)NCBI
GRCh376105,384,874 - 105,531,207 (+)NCBI
Build 366105,511,616 - 105,637,899 (+)NCBI Archive
HuRef6102,848,044 - 102,974,520 (+)NCBI
CHM1_16105,666,790 - 105,793,230 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006715477   ⟹   XP_006715540
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386104,936,999 - 105,083,332 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011535818   ⟹   XP_011534120
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386104,940,867 - 105,083,332 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001004317   ⟸   NM_001004317
- UniProtKB: Q6ZN17 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006715540   ⟸   XM_006715477
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011534120   ⟸   XM_011535818
- Peptide Label: isoform X2
- UniProtKB: A0A1B0GVD3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000344401   ⟸   ENST00000345080
RefSeq Acc Id: ENSP00000489735   ⟸   ENST00000635857
RefSeq Acc Id: ENSP00000490468   ⟸   ENST00000637759
Protein Domains
CCHC-type   CSD

Promoters
RGD ID:7208781
Promoter ID:EPDNEW_H10136
Type:initiation region
Name:LIN28B_1
Description:lin-28 homolog B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386104,957,108 - 104,957,168EPDNEW
RGD ID:6804109
Promoter ID:HG_KWN:54474
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   NB4
Transcripts:ENST00000392704,   OTTHUMT00000041646,   UC010KDA.1
Position:
Human AssemblyChrPosition (strand)Source
Build 366105,510,716 - 105,512,767 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001004317.4(LIN28B):c.5C>A (p.Ala2Asp) single nucleotide variant not provided [RCV000122477] Chr6:104957255 [GRCh38]
Chr6:105405130 [GRCh37]
Chr6:6q16.3
uncertain significance
GRCh38/hg38 6q16.3-21(chr6:102356502-111049879)x1 copy number loss See cases [RCV000134806] Chr6:102356502..111049879 [GRCh38]
Chr6:102804377..111371082 [GRCh37]
Chr6:102911070..111477775 [NCBI36]
Chr6:6q16.3-21
pathogenic
GRCh38/hg38 6q16.1-22.31(chr6:96609994-122161548)x1 copy number loss See cases [RCV000139465] Chr6:96609994..122161548 [GRCh38]
Chr6:97057870..122482694 [GRCh37]
Chr6:97164591..122524393 [NCBI36]
Chr6:6q16.1-22.31
pathogenic
GRCh38/hg38 6q13-24.1(chr6:74382807-142040500)x3 copy number gain See cases [RCV000139729] Chr6:74382807..142040500 [GRCh38]
Chr6:75092523..142361637 [GRCh37]
Chr6:75149243..142403330 [NCBI36]
Chr6:6q13-24.1
pathogenic
GRCh38/hg38 6q16.3-21(chr6:103279465-113934239)x1 copy number loss See cases [RCV000142287] Chr6:103279465..113934239 [GRCh38]
Chr6:103727340..114255403 [GRCh37]
Chr6:103834033..114362096 [NCBI36]
Chr6:6q16.3-21
pathogenic
GRCh38/hg38 6q16.3-22.31(chr6:100054889-120488154)x1 copy number loss See cases [RCV000143227] Chr6:100054889..120488154 [GRCh38]
Chr6:100502765..120809300 [GRCh37]
Chr6:100609486..120850999 [NCBI36]
Chr6:6q16.3-22.31
pathogenic
GRCh37/hg19 6q14.3-22.31(chr6:85988428-120548687)x1 copy number loss See cases [RCV000445666] Chr6:85988428..120548687 [GRCh37]
Chr6:6q14.3-22.31
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q16.1-21(chr6:97384446-110247755)x1 copy number loss See cases [RCV000510703] Chr6:97384446..110247755 [GRCh37]
Chr6:6q16.1-21
pathogenic
GRCh37/hg19 6q16.1-21(chr6:94202605-109878834)x1 copy number loss See cases [RCV000512470] Chr6:94202605..109878834 [GRCh37]
Chr6:6q16.1-21
pathogenic
GRCh37/hg19 6q16.1-22.1(chr6:95549951-116684929)x1 copy number loss not provided [RCV000682693] Chr6:95549951..116684929 [GRCh37]
Chr6:6q16.1-22.1
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q16.3-21(chr6:105133622-105536848)x3 copy number gain not provided [RCV000745954] Chr6:105133622..105536848 [GRCh37]
Chr6:6q16.3-21
benign
GRCh37/hg19 6q16.3(chr6:105268161-105427647)x3 copy number gain not provided [RCV000849050] Chr6:105268161..105427647 [GRCh37]
Chr6:6q16.3
uncertain significance
GRCh37/hg19 6q16.3(chr6:105277427-105427647)x3 copy number gain not provided [RCV000846270] Chr6:105277427..105427647 [GRCh37]
Chr6:6q16.3
uncertain significance
NM_001004317.4(LIN28B):c.342C>T (p.Pro114=) single nucleotide variant not provided [RCV000911613] Chr6:105026441 [GRCh38]
Chr6:105474316 [GRCh37]
Chr6:6q21
benign
GRCh37/hg19 6q16.3-22.1(chr6:101296547-117004249)x3 copy number gain Microcephaly [RCV001251053] Chr6:101296547..117004249 [GRCh37]
Chr6:6q16.3-22.1
pathogenic
GRCh37/hg19 6q16.1-21(chr6:98949950-114533905)x1 copy number loss Deletion 6q16 q21 [RCV001263224] Chr6:98949950..114533905 [GRCh37]
Chr6:6q16.1-21
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:32207 AgrOrtholog
COSMIC LIN28B COSMIC
Ensembl Genes ENSG00000187772 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000344401 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000489735 UniProtKB/TrEMBL
  ENSP00000490468 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENST00000345080 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000635857 UniProtKB/TrEMBL
  ENST00000637759 ENTREZGENE, UniProtKB/TrEMBL
GTEx ENSG00000187772 GTEx
HGNC ID HGNC:32207 ENTREZGENE
Human Proteome Map LIN28B Human Proteome Map
InterPro CSD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CSP_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_CCHC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_CCHC_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:389421 UniProtKB/Swiss-Prot
NCBI Gene 389421 ENTREZGENE
OMIM 611044 OMIM
Pfam CSD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-CCHC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA142671543 PharmGKB
PRINTS COLDSHOCK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CSD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_CCHC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CSP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C2HC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50249 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57756 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1B0GTK2_HUMAN UniProtKB/TrEMBL
  A0A1B0GVD3 ENTREZGENE, UniProtKB/TrEMBL
  A7E2T3_HUMAN UniProtKB/TrEMBL
  LN28B_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A1L165 UniProtKB/Swiss-Prot
  B2RPN6 UniProtKB/Swiss-Prot
  Q5TCM4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 LIN28B  lin-28 homolog B  LIN28B  lin-28 homolog B (C. elegans)  Symbol and/or name change 5135510 APPROVED