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Gene: Ghrl (ghrelin and obestatin prepropeptide) Rattus norvegicus
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Symbol: Ghrl
Name: ghrelin and obestatin prepropeptide
Description: Exhibits ghrelin receptor binding activity and growth hormone-releasing hormone activity. Involved in several processes, including gastric emptying; regulation of digestive system process; and regulation of peptide secretion. Localizes to the Schaffer collateral - CA1 synapse; cytoplasm; and glutamatergic synapse. Used to study middle cerebral artery infarction. Biomarker of obstructive sleep apnea. Human ortholog(s) of this gene implicated in diabetic neuropathy; morbid obesity; obesity; and type 2 diabetes mellitus. Orthologous to human GHRL (ghrelin and obestatin prepropeptide); PARTICIPATES IN ghrelin system pathway; INTERACTS WITH 2,3,4,7,8-Pentachlorodibenzofuran; 3,4-methylenedioxymethamphetamine; 3,7-dihydropurine-6-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: appetite-regulating hormone; ghrelin; ghrelin precursor; ghrelin/obestatin prepropeptide; growth hormone secretagogue; growth hormone-releasing peptide; LOC59301; motilin-related peptide
Orthologs:
Homo sapiens (human) : GHRL (ghrelin and obestatin prepropeptide)  HGNC  Alliance
Mus musculus (house mouse) : Ghrl (ghrelin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ghrl (ghrelin and obestatin prepropeptide)
Pan paniscus (bonobo/pygmy chimpanzee) : GHRL (ghrelin and obestatin prepropeptide)
Canis lupus familiaris (dog) : GHRL (ghrelin and obestatin prepropeptide)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ghrl (ghrelin and obestatin prepropeptide)
Sus scrofa (pig) : GHRL (ghrelin and obestatin prepropeptide)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04145,674,157 - 145,678,066 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04208,969,963 - 208,976,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44149,622,566 - 149,628,111 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14149,867,406 - 149,872,952 (-)NCBI
Celera4135,420,041 - 135,423,946 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ghrl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 632283
Created: 2003-08-29
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.