Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Ghrl (ghrelin and obestatin prepropeptide) Rattus norvegicus
Symbol: Ghrl
Name: ghrelin and obestatin prepropeptide
RGD ID: 632283
Description: Exhibits ghrelin receptor binding activity and growth hormone-releasing hormone activity. Involved in several processes, including negative regulation of cytokine production; regulation of digestive system process; and regulation of peptide hormone secretion. Localizes to cytoplasm and glutamatergic synapse. Used to study middle cerebral artery infarction. Biomarker of multiple endocrine neoplasia and obstructive sleep apnea. Human ortholog(s) of this gene implicated in diabetic neuropathy; morbid obesity; obesity; and type 2 diabetes mellitus. Orthologous to human GHRL (ghrelin and obestatin prepropeptide); PARTICIPATES IN ghrelin system pathway; INTERACTS WITH 2,3,4,7,8-Pentachlorodibenzofuran; 3,4-methylenedioxymethamphetamine; 3,7-dihydropurine-6-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: appetite-regulating hormone; ghrelin; ghrelin precursor; ghrelin/obestatin prepropeptide; growth hormone secretagogue; growth hormone-releasing peptide; LOC59301; motilin-related peptide
Homo sapiens (human) : GHRL (ghrelin and obestatin prepropeptide)  HGNC  Alliance
Mus musculus (house mouse) : Ghrl (ghrelin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ghrl (ghrelin and obestatin prepropeptide)
Pan paniscus (bonobo/pygmy chimpanzee) : GHRL (ghrelin and obestatin prepropeptide)
Canis lupus familiaris (dog) : GHRL (ghrelin and obestatin prepropeptide)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ghrl (ghrelin and obestatin prepropeptide)
Sus scrofa (pig) : GHRL (ghrelin and obestatin prepropeptide)
Chlorocebus sabaeus (African green monkey) : GHRL (ghrelin and obestatin prepropeptide)
Heterocephalus glaber (naked mole-rat) : Ghrl (ghrelin and obestatin prepropeptide)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04145,674,157 - 145,678,066 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4145,674,157 - 145,678,066 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04208,969,963 - 208,976,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44149,622,566 - 149,628,111 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14149,867,406 - 149,872,952 (-)NCBI
Celera4135,420,041 - 135,423,946 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ghrl
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 632283
Created: 2003-08-29
Species: Rattus norvegicus
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.