Dnajc3 (DnaJ heat shock protein family (Hsp40) member C3)

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Gene: Dnajc3 (DnaJ heat shock protein family (Hsp40) member C3) Rattus norvegicus

Analyze

Symbol:

Dnajc3

Name:

DnaJ heat shock protein family (Hsp40) member C3

RGD ID:

708518

Description:

Predicted to enable several functions, including misfolded protein binding activity; protein kinase inhibitor activity; and protein-folding chaperone binding activity. Predicted to be involved in several processes, including cellular response to cold; protein folding in endoplasmic reticulum; and regulation of translational initiation. Located in smooth endoplasmic reticulum. Orthologous to human DNAJC3 (DnaJ heat shock protein family (Hsp40) member C3); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; influenza A pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

DnaJ (Hsp40) homolog, subfamily C, member 3; dnaJ homolog subfamily C member 3; interferon-induced, double-stranded RNA-activated protein kinase inhibitor; LOC63880; protein kinase inhibitor of 58 kDa; protein kinase inhibitor p58

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	15	96,025,729 - 96,065,114 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	96,025,624 - 96,065,181 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	99,935,638 - 99,977,285 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	15	101,066,102 - 101,108,631 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	15	97,995,046 - 98,037,458 (+)	NCBI	Rnor_WKY
Rnor_6.0	15	104,186,918 - 104,226,236 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	104,186,792 - 104,226,329 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	107,610,329 - 107,649,355 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	103,881,634 - 103,921,295 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	103,897,413 - 103,937,075 (+)	NCBI
Celera	15	94,875,150 - 94,914,827 (+)	NCBI		Celera
Cytogenetic Map	15	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Anal Atresia, Hypospadias, and Penoscrotal Inversion (ISO)

Combined Cerebellar and Peripheral Ataxia with Hearing Loss and Diabetes Mellitus (ISO)

genetic disease (ISO)

holoprosencephaly 5 (ISO)

prostate cancer (ISO)

Prostatic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,6-di-tert-butyl-4-methylphenol (ISO)

2-amino-2-deoxy-D-glucopyranose (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

4-hydroxynon-2-enal (ISO)

5-aza-2'-deoxycytidine (ISO)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucosamine (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

amiodarone (EXP,ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

atrazine (EXP)

benzbromarone (EXP)

benzene (ISO)

benzo[a]pyrene (ISO)

beta-D-glucosamine (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

cadmium dichloride (EXP,ISO)

calcitriol (ISO)

calcium atom (ISO)

calcium(0) (ISO)

carbaryl (ISO)

carbon nanotube (ISO)

chenodeoxycholic acid (ISO)

clobetasol (ISO)

clofibrate (EXP,ISO)

copper atom (ISO)

copper(0) (ISO)

coumarin (EXP)

crocidolite asbestos (ISO)

CU-O LINKAGE (ISO)

cyclosporin A (ISO)

D-glucose (ISO)

DDT (EXP)

deoxycholic acid (ISO)

deoxynivalenol (ISO)

dibutyl phthalate (ISO)

diclofenac (ISO)

disulfiram (ISO)

dorsomorphin (ISO)

doxorubicin (EXP,ISO)

endosulfan (EXP)

ethanol (ISO)

fenofibrate (ISO)

folic acid (ISO)

genistein (ISO)

gentamycin (EXP)

glafenine (EXP)

glucose (ISO)

glycochenodeoxycholic acid (ISO)

glycocholic acid (ISO)

glycodeoxycholic acid (ISO)

hydralazine (ISO)

hydrazine (ISO)

hydrogen cyanide (ISO)

ionomycin (ISO)

isotretinoin (ISO)

ivermectin (ISO)

L-ethionine (EXP)

L-serine (ISO)

lead(0) (ISO)

lead(2+) (ISO)

methamphetamine (EXP)

methapyrilene (EXP)

methidathion (ISO)

methylparaben (ISO)

motexafin gadolinium (ISO)

N-methyl-4-phenylpyridinium (ISO)

nefazodone (ISO)

Nonidet P-40 (ISO)

omeprazole (EXP)

paracetamol (ISO)

paraquat (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phlorizin (ISO)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (EXP,ISO)

potassium cyanide (ISO)

propiconazole (ISO)

quercetin (ISO)

quinolin-8-ol (ISO)

resveratrol (ISO)

retinyl acetate (ISO)

rotenone (EXP)

SB 431542 (ISO)

SCH 23390 (EXP)

serpentine asbestos (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

succimer (ISO)

sunitinib (ISO)

tamoxifen (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP,ISO)

tunicamycin (ISO)

urethane (ISO)

ursodeoxycholic acid (EXP,ISO)

valproic acid (ISO)

vitamin E (ISO)

zinc acetate (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to cold (ISO,ISS)

negative regulation of apoptotic process (ISO)

negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation (ISO,ISS)

positive regulation of translation initiation in response to endoplasmic reticulum stress (ISO,ISS)

protein folding in endoplasmic reticulum (IBA)

proteolysis involved in protein catabolic process (ISO)

response to endoplasmic reticulum stress (ISO)

response to unfolded protein (IEA)

Cellular Component

cytoplasm (ISO)

cytosol (ISO,ISS)

endoplasmic reticulum (IBA,ISO)

endoplasmic reticulum lumen (ISO)

smooth endoplasmic reticulum (IDA)

Molecular Function

misfolded protein binding (IBA,ISO)

protein binding (ISO)

protein kinase binding (ISO,ISS)

protein kinase inhibitor activity (ISO,ISS)

protein-folding chaperone binding (IBA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Endoplasmic Reticulum-associated degradation pathway (IEA)

influenza A pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	An interaction map of endoplasmic reticulum chaperones and foldases.	Jansen G, etal., Mol Cell Proteomics. 2012 Sep;11(9):710-23. doi: 10.1074/mcp.M111.016550. Epub 2012 Jun 4.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
9.	Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK.	Yan W, etal., Proc Natl Acad Sci U S A 2002 Dec 10;99(25):15920-5. Epub 2002 Nov 22.

Additional References at PubMed

PMID:8666242	PMID:15489334	PMID:16923392	PMID:18923430	PMID:19199708	PMID:19946888	PMID:21245960	PMID:22064321	PMID:23376485	PMID:23395000	PMID:24769233	PMID:25329545

Genomics

Comparative Map Data

Dnajc3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	15	96,025,729 - 96,065,114 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	96,025,624 - 96,065,181 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	99,935,638 - 99,977,285 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	15	101,066,102 - 101,108,631 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	15	97,995,046 - 98,037,458 (+)	NCBI	Rnor_WKY
Rnor_6.0	15	104,186,918 - 104,226,236 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	104,186,792 - 104,226,329 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	107,610,329 - 107,649,355 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	103,881,634 - 103,921,295 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	103,897,413 - 103,937,075 (+)	NCBI
Celera	15	94,875,150 - 94,914,827 (+)	NCBI		Celera
Cytogenetic Map	15	q24	NCBI

DNAJC3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	95,677,139 - 95,794,988 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	13	95,677,139 - 95,794,988 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	13	96,329,393 - 96,447,242 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	95,127,484 - 95,241,285 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	13	95,127,483 - 95,241,285	NCBI
Celera	13	77,177,188 - 77,295,039 (+)	NCBI		Celera
Cytogenetic Map	13	q32.1	NCBI
HuRef	13	76,927,193 - 77,044,763 (+)	NCBI		HuRef
CHM1_1	13	96,299,542 - 96,417,377 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	13	94,881,700 - 94,999,557 (+)	NCBI		T2T-CHM13v2.0

Dnajc3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	119,175,344 - 119,219,114 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	119,175,388 - 119,219,109 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	118,937,932 - 118,981,702 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	118,937,976 - 118,981,697 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	119,337,154 - 119,380,924 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	119,337,209 - 119,379,121 (+)	NCBI		MGSCv36	mm8
Celera	14	117,490,628 - 117,537,345 (+)	NCBI		Celera
Cytogenetic Map	14	E4	NCBI

Dnajc3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955404	14,360,832 - 14,412,533 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955404	14,361,540 - 14,412,533 (-)	NCBI	ChiLan1.0	ChiLan1.0

DNAJC3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	13	95,975,607 - 96,114,256 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	96,033,605 - 96,114,165 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	13	76,853,053 - 76,963,530 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

DNAJC3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	46,323,263 - 46,402,240 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	22	46,307,905 - 46,398,625 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	46,093,175 - 46,185,499 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	22	46,737,351 - 46,829,808 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	22	46,736,369 - 46,844,494 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	22	46,400,716 - 46,493,029 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	22	46,433,934 - 46,526,175 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	22	46,439,531 - 46,531,587 (+)	NCBI		UU_Cfam_GSD_1.0

Dnajc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	181,825,991 - 181,896,607 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936472	14,055,532 - 14,126,211 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936472	14,055,548 - 14,126,173 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DNAJC3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	65,230,162 - 65,303,834 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	11	65,230,145 - 65,299,084 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	72,092,332 - 72,161,773 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DNAJC3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	74,474,643 - 74,582,942 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	74,474,548 - 74,579,048 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666046	30,900,130 - 31,009,831 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dnajc3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624879	2,369,237 - 2,434,433 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624879	2,369,332 - 2,434,433 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dnajc3
129 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	149
Count of miRNA genes:	113
Interacting mature miRNAs:	119
Transcripts:	ENSRNOT00000014182
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	22806240	98288169	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	22806240	98288169	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	22806240	98288169	Rat
1300144	Rf23	Renal function QTL 23	3.61		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	15	40631268	98288169	Rat
1576315	Schws6	Schwannoma susceptibility QTL 6		0.0069	nervous system integrity trait (VT:0010566)	post-insult time of death (CMO:0002005)	15	53806152	98806152	Rat
631655	Bp126	Blood pressure QTL 126	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	15	58156477	101769107	Rat
731177	Uae26	Urinary albumin excretion QTL 26	2.4	0.025	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	15	67588667	101769107	Rat
2300326	Plaw1	Placental weight QTL 1	15	0.005	placenta mass (VT:0004257)	placenta wet weight (CMO:0002088)	15	68327165	100062518	Rat
1641889	Colcr6	Colorectal carcinoma resistance QTL 6	2.9	0.0126	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	15	73690518	99794247	Rat
2317055	Aia10	Adjuvant induced arthritis QTL 10	3.41		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	15	75788062	101769107	Rat
1549844	Bss7	Bone structure and strength QTL 7	6.4		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	15	75788062	101769107	Rat
70155	Gcs1	Gastric cancer susceptibility QTL1	3.8		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	15	76306099	101769107	Rat
1300118	Bp190	Blood pressure QTL 190	2.94		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	15	82262520	98288169	Rat
1300120	Kidm7	Kidney mass QTL 7	3.55		kidney mass (VT:0002707)	left kidney wet weight to body weight ratio (CMO:0001954)	15	82262520	98288169	Rat

Markers in Region

S100a10

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	96,029,801 - 96,030,319 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	104,190,990 - 104,191,507	NCBI	Rnor6.0
Rnor_5.0	15	107,614,401 - 107,614,918	UniSTS	Rnor5.0
RGSC_v3.4	15	103,885,706 - 103,886,223	UniSTS	RGSC3.4
Celera	15	94,879,221 - 94,879,738	UniSTS
Cytogenetic Map	15	q24	UniSTS
Cytogenetic Map	2	q31-q34	UniSTS

RH128467

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	179,229,330 - 179,229,523 (+)	MAPPER	mRatBN7.2
mRatBN7.2	15	96,029,873 - 96,030,066 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	104,191,062 - 104,191,254	NCBI	Rnor6.0
Rnor_6.0	2	193,900,908 - 193,901,100	NCBI	Rnor6.0
Rnor_5.0	15	107,614,473 - 107,614,665	UniSTS	Rnor5.0
Rnor_5.0	2	210,966,438 - 210,966,630	UniSTS	Rnor5.0
RGSC_v3.4	2	186,653,993 - 186,654,185	UniSTS	RGSC3.4
RGSC_v3.4	15	103,885,778 - 103,885,970	UniSTS	RGSC3.4
Celera	15	94,879,293 - 94,879,485	UniSTS
Celera	2	171,057,250 - 171,057,442	UniSTS
Cytogenetic Map	2	q31-q34	UniSTS
Cytogenetic Map	15	q24	UniSTS

RH124908

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	96,029,917 - 96,030,073 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	104,191,106 - 104,191,261	NCBI	Rnor6.0
Rnor_5.0	15	107,614,517 - 107,614,672	UniSTS	Rnor5.0
RGSC_v3.4	15	103,885,822 - 103,885,977	UniSTS	RGSC3.4
Celera	15	94,879,337 - 94,879,492	UniSTS
Cytogenetic Map	15	q24	UniSTS

RH125510

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	96,029,919 - 96,030,073 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	104,191,108 - 104,191,261	NCBI	Rnor6.0
Rnor_5.0	15	107,614,519 - 107,614,672	UniSTS	Rnor5.0
RGSC_v3.4	15	103,885,824 - 103,885,977	UniSTS	RGSC3.4
Celera	15	94,879,339 - 94,879,492	UniSTS
Cytogenetic Map	15	q24	UniSTS

S100a10

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	96,029,897 - 96,030,246 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	104,191,086 - 104,191,434	NCBI	Rnor6.0
Rnor_5.0	15	107,614,497 - 107,614,845	UniSTS	Rnor5.0
RGSC_v3.4	15	103,885,802 - 103,886,150	UniSTS	RGSC3.4
Celera	15	94,879,317 - 94,879,665	UniSTS
Cytogenetic Map	2	q31-q34	UniSTS
Cytogenetic Map	15	q24	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022232	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB017702	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC061764	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000014182 ⟹ ENSRNOP00000014182

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	96,025,624 - 96,065,181 (+)	Ensembl
Rnor_6.0 Ensembl	15	104,186,792 - 104,226,329 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000093411 ⟹ ENSRNOP00000076327

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	96,038,395 - 96,065,181 (+)	Ensembl
Rnor_6.0 Ensembl	15	104,220,316 - 104,223,548 (+)	Ensembl

RefSeq Acc Id:

NM_022232 ⟹ NP_071568

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	96,025,729 - 96,065,114 (+)	NCBI
Rnor_6.0	15	104,186,918 - 104,226,236 (+)	NCBI
Rnor_5.0	15	107,610,329 - 107,649,355 (+)	NCBI
RGSC_v3.4	15	103,881,634 - 103,921,295 (+)	RGD
Celera	15	94,875,150 - 94,914,827 (+)	RGD

Sequence:

show sequence

ATGGTGGCCCCCGGCTCGGTGCGCAGCCGGCTGGGCGCGGTGTTCCCGTTCCTGCTTGTCCTGG
TGGACCTGCAGTACGAAGGTGCTGAATGTGGAGTAAATGCAGATGTAGAGAAGCATCTTGAACT
GGGAAAGAAGTTACTTGCAGCTGGACAGCTGGCCGATGCCTTATCTCAGTTTCATGCTGCAGTC
GATGGTGACCCTGATAACTATATTGCATACTATAGGAGAGCTACTGTCTTCTTAGCCATGGGAA
AATCCAAAGCAGCACTGCCTGATTTAACGAGAGTGATTGAACTGAAGATGGATTTCACTGCGGC
AAGATTACAGAGAGGTCACTTACTACTCAAACAAGGAAGGCTCGCCGAAGCAGAGGATGACTTT
AAGAAAGTGCTCAAATCTAATCCAAGTGAGAATGAAGAGAAGGAAGCCCAGTCTCAACTCGTAA
AAGCCGATGAGATGCAGCGCCTGCGCGCCCAAGCACTCGATGCCTTTGACAGCGCTGACTACAC
TGCGGCTATAACCTTCCTTGATGAGATTTTAGAGGTTTGTGTTTGGGATGCAGAATTGCGTGAG
CTGCGAGCAGAGTGCTTCATAAAGGAAGGAGAGCCTAGGAAAGCCATCAGTGACTTAAAGGCTG
CTTCAAAGCTCAAGAATGACAACACAGAGGCGTTTTACAAGATCAGCATTCTCTACTACCAGCT
AGGAGACCACGAGCTGTCTCTCAGTGAAGTTCGTGAATGTCTGAAACTTGACCAGGACCACAAG
CGGTGTTTTGCACACTATAAGCAAGTGAAGAAACTTAACAAGCTGATTGGGTCAGCTGAAGAGC
TGATCAGAGATGGGAGATACACAGATGCAACCAGCAAATACGAATCTGTCATGAAGGCAGAGCC
CAGTGTTGCTGAGTACACAGTCCGCTCCAAAGAAAGGGTCTGTCACTGCTTCTCCAAGGATGAG
AAGCCAGTCGAAGCCATTAAAATATGCTCTGAAGTTTTACAGCTGGAGCCCGACAATGTAAATG
CTCTGAAAGATCGAACGGAGGCCTATCTAATAGAGGAAATGTATGATGAAGCCATCCAGGACTA
TGAAGCTGCCCAGGAACAGAACGAAAACGATCAGCAGATTCGGGAAGGCTTAGAGAAAGCCCAG
CGGTTACTGAAACAGTCACAGAAGCGGGATTATTACAAAATCCTGGGAGTAAAAAGAAATGCCA
AAAAACAAGAAATCATTAAAGCATACCGAAAGTTAGCACTGCAGTGGCATCCAGATAATTTCCA
GAGTGAAGAGGAAAAGAAAAAAGCAGAGAAAAAGTTCATTGACATAGCAGCCGCTAAAGAAGTC
CTCTCCGACCCAGAAATGAGAAGGAAGTTTGATGACGGAGAAGACCCTCTTGATGCGGAGACTC
AGCAAGGAGGTGGTAGCAATCCCTTCCACAGAAGTTGGGACTCATGGCAAGGGTTCAATCCCTT
CAGCTCAGGCGGACCGTTTAGATTTAAGTTCCACTTCAATTAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_071568	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH61764	(Get FASTA)	NCBI Sequence Viewer
	BAA86882	(Get FASTA)	NCBI Sequence Viewer
	EDM02535	(Get FASTA)	NCBI Sequence Viewer
	EDM02536	(Get FASTA)	NCBI Sequence Viewer
	Q9R0T3	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_071568 ⟸ NM_022232
- Peptide Label:	precursor
- UniProtKB:	Q6P7A0 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MVAPGSVRSRLGAVFPFLLVLVDLQYEGAECGVNADVEKHLELGKKLLAAGQLADALSQFHAAV DGDPDNYIAYYRRATVFLAMGKSKAALPDLTRVIELKMDFTAARLQRGHLLLKQGRLAEAEDDF KKVLKSNPSENEEKEAQSQLVKADEMQRLRAQALDAFDSADYTAAITFLDEILEVCVWDAELRE LRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISILYYQLGDHELSLSEVRECLKLDQDHK RCFAHYKQVKKLNKLIGSAEELIRDGRYTDATSKYESVMKAEPSVAEYTVRSKERVCHCFSKDE KPVEAIKICSEVLQLEPDNVNALKDRTEAYLIEEMYDEAIQDYEAAQEQNENDQQIREGLEKAQ RLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQSEEEKKKAEKKFIDIAAAKEV LSDPEMRRKFDDGEDPLDAETQQGGGSNPFHRSWDSWQGFNPFSSGGPFRFKFHFN hide sequence

RefSeq Acc Id:

ENSRNOP00000014182 ⟸ ENSRNOT00000014182

RefSeq Acc Id:

ENSRNOP00000076327 ⟸ ENSRNOT00000093411

Protein Domains

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9R0T3-F1-model_v2	AlphaFold	Q9R0T3	1-504	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699876

Promoter ID:

EPDNEW_R10399

Type:

initiation region

Name:

Dnajc3_1

Description:

DnaJ heat shock protein family member C3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	15	104,186,804 - 104,186,864	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:708518	AgrOrtholog
BioCyc Gene	G2FUF-12431	BioCyc
Ensembl Genes	ENSRNOG00000010352	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000014182	ENTREZGENE
	ENSRNOP00000014182.2	UniProtKB/Swiss-Prot
	ENSRNOP00000076327.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000014182	ENTREZGENE
	ENSRNOT00000014182.6	UniProtKB/Swiss-Prot
	ENSRNOT00000093411.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.287.110	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	1.25.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5621087	IMAGE-MGC_LOAD
InterPro	DnaJ_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	J_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR-like_helical_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR_repeat	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:63880	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72454	IMAGE-MGC_LOAD
NCBI Gene	63880	ENTREZGENE
PANTHER	DNAJ HOMOLOG SUBFAMILY C MEMBER 3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LD25575P	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	DnaJ	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR_19	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR_8	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Dnajc3	PhenoGen
PRINTS	JDOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	DNAJ_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR_REGION	UniProtKB/Swiss-Prot
SMART	DnaJ	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF46565	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF48452	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A1W2Q6P6_RAT	UniProtKB/TrEMBL
	DNJC3_RAT	UniProtKB/Swiss-Prot
	Q6P7A0	ENTREZGENE
	Q9R0T3	ENTREZGENE
UniProt Secondary	Q6P7A0	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-11-25	Dnajc3	DnaJ heat shock protein family (Hsp40) member C3	Dnajc3	DnaJ (Hsp40) homolog, subfamily C, member 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-06-27			Dnajc3	DnaJ (Hsp40) homolog, subfamily C, member 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Dnajc3	DnaJ (Hsp40) homolog, subfamily C, member 3		protein kinase inhibitor p58	Name updated	1299863	APPROVED
2004-09-10	Dnajc3	protein kinase inhibitor p58	LOC63880		Symbol and Name updated	1299863	APPROVED

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)