Mt-nd6 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6)

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Gene: Mt-nd6 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6) Rattus norvegicus

Analyze

Symbol:

Mt-nd6

Name:

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6

RGD ID:

620561

Description:

Predicted to enable NADH dehydrogenase (ubiquinone) activity. Involved in response to cocaine; response to hydrogen peroxide; and response to nicotine. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial respiratory chain complex I. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; Leigh disease; and spinal muscular atrophy with lower extremity predominant 2B. Orthologous to human MT-ND6 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

mitochondrially encoded NADH dehydrogenase 6; NADH dehydrogenase 6, mitochondrial; NADH dehydrogenase subunit 6; Nd6

RGD Orthologs

Human

Mouse

Dog

Pig

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	MT	13,543 - 14,061 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	MT	13,543 - 14,061 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	MT	13,543 - 14,061 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	MT	13,543 - 14,061 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	MT	13,543 - 14,061 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	MT	13,543 - 14,061 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Cytogenetic Map	MT		NCBI

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute megakaryocytic leukemia (ISO)

Bilateral Striatal Necrosis with Dystonia (ISO)

blindness (ISO)

Chemical and Drug Induced Liver Injury (IEP)

Cognitive Dysfunction (ISO)

COVID-19 (ISO)

dilated cardiomyopathy (ISO)

Disease Susceptibility (ISO)

dystonia (ISO)

Hereditary Optic Atrophies (ISO)

lactic acidosis (ISS)

Leber hereditary optic neuropathy (ISO)

Leigh disease (ISO)

Leigh Syndrome Due To Mitochondrial Complex I Deficiency (ISO)

MELAS syndrome (ISO)

Mitochondrial Cytopathy (ISO)

mitochondrial metabolism disease (ISO)

Myoclonic Epilepsies (ISO)

oxyphilic adenoma (ISO)

Parkinson's disease 6 (ISO)

spinal muscular atrophy with predominant lower extremity 2B (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

(-)-epigallocatechin 3-gallate (ISO)

(R)-carnitine (ISO)

1,2-dichloroethane (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid (ISO)

alpha-D-galactose (ISO)

antimycin A (ISO)

aristolochic acid A (ISO)

astaxanthin (ISO)

atrazine (EXP,ISO)

azoxystrobin (ISO)

beauvericin (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

Benzo[k]fluoranthene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chrysene (ISO)

citraconic acid (ISO)

copper(II) sulfate (ISO)

deguelin (ISO)

desferrioxamine B (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

dioxygen (ISO)

doxorubicin (EXP,ISO)

enniatin (ISO)

flutamide (ISO)

folic acid (ISO)

formaldehyde (ISO)

galactose (ISO)

geldanamycin (ISO)

gentamycin (EXP)

indometacin (ISO)

Licochalcone B (ISO)

methidathion (ISO)

methylmercury chloride (ISO)

microcystin-LR (EXP)

monosodium L-glutamate (ISO)

N-methyl-4-phenylpyridinium (ISO)

nickel dichloride (ISO)

ochratoxin A (ISO)

perfluorooctanoic acid (EXP)

picoxystrobin (ISO)

potassium chromate (ISO)

pyrimidifen (ISO)

reactive oxygen species (ISO)

rotenone (ISO)

silicon dioxide (ISO)

T-2 toxin (EXP)

tebufenpyrad (ISO)

tetraphene (ISO)

thapsigargin (ISO)

thifluzamide (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vincristine (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mitochondrial electron transport, NADH to ubiquinone (ISO,ISS)

mitochondrial respiratory chain complex I assembly (ISO,ISS)

response to cocaine (IEP)

response to hydrogen peroxide (IEP)

response to nicotine (IEP)

Cellular Component

cellular_component (ND)

mitochondrial inner membrane (ISS)

mitochondrial respiratory chain complex I (ISO)

mitochondrion (IBA)

Molecular Function

molecular_function (ND)

NADH dehydrogenase (ubiquinone) activity (ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Cocaine self-administration alters brain NADH dehydrogenase mRNA levels.	Couceyro P, etal., Neuroreport. 1997 Jul 28;8(11):2437-41.
2.	Progressive myoclonic epilepsy as an adult-onset manifestation of Leigh syndrome due to m.14487T>C.	Dermaut B, etal., J Neurol Neurosurg Psychiatry. 2010 Jan;81(1):90-3.
3.	The complete nucleotide sequence of the Rattus norvegicus mitochondrial genome: cryptic signals revealed by comparative analysis between vertebrates.	Gadaleta G, etal., J Mol Evol 1989 Jun;28(6):497-516.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Modulation of mitochondrial gene expression in pulmonary epithelial cells exposed to oxidants.	Janssen YM, etal., Environ Health Perspect. 1998 Oct;106 Suppl 5:1191-5.
6.	A mitochondrial DNA mutation at nucleotide pair 14459 of the NADH dehydrogenase subunit 6 gene associated with maternally inherited Leber hereditary optic neuropathy and dystonia.	Jun AS, etal., Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6206-10.
7.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
8.	Frequency and spectrum of mitochondrial ND6 mutations in 1218 Han Chinese subjects with Leber's hereditary optic neuropathy.	Liang M, etal., Invest Ophthalmol Vis Sci. 2014 Mar 6;55(3):1321-31. doi: 10.1167/iovs.13-13011.
9.	Mouse mtDNA mutant model of Leber hereditary optic neuropathy.	Lin CS, etal., Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20065-70. doi: 10.1073/pnas.1217113109. Epub 2012 Nov 5.
10.	Novel mutations of ND genes in complex I deficiency associated with mitochondrial encephalopathy.	Malfatti E, etal., Brain. 2007 Jul;130(Pt 7):1894-904. Epub 2007 May 29.
11.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
12.	GOA pipeline	RGD automated data pipeline
13.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
15.	Comprehensive gene review and curation	RGD comprehensive gene curation
16.	Significant modulation of mitochondrial electron transport system by nicotine in various rat brain regions.	Wang J, etal., Mitochondrion. 2009 Jun;9(3):186-95. Epub 2009 Jan 30.
17.	Predose blood gene expression profiles might identify the individuals susceptible to carbon tetrachloride-induced hepatotoxicity.	Yun JW, etal., Toxicol Sci. 2010 May;115(1):12-21. doi: 10.1093/toxsci/kfq037. Epub 2010 Feb 3.
18.	A novel mtDNA ND6 gene mutation associated with LHON in a Caucasian family.	Zhadanov SI, etal., Biochem Biophys Res Commun. 2005 Jul 15;332(4):1115-21.
19.	Mitochondrial haplotypes may modulate the phenotypic manifestation of the LHON-associated m.14484T>C (MT-ND6) mutation in Chinese families.	Zhang J, etal., Mitochondrion. 2013 Nov;13(6):772-81. doi: 10.1016/j.mito.2013.05.002. Epub 2013 May 9.
20.	Leber's hereditary optic neuropathy is associated with mitochondrial ND6 T14502C mutation.	Zhao F, etal., Biochem Biophys Res Commun. 2009 Nov 20;389(3):466-72. doi: 10.1016/j.bbrc.2009.08.168. Epub 2009 Sep 2.

Genomics

Comparative Map Data

Mt-nd6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	MT	13,543 - 14,061 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	MT	13,543 - 14,061 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	MT	13,543 - 14,061 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	MT	13,543 - 14,061 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	MT	13,543 - 14,061 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	MT	13,543 - 14,061 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Cytogenetic Map	MT		NCBI

MT-ND6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	MT	14,149 - 14,673 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	MT	14,149 - 14,673 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	MT	14,149 - 14,673 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	MT	14,150 - 14,674 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36

mt-Nd6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	MT	13,552 - 14,070 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	MT	13,552 - 14,070 (-)	Ensembl		GRCm39 Ensembl
GRCm38	MT	13,552 - 14,070 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	MT	13,552 - 14,070 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	MT	13,552 - 14,070 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37

MT-ND6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	MT	13,582 - 14,109 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	MT	13,582 - 14,109 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	MT	13,582 - 14,109 (-)	NCBI		Dog10K_Boxer_Tasha

MT-ND6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	MT	14,739 - 15,266 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	MT	14,739 - 15,266 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	MT	14,739 - 15,266 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Variants

Variants in Mt-nd6
6 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	216
Count of miRNA genes:	161
Interacting mature miRNAs:	177
Transcripts:	ENSRNOT00000051268
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High	3	3	3	3	1	3		3	3	3	2	2
Medium		40	54	38	18	38	8	8	71	32	39	9	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


GenBank Nucleotide	AY172581	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FJ919765	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KJ939360	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KJ939361	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM009112	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM009113	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM009114	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM114603	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM114604	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM114605	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM114606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM114607	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM114608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM577635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM657952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM657953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KP244683	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000051268 ⟹ ENSRNOP00000045645

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	MT	13,543 - 14,061 (-)	Ensembl
Rnor_6.0 Ensembl	MT	13,543 - 14,061 (-)	Ensembl

Protein Sequences


Protein RefSeqs	YP_665640	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAN77605	(Get FASTA)	NCBI Sequence Viewer
	ACP50369	(Get FASTA)	NCBI Sequence Viewer
	AIU45586	(Get FASTA)	NCBI Sequence Viewer
	AIU45599	(Get FASTA)	NCBI Sequence Viewer
	AIU45612	(Get FASTA)	NCBI Sequence Viewer
	AIU45625	(Get FASTA)	NCBI Sequence Viewer
	AIU45638	(Get FASTA)	NCBI Sequence Viewer
	AIU45651	(Get FASTA)	NCBI Sequence Viewer
	AIU45664	(Get FASTA)	NCBI Sequence Viewer
	AIU45677	(Get FASTA)	NCBI Sequence Viewer
	AIU45690	(Get FASTA)	NCBI Sequence Viewer
	AIU45703	(Get FASTA)	NCBI Sequence Viewer
	AIU45716	(Get FASTA)	NCBI Sequence Viewer
	AIY51553	(Get FASTA)	NCBI Sequence Viewer
	AIZ58333	(Get FASTA)	NCBI Sequence Viewer
	AIZ58346	(Get FASTA)	NCBI Sequence Viewer
	AJK30568	(Get FASTA)	NCBI Sequence Viewer
	P03926	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

ENSRNOP00000045645 ⟸ ENSRNOT00000051268

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P03926-F1-model_v2	AlphaFold	P03926	1-172	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620561	AgrOrtholog
BioCyc Gene	G2FUF-5	BioCyc
BioCyc Pathway	PWY-3781 [aerobic respiration I (cytochrome c)]	BioCyc
Ensembl Genes	ENSRNOG00000029042	Ensembl, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000045645	ENTREZGENE
	ENSRNOP00000045645.3	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000051268.3	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.120.1200	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	NADH_UbQ/plastoQ_OxRdtase_su6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Nuo/plastoQ_OxRdtase_6_NuoJ	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:26203	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	26203	ENTREZGENE
PANTHER	NADH UBIQUINONE OXIDOREDUCTASE SUBUNIT ND6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Oxidored_q3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Mt-nd6	PhenoGen
UniProt	NU6M_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q8HIC5	ENTREZGENE, UniProtKB/TrEMBL
	Q9ZZM7	ENTREZGENE
UniProt Secondary	Q9ZZM7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-03-17	Mt-nd6	mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6	Mt-nd6	mitochondrially encoded NADH dehydrogenase 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-08-29	Mt-nd6	mitochondrially encoded NADH dehydrogenase 6	mt-Nd6	NADH dehydrogenase 6, mitochondrial	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-02-11	mt-Nd6	NADH dehydrogenase 6, mitochondrial			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	mt-Nd6	NADH dehydrogenase 6, mitochondrial			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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