Ube2n (ubiquitin-conjugating enzyme E2N) - Rat Genome Database

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Gene: Ube2n (ubiquitin-conjugating enzyme E2N) Rattus norvegicus
Analyze
Symbol: Ube2n
Name: ubiquitin-conjugating enzyme E2N
RGD ID: 621096
Description: Enables ubiquitin-protein transferase activity. Involved in regulation protein catabolic process at postsynapse. Is active in glutamatergic synapse and postsynapse. Orthologous to human UBE2N (ubiquitin conjugating enzyme E2 N); PARTICIPATES IN altered ubiquitin/proteasome degradation pathway; Alzheimer's disease pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,4-dinitrotoluene; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: bendless protein; bendless-like ubiquitin-conjugating enzyme; E2 ubiquitin-conjugating enzyme N; MGC93937; ubiquitin carrier protein N; ubiquitin-conjugating enzyme E2 N; ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13); ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast); ubiquitin-protein ligase N
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8732,041,190 - 32,071,252 (+)NCBIGRCr8
mRatBN7.2730,154,330 - 30,184,373 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl730,154,616 - 30,184,355 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx732,140,834 - 32,170,868 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0734,314,601 - 34,344,553 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0734,089,552 - 34,119,441 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0736,610,147 - 36,640,190 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl736,610,147 - 36,640,189 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0736,673,991 - 36,674,365 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4732,719,959 - 32,750,002 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1732,740,229 - 32,770,272 (+)NCBI
Celera727,227,481 - 27,257,458 (+)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Embryo Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
choline  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dieldrin  (EXP,ISO)
diethylstilbestrol  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (EXP,ISO)
fumonisin B1  (ISO)
geraniol  (ISO)
glafenine  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
inulin  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
L-methionine  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
Monobutylphthalate  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
nitrates  (EXP)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phlorizin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. ATM protein kinase: the linchpin of cellular defenses to stress. Bhatti S, etal., Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
4. Defective ubiquitination of cerebral proteins in Alzheimer's disease. Lopez Salon M, etal., J Neurosci Res 2000 Oct 15;62(2):302-10.
5. Proteasome-independent polyubiquitin linkage regulates synapse scaffolding, efficacy, and plasticity. Ma Q, etal., Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8760-E8769. doi: 10.1073/pnas.1620153114. Epub 2017 Sep 25.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Double-strand break repair: 53BP1 comes into focus. Panier S and Boulton SJ, Nat Rev Mol Cell Biol. 2014 Jan;15(1):7-18. doi: 10.1038/nrm3719. Epub 2013 Dec 11.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. Control of ubiquitination of proteins in rat tissues by ubiquitin conjugating enzymes and isopeptidases. Rajapurohitam V, etal., Am J Physiol Endocrinol Metab 2002 Apr;282(4):E739-45.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Verstrepen L, etal., Cell Mol Life Sci. 2008 Oct;65(19):2964-78.
16. Interleukin-1 (IL-1) pathway. Weber A, etal., Sci Signal. 2010 Jan 19;3(105):cm1. doi: 10.1126/scisignal.3105cm1.
Additional References at PubMed
PMID:12039045   PMID:12477932   PMID:14406273   PMID:14695475   PMID:15125833   PMID:15383616   PMID:15489334   PMID:16122702   PMID:16129784   PMID:16307917   PMID:17349954   PMID:18410486  
PMID:19340006   PMID:20061386   PMID:20458337   PMID:21512573   PMID:22424771   PMID:22681889   PMID:22797923   PMID:22871113   PMID:23376485   PMID:23533145   PMID:25936802   PMID:28039360  
PMID:29097665   PMID:31006531  


Genomics

Comparative Map Data
Ube2n
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8732,041,190 - 32,071,252 (+)NCBIGRCr8
mRatBN7.2730,154,330 - 30,184,373 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl730,154,616 - 30,184,355 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx732,140,834 - 32,170,868 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0734,314,601 - 34,344,553 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0734,089,552 - 34,119,441 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0736,610,147 - 36,640,190 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl736,610,147 - 36,640,189 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0736,673,991 - 36,674,365 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4732,719,959 - 32,750,002 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1732,740,229 - 32,770,272 (+)NCBI
Celera727,227,481 - 27,257,458 (+)NCBICelera
Cytogenetic Map7q13NCBI
UBE2N
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381293,405,684 - 93,441,947 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1293,405,673 - 93,441,947 (-)EnsemblGRCh38hg38GRCh38
GRCh371293,799,460 - 93,835,723 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361292,326,219 - 92,360,157 (-)NCBINCBI36Build 36hg18NCBI36
Build 341292,304,555 - 92,338,494NCBI
Celera1293,472,777 - 93,506,718 (-)NCBICelera
Cytogenetic Map12q22NCBI
HuRef1290,868,751 - 90,902,701 (-)NCBIHuRef
CHM1_11293,767,035 - 93,800,979 (-)NCBICHM1_1
T2T-CHM13v2.01293,386,662 - 93,422,932 (-)NCBIT2T-CHM13v2.0
Ube2n
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391095,351,024 - 95,381,520 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1095,351,007 - 95,381,519 (+)EnsemblGRCm39 Ensembl
GRCm381095,515,162 - 95,545,658 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1095,515,145 - 95,545,657 (+)EnsemblGRCm38mm10GRCm38
MGSCv371094,977,796 - 95,008,292 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361094,944,850 - 94,975,346 (+)NCBIMGSCv36mm8
Celera1097,490,812 - 97,521,349 (+)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1049.41NCBI
Ube2n
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540530,240,408 - 30,278,360 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540530,240,402 - 30,278,362 (-)NCBIChiLan1.0ChiLan1.0
UBE2N
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210101,450,349 - 101,486,347 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112101,447,738 - 101,482,741 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01290,951,446 - 90,984,075 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11294,353,010 - 94,355,957 (-)NCBIpanpan1.1PanPan1.1panPan2
UBE2N
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11041,470,073 - 41,470,738 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1041,470,073 - 41,470,738 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1534,102,683 - 34,137,381 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01534,322,738 - 34,357,275 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1534,319,244 - 34,357,300 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11533,601,301 - 33,635,863 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01533,690,613 - 33,725,132 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01533,954,910 - 33,989,442 (-)NCBIUU_Cfam_GSD_1.0
Ube2n
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494526,350,027 - 26,359,632 (+)NCBIHiC_Itri_2
UBE2N
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl589,702,682 - 89,714,279 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1589,673,306 - 89,716,345 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2593,613,063 - 93,637,519 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UBE2N
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11188,810,505 - 88,842,895 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037156,319,857 - 156,353,219 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ube2n
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475013,432,661 - 13,457,776 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475013,432,657 - 13,468,797 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ube2n
188 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:668
Count of miRNA genes:248
Interacting mature miRNAs:302
Transcripts:ENSRNOT00000074031, ENSRNOT00000074669, ENSRNOT00000075538
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)71903280735526300Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)72940968353612950Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat

Markers in Region
RH142361  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2730,184,095 - 30,184,262 (-)MAPPERmRatBN7.2
mRatBN7.2730,184,095 - 30,184,262 (+)MAPPERmRatBN7.2
mRatBN7.2184,971,953 - 84,972,120 (-)MAPPERmRatBN7.2
mRatBN7.2184,971,953 - 84,972,120 (+)MAPPERmRatBN7.2
Rnor_6.0736,639,912 - 36,640,078NCBIRnor6.0
Rnor_6.0187,631,638 - 87,631,804NCBIRnor6.0
Rnor_5.0188,808,801 - 88,808,967UniSTSRnor5.0
RGSC_v3.4732,749,724 - 32,749,890UniSTSRGSC3.4
RGSC_v3.4184,759,524 - 84,759,690UniSTSRGSC3.4
Celera179,348,543 - 79,348,709UniSTS
Cytogenetic Map7q13UniSTS
RH125323  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2730,183,019 - 30,183,813 (+)MAPPERmRatBN7.2
Rnor_6.0736,638,836 - 36,639,629NCBIRnor6.0
Rnor_6.0187,632,087 - 87,632,312NCBIRnor6.0
Rnor_5.0188,809,250 - 88,809,475UniSTSRnor5.0
RGSC_v3.4184,759,973 - 84,760,196UniSTSRGSC3.4
RGSC_v3.4732,748,648 - 32,749,441UniSTSRGSC3.4
Celera727,256,154 - 27,256,954UniSTS
Celera179,348,992 - 79,349,215UniSTS
Cytogenetic Map7q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000089874   ⟹   ENSRNOP00000071283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl730,154,616 - 30,184,355 (+)Ensembl
Rnor_6.0 Ensembl736,610,147 - 36,640,189 (+)Ensembl
RefSeq Acc Id: NM_053928   ⟹   NP_446380
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8732,041,209 - 32,071,252 (+)NCBI
mRatBN7.2730,154,330 - 30,184,373 (+)NCBI
Rnor_6.0736,610,147 - 36,640,190 (+)NCBI
Rnor_5.0736,673,991 - 36,674,365 (+)NCBI
RGSC_v3.4732,719,959 - 32,750,002 (+)RGD
Celera727,227,481 - 27,257,458 (+)RGD
Sequence:
RefSeq Acc Id: XM_063262876   ⟹   XP_063118946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8732,041,190 - 32,071,252 (+)NCBI
Protein Sequences
Protein RefSeqs NP_446380 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118946 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH90072 (Get FASTA)   NCBI Sequence Viewer  
  BAB20414 (Get FASTA)   NCBI Sequence Viewer  
  EDM16856 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071283.1
  ENSRNOP00055007651
  ENSRNOP00060005780
  ENSRNOP00065014979
GenBank Protein Q9EQX9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446380   ⟸   NM_053928
- UniProtKB: Q9EQX9 (UniProtKB/Swiss-Prot),   A6IG42 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071283   ⟸   ENSRNOT00000089874
RefSeq Acc Id: XP_063118946   ⟸   XM_063262876
- Peptide Label: isoform X1
Protein Domains
UBC core

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EQX9-F1-model_v2 AlphaFold Q9EQX9 1-152 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695159
Promoter ID:EPDNEW_R5684
Type:multiple initiation site
Name:Ube2n_2
Description:ubiquitin-conjugating enzyme E2N
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5685  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0736,610,159 - 36,610,219EPDNEW
RGD ID:13695160
Promoter ID:EPDNEW_R5685
Type:initiation region
Name:Ube2n_1
Description:ubiquitin-conjugating enzyme E2N
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5684  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0736,610,423 - 36,610,483EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621096 AgrOrtholog
BioCyc Gene G2FUF-34333 BioCyc
BioCyc Pathway PWY-7511 [protein ubiquitination] BioCyc
BioCyc Pathway Image PWY-7511 BioCyc
Ensembl Genes ENSRNOG00000058053 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055006099 UniProtKB/Swiss-Prot
  ENSRNOG00060004628 UniProtKB/Swiss-Prot
  ENSRNOG00065012014 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000089874.2 UniProtKB/Swiss-Prot
  ENSRNOT00055009893 UniProtKB/Swiss-Prot
  ENSRNOT00060007715 UniProtKB/Swiss-Prot
  ENSRNOT00065019543 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7113593 IMAGE-MGC_LOAD
InterPro UBQ-conjugat_E2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBQ-conjugating_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBQ-conjugating_enzyme/RWD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116725 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93937 IMAGE-MGC_LOAD
NCBI Gene 116725 ENTREZGENE
PANTHER UBIQUITIN-CONJUGATING ENZYME UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBIQUITIN-CONJUGATING ENZYME E2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam UQ_con UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ube2n PhenoGen
PROSITE UBC_1 UniProtKB/TrEMBL
  UBC_2 UniProtKB/TrEMBL
  UBIQUITIN_CONJUGAT_1 UniProtKB/Swiss-Prot
  UBIQUITIN_CONJUGAT_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000058053 RatGTEx
  ENSRNOG00055006099 RatGTEx
  ENSRNOG00060004628 RatGTEx
  ENSRNOG00065012014 RatGTEx
SMART UBCc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54495 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IG42 ENTREZGENE, UniProtKB/TrEMBL
  Q9EQX9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Ube2n  ubiquitin-conjugating enzyme E2N  Ube2n  ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-25 Ube2n  ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)  Ube2n  ubiquitin-conjugating enzyme E2N  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Ube2n  ubiquitin-conjugating enzyme E2N    ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13)  Name updated 1299863 APPROVED
2002-08-07 Ube2n  ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function interacts with specific E3s; may mediate substrate selectivity 724779