Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (R)-noradrenaline | multiple interactions | ISO | RGD:1346236 | 6480464 | SLC6A2 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein] more ... | CTD | PMID:17234900 | (R)-octopamine | multiple interactions | ISO | RGD:1346236 | 6480464 | [Octopamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP more ... | CTD | PMID:17234900, PMID:19725810 | (R)-octopamine | multiple interactions | ISO | RGD:1553140 | 6480464 | [Octopamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | (R)-octopamine | increases activity | ISO | RGD:1346236 | 6480464 | Octopamine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | (R)-octopamine | increases activity | ISO | RGD:1553140 | 6480464 | Octopamine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | (S)-amphetamine | increases uptake | ISO | RGD:1553140 | 6480464 | TAAR1 protein results in increased uptake of Dextroamphetamine | CTD | PMID:30776375 | (S)-amphetamine | increases uptake | EXP | | 6480464 | TAAR1 protein results in increased uptake of Dextroamphetamine | CTD | PMID:30776375 | 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile | multiple interactions | ISO | RGD:1346236 | 6480464 | Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]] more ... | CTD | PMID:17234900 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of TAAR1 mRNA, [Testosterone co-treated with Estradiol] results in increased expression of TAAR1 mRNA | CTD | PMID:26496021, PMID:32741896 | 2-phenylethylamine | multiple interactions | ISO | RGD:1346236 | 6480464 | [phenethylamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP more ... | CTD | PMID:17234900, PMID:19725810 | 2-phenylethylamine | multiple interactions | ISO | RGD:1553140 | 6480464 | [phenethylamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | 2-phenylethylamine | increases activity | ISO | RGD:1553140 | 6480464 | phenethylamine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | 2-phenylethylamine | increases activity | ISO | RGD:1346236 | 6480464 | phenethylamine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | 3',5'-cyclic AMP | multiple interactions | ISO | RGD:1346236 | 6480464 | [Octopamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP more ... | CTD | PMID:19725810 | 3',5'-cyclic AMP | multiple interactions | ISO | RGD:1553140 | 6480464 | [3-hydroxy-4-methoxyphenethylamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP more ... | CTD | PMID:19725810 | 3,4-methylenedioxymethamphetamine | increases uptake | EXP | | 6480464 | TAAR1 protein results in increased uptake of N-Methyl-3, 4-methylenedioxyamphetamine | CTD | PMID:30776375 | 3,4-methylenedioxymethamphetamine | increases uptake | ISO | RGD:1553140 | 6480464 | TAAR1 protein results in increased uptake of N-Methyl-3, 4-methylenedioxyamphetamine | CTD | PMID:30776375 | 3-methoxytyramine | increases activity | ISO | RGD:1553140 | 6480464 | 3-methoxytyramine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | 3-methoxytyramine | multiple interactions | ISO | RGD:1553140 | 6480464 | [3-methoxytyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | 4-methoxyphenylethylamine | increases activity | ISO | RGD:1553140 | 6480464 | O-methyltyramine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | 4-methoxyphenylethylamine | multiple interactions | ISO | RGD:1553140 | 6480464 | [O-methyltyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | 4-Methoxytyramine | increases activity | ISO | RGD:1553140 | 6480464 | 3-hydroxy-4-methoxyphenethylamine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | 4-Methoxytyramine | multiple interactions | ISO | RGD:1553140 | 6480464 | [3-hydroxy-4-methoxyphenethylamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | 4-phenyl-1,2,3,4-tetrahydroisoquinoline | multiple interactions | ISO | RGD:1553140 | 6480464 | [4-phenyl-1 more ... | CTD | PMID:19725810 | 4-phenyl-1,2,3,4-tetrahydroisoquinoline | increases activity | ISO | RGD:1553140 | 6480464 | 4-phenyl-1 more ... | CTD | PMID:19725810 | 5-methoxytryptamine | increases activity | ISO | RGD:1553140 | 6480464 | 5-Methoxytryptamine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | 5-methoxytryptamine | multiple interactions | ISO | RGD:1553140 | 6480464 | [5-Methoxytryptamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of TAAR1 mRNA | CTD | PMID:28959563 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of TAAR1 mRNA | CTD | PMID:16483693 | antazoline | increases activity | ISO | RGD:1553140 | 6480464 | Antazoline results in increased activity of TAAR1 protein | CTD | PMID:19725810 | antazoline | multiple interactions | ISO | RGD:1553140 | 6480464 | [Antazoline results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of TAAR1 mRNA | CTD | PMID:26496021 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of TAAR1 mRNA | CTD | PMID:25181051 | citalopram | multiple interactions | ISO | RGD:1346236 | 6480464 | Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]] more ... | CTD | PMID:17234900 | clonidine | increases activity | ISO | RGD:1553140 | 6480464 | Clonidine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | clonidine | multiple interactions | ISO | RGD:1553140 | 6480464 | [Clonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | clonidine (amino form) | increases activity | ISO | RGD:1553140 | 6480464 | Clonidine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | clonidine (amino form) | multiple interactions | ISO | RGD:1553140 | 6480464 | [Clonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | clonidine (imino form) | increases activity | ISO | RGD:1553140 | 6480464 | Clonidine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | clonidine (imino form) | multiple interactions | ISO | RGD:1553140 | 6480464 | [Clonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | desipramine | multiple interactions | ISO | RGD:1346236 | 6480464 | Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]] more ... | CTD | PMID:17234900 | dichloroacetic acid | increases expression | ISO | RGD:1553140 | 6480464 | Dichloroacetic Acid results in increased expression of TAAR1 mRNA | CTD | PMID:28962523 | dopamine | multiple interactions | ISO | RGD:1346236 | 6480464 | Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]] more ... | CTD | PMID:17234900 | fenoldopam | increases activity | ISO | RGD:1553140 | 6480464 | Fenoldopam results in increased activity of TAAR1 protein | CTD | PMID:19725810 | fenoldopam | multiple interactions | ISO | RGD:1553140 | 6480464 | [Fenoldopam results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of TAAR1 mRNA | CTD | PMID:30307764 | flavonoids | decreases expression | EXP | | 6480464 | Flavonoids results in decreased expression of TAAR1 mRNA | CTD | PMID:18035473 | Guanabenz | increases activity | ISO | RGD:1553140 | 6480464 | Guanabenz results in increased activity of TAAR1 protein | CTD | PMID:19725810 | Guanabenz | multiple interactions | ISO | RGD:1553140 | 6480464 | [Guanabenz results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | harman | increases activity | ISO | RGD:1553140 | 6480464 | harman results in increased activity of TAAR1 protein | CTD | PMID:19725810 | harman | multiple interactions | ISO | RGD:1553140 | 6480464 | [harman results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | histamine | multiple interactions | ISO | RGD:1553140 | 6480464 | [Histamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | histamine | increases activity | ISO | RGD:1553140 | 6480464 | Histamine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | idazoxan | multiple interactions | ISO | RGD:1553140 | 6480464 | [Idazoxan results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | idazoxan | increases activity | ISO | RGD:1553140 | 6480464 | Idazoxan results in increased activity of TAAR1 protein | CTD | PMID:19725810 | m-tyramine | increases activity | ISO | RGD:1553140 | 6480464 | 3-tyramine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | m-tyramine | multiple interactions | ISO | RGD:1553140 | 6480464 | [3-tyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | methamphetamine | multiple interactions | ISO | RGD:1346236 | 6480464 | Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]] more ... | CTD | PMID:17234900 | methamphetamine | multiple interactions | ISO | RGD:1553140 | 6480464 | TAAR1 protein affects the reaction [Methamphetamine results in decreased expression of TH protein], TAAR1 protein affects the reaction [Methamphetamine results in increased expression of GFAP protein] | CTD | PMID:28919515 | methamphetamine | affects response to substance | ISO | RGD:1553140 | 6480464 | TAAR1 protein affects the susceptibility to Methamphetamine | CTD | PMID:28919515 | methylphenidate | multiple interactions | ISO | RGD:1346236 | 6480464 | Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]] more ... | CTD | PMID:17234900 | Moxonidine | multiple interactions | ISO | RGD:1553140 | 6480464 | [moxonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | Moxonidine | increases activity | ISO | RGD:1553140 | 6480464 | moxonidine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | N-methylquipazine | increases activity | ISO | RGD:1553140 | 6480464 | N-methylquipazine analog results in increased activity of TAAR1 protein | CTD | PMID:19725810 | N-methylquipazine | multiple interactions | ISO | RGD:1553140 | 6480464 | [N-methylquipazine analog results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | octopamine | multiple interactions | ISO | RGD:1346236 | 6480464 | [Octopamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP more ... | CTD | PMID:17234900, PMID:19725810 | octopamine | increases activity | ISO | RGD:1553140 | 6480464 | Octopamine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | octopamine | multiple interactions | ISO | RGD:1553140 | 6480464 | [Octopamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | octopamine | increases activity | ISO | RGD:1346236 | 6480464 | Octopamine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | phenobarbital | decreases expression | ISO | RGD:1553140 | 6480464 | Phenobarbital results in decreased expression of TAAR1 mRNA | CTD | PMID:25270620 | Rilmenidine | increases activity | ISO | RGD:1553140 | 6480464 | rilmenidine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | Rilmenidine | multiple interactions | ISO | RGD:1553140 | 6480464 | [rilmenidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | serotonin | multiple interactions | ISO | RGD:1346236 | 6480464 | SLC6A2 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein] more ... | CTD | PMID:17234900 | Tesaglitazar | increases expression | EXP | | 6480464 | tesaglitazar results in increased expression of TAAR1 mRNA | CTD | PMID:21515302 | testosterone | multiple interactions | EXP | | 6480464 | [Testosterone co-treated with Estradiol] results in increased expression of TAAR1 mRNA | CTD | PMID:32741896 | tranylcypromine | increases activity | ISO | RGD:1553140 | 6480464 | Tranylcypromine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | tranylcypromine | multiple interactions | ISO | RGD:1553140 | 6480464 | [Tranylcypromine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | tryptamine | multiple interactions | ISO | RGD:1346236 | 6480464 | [tryptamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP more ... | CTD | PMID:17234900, PMID:19725810 | tryptamine | multiple interactions | ISO | RGD:1553140 | 6480464 | [tryptamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | tryptamine | increases activity | ISO | RGD:1553140 | 6480464 | tryptamine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | tryptamine | increases activity | ISO | RGD:1346236 | 6480464 | tryptamine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | tryptamines | multiple interactions | ISO | RGD:1553140 | 6480464 | [Tryptamines analog results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | tryptamines | increases activity | ISO | RGD:1553140 | 6480464 | Tryptamines analog results in increased activity of TAAR1 protein | CTD | PMID:19725810 | tyramine | multiple interactions | ISO | RGD:1346236 | 6480464 | [Tyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP more ... | CTD | PMID:17234900, PMID:19725810 | tyramine | multiple interactions | ISO | RGD:1553140 | 6480464 | [Tyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP | CTD | PMID:19725810 | tyramine | increases activity | ISO | RGD:1553140 | 6480464 | Tyramine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | tyramine | increases activity | ISO | RGD:1346236 | 6480464 | Tyramine results in increased activity of TAAR1 protein | CTD | PMID:19725810 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
References - curated
| 1. | Bunzow JR, etal., Mol Pharmacol 2001 Dec;60(6):1181-8. |
| 2. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 3. | Harmeier A, etal., Eur Neuropsychopharmacol. 2015 Nov;25(11):2049-61. doi: 10.1016/j.euroneuro.2015.08.011. Epub 2015 Aug 20. |
| 4. | MGD data from the GO Consortium |
| 5. | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 6. | RGD automated data pipeline |
| 7. | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:11459929 | PMID:15718104 | PMID:15955414 | PMID:21073468 | PMID:22442117 | PMID:23072560 | PMID:27544651 | PMID:28123023 |
Genomics
