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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621621
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Taar1
Name: trace-amine-associated receptor 1
Acc ID: CHEBI:17134
Term: octopamine
Definition: Octopamine is a biogenic phenylethanolamine, which has been found to act as a neurotransmitter, neurohormone or neuromodulator in invertebrates.
Chemical ID: MESH:D009655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISORGD:13462366480464CTDOctopamine results in increased activity of TAAR1 protein

PMID:19725810
increases activityISORGD:15531406480464CTDOctopamine results in increased activity of TAAR1 protein

PMID:19725810
multiple interactionsISORGD:13462366480464CTD[Octopamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP, Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]], Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]], indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]], indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]], indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]], Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]], SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein], SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein], SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]

PMID:17234900, PMID:19725810
multiple interactionsISORGD:15531406480464CTD[Octopamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP

PMID:19725810
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.