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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621621
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Taar1
Name: trace-amine-associated receptor 1
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Taar1affects response to substanceISOTaar1 (Mus musculus)6480464CTDTAAR1 protein affects the susceptibility to MethamphetaminePMID:28919515
Taar1multiple interactionsISOTAAR1 (Homo sapiens)6480464CTDCitalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]PMID:17234900
Taar1multiple interactionsISOTaar1 (Mus musculus)6480464CTDTAAR1 protein affects the reaction [Methamphetamine results in decreased expression of TH protein]; TAAR1 protein affects the reaction [Methamphetamine results in increased expression of GFAP protein]PMID:28919515
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