Afm (afamin) - Rat Genome Database

Name: Afm
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Advanced Search (OLGA)

Gene: Afm (afamin) Rattus norvegicus

Analyze

Symbol:

Afm

Name:

afamin

RGD ID:

628614

Description:

Predicted to enable vitamin E binding activity. Predicted to be involved in protein stabilization; protein transport within extracellular region; and vitamin transport. Located in extracellular space. Orthologous to human AFM (afamin); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

alpha albumin; alpha-Alb; alpha-albumin

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AFM (afamin)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Afm (afamin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AFM (afamin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AFM (afamin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AFM (afamin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AFM (afamin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Afm (afamin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RPS6KC1 (ribosomal protein S6 kinase C1)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Afm (afamin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	AFM (afamin)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	17,815,194 - 17,848,042 (-)	NCBI		GRCr8
mRatBN7.2	14	17,531,022 - 17,563,868 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	17,531,024 - 17,563,870 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	17,525,337 - 17,550,140 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	18,844,268 - 18,869,067 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	17,536,413 - 17,568,193 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	19,078,678 - 19,132,212 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	19,078,680 - 19,132,208 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	19,035,336 - 19,039,510 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	14	18,988,809 - 19,008,149 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	19,049,664 - 19,082,977 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	19,049,663 - 19,082,977 (-)	NCBI
Celera	14	16,899,392 - 16,930,240 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (ISO)

Experimental Liver Cirrhosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

4,4'-diaminodiphenylmethane (EXP,ISO)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

amiodarone (EXP)

ammonium chloride (EXP)

benzbromarone (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

buta-1,3-diene (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

cisplatin (EXP,ISO)

clofibrate (EXP)

copper atom (ISO)

copper(0) (ISO)

cyclosporin A (ISO)

doxorubicin (EXP)

endosulfan (ISO)

flutamide (EXP)

fumonisin B1 (ISO)

glafenine (EXP)

L-ethionine (EXP)

microcystin-LR (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-nitrosodiethylamine (EXP,ISO)

N-Nitrosopyrrolidine (ISO)

nefazodone (EXP)

nimesulide (EXP)

O-methyleugenol (ISO)

olanzapine (ISO)

omeprazole (EXP)

paracetamol (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

pirinixic acid (EXP,ISO)

potassium dichromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

rotenone (EXP)

sodium arsenite (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

Triptolide (EXP,ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein stabilization (IEA,ISO,ISS)

protein transport within extracellular region (IEA,ISO,ISS)

vitamin transport (IBA,IEA,ISO,ISS)

Cellular Component

cytoplasm (IBA)

extracellular space (IDA,IEA,ISO)

Molecular Function

metal ion binding (IEA)

protein binding (ISO)

vitamin E binding (IBA,IEA,ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	New albumin gene 3' adjacent to the alpha 1-fetoprotein locus.	Belanger L, etal., J Biol Chem 1994 Feb 25;269(8):5481-4.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes.	Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12463752	PMID:12477932	PMID:15952736	PMID:16502470	PMID:19046407	PMID:22516433	PMID:23376485	PMID:23533145	PMID:26902720

Genomics

Comparative Map Data

Afm
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	17,815,194 - 17,848,042 (-)	NCBI		GRCr8
mRatBN7.2	14	17,531,022 - 17,563,868 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	17,531,024 - 17,563,870 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	17,525,337 - 17,550,140 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	18,844,268 - 18,869,067 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	17,536,413 - 17,568,193 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	19,078,678 - 19,132,212 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	19,078,680 - 19,132,208 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	19,035,336 - 19,039,510 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	14	18,988,809 - 19,008,149 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	19,049,664 - 19,082,977 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	19,049,663 - 19,082,977 (-)	NCBI
Celera	14	16,899,392 - 16,930,240 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

AFM
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	73,481,745 - 73,504,001 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	73,481,745 - 73,504,001 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	74,347,462 - 74,369,718 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	74,566,326 - 74,588,582 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	74,712,496 - 74,734,753	NCBI
Celera	4	71,707,194 - 71,729,436 (+)	NCBI		Celera
Cytogenetic Map	4	q13.3	NCBI
HuRef	4	70,158,855 - 70,181,099 (+)	NCBI		HuRef
CHM1_1	4	74,383,462 - 74,405,708 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	76,825,372 - 76,847,610 (+)	NCBI		T2T-CHM13v2.0

Afm
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	90,666,808 - 90,701,403 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	90,666,791 - 90,701,402 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	90,518,949 - 90,553,544 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	90,518,932 - 90,553,543 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	90,947,975 - 90,982,570 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	91,594,163 - 91,641,425 (+)	NCBI		MGSCv36	mm8
Celera	5	88,680,306 - 88,704,975 (+)	NCBI		Celera
Cytogenetic Map	5	E1	NCBI
cM Map	5	44.78	NCBI

AFM
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	56,559,516 - 56,583,201 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	56,748,574 - 56,771,840 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	50,691,556 - 50,714,140 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	56,523,712 - 56,545,919 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	56,519,389 - 56,545,974 (-)	Ensembl	panpan1.1		panPan2

AFM
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	62,212,230 - 62,235,136 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	62,053,814 - 62,294,709 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	61,881,887 - 61,904,769 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	63,021,767 - 63,044,655 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	63,021,855 - 63,044,642 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	62,633,366 - 62,656,263 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	62,126,432 - 62,149,372 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	63,262,556 - 63,285,453 (+)	NCBI		UU_Cfam_GSD_1.0

AFM
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	69,706,896 - 69,728,255 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	69,706,823 - 69,728,269 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	73,806,942 - 73,828,360 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AFM
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	21,950,222 - 21,972,612 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	21,950,705 - 21,972,739 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666084	824,453 - 846,386 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Afm
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624735	33,945,107 - 34,015,900 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Afm
677 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	70
Count of miRNA genes:	66
Interacting mature miRNAs:	68
Transcripts:	ENSRNOT00000060535
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300114	Srn2	Serum renin concentration QTL 2	3.27		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	3813074	21217635	Rat
2293089	Iddm31	Insulin dependent diabetes mellitus QTL 31	4.7		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	14	3813074	18274691	Rat
1581500	Renag1	Renal agenesis QTL 1			kidney development trait (VT:0000527)	percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)	14	8170668	68298175	Rat
731183	Pia20	Pristane induced arthritis QTL 20	3.55		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	9088978	39057237	Rat
631212	Bw5	Body weight QTL5	5.43		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	14	11030812	30320092	Rat
2302277	Gluco38	Glucose level QTL 38	5.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	28035204	Rat
1331740	Bw26	Body weight QTL 26	3.028		body mass (VT:0001259)	body weight (CMO:0000012)	14	3813074	30767156	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
1358296	Ael3	Aortic elastin QTL 3	3.7	0.00051	aorta elastin amount (VT:0003905)	aortic elastin	14	8267090	53267090	Rat
70195	Mcs8	Mammary carcinoma susceptibility QTL 8	4.28		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	14	3813074	24531477	Rat
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	95876975	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
2302045	Pia39	Pristane induced arthritis QTL 39	4.9	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G2a level (CMO:0002116)	14	8267090	53267090	Rat
1300140	Srn3	Serum renin concentration QTL 3	3.19		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	14875168	30883947	Rat

Markers in Region

D14Got24

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	17,565,285 - 17,565,435 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	19,133,629 - 19,133,778	NCBI	Rnor6.0
Rnor_5.0	14	19,040,970 - 19,041,119	UniSTS	Rnor5.0
RGSC_v3.4	14	19,084,436 - 19,084,586	RGD	RGSC3.4
RGSC_v3.4	14	19,084,437 - 19,084,586	UniSTS	RGSC3.4
RGSC_v3.1	14	19,084,437 - 19,084,586	RGD
Celera	14	16,931,700 - 16,931,849	UniSTS
RH 3.4 Map	14	221.6	RGD
RH 3.4 Map	14	221.6	UniSTS
Cytogenetic Map	14	p22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
6	9	14	55	86	82	59	22	59	5	170	52	38	45	50	23

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_172320	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091644	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC091391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474060	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213773	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219466	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X76456	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000060535 ⟹ ENSRNOP00000057275

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	17,531,024 - 17,563,870 (-)	Ensembl
Rnor_6.0 Ensembl	14	19,078,680 - 19,132,208 (-)	Ensembl

RefSeq Acc Id:

NM_172320 ⟹ NP_758823

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	17,815,194 - 17,848,039 (-)	NCBI
mRatBN7.2	14	17,531,022 - 17,563,865 (-)	NCBI
Rnor_6.0	14	19,079,601 - 19,132,169 (-)	NCBI
Rnor_5.0	14	18,988,809 - 19,008,149 (-)	NCBI
Rnor_5.0	14	19,035,336 - 19,039,510 (-)	NCBI
RGSC_v3.4	14	19,049,664 - 19,082,977 (-)	RGD
Celera	14	16,899,392 - 16,930,240 (-)	RGD

Sequence:

show sequence

ATGAGACACTTAAAACTTACAGGTTTTATTTTTTTCCTGTTGTCTTTGACTGAATCCCTAGCCC
TACCCACAAAGCCTCAGGATGTAGATCATTTCAATGCTACTCAGAAATTCATAAATGAGAACGT
TGCATACCTGACCATCATTGCATCTGCCCAGTATGTTCAGGAAGCATCCTTTGAGGAGGTGGAA
ATGCTGGTGAAGGTCATGCTGGATTACAAGGATAGGTGCTTGGCTGACAGCACACTTCCGGAGT
GTTCAAAGATAGCTAATGATGCTATCCAGGACATGCTCTGTGATATGAAGGGGCTGCCACAGAA
GCATAACTTCTCCCATTGCTGTAGGCAAGCCGGCTTTCAAAGAAGACTCTGCTTCTTCTACAAC
AAGAAAGCTAATGTAGGATTTCTGCCCCCTTTCCCTACTCTGGATCCAGAAGAGAAATGCCAAG
CTTATAAAAATAACAGTGAATCTTTTCTCAACCTCTATATGTATGAGGTGGCCAGAAGGAACCC
CTTTGCCTTCGCCCCAGTTCTTCTGAACGTTGCCGCTAGGTTTGAGGAGGCGGCGACCACGTGC
TGTGAACAGCAACAGAAAGCCACCTACTTTCAAGACAAGGCAGCCCCCATCACACAGTATTTAA
AAGCGTTATCTTCTTATCAAAGAAATGTTTGTGGAGCCCTTTTAAAATTTGGACCCAAGACCTT
AAACTCTATAAACATCGCCGTGTTTAGTAAGAAGTTCCCCAAGATTGGATTTGAAGACCTTACG
TCCCTCTTAGAAGATGTTTCTTCCATGTATGACGGGTGCTGTGAAGGGGACGTCGTGCAGTGCA
TCCGGAGCCAGAGCCAGGTTATGCACCATATTTGTTCAAAACAAGACTCCATCTCAAGTAAGAT
CAAAGCGTGCTGTGAGAAGAAACTGCCAGAGCGCGCAGACTGCATAATCAACGCAAACAAGGAT
GACAGACCAGAAGACTTATCTCTGAGAACACCCAAATTTACCGACAGTGAAAATGTGTGCCAAG
AGCGAGATTCCGAGCAGGACAAGTTCTTTGCTGAGTTTCTTTATGATTACTCCAGAAGACATAC
TGAACTGTCTACACCAGAGCTCCTAAGAATTACTAAAGTGTATAAGGATCTCCTGGAAGATTGC
TGCAACAGAAAAAACCCGTTAAGCTGTTACCGCCATGCGGAGGATAAGTTCAACGAGACAACAG
AGCGAAGCCTTGCGATGGTCCAGCAAGAGTGCAAACAGTTCCAGGAATTGGGGAAGGACGCTCT
ACAACGCCATTTCCTTGTCAAGTTCACCAAGGCAGCCCCTCAACTCCCCATGGAAGAACTGGTC
TCCCTTAGTAAGGAAATGGTGGCGGCTTTGGCAACCTGCTGCACTCTCAGTGACGAGTTCGCCT
GTGTGGACAACTTGGCAGATTTAGTTCTTGGAGAATTATGTGGAATGAATAAGAATCGAACTAT
CAATCCCACTGTGGATCACTGCTGCAGAGCTGACTTTGCCTTCAGGAGACCCTGCTTTGAGCAC
CTGAAAGCCGACACCACCTATGCACTCCCATCAGTCTCTGCACTTGTATCTGCTTTGCGTGCAG
ACTGGTGTCAGCCTCTCAAGGAGGACCTTCAGAATAAGAGACACAGGTTTCTGGTCAACTTAGT
GAAGTGGATGCCAGAGATCACAGATGAGGAACGTCTGTGTTTGTTCACAAAGTTCACGGCTGCT
GGGGAGGAGTGTGGCAACATACAGAAGCCTGAGGCCTGTTTCAGTCCAGAGAGTTCAAAAACCG
GTGATGTGAGTCAAGATGCAGAGAAACAAAGGTGA

hide sequence

RefSeq Acc Id:

XM_039091644 ⟹ XP_038947572

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	17,815,210 - 17,848,042 (-)	NCBI
mRatBN7.2	14	17,531,034 - 17,563,868 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_758823	(Get FASTA)	NCBI Sequence Viewer
	XP_038947572	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH91391	(Get FASTA)	NCBI Sequence Viewer
	CAA53994	(Get FASTA)	NCBI Sequence Viewer
	EDL88553	(Get FASTA)	NCBI Sequence Viewer
	EDL88554	(Get FASTA)	NCBI Sequence Viewer
	EDL88555	(Get FASTA)	NCBI Sequence Viewer
	EDL88556	(Get FASTA)	NCBI Sequence Viewer
	EDL88557	(Get FASTA)	NCBI Sequence Viewer
	EDL88558	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000057275.2
GenBank Protein	P36953	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_758823 ⟸ NM_172320
- Peptide Label:	precursor
- UniProtKB:	G3V9R9 (UniProtKB/TrEMBL), A6KKF6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRHLKLTGFIFFLLSLTESLALPTKPQDVDHFNATQKFINENVAYLTIIASAQYVQEASFEEVE MLVKVMLDYKDRCLADSTLPECSKIANDAIQDMLCDMKGLPQKHNFSHCCRQAGFQRRLCFFYN KKANVGFLPPFPTLDPEEKCQAYKNNSESFLNLYMYEVARRNPFAFAPVLLNVAARFEEAATTC CEQQQKATYFQDKAAPITQYLKALSSYQRNVCGALLKFGPKTLNSINIAVFSKKFPKIGFEDLT SLLEDVSSMYDGCCEGDVVQCIRSQSQVMHHICSKQDSISSKIKACCEKKLPERADCIINANKD DRPEDLSLRTPKFTDSENVCQERDSEQDKFFAEFLYDYSRRHTELSTPELLRITKVYKDLLEDC CNRKNPLSCYRHAEDKFNETTERSLAMVQQECKQFQELGKDALQRHFLVKFTKAAPQLPMEELV SLSKEMVAALATCCTLSDEFACVDNLADLVLGELCGMNKNRTINPTVDHCCRADFAFRRPCFEH LKADTTYALPSVSALVSALRADWCQPLKEDLQNKRHRFLVNLVKWMPEITDEERLCLFTKFTAA GEECGNIQKPEACFSPESSKTGDVSQDAEKQR hide sequence

Ensembl Acc Id:

ENSRNOP00000057275 ⟸ ENSRNOT00000060535

RefSeq Acc Id:	XP_038947572 ⟸ XM_039091644
- Peptide Label:	isoform X1

Protein Domains

Albumin

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P36953-F1-model_v2	AlphaFold	P36953	1-608	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699232

Promoter ID:

EPDNEW_R9757

Type:

single initiation site

Name:

Afm_1

Description:

afamin

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	19,132,205 - 19,132,265	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628614	AgrOrtholog
BioCyc Gene	G2FUF-16188	BioCyc
Ensembl Genes	ENSRNOG00000002878	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000060535.5	UniProtKB/TrEMBL
Gene3D-CATH	1.10.246.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7322187	IMAGE-MGC_LOAD
InterPro	ALB/AFP/VDB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Serum_albumin-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Serum_albumin/AFP/Afamin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Serum_albumin_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Serum_albumin_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:282708	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:109482	IMAGE-MGC_LOAD
NCBI Gene	282708	ENTREZGENE
PANTHER	AFAMIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11385	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Serum_albumin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Afm	PhenoGen
PIRSF	Serum_albumin_subgroup	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	AFETOPROTEIN	UniProtKB/TrEMBL
	SERUMALBUMIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ALBUMIN_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ALBUMIN_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000002878	RatGTEx
SMART	ALBUMIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48552	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6KKF2_RAT	UniProtKB/TrEMBL
	A6KKF3_RAT	UniProtKB/TrEMBL
	A6KKF4_RAT	UniProtKB/TrEMBL
	A6KKF6	ENTREZGENE, UniProtKB/TrEMBL
	A6KKF7_RAT	UniProtKB/TrEMBL
	AFAM_RAT	UniProtKB/Swiss-Prot
	G3V9R9	ENTREZGENE, UniProtKB/TrEMBL
	P36953	ENTREZGENE
	Q5BJP7_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Afm	afamin			Symbol and Name status set to approved	1299863	APPROVED
2003-02-27	Afm	afamin			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expression is decreased 2.5 fold in SHR rats compared to WKY rats	1357414
gene_process	possible role in the transport of yet unknown ligand	724707

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD