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Gene: Itih4 (inter-alpha-trypsin inhibitor heavy chain 4) Rattus norvegicus
Symbol: Itih4
Name: inter-alpha-trypsin inhibitor heavy chain 4
Description: Predicted to have serine-type endopeptidase inhibitor activity. Predicted to be involved in acute-phase response and response to cytokine. Predicted to localize to cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in intermediate coronary syndrome and myocardial infarction. Orthologous to human ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4); INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: inter alpha-trypsin inhibitor, heavy chain 4; inter-alpha-inhibitor H4 heavy chain; inter-alpha-trypsin inhibitor heavy chain family, member 4; inter-alpha-trypsin inhibitor heavy chain H4
Homo sapiens (human) : ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4)  HGNC  Alliance
Mus musculus (house mouse) : Itih4 (inter alpha-trypsin inhibitor, heavy chain 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itih4 (inter-alpha-trypsin inhibitor heavy chain 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4)
Canis lupus familiaris (dog) : ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itih4 (inter-alpha-trypsin inhibitor heavy chain 4)
Sus scrofa (pig) : ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4)
Chlorocebus sabaeus (African green monkey) : ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4)
Heterocephalus glaber (naked mole-rat) : Itih4 (inter-alpha-trypsin inhibitor heavy chain 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0166,970,367 - 6,985,538 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl166,970,342 - 6,985,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,896,782 - 6,912,274 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,319,608 - 6,334,782 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1166,319,608 - 6,334,777 (+)NCBI
Celera169,093,866 - 9,109,046 (-)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Itih4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 70881
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.