Lbp (lipopolysaccharide binding protein) - Rat Genome Database

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Gene: Lbp (lipopolysaccharide binding protein) Rattus norvegicus
Analyze
Symbol: Lbp
Name: lipopolysaccharide binding protein
RGD ID: 61865
Description: Enables lipopolysaccharide binding activity. Involved in several processes, including liver development; positive regulation of macrophage activation; and positive regulation of phagocytosis, engulfment. Located in extracellular space. Used to study obesity. Biomarker of liver cirrhosis; obstructive jaundice; and periodontitis. Orthologous to human LBP (lipopolysaccharide binding protein); PARTICIPATES IN interleukin-6 signaling pathway; Toll-like receptor signaling pathway; tuberculosis pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BPI fold containing family D, member 2; Bpifd2; lipopolysaccharide-binding protein; MGC124626
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83167,373,786 - 167,400,941 (+)NCBIGRCr8
mRatBN7.23146,953,889 - 146,981,032 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3146,954,015 - 146,981,586 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3150,786,436 - 150,813,463 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03159,285,723 - 159,312,752 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03157,020,490 - 157,047,489 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03154,786,232 - 154,812,910 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3154,786,215 - 154,813,464 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03160,793,301 - 160,819,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43149,016,605 - 149,043,530 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13148,922,500 - 148,949,992 (+)NCBI
Celera3145,655,280 - 145,682,077 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acids  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzylpenicillin  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chloroform  (EXP)
ciguatoxin CTX1B  (ISO)
cobalt dichloride  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP)
diclofenac  (ISO)
diiodine  (ISO)
dimethylarsinic acid  (ISO)
doxorubicin  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
erythromycin A  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP)
fluoranthene  (EXP)
flutamide  (EXP)
fulvestrant  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
Ginkgolide A  (ISO)
glafenine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
graphene oxide  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
ketamine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
levofloxacin  (EXP)
lipopolysaccharide  (EXP,ISO)
menadione  (ISO)
methimazole  (EXP)
methotrexate  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naloxone  (EXP)
nefazodone  (ISO)
nickel atom  (ISO)
Nonylphenol  (EXP)
O-methyleugenol  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenacetin  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
phenylhydrazine  (EXP)
pipoxolan  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
quinidine  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
senecionine  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sulfadimethoxine  (EXP)
sulindac  (EXP)
Sunset Yellow FCF  (ISO)
tacrolimus hydrate  (EXP)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
theophylline  (EXP)
tolcapone  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell surface  (IEA,ISO)
extracellular space  (IBA,IDA,IEA,ISO)
membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Lipopolysaccharide-binding protein and lipopolysaccharide receptor CD14 gene expression after thermal injury and its potential mechanism(s). Fang CW, etal., J Trauma. 2002 Nov;53(5):957-67.
2. Serum LBP levels reflect the impaired synthetic capacity of the remnant liver after partial hepatectomy in rats. Fang H, etal., J Immunol Methods. 2012 Aug 31;382(1-2):68-75. doi: 10.1016/j.jim.2012.05.006. Epub 2012 May 8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Induction of hepatocyte lipopolysaccharide binding protein in models of sepsis and the acute-phase response. Geller DA, etal., Arch Surg. 1993 Jan;128(1):22-7; discussion 27-8.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Dietary supplementation of n-3 PUFA reduces weight gain and improves postprandial lipaemia and the associated inflammatory response in the obese JCR:LA-cp rat. Hassanali Z, etal., Diabetes Obes Metab. 2010 Feb;12(2):139-47. doi: 10.1111/j.1463-1326.2009.01130.x. Epub 2009 Nov 16.
7. Lipopolysaccharide-binding protein accelerates and augments Escherichia coli phagocytosis by alveolar macrophages. Klein RD, etal., J Surg Res. 2000 Dec;94(2):159-66.
8. Postnatal development of hepatic innate immune response. Le Rouzic V, etal., Inflammation. 2011 Dec;34(6):576-84. doi: 10.1007/s10753-010-9265-5.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Activity of lipopolysaccharide-binding protein-bactericidal/permeability-increasing protein fusion peptide in an experimental model of Pseudomonas sepsis. Opal SM, etal., Antimicrob Agents Chemother. 1995 Dec;39(12):2813-5.
12. Myeloid differentiation 2 as a therapeutic target of inflammatory disorders. Park SH, etal., Pharmacol Ther. 2012 Mar;133(3):291-8. doi: 10.1016/j.pharmthera.2011.11.001. Epub 2011 Nov 19.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism. Sheth P, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G308-18. Epub 2007 Apr 19.
19. Altered gene expression in gingival tissues and enhanced bone loss in rats with diabetes with experimental periodontitis. Soboku K, etal., J Periodontol. 2014 Mar;85(3):455-64. doi: 10.1902/jop.2013.120705. Epub 2013 Jun 3.
20. Surfactant protein a inhibits lipopolysaccharide-induced immune cell activation by preventing the interaction of lipopolysaccharide with lipopolysaccharide-binding protein. Stamme C, etal., Am J Respir Cell Mol Biol 2002 Sep;27(3):353-60.
21. Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4. Su GL, etal., Hepatology. 2000 Apr;31(4):932-6.
22. Molecular cloning, characterization, and tissue distribution of rat lipopolysaccharide binding protein. Evidence for extrahepatic expression. Su GL, etal., J Immunol 1994 Jul 15;153(2):743-52.
23. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
24. High-density lipoprotein administration attenuates liver proinflammatory response, restores liver endothelial nitric oxide synthase activity, and lowers portal pressure in cirrhotic rats. Thabut D, etal., Hepatology. 2007 Dec;46(6):1893-906.
25. The Kinetic Expression of Lipopolysaccharide-Binding Protein and CD14 Gene in Obstructive Jaundice. Tsai CH, etal., J Invest Surg. 2014 Aug 5.
26. Activation of the lipopolysaccharide signaling pathway in hepatic transplantation preservation injury. Tsoulfas G, etal., Transplantation. 2002 Jul 15;74(1):7-13.
27. LBP inhibitory peptide reduces endotoxin-induced macrophage activation and mortality. Wu X, etal., Inflamm Res. 2005 Nov;54(11):451-7.
28. [Role of endotoxin translocation on mesenteric lymph reperfusion aggravating multiple organ injury in SMAO shock rats]. Yang LN, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2012 Jan;28(1):74-8.
Additional References at PubMed
PMID:2402637   PMID:8409400   PMID:8985160   PMID:9338787   PMID:11079463   PMID:11528597   PMID:11739189   PMID:12055258   PMID:12477932   PMID:12594207   PMID:12932360   PMID:14739326  
PMID:15294986   PMID:15828022   PMID:17254389   PMID:19056867   PMID:23376485   PMID:23437199   PMID:23533145   PMID:23958732   PMID:24120359   PMID:24380872   PMID:25874537   PMID:31714656  
PMID:38114435  


Genomics

Comparative Map Data
Lbp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83167,373,786 - 167,400,941 (+)NCBIGRCr8
mRatBN7.23146,953,889 - 146,981,032 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3146,954,015 - 146,981,586 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3150,786,436 - 150,813,463 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03159,285,723 - 159,312,752 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03157,020,490 - 157,047,489 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03154,786,232 - 154,812,910 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3154,786,215 - 154,813,464 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03160,793,301 - 160,819,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43149,016,605 - 149,043,530 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13148,922,500 - 148,949,992 (+)NCBI
Celera3145,655,280 - 145,682,077 (+)NCBICelera
Cytogenetic Map3q42NCBI
LBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382038,346,482 - 38,377,013 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2038,346,482 - 38,377,013 (+)EnsemblGRCh38hg38GRCh38
GRCh372036,974,885 - 37,005,655 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362036,408,299 - 36,439,067 (+)NCBINCBI36Build 36hg18NCBI36
Build 342036,408,298 - 36,439,067NCBI
Celera2033,683,680 - 33,714,456 (+)NCBICelera
Cytogenetic Map20q11.23NCBI
HuRef2033,709,729 - 33,740,760 (+)NCBIHuRef
CHM1_12036,878,602 - 36,909,384 (+)NCBICHM1_1
T2T-CHM13v2.02040,072,800 - 40,104,597 (+)NCBIT2T-CHM13v2.0
Lbp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392158,148,413 - 158,174,772 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2158,148,413 - 158,174,772 (+)EnsemblGRCm39 Ensembl
GRCm382158,306,493 - 158,332,852 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2158,306,493 - 158,332,852 (+)EnsemblGRCm38mm10GRCm38
MGSCv372158,132,229 - 158,158,588 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362157,997,986 - 158,023,737 (+)NCBIMGSCv36mm8
Celera2164,244,570 - 164,269,152 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map278.72NCBI
LBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22144,070,881 - 44,103,778 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12044,063,979 - 44,096,876 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02034,670,128 - 34,703,046 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12035,780,768 - 35,813,188 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2035,780,768 - 35,813,188 (+)Ensemblpanpan1.1panPan2
LBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12426,810,369 - 26,833,515 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2426,809,843 - 26,833,434 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2426,456,134 - 26,479,256 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02427,506,422 - 27,529,551 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2427,506,460 - 27,529,472 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12426,780,778 - 26,803,800 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02426,888,642 - 26,911,780 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02427,377,130 - 27,400,265 (+)NCBIUU_Cfam_GSD_1.0
Lbp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640175,713,998 - 175,732,560 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365613,016,926 - 3,035,552 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365613,017,471 - 3,035,481 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1741,393,818 - 41,429,551 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11741,398,935 - 41,429,467 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21746,838,042 - 46,868,577 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1225,375,364 - 25,407,181 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl225,374,755 - 25,406,839 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605074,213,568 - 74,246,762 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lbp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248421,301,831 - 1,332,346 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248421,306,299 - 1,332,269 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lbp
323 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:94
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000019787
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145956084157309487Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3145956084161299569Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat

Markers in Region
D3Got121  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23146,975,869 - 146,976,080 (+)MAPPERmRatBN7.2
Rnor_6.03154,807,748 - 154,807,958NCBIRnor6.0
Rnor_5.03160,798,253 - 160,798,463UniSTSRnor5.0
RGSC_v3.43149,038,367 - 149,038,578RGDRGSC3.4
RGSC_v3.43149,038,368 - 149,038,578UniSTSRGSC3.4
RGSC_v3.13148,944,277 - 148,944,487RGD
Celera3145,676,915 - 145,677,125UniSTS
RH 3.4 Map31357.9RGD
RH 3.4 Map31357.9UniSTS
Cytogenetic Map3q42UniSTS
D3Got125  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23146,975,873 - 146,976,091 (+)MAPPERmRatBN7.2
Rnor_6.03154,807,752 - 154,807,969NCBIRnor6.0
Rnor_5.03160,798,242 - 160,798,459UniSTSRnor5.0
RGSC_v3.43149,038,371 - 149,038,589RGDRGSC3.4
RGSC_v3.43149,038,372 - 149,038,589UniSTSRGSC3.4
RGSC_v3.13148,944,281 - 148,944,498RGD
Celera3145,676,919 - 145,677,136UniSTS
RH 3.4 Map31357.6RGD
RH 3.4 Map31357.6UniSTS
Cytogenetic Map3q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 27 27 27 7 10
Low 2 34 30 14 19 14 7 9 39 33 33 1 7
Below cutoff 1 6 1 2 35 2 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000019787   ⟹   ENSRNOP00000019787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3146,954,015 - 146,981,586 (+)Ensembl
Rnor_6.0 Ensembl3154,786,215 - 154,813,464 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096776   ⟹   ENSRNOP00000095950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3146,954,015 - 146,978,615 (+)Ensembl
RefSeq Acc Id: NM_017208   ⟹   NP_058904
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83167,373,941 - 167,400,941 (+)NCBI
mRatBN7.23146,954,032 - 146,981,032 (+)NCBI
Rnor_6.03154,786,232 - 154,812,910 (+)NCBI
Rnor_5.03160,793,301 - 160,819,979 (-)NCBI
RGSC_v3.43149,016,605 - 149,043,530 (+)RGD
Celera3145,655,280 - 145,682,077 (+)RGD
Sequence:
RefSeq Acc Id: XM_039104446   ⟹   XP_038960374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83167,380,486 - 167,400,936 (+)NCBI
mRatBN7.23146,960,578 - 146,981,032 (+)NCBI
RefSeq Acc Id: XM_039104447   ⟹   XP_038960375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83167,373,786 - 167,390,903 (+)NCBI
mRatBN7.23146,953,889 - 146,970,988 (+)NCBI
RefSeq Acc Id: XM_039104448   ⟹   XP_038960376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83167,382,830 - 167,400,936 (+)NCBI
mRatBN7.23146,962,939 - 146,981,032 (+)NCBI
RefSeq Acc Id: NP_058904   ⟸   NM_017208
- Peptide Label: precursor
- UniProtKB: Q63313 (UniProtKB/Swiss-Prot),   Q3MID7 (UniProtKB/TrEMBL),   F7FLI1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019787   ⟸   ENSRNOT00000019787
RefSeq Acc Id: XP_038960375   ⟸   XM_039104447
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038960374   ⟸   XM_039104446
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038960376   ⟸   XM_039104448
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000095950   ⟸   ENSRNOT00000096776
Protein Domains
Lipid-binding serum glycoprotein C-terminal   Lipid-binding serum glycoprotein N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63313-F1-model_v2 AlphaFold Q63313 1-481 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692620
Promoter ID:EPDNEW_R3144
Type:multiple initiation site
Name:Lbp_1
Description:lipopolysaccharide binding protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03154,786,219 - 154,786,279EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61865 AgrOrtholog
BioCyc Gene G2FUF-47034 BioCyc
Ensembl Genes ENSRNOG00000014532 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019787.3 UniProtKB/TrEMBL
  ENSRNOT00000096776.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7933709 IMAGE-MGC_LOAD
InterPro Bactericidal_perm-incr_a/b_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BPI/LBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BPI/LBP/Plunc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipid-bd_serum_glycop_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipid-bd_serum_glycop_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipid-bd_serum_glycop_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29469 UniProtKB/TrEMBL
MGC_CLONE MGC:124626 IMAGE-MGC_LOAD
NCBI Gene 29469 ENTREZGENE
PANTHER PTHR10504 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10504:SF66 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LBP_BPI_CETP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LBP_BPI_CETP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lbp PhenoGen
PIRSF Lipid_binding_protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LBP_BPI_CETP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014532 RatGTEx
SMART BPI1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BPI2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55394 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216800
UniProt A0A8I6AMU5_RAT UniProtKB/TrEMBL
  F7FLI1 ENTREZGENE, UniProtKB/TrEMBL
  LBP_RAT UniProtKB/Swiss-Prot
  Q3MID7 ENTREZGENE, UniProtKB/TrEMBL
  Q63313 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Lbp  lipopolysaccharide binding protein      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation interaction with lipopolysaccharide is inhibited by Pulmonary surfactant protein (SP)-A binding to lipopolysaccharide 727417