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Activity of lipopolysaccharide-binding protein-bactericidal/permeability-increasing protein fusion peptide in an experimental model of Pseudomonas sepsis.

Authors: Opal, SM  Palardy, JE  Jhung, JW  Donsky, C  Romulo, RL  Parejo, N  Marra, MN 
Citation: Opal SM, etal., Antimicrob Agents Chemother. 1995 Dec;39(12):2813-5.
Pubmed: (View Article at PubMed) PMID:8593028

A chimeric protein consisting of the N-terminal domain of lipopolysaccharide-binding protein and the C-terminal domain of bactericidal/permeability-increasing protein demonstrated a dose-dependent survival benefit (P = 0.001) and reduced endotoxin levels (P < 0.01) in neutropenic rats with Pseudomonas aeruginosa sepsis. This lipopolysaccharide-binding protein-bactericidal/ permeability-increasing peptide has favorable pharmacokinetics and antiendotoxin properties which may be of value for human sepsis.


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RGD Object Information
RGD ID: 9685196
Created: 2014-12-23
Species: All species
Last Modified: 2014-12-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.