RGD Reference Report - Induction of hepatocyte lipopolysaccharide binding protein in models of sepsis and the acute-phase response. - Rat Genome Database

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Induction of hepatocyte lipopolysaccharide binding protein in models of sepsis and the acute-phase response.

Authors: Geller, DA  Kispert, PH  Su, GL  Wang, SC  Di Silvio, M  Tweardy, DJ  Billiar, TR  Simmons, RL 
Citation: Geller DA, etal., Arch Surg. 1993 Jan;128(1):22-7; discussion 27-8.
RGD ID: 9685191
Pubmed: PMID:8418776   (View Abstract at PubMed)

Lipopolysaccharide binding protein (LBP) is a serum glycoprotein that complexes with lipopolysaccharide (LPS) to facilitate macrophage response to endotoxin. To determine the conditions that stimulate LBP production in vivo, we measured the induction of LBP in models of inflammation produced by LPS, Corynebacterium parvum, and turpentine injection. Plasma aspartate aminotransferase and alanine aminotransferase concentrations and hepatocyte fibrinogen synthesis were elevated in all models. Northern blot analysis revealed 17-, 14-, and 20-fold upregulation of hepatocyte LBP mRNA following treatment with LPS, C parvum, and turpentine, respectively. Peritoneal macrophage interleukin 6 and tumor necrosis factor production following endotoxin stimulation was augmented by cultured hepatocyte supernatants, suggesting increased LBP synthesis in these groups. The results show that LBP mRNA is induced during hepatic inflammation and suggest that LBP is an acute-phase protein important in regulating the in vivo response to endotoxin.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LBPHumanEndotoxemia  ISOLbp (Rattus norvegicus)mRNA:increased expression:hepatocyteRGD 
LbpRatEndotoxemia  IEP mRNA:increased expression:hepatocyteRGD 
LbpMouseEndotoxemia  ISOLbp (Rattus norvegicus)mRNA:increased expression:hepatocyteRGD 

Objects Annotated

Genes (Rattus norvegicus)
Lbp  (lipopolysaccharide binding protein)

Genes (Mus musculus)
Lbp  (lipopolysaccharide binding protein)

Genes (Homo sapiens)
LBP  (lipopolysaccharide binding protein)


Additional Information