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Gene: Ears2 (glutamyl-tRNA synthetase 2, mitochondrial) Rattus norvegicus
Symbol: Ears2
Name: glutamyl-tRNA synthetase 2, mitochondrial
Description: Predicted to have glutamate-tRNA ligase activity and glutamate-tRNA(Gln) ligase activity. Predicted to be involved in glutamyl-tRNA aminoacylation and tRNA aminoacylation for mitochondrial protein translation. Predicted to localize to the mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency. Orthologous to human EARS2 (glutamyl-tRNA synthetase 2, mitochondrial); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; homocarnosinosis pathway; INTERACTS WITH 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole; 6-propyl-2-thiouracil; amiodarone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: glutamyl-tRNA synthetase 2 mitochondrial (putative); LOC361641; probable glutamate--tRNA ligase, mitochondrial; probable glutamyl-tRNA synthetase, mitochondrial; RGD1307904; similar to RIKEN cDNA 3230401I01
Homo sapiens (human) : EARS2 (glutamyl-tRNA synthetase 2, mitochondrial)  HGNC  Alliance
Mus musculus (house mouse) : Ears2 (glutamyl-tRNA synthetase 2, mitochondrial)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ears2 (glutamyl-tRNA synthetase 2, mitochondrial)
Pan paniscus (bonobo/pygmy chimpanzee) : EARS2 (glutamyl-tRNA synthetase 2, mitochondrial)
Canis lupus familiaris (dog) : EARS2 (glutamyl-tRNA synthetase 2, mitochondrial)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ears2 (glutamyl-tRNA synthetase 2, mitochondrial)
Sus scrofa (pig) : EARS2 (glutamyl-tRNA synthetase 2, mitochondrial)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01191,997,512 - 192,025,350 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01199,083,532 - 199,087,792 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01198,699,309 - 198,716,446 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41180,861,635 - 180,889,473 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11181,001,656 - 181,029,365 (-)NCBI
Celera1174,307,704 - 174,335,598 (-)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Ears2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1307904
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.