Hrh1 (histamine receptor H 1) - Rat Genome Database

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Gene: Hrh1 (histamine receptor H 1) Rattus norvegicus
Analyze
Symbol: Hrh1
Name: histamine receptor H 1
RGD ID: 2830
Description: Enables histamine binding activity. Involved in several processes, including negative regulation of steroid biosynthetic process; positive regulation of nitric oxide biosynthetic process; and positive regulation of vasoconstriction. Predicted to be located in cytosol. Predicted to be active in dendrite and plasma membrane. Orthologous to human HRH1 (histamine receptor H1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-pyridylethylamine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: H1R; HH1R; Hisr; histamine H1 receptor; Histamine receptor H1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84149,120,511 - 149,204,267 (+)NCBIGRCr8
mRatBN7.24147,564,963 - 147,649,353 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4147,645,995 - 147,647,455 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4152,949,786 - 153,033,522 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04148,730,672 - 148,814,402 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04147,360,109 - 147,443,854 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04146,374,596 - 146,458,148 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4146,455,332 - 146,457,074 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04209,668,412 - 209,751,766 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44150,431,239 - 150,432,699 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14150,676,079 - 150,677,540 (+)NCBI
Celera4136,197,254 - 136,198,714 (+)NCBICelera
RH 3.4 Map4950.0RGD
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-ropivacaine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
2-pyridylethylamine  (EXP,ISO)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
aminophylline  (ISO)
ammonium chloride  (EXP)
asbestos  (ISO)
astemizole  (ISO)
atrazine  (EXP)
azatadine  (ISO)
azelastine  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
betahistine  (EXP)
bisphenol A  (EXP,ISO)
bupivacaine  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
cetirizine  (ISO)
chlordecone  (ISO)
chlorphenamine  (EXP,ISO)
cimetidine  (ISO)
cisplatin  (ISO)
clemastine  (ISO)
clobenpropit  (EXP)
clozapine  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
desloratadine  (ISO)
dexamethasone  (EXP)
dimetindene  (ISO)
diphenhydramine  (EXP,ISO)
diphenylpyraline  (ISO)
dopamine  (EXP)
doxorubicin  (ISO)
epinastine  (EXP)
epoxiconazole  (ISO)
erythromycin A  (EXP)
ethanol  (ISO)
Fexofenadine hydrochloride  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
galangin  (ISO)
gallic acid  (ISO)
GTP  (ISO)
histamine  (EXP,ISO)
hydroxyzine  (ISO)
lamotrigine  (ISO)
lead(0)  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
loratadine  (ISO)
manganese(II) chloride  (ISO)
mepyramine  (EXP,ISO)
methotrexate  (ISO)
milnacipran  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
olanzapine  (ISO)
Olopatadine hydrochloride  (EXP,ISO)
paracetamol  (ISO)
paroxetine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium atom  (EXP)
potassium chromate  (ISO)
procaine  (ISO)
promethazine  (ISO)
quercetin  (EXP,ISO)
resveratrol  (ISO)
rifampicin  (ISO)
Ro 31-8220  (EXP)
rotenone  (EXP)
scopolamine  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tacrine  (EXP)
Terfenadine  (ISO)
tetracaine  (ISO)
tetrachloromethane  (ISO)
toluene 2,4-diisocyanate  (EXP)
tributylstannane  (ISO)
Tripelennamine  (EXP)
triprolidine  (EXP,ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)
dendrite  (IBA)
plasma membrane  (IBA,IEA,ISO,ISS)
synapse  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of mRNA encoding the H1, H2, and H3 histamine receptors in the rat cochlea. Azuma H, etal., Neuroreport 2003 Mar 3;14(3):423-5.
2. Genomic cloning of the rat histamine H1 receptor. Fujimoto K, etal., Biochem Biophys Res Commun 1993 Jan 15;190(1):294-301.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Dual role of histamine in modulation of Leydig cell steroidogenesis via HRH1 and HRH2 receptor subtypes. Mondillo C, etal., Biol Reprod. 2005 Nov;73(5):899-907. Epub 2005 May 25.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Potentiation by neuropeptide Y of histamine H1 receptor-mediated contraction in rat blood vessels. Piao H, etal., Vascul Pharmacol. 2007 Apr;46(4):260-70. Epub 2006 Oct 27.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Effects of hypergravity on histamine H1 receptor mRNA expression in hypothalamus and brainstem of rats: implications for development of motion sickness. Sato G, etal., Acta Otolaryngol. 2009 Jan;129(1):45-51.
15. Histamine H1-receptor modulation of inter-neuronal coupling among vasopressinergic neurons depends on nitric oxide synthase activation. Yang QZ and Hatton GI, Brain Res 2002 Nov 15;955(1-2):115-22.
Additional References at PubMed
PMID:12581497   PMID:15167971   PMID:15899242   PMID:16181737   PMID:16354729   PMID:16797837   PMID:17145090   PMID:17562388   PMID:18345501   PMID:18345503   PMID:19393269   PMID:20096284  
PMID:20117984   PMID:20811878   PMID:21602597   PMID:21622829   PMID:23497494   PMID:23713466   PMID:24702851   PMID:25112718   PMID:25192644   PMID:27904941   PMID:28722302   PMID:28964277  
PMID:29498008   PMID:34638832   PMID:36766852   PMID:38483045  


Genomics

Comparative Map Data
Hrh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84149,120,511 - 149,204,267 (+)NCBIGRCr8
mRatBN7.24147,564,963 - 147,649,353 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4147,645,995 - 147,647,455 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4152,949,786 - 153,033,522 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04148,730,672 - 148,814,402 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04147,360,109 - 147,443,854 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04146,374,596 - 146,458,148 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4146,455,332 - 146,457,074 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04209,668,412 - 209,751,766 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44150,431,239 - 150,432,699 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14150,676,079 - 150,677,540 (+)NCBI
Celera4136,197,254 - 136,198,714 (+)NCBICelera
RH 3.4 Map4950.0RGD
Cytogenetic Map4q42NCBI
HRH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38311,137,238 - 11,263,557 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl311,137,093 - 11,263,557 (+)EnsemblGRCh38hg38GRCh38
GRCh37311,178,924 - 11,305,243 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36311,153,779 - 11,279,939 (+)NCBINCBI36Build 36hg18NCBI36
Build 34311,269,399 - 11,279,415NCBI
Celera311,114,216 - 11,240,363 (+)NCBICelera
Cytogenetic Map3p25.3NCBI
HuRef311,113,586 - 11,239,205 (+)NCBIHuRef
CHM1_1311,128,810 - 11,254,995 (+)NCBICHM1_1
T2T-CHM13v2.0311,131,678 - 11,258,484 (+)NCBIT2T-CHM13v2.0
Hrh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396114,374,897 - 114,459,432 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6114,374,897 - 114,460,257 (+)EnsemblGRCm39 Ensembl
GRCm386114,397,936 - 114,483,298 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6114,397,936 - 114,483,296 (+)EnsemblGRCm38mm10GRCm38
MGSCv376114,347,930 - 114,433,290 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366114,363,531 - 114,448,891 (+)NCBIMGSCv36mm8
Celera6116,219,517 - 116,304,883 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.05NCBI
Hrh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542914,067,405 - 14,068,853 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542914,022,332 - 14,069,931 (+)NCBIChiLan1.0ChiLan1.0
HRH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2211,134,626 - 11,259,909 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1311,139,386 - 11,264,669 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0311,074,451 - 11,199,871 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1311,439,705 - 11,545,509 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl311,541,294 - 11,542,757 (+)Ensemblpanpan1.1panPan2
HRH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1207,160,903 - 7,236,147 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl207,162,393 - 7,235,869 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha207,195,842 - 7,270,946 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0207,190,337 - 7,265,418 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl207,190,251 - 7,265,315 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1206,906,408 - 6,981,475 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0207,262,781 - 7,337,859 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0207,234,680 - 7,309,540 (-)NCBIUU_Cfam_GSD_1.0
Hrh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494216,634,611 - 16,727,741 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366022,183,831 - 2,185,297 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366022,182,053 - 2,185,297 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HRH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1367,209,127 - 67,411,170 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11367,209,261 - 67,411,174 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21374,579,748 - 74,631,302 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HRH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12247,187,156 - 47,298,761 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2247,295,011 - 47,296,471 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041119,219,292 - 119,336,578 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hrh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624943484,942 - 486,390 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624943483,230 - 505,678 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hrh1
564 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:22
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000009775
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4120926564148090731Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 21 53 21 14 6 140 24 69 33 6
Below cutoff 63 72 45 36 45 22 39 86 88 67 24 18

Sequence


Ensembl Acc Id: ENSRNOT00000009775   ⟹   ENSRNOP00000009775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4147,645,995 - 147,647,455 (+)Ensembl
Rnor_6.0 Ensembl4146,455,332 - 146,457,074 (+)Ensembl
RefSeq Acc Id: NM_017018   ⟹   NP_058714
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84149,120,511 - 149,204,267 (+)NCBI
mRatBN7.24147,564,963 - 147,648,723 (+)NCBI
Rnor_6.04146,455,420 - 146,456,880 (+)NCBI
Rnor_5.04209,668,412 - 209,751,766 (+)NCBI
RGSC_v3.44150,431,239 - 150,432,699 (+)RGD
Celera4136,197,254 - 136,198,714 (+)RGD
Sequence:
RefSeq Acc Id: XM_039107019   ⟹   XP_038962947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84149,120,623 - 149,204,261 (+)NCBI
mRatBN7.24147,565,101 - 147,649,353 (+)NCBI
Protein Sequences
Protein RefSeqs NP_058714 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962947 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA02245 (Get FASTA)   NCBI Sequence Viewer  
  EDL91568 (Get FASTA)   NCBI Sequence Viewer  
  EDL91569 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009775.2
GenBank Protein P31390 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058714   ⟸   NM_017018
- UniProtKB: P31390 (UniProtKB/Swiss-Prot),   G3V6X5 (UniProtKB/TrEMBL),   A6IBV0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009775   ⟸   ENSRNOT00000009775
RefSeq Acc Id: XP_038962947   ⟸   XM_039107019
- Peptide Label: isoform X1
- UniProtKB: P31390 (UniProtKB/Swiss-Prot),   G3V6X5 (UniProtKB/TrEMBL),   A6IBV0 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31390-F1-model_v2 AlphaFold P31390 1-486 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2830 AgrOrtholog
BioCyc Gene G2FUF-43342 BioCyc
Ensembl Genes ENSRNOG00000007420 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009775.5 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histamine_H1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24448 UniProtKB/Swiss-Prot
NCBI Gene 24448 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HISTAMINE H1 RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HRH1 RGD
PhenoGen Hrh1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HISTAMINEH1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007420 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IBV0 ENTREZGENE, UniProtKB/TrEMBL
  G3V6X5 ENTREZGENE, UniProtKB/TrEMBL
  HRH1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Hrh1  Histamine receptor H1      Symbol and Name status set to approved 70586 APPROVED