Car7 (carbonic anhydrase 7) - Rat Genome Database

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Gene: Car7 (carbonic anhydrase 7) Rattus norvegicus
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Symbol: Car7
Name: carbonic anhydrase 7
RGD ID: 1306842
Description: Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process and regulation of intracellular pH. Predicted to act upstream of or within several processes, including positive regulation of GABAergic synaptic transmission; positive regulation of cellular pH reduction; and regulation of chloride transport. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human CA7 (carbonic anhydrase 7); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 3,7-dihydropurine-6-thione; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ca7; carbonic anhydrase VII
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr819435,520 - 444,927 (-)NCBIGRCr8
mRatBN7.219429,063 - 438,478 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl19429,075 - 438,467 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx19424,817 - 434,251 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01951,853 - 61,284 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.019466,826 - 476,258 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.019636,545 - 645,935 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl19636,545 - 645,937 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.019630,356 - 639,746 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.419365,680 - 375,074 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.119365,695 - 375,513 (-)NCBI
Celera19424,600 - 433,992 (-)NCBICelera
Cytogenetic Map19p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15028762   PMID:23881097  


Genomics

Comparative Map Data
Car7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr819435,520 - 444,927 (-)NCBIGRCr8
mRatBN7.219429,063 - 438,478 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl19429,075 - 438,467 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx19424,817 - 434,251 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01951,853 - 61,284 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.019466,826 - 476,258 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.019636,545 - 645,935 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl19636,545 - 645,937 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.019630,356 - 639,746 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.419365,680 - 375,074 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.119365,695 - 375,513 (-)NCBI
Celera19424,600 - 433,992 (-)NCBICelera
Cytogenetic Map19p14NCBI
CA7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381666,844,414 - 66,854,147 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1666,844,414 - 66,854,153 (+)EnsemblGRCh38hg38GRCh38
GRCh371666,878,317 - 66,888,050 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361665,435,783 - 65,445,551 (+)NCBINCBI36Build 36hg18NCBI36
Build 341665,435,891 - 65,445,541NCBI
Celera1651,386,593 - 51,396,359 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1652,752,480 - 52,762,235 (+)NCBIHuRef
CHM1_11668,285,378 - 68,295,146 (+)NCBICHM1_1
T2T-CHM13v2.01672,638,709 - 72,648,442 (+)NCBIT2T-CHM13v2.0
Car7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398105,261,326 - 105,276,979 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8105,261,321 - 105,276,975 (+)EnsemblGRCm39 Ensembl
GRCm388104,534,694 - 104,550,347 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8104,534,689 - 104,550,343 (+)EnsemblGRCm38mm10GRCm38
MGSCv378107,064,707 - 107,074,243 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368107,429,936 - 107,439,472 (+)NCBIMGSCv36mm8
Celera8108,773,242 - 108,782,734 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
Ca7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543323,365,718 - 23,374,548 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543323,365,832 - 23,374,517 (+)NCBIChiLan1.0ChiLan1.0
CA7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21876,345,564 - 76,355,356 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11682,258,074 - 82,267,859 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01647,161,021 - 47,170,800 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11666,262,259 - 66,272,316 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1666,262,362 - 66,271,665 (+)Ensemblpanpan1.1panPan2
CA7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1582,446,239 - 82,455,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl582,446,246 - 82,455,590 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha582,434,936 - 82,444,145 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0582,882,872 - 82,892,083 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl582,882,877 - 82,892,233 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1582,706,026 - 82,715,234 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0582,392,889 - 82,402,094 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0583,031,862 - 83,041,073 (-)NCBIUU_Cfam_GSD_1.0
Ca7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934942,469,000 - 42,477,123 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647517,112,004 - 17,120,105 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647517,112,004 - 17,120,105 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl627,548,706 - 27,563,861 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1627,548,647 - 27,563,966 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CA7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1552,541,008 - 52,551,307 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl552,541,527 - 52,551,389 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604723,360,443 - 23,370,286 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ca7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474619,640,463 - 19,648,615 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474619,640,436 - 19,648,708 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Car7
39 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:397
Count of miRNA genes:200
Interacting mature miRNAs:228
Transcripts:ENSRNOT00000016521
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 71 10
Low 12 143 141 141 73 71 106 18
Below cutoff 9 64 63 6 48 6 17 15 75 34 33 34 9

Sequence


Ensembl Acc Id: ENSRNOT00000016521   ⟹   ENSRNOP00000016521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl19429,075 - 438,467 (-)Ensembl
Rnor_6.0 Ensembl19636,545 - 645,937 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116794   ⟹   ENSRNOP00000091957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl19429,075 - 436,065 (-)Ensembl
RefSeq Acc Id: NM_001106165   ⟹   NP_001099635
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr819435,522 - 444,914 (-)NCBI
mRatBN7.219429,075 - 438,467 (-)NCBI
Rnor_6.019636,545 - 645,935 (-)NCBI
Rnor_5.019630,356 - 639,746 (-)NCBI
RGSC_v3.419365,680 - 375,074 (-)RGD
Celera19424,600 - 433,992 (-)RGD
Sequence:
RefSeq Acc Id: XM_006255051   ⟹   XP_006255113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr819435,520 - 444,704 (-)NCBI
mRatBN7.219429,063 - 438,278 (-)NCBI
Rnor_6.019636,547 - 645,569 (-)NCBI
Rnor_5.019630,356 - 639,746 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772243   ⟹   XP_008770465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr819435,520 - 444,927 (-)NCBI
mRatBN7.219429,063 - 438,478 (-)NCBI
Rnor_6.019636,547 - 645,893 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063277835   ⟹   XP_063133905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr819435,520 - 444,708 (-)NCBI
RefSeq Acc Id: NP_001099635   ⟸   NM_001106165
- UniProtKB: B2RZ61 (UniProtKB/TrEMBL),   A6JXV1 (UniProtKB/TrEMBL),   A0A8I6AD38 (UniProtKB/TrEMBL),   F7FEQ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255113   ⟸   XM_006255051
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AD38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770465   ⟸   XM_008772243
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AD38 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016521   ⟸   ENSRNOT00000016521
Ensembl Acc Id: ENSRNOP00000091957   ⟸   ENSRNOT00000116794
RefSeq Acc Id: XP_063133905   ⟸   XM_063277835
- Peptide Label: isoform X3
Protein Domains
Alpha-carbonic anhydrase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RZ61-F1-model_v2 AlphaFold B2RZ61 1-264 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306842 AgrOrtholog
BioCyc Gene G2FUF-6651 BioCyc
Ensembl Genes ENSRNOG00000012371 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016521.8 UniProtKB/TrEMBL
  ENSRNOT00000116794.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.200.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9090629 IMAGE-MGC_LOAD
InterPro alpha_CA_VII UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class_cat UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class_CS UniProtKB/TrEMBL
  Carbonic_anhydrase_a_sf UniProtKB/TrEMBL
KEGG Report rno:291819 UniProtKB/TrEMBL
MGC_CLONE MGC:189301 IMAGE-MGC_LOAD
NCBI Gene 291819 ENTREZGENE
PANTHER CARBONIC ANHYDRASE 7 UniProtKB/TrEMBL
  Euk_COanhd UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/TrEMBL
PhenoGen Car7 PhenoGen
PROSITE ALPHA_CA_1 UniProtKB/TrEMBL
  ALPHA_CA_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012371 RatGTEx
SMART Carb_anhydrase UniProtKB/TrEMBL
Superfamily-SCOP Euk_COanhd UniProtKB/TrEMBL
UniProt A0A8I6AD38 ENTREZGENE, UniProtKB/TrEMBL
  A6JXV1 ENTREZGENE, UniProtKB/TrEMBL
  B2RZ61 ENTREZGENE
  F7FEQ2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B2RZ61 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Car7  carbonic anhydrase 7   Car7_predicted  carbonic anhydrase 7 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Car7_predicted  carbonic anhydrase 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED