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Gene: Flg (filaggrin) Rattus norvegicus
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Symbol: Flg
Name: filaggrin
RGD ID: 2620
Description: Predicted to have keratin filament binding activity. Involved in epidermal cell differentiation. Predicted to localize to cornified envelope; cytoplasmic ribonucleoprotein granule; and keratohyalin granule. Human ortholog(s) of this gene implicated in atopic dermatitis 2 and ichthyosis vulgaris. Orthologous to human FLG (filaggrin); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: MODEL
Also known as: Filaggrin (profilaggrin); LOC679174; LOW QUALITY PROTEIN: filaggrin; Pflg
Orthologs:
Homo sapiens (human) : FLG (filaggrin)  HGNC  Alliance
Mus musculus (house mouse) : Flg (filaggrin)  MGI
Pan paniscus (bonobo/pygmy chimpanzee) : FLG (filaggrin)
Canis lupus familiaris (dog) : FLG (filaggrin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02193,565,401 - 193,574,297 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02211,289,344 - 211,294,588 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42186,307,359 - 186,311,549 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12186,259,903 - 186,260,929 (+)NCBI
Celera2171,386,515 - 171,395,603 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)

Expression


Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Flg
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2620
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.