Flg (filaggrin) - Rat Genome Database

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Gene: Flg (filaggrin) Rattus norvegicus
Analyze
Symbol: Flg
Name: filaggrin
RGD ID: 2620
Description: Predicted to enable keratin filament binding activity. Predicted to be a structural constituent of skin epidermis. Involved in epidermal cell differentiation. Predicted to be located in cytoplasmic ribonucleoprotein granule. Predicted to be active in cornified envelope and keratohyalin granule. Human ortholog(s) of this gene implicated in atopic dermatitis 2 and ichthyosis vulgaris. Orthologous to human FLG (filaggrin); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Filaggrin (profilaggrin); LOC679174; Pflg; profilaggrin
RGD Orthologs
Human
Mouse
Bonobo
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82181,583,801 - 181,596,464 (+)NCBIGRCr8
mRatBN7.22178,884,793 - 178,912,986 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2186,449,517 - 186,478,945 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02184,429,834 - 184,448,291 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02179,092,619 - 179,122,045 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02193,565,401 - 193,574,297 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02211,289,344 - 211,294,588 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42186,307,359 - 186,311,549 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12186,259,903 - 186,260,929 (+)NCBI
Celera2171,386,515 - 171,395,603 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,3,5-trinitro-1,3,5-triazinane  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,5-trichlorophenol  (ISO)
2,4-D  (ISO)
2,4-Dihydroxybenzophenone  (ISO)
4-Hydroxybenzophenone  (ISO)
9-cis-retinoic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
ammonium chloride  (EXP)
antimonite  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
avobenzone  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
beta-damascenone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcipotriol  (ISO)
calcitriol  (ISO)
clofibrate  (ISO)
cortisol  (ISO)
D-glucose  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
doxorubicin  (ISO)
folic acid  (ISO)
fructose  (ISO)
fucoxanthin  (ISO)
fulvestrant  (ISO)
glucose  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (EXP)
iron dichloride  (ISO)
isotretinoin  (ISO)
lucanthone  (ISO)
LY294002  (ISO)
methylparaben  (ISO)
mono(2-ethyl-5-hydroxyhexyl) phthalate  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
mono(5-carboxy-2-ethylpentyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
NS-398  (ISO)
oxybenzone  (ISO)
paracetamol  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluoropentanoic acid  (ISO)
phenacetin  (EXP)
phenylhydrazine  (EXP)
pirinixic acid  (ISO)
propylparaben  (ISO)
quercitrin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
trans-urocanic acid  (ISO)
triclosan  (ISO)
triptonide  (ISO)
urocanic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. Filaggrin, an intermediate filament-associated protein: structural and functional implications from the sequence of a cDNA from rat. Haydock PV and Dale BA, DNA Cell Biol 1990 May;9(4):251-61.
3. Antisense profilaggrin RNA delays and decreases profilaggrin expression and alters in vitro differentiation of rat epidermal keratinocytes. Haydock PV, etal., J Invest Dermatol. 1993 Aug;101(2):118-26.
4. Induction of selected lipid metabolic enzymes and differentiation-linked structural proteins by air exposure in fetal rat skin explants. Komuves LG, etal., J Invest Dermatol. 1999 Mar;112(3):303-9.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Functional analysis of the profilaggrin N-terminal peptide: identification of domains that regulate nuclear and cytoplasmic distribution. Pearton DJ, etal., J Invest Dermatol. 2002 Sep;119(3):661-9.
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Smith FJ, etal., Nat Genet. 2006 Mar;38(3):337-42. Epub 2006 Jan 29.
Additional References at PubMed
PMID:1429717   PMID:4557539   PMID:6170061   PMID:6174530   PMID:7543090   PMID:11572870   PMID:12850301   PMID:20376063   PMID:21464233   PMID:21630459   PMID:21744336   PMID:22366455  
PMID:23403047   PMID:24084074   PMID:33450132  


Genomics

Comparative Map Data
Flg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82181,583,801 - 181,596,464 (+)NCBIGRCr8
mRatBN7.22178,884,793 - 178,912,986 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2186,449,517 - 186,478,945 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02184,429,834 - 184,448,291 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02179,092,619 - 179,122,045 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02193,565,401 - 193,574,297 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02211,289,344 - 211,294,588 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42186,307,359 - 186,311,549 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12186,259,903 - 186,260,929 (+)NCBI
Celera2171,386,515 - 171,395,603 (-)NCBICelera
Cytogenetic Map2q34NCBI
FLG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381152,302,165 - 152,325,239 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1152,302,165 - 152,325,239 (-)EnsemblGRCh38hg38GRCh38
GRCh371152,274,641 - 152,297,715 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361150,541,275 - 150,564,303 (-)NCBINCBI36Build 36hg18NCBI36
Celera1125,386,606 - 125,408,667 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1123,649,333 - 123,671,391 (-)NCBIHuRef
CHM1_11153,670,002 - 153,693,030 (-)NCBICHM1_1
T2T-CHM13v2.01151,437,741 - 151,461,789 (-)NCBIT2T-CHM13v2.0
Flg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39393,180,853 - 93,200,996 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl393,180,830 - 93,200,993 (+)EnsemblGRCm39 Ensembl
GRCm38393,273,546 - 93,293,689 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl393,273,523 - 93,293,686 (+)EnsemblGRCm38mm10GRCm38
MGSCv37393,089,108 - 93,097,615 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36393,367,872 - 93,379,097 (+)NCBIMGSCv36mm8
Celera393,804,333 - 93,822,603 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.16NCBI
FLG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2197,536,576 - 97,547,401 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,286,770 - 97,298,567 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01127,634,416 - 127,649,659 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11131,276,648 - 131,285,336 (-)NCBIpanpan1.1PanPan1.1panPan2
FLG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11761,217,915 - 61,233,068 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1760,662,290 - 60,679,224 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01762,238,036 - 62,255,220 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11761,075,602 - 61,083,175 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01761,151,018 - 61,170,965 (-)NCBIUNSW_CanFamBas_1.0

Variants

.
Variants in Flg
45 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat

Markers in Region
Flg  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22178,909,027 - 178,909,309 (+)MAPPERmRatBN7.2
mRatBN7.22178,891,975 - 178,892,257 (+)MAPPERmRatBN7.2
mRatBN7.22178,893,193 - 178,893,475 (+)MAPPERmRatBN7.2
mRatBN7.22178,899,283 - 178,899,565 (+)MAPPERmRatBN7.2
mRatBN7.22178,900,501 - 178,900,783 (+)MAPPERmRatBN7.2
mRatBN7.22178,904,155 - 178,904,437 (+)MAPPERmRatBN7.2
mRatBN7.22178,905,373 - 178,905,655 (+)MAPPERmRatBN7.2
mRatBN7.22178,906,591 - 178,906,873 (+)MAPPERmRatBN7.2
mRatBN7.22178,907,809 - 178,908,091 (+)MAPPERmRatBN7.2
mRatBN7.22178,890,757 - 178,891,039 (+)MAPPERmRatBN7.2
mRatBN7.22178,910,245 - 178,910,527 (+)MAPPERmRatBN7.2
mRatBN7.22178,911,463 - 178,911,745 (+)MAPPERmRatBN7.2
mRatBN7.22178,898,065 - 178,898,347 (+)MAPPERmRatBN7.2
mRatBN7.22178,896,847 - 178,897,129 (+)MAPPERmRatBN7.2
mRatBN7.22178,895,629 - 178,895,911 (+)MAPPERmRatBN7.2
mRatBN7.22178,894,411 - 178,894,693 (+)MAPPERmRatBN7.2
Rnor_6.02193,572,763 - 193,573,044NCBIRnor6.0
Rnor_5.02211,292,237 - 211,292,518UniSTSRnor5.0
Cytogenetic Map2q34UniSTS


Expression


Sequence


RefSeq Acc Id: NM_001393766   ⟹   NP_001380695
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82181,583,801 - 181,596,464 (+)NCBI
mRatBN7.22178,884,793 - 178,912,986 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001380695 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41161 (Get FASTA)   NCBI Sequence Viewer  
  AAM54369 (Get FASTA)   NCBI Sequence Viewer  
  EDL87862 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001380695   ⟸   NM_001393766
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2620 AgrOrtholog
BioCyc Gene G2FUF-52243 BioCyc
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Filaggrin UniProtKB/TrEMBL
  S-100_dom UniProtKB/TrEMBL
  S100/CaBP-9k_CS UniProtKB/TrEMBL
  S100_Ca-bd_sub UniProtKB/TrEMBL
NCBI Gene 24641 ENTREZGENE
PANTHER ERYTHROCYTE MEMBRANE PROTEIN 3 UniProtKB/TrEMBL
  FILAGGRIN UniProtKB/TrEMBL
  FILAGGRIN-RELATED UniProtKB/TrEMBL
Pfam Filaggrin UniProtKB/TrEMBL
  S_100 UniProtKB/TrEMBL
PhenoGen Flg PhenoGen
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  S100_CABP UniProtKB/TrEMBL
SMART S_100 UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A6KMN2_RAT UniProtKB/TrEMBL
  Q8CIU0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-29 Flg  filaggrin  LOC679174  similar to filaggrin  Data merged from RGD:1591824 737654 PROVISIONAL
2006-11-20 LOC679174  similar to filaggrin      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-11-06 Flg  filaggrin    Filaggrin (profilaggrin)  Name updated 625702 APPROVED
2002-06-10 Flg  Filaggrin (profilaggrin)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains two repeats of 406 amino acid with a filaggrin domain in each repeat 632675
gene_expression expressed in fully cornified cells of the mammalian epidermis, mRNA highly expressed only in keratinizing epithelia 632675
gene_process responsible for epidermal differentiation 632675
gene_transcript cDNA is 2,314 bp long and has a 1,875 bp long coding region ending with an A-T rich 3' noncoding region 632675