Enpep (glutamyl aminopeptidase) - Rat Genome Database

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Gene: Enpep (glutamyl aminopeptidase) Rattus norvegicus
Analyze
Symbol: Enpep
Name: glutamyl aminopeptidase
RGD ID: 621228
Description: Enables aminopeptidase activity and peptide binding activity. Involved in peptide catabolic process and protein processing. Located in brush border membrane. Orthologous to human ENPEP (glutamyl aminopeptidase); PARTICIPATES IN angiotensin III signaling pathway; renin-angiotensin cascade pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aminopeptidase A; AP-A; EAP; glutamyl aminopeptidase-like; LOC100910501
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22217,781,985 - 217,851,947 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2217,782,005 - 217,851,947 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2225,456,243 - 225,526,211 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02223,355,888 - 223,425,871 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02218,213,588 - 218,283,553 (-)NCBIRnor_WKY
Rnor_6.02233,667,253 - 233,743,866 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2233,667,254 - 233,743,866 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02252,991,592 - 253,066,142 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42226,731,079 - 226,732,069 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12226,717,758 - 226,718,749 (-)NCBI
Celera2210,077,457 - 210,147,068 (-)NCBICelera
Cytogenetic Map2q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-naphthylamine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cyclosporin A  (EXP,ISO)
dextran sulfate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
felbamate  (EXP)
flutamide  (EXP)
fulvestrant  (ISO)
fumonisin B1  (ISO)
glafenine  (EXP)
indole-3-methanol  (EXP)
L-ethionine  (EXP)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nimesulide  (EXP)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
toluene  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
undecane  (EXP)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Renin-angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with breast cancer induced by N-methyl-nitrosourea. Carrera MP, etal., Cancer Invest. 2006 Mar;24(2):149-53.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Targeting the renin-angiotensin system: what's new? Leckie BJ Curr Med Chem Cardiovasc Hematol Agents. 2005 Jan;3(1):23-32.
5. Molecular cloning and expression of aminopeptidase A isoforms from rat hippocampus. Lee HJ, etal., Biochim Biophys Acta 2000 Sep 7;1493(1-2):273-8.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. The luminal membrane of rat thick limb expresses AT1 receptor and aminopeptidase activities. Poumarat JS, etal., Kidney Int. 2002 Aug;62(2):434-45.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Rat kidney glutamyl aminopeptidase (aminopeptidase A): molecular identity and cellular localization. Song L, etal., Am J Physiol 1994 Oct;267(4 Pt 2):F546-57.
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Expression of aminopeptidase A, an angiotensinase, in glomerular mesangial cells. Troyanovskaya M, etal., Hypertension 1996 Mar;27(3 Pt 2):518-22.
Additional References at PubMed
PMID:7795661   PMID:8244382   PMID:8346219   PMID:10692253   PMID:14998491   PMID:15489334   PMID:15682487   PMID:16286663   PMID:16790432   PMID:17519555   PMID:17897319   PMID:19056867  
PMID:19608358   PMID:22206666   PMID:23376485   PMID:23533145   PMID:23888046   PMID:25960007   PMID:33161775  


Genomics

Comparative Map Data
Enpep
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22217,781,985 - 217,851,947 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2217,782,005 - 217,851,947 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2225,456,243 - 225,526,211 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02223,355,888 - 223,425,871 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02218,213,588 - 218,283,553 (-)NCBIRnor_WKY
Rnor_6.02233,667,253 - 233,743,866 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2233,667,254 - 233,743,866 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02252,991,592 - 253,066,142 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42226,731,079 - 226,732,069 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12226,717,758 - 226,718,749 (-)NCBI
Celera2210,077,457 - 210,147,068 (-)NCBICelera
Cytogenetic Map2q42NCBI
ENPEP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384110,476,155 - 110,565,285 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4110,365,733 - 110,565,285 (+)EnsemblGRCh38hg38GRCh38
GRCh374111,397,311 - 111,486,441 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364111,616,678 - 111,703,942 (+)NCBINCBI36Build 36hg18NCBI36
Build 344111,754,928 - 111,841,027NCBI
Celera4108,691,011 - 108,778,278 (+)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4107,128,917 - 107,216,191 (+)NCBIHuRef
CHM1_14111,373,917 - 111,461,184 (+)NCBICHM1_1
T2T-CHM13v2.04113,778,214 - 113,867,343 (+)NCBIT2T-CHM13v2.0
Enpep
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393129,062,826 - 129,126,398 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3129,062,824 - 129,126,369 (-)EnsemblGRCm39 Ensembl
GRCm383129,269,177 - 129,332,749 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,269,175 - 129,332,720 (-)EnsemblGRCm38mm10GRCm38
MGSCv373128,972,095 - 129,035,667 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363129,261,642 - 129,324,742 (-)NCBIMGSCv36mm8
Celera3135,776,158 - 135,839,883 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map357.92NCBI
Enpep
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545715,863,881 - 15,943,074 (-)NCBIChiLan1.0ChiLan1.0
ENPEP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14113,534,565 - 113,620,654 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4113,532,126 - 113,620,654 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04102,969,397 - 103,056,978 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ENPEP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13230,553,055 - 30,639,790 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3230,553,182 - 30,638,522 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3211,396,688 - 11,483,396 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03230,773,999 - 30,860,935 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3230,774,117 - 30,859,344 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13230,760,121 - 30,846,715 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03230,511,400 - 30,597,700 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,256,791 - 9,343,499 (-)NCBIUU_Cfam_GSD_1.0
Enpep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530110,285,323 - 10,365,581 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365631,585,450 - 1,665,663 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENPEP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8111,748,514 - 111,858,510 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18111,765,839 - 111,858,349 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28119,968,866 - 120,060,970 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ENPEP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1758,363,816 - 58,448,231 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl758,364,445 - 58,447,574 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603737,045,128 - 37,128,693 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Enpep
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248384,742,794 - 4,828,724 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248384,742,841 - 4,826,767 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
D2Wox67  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22217,853,183 - 217,853,423 (+)MAPPERmRatBN7.2
Rnor_6.02233,984,120 - 233,984,359NCBIRnor6.0
Rnor_6.02233,745,103 - 233,745,342NCBIRnor6.0
Rnor_5.02253,067,379 - 253,067,618UniSTSRnor5.0
Rnor_5.02253,306,223 - 253,306,462UniSTSRnor5.0
RGSC_v3.42226,734,175 - 226,734,414UniSTSRGSC3.4
Celera2210,148,305 - 210,148,544UniSTS
Cytogenetic Map2q42UniSTS
RH133895  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22217,782,221 - 217,782,439 (+)MAPPERmRatBN7.2
Rnor_6.02233,667,471 - 233,667,688NCBIRnor6.0
Rnor_5.02252,991,810 - 252,992,027UniSTSRnor5.0
Celera2210,077,694 - 210,077,911UniSTS
RH 3.4 Map21557.4UniSTS
Cytogenetic Map2q42UniSTS
BE111146  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22217,819,206 - 217,819,402 (+)MAPPERmRatBN7.2
Rnor_6.02233,704,485 - 233,704,680NCBIRnor6.0
Rnor_5.02253,028,989 - 253,029,184UniSTSRnor5.0
Celera2210,114,297 - 210,114,492UniSTS
RH 3.4 Map21546.7UniSTS
Cytogenetic Map2q42UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
2299161Iddm33Insulin dependent diabetes mellitus QTL 332.98blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2206312063220876787Rat
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2206665645219003804Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:335
Count of miRNA genes:186
Interacting mature miRNAs:205
Transcripts:ENSRNOT00000074879
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 41 29 19 4 19 2 2 35 22 11 2
Low 1 2 28 22 14 22 6 9 74 16 6
Below cutoff 1 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000087062   ⟹   ENSRNOP00000068728
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2217,782,005 - 217,851,947 (-)Ensembl
Rnor_6.0 Ensembl2233,667,254 - 233,743,866 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107896   ⟹   ENSRNOP00000085978
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2217,782,005 - 217,851,947 (-)Ensembl
RefSeq Acc Id: NM_022251   ⟹   NP_071587
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22217,781,985 - 217,851,947 (-)NCBI
Rnor_6.02233,667,253 - 233,743,866 (-)NCBI
Rnor_5.02252,991,592 - 253,066,142 (-)NCBI
RGSC_v3.42226,731,079 - 226,732,069 (-)RGD
Celera2210,077,457 - 210,147,068 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_071587 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF37622 (Get FASTA)   NCBI Sequence Viewer  
  AAF66710 (Get FASTA)   NCBI Sequence Viewer  
  AAH66663 (Get FASTA)   NCBI Sequence Viewer  
  P50123 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_071587   ⟸   NM_022251
- UniProtKB: P50123 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068728   ⟸   ENSRNOT00000087062
RefSeq Acc Id: ENSRNOP00000085978   ⟸   ENSRNOT00000107896
Protein Domains
ERAP1_C   Peptidase_M1   Peptidase_M1_N

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50123-F1-model_v2 AlphaFold P50123 1-945 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691746
Promoter ID:EPDNEW_R2271
Type:multiple initiation site
Name:Enpep_1
Description:glutamyl aminopeptidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02233,743,698 - 233,743,758EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621228 AgrOrtholog
BioCyc Gene G2FUF-51247 BioCyc
Ensembl Genes ENSRNOG00000051854 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000068728 ENTREZGENE
  ENSRNOP00000068728.2 UniProtKB/TrEMBL
  ENSRNOP00000085978.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087062 ENTREZGENE
  ENSRNOT00000087062.2 UniProtKB/TrEMBL
  ENSRNOT00000107896.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1730 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623429 IMAGE-MGC_LOAD
InterPro Aminopeptidase_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aminopeptidase_N-like_N UniProtKB/Swiss-Prot
  Aminopeptidase_N-like_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aminopeptidase_N-like_N UniProtKB/TrEMBL
  ERAP1-like_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M1_APN-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M4/M1_CTD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64017 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72453 IMAGE-MGC_LOAD
NCBI Gene 64017 ENTREZGENE
PANTHER PTHR11533:SF242 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ERAP1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Enpep PhenoGen
PRINTS ALADIPTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ZINC_PROTEASE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF63737 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JTI8_RAT UniProtKB/TrEMBL
  A0A8I6A4U4_RAT UniProtKB/TrEMBL
  AMPE_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q64200 UniProtKB/Swiss-Prot
  Q9JLQ7 UniProtKB/Swiss-Prot
  Q9JLQ9 UniProtKB/Swiss-Prot
  Q9QV24 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Enpep  glutamyl aminopeptidase  LOC100910501  glutamyl aminopeptidase-like  Data Merged 737654 PROVISIONAL
2012-07-05 LOC100910501  glutamyl aminopeptidase-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Enpep  glutamyl aminopeptidase    aminopeptidase A  Name updated 1299863 APPROVED
2002-08-07 Enpep  aminopeptidase A      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the glomerular mesangial cells 631868
gene_process may play a role in modulating the activity of intrarenal angiotensin II  
gene_process minimizes the contraction due to angiotensin II in stimulated mesangial cells 631868