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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2,4-trimethylbenzene | increases expression | EXP | | 6480464 | pseudocumene results in increased expression of ENPEP protein | CTD | PMID:17337753 | 1,2-dimethylhydrazine | decreases expression | ISO | RGD:732267 | 6480464 | 1, 2-Dimethylhydrazine results in decreased expression of ENPEP mRNA | CTD | PMID:22206623 | 1-naphthyl isothiocyanate | decreases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in decreased expression of ENPEP mRNA | CTD | PMID:25380136 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ENPEP mRNA | CTD | PMID:20959002 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:732267 | 6480464 | Tetrachlorodibenzodioxin affects the expression of ENPEP mRNA | CTD | PMID:26377647 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:732267 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ENPEP mRNA | CTD | PMID:16214954 more ... | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:732267 | 6480464 | AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ENPEP mRNA] | CTD | PMID:16214954 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2, 4-dinitrotoluene affects the expression of ENPEP mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2, 6-dinitrotoluene affects the expression of ENPEP mRNA | CTD | PMID:21346803 | 2-naphthylamine | increases metabolic processing | ISO | RGD:732266 | 6480464 | ENPEP protein results in increased metabolism of 2-Naphthylamine analog | CTD | PMID:11732752 | 2-naphthylamine | increases metabolic processing | EXP | | 6480464 | ENPEP protein results in increased metabolism of 2-Naphthylamine analog | CTD | PMID:11732752 | 3,3',4,4',5-pentachlorobiphenyl | decreases expression | EXP | | 6480464 | 3 more ... | CTD | PMID:20959002 | 3-methylcholanthrene | decreases expression | ISO | RGD:732267 | 6480464 | Methylcholanthrene results in decreased expression of ENPEP mRNA | CTD | PMID:20713471 | 3H-1,2-dithiole-3-thione | decreases expression | EXP | | 6480464 | 1, 2-dithiol-3-thione results in decreased expression of ENPEP mRNA | CTD | PMID:19162173 | 4,4'-diaminodiphenylmethane | decreases expression | EXP | | 6480464 | 4, 4'-diaminodiphenylmethane results in decreased expression of ENPEP mRNA | CTD | PMID:25380136, PMID:30723492 | 4,4'-diaminodiphenylmethane | affects expression | ISO | RGD:732267 | 6480464 | 4, 4'-diaminodiphenylmethane affects the expression of ENPEP mRNA | CTD | PMID:18648102 | 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole | affects expression | EXP | | 6480464 | Omeprazole affects the expression of ENPEP mRNA | CTD | PMID:19483382 | 6-propyl-2-thiouracil | affects expression | EXP | | 6480464 | Propylthiouracil affects the expression of ENPEP mRNA | CTD | PMID:19483382 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of ENPEP mRNA | CTD | PMID:24780913 | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of ENPEP mRNA | CTD | PMID:31881176 | aflatoxin B1 | decreases expression | ISO | RGD:732267 | 6480464 | Aflatoxin B1 results in decreased expression of ENPEP mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases methylation | ISO | RGD:732266 | 6480464 | Aflatoxin B1 results in increased methylation of ENPEP intron | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | ISO | RGD:732266 | 6480464 | Tretinoin results in increased expression of ENPEP mRNA | CTD | PMID:21934132 | amiodarone | affects expression | EXP | | 6480464 | Amiodarone affects the expression of ENPEP mRNA | CTD | PMID:19483382 | antirheumatic drug | increases expression | ISO | RGD:732266 | 6480464 | Antirheumatic Agents results in increased expression of ENPEP mRNA | CTD | PMID:24449571 | benzbromarone | affects expression | EXP | | 6480464 | Benzbromarone affects the expression of ENPEP mRNA | CTD | PMID:19483382 | benzo[a]pyrene | decreases expression | ISO | RGD:732267 | 6480464 | Benzoapyrene results in decreased expression of ENPEP mRNA | CTD | PMID:19770486 more ... | benzo[a]pyrene | decreases expression | ISO | RGD:732266 | 6480464 | Benzoapyrene results in decreased expression of ENPEP mRNA | CTD | PMID:32234424 | benzo[a]pyrene | affects methylation | ISO | RGD:732266 | 6480464 | Benzoapyrene affects the methylation of ENPEP exon, Benzoapyrene affects the methylation of ENPEP intron | CTD | PMID:27901495, PMID:30157460 | benzo[a]pyrene | decreases methylation | ISO | RGD:732266 | 6480464 | Benzoapyrene results in decreased methylation of ENPEP promoter | CTD | PMID:27901495 | benzo[e]pyrene | increases methylation | ISO | RGD:732266 | 6480464 | benzoepyrene results in increased methylation of ENPEP intron | CTD | PMID:30157460 | bis(2-chloroethyl) sulfide | increases expression | ISO | RGD:732267 | 6480464 | Mustard Gas results in increased expression of ENPEP mRNA | CTD | PMID:15674844 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | RGD:732266 | 6480464 | Diethylhexyl Phthalate results in decreased expression of ENPEP protein | CTD | PMID:31163220 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of ENPEP mRNA | CTD | PMID:25181051 | buspirone | decreases expression | EXP | | 6480464 | Buspirone results in decreased expression of ENPEP mRNA | CTD | PMID:24136188 | carbamazepine | increases expression | EXP | | 6480464 | Carbamazepine results in increased expression of ENPEP mRNA | CTD | PMID:17381134 | carbon nanotube | decreases expression | ISO | RGD:732267 | 6480464 | Nanotubes more ... | CTD | PMID:25554681, PMID:25620056 | clofibrate | affects expression | EXP | | 6480464 | Clofibrate affects the expression of ENPEP mRNA | CTD | PMID:19483382 | clofibrate | decreases expression | ISO | RGD:732267 | 6480464 | Clofibrate results in decreased expression of ENPEP mRNA | CTD | PMID:17585979 | clofibrate | multiple interactions | ISO | RGD:732267 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of ENPEP mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ENPEP mRNA] | CTD | PMID:17585979 | clofibric acid | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ENPEP mRNA | CTD | PMID:17602206 | cyclosporin A | decreases expression | ISO | RGD:732266 | 6480464 | Cyclosporine results in decreased expression of ENPEP mRNA | CTD | PMID:20106945 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of ENPEP mRNA | CTD | PMID:21865292 | cyclosporin A | decreases expression | ISO | RGD:732267 | 6480464 | Cyclosporine results in decreased expression of ENPEP mRNA | CTD | PMID:19770486 | dextran sulfate | multiple interactions | ISO | RGD:732267 | 6480464 | Erianin inhibits the reaction [Dextran Sulfate results in increased expression of ENPEP protein] | CTD | PMID:32272095 | dextran sulfate | increases expression | ISO | RGD:732267 | 6480464 | Dextran Sulfate results in increased expression of ENPEP protein | CTD | PMID:32272095 | dioxygen | multiple interactions | ISO | RGD:732267 | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of ENPEP mRNA | CTD | PMID:30529165 | disodium selenite | decreases expression | ISO | RGD:732266 | 6480464 | Sodium Selenite results in decreased expression of ENPEP mRNA | CTD | PMID:18175754 | dorsomorphin | multiple interactions | ISO | RGD:732266 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1 more ... | CTD | PMID:27188386 | entinostat | decreases expression | ISO | RGD:732266 | 6480464 | entinostat results in decreased expression of ENPEP mRNA | CTD | PMID:26272509 | felbamate | increases expression | EXP | | 6480464 | felbamate results in increased expression of ENPEP mRNA | CTD | PMID:17381134 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of ENPEP mRNA | CTD | PMID:24136188 | fumonisin B1 | decreases expression | ISO | RGD:732267 | 6480464 | fumonisin B1 results in decreased expression of ENPEP mRNA | CTD | PMID:16221962 | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of ENPEP mRNA | CTD | PMID:24136188 | indole-3-methanol | affects expression | EXP | | 6480464 | indole-3-carbinol affects the expression of ENPEP mRNA | CTD | PMID:21396975 | L-ethionine | affects expression | EXP | | 6480464 | Ethionine affects the expression of ENPEP mRNA | CTD | PMID:19483382 | methapyrilene | increases methylation | ISO | RGD:732266 | 6480464 | Methapyrilene results in increased methylation of ENPEP intron | CTD | PMID:30157460 | methylmercury chloride | decreases expression | ISO | RGD:732266 | 6480464 | methylmercuric chloride results in decreased expression of ENPEP mRNA | CTD | PMID:28001369 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ENPEP mRNA | CTD | PMID:17602206 | N-nitrosodimethylamine | decreases expression | EXP | | 6480464 | Dimethylnitrosamine results in decreased expression of ENPEP mRNA | CTD | PMID:25380136 | nimesulide | decreases expression | EXP | | 6480464 | nimesulide results in decreased expression of ENPEP mRNA | CTD | PMID:24136188 | omeprazole | affects expression | EXP | | 6480464 | Omeprazole affects the expression of ENPEP mRNA | CTD | PMID:19483382 | paracetamol | decreases expression | ISO | RGD:732266 | 6480464 | Acetaminophen results in decreased expression of ENPEP mRNA | CTD | PMID:21420995, PMID:29067470 | paracetamol | multiple interactions | ISO | RGD:732267 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of ENPEP mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ENPEP mRNA] | CTD | PMID:17585979 | paracetamol | affects expression | ISO | RGD:732267 | 6480464 | Acetaminophen affects the expression of ENPEP mRNA | CTD | PMID:17562736 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of ENPEP mRNA | CTD | PMID:17381134 | phenobarbital | affects expression | ISO | RGD:732267 | 6480464 | Phenobarbital affects the expression of ENPEP mRNA | CTD | PMID:23091169 | phenylmercury acetate | multiple interactions | ISO | RGD:732266 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of ENPEP mRNA | CTD | PMID:27188386 | phenytoin | decreases expression | EXP | | 6480464 | Phenytoin results in decreased expression of ENPEP mRNA | CTD | PMID:17381134 | phenytoin | increases expression | EXP | | 6480464 | Phenytoin results in increased expression of ENPEP mRNA | CTD | PMID:17381134 | pirinixic acid | multiple interactions | ISO | RGD:732267 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ENPEP mRNA more ... | CTD | PMID:19710929 more ... | pirinixic acid | decreases expression | ISO | RGD:732267 | 6480464 | pirinixic acid results in decreased expression of ENPEP mRNA | CTD | PMID:16221962 more ... | pirinixic acid | affects expression | EXP | | 6480464 | pirinixic acid affects the expression of ENPEP mRNA | CTD | PMID:19483382 | progesterone | increases expression | ISO | RGD:732266 | 6480464 | Progesterone results in increased expression of ENPEP mRNA | CTD | PMID:17404688 more ... | resveratrol | multiple interactions | EXP | | 6480464 | [resveratrol co-treated with Streptozocin] results in decreased expression of ENPEP mRNA | CTD | PMID:25905778 | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of ENPEP mRNA | CTD | PMID:28374803 | SB 431542 | multiple interactions | ISO | RGD:732266 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1 more ... | CTD | PMID:27188386 | silver atom | increases expression | ISO | RGD:732266 | 6480464 | Silver results in increased expression of ENPEP mRNA | CTD | PMID:26551752 | silver(0) | increases expression | ISO | RGD:732266 | 6480464 | Silver results in increased expression of ENPEP mRNA | CTD | PMID:26551752 | sodium arsenite | decreases expression | ISO | RGD:732266 | 6480464 | sodium arsenite results in decreased expression of ENPEP mRNA | CTD | PMID:29301061 | sodium dichromate | increases expression | EXP | | 6480464 | sodium bichromate results in increased expression of ENPEP mRNA | CTD | PMID:22561333 | sodium dichromate | decreases expression | EXP | | 6480464 | sodium bichromate results in decreased expression of ENPEP mRNA | CTD | PMID:25993096 | sodium fluoride | decreases expression | ISO | RGD:732267 | 6480464 | Sodium Fluoride results in decreased expression of ENPEP protein | CTD | PMID:28918527 | streptozocin | multiple interactions | EXP | | 6480464 | [resveratrol co-treated with Streptozocin] results in decreased expression of ENPEP mRNA | CTD | PMID:25905778 | sulforaphane | decreases expression | ISO | RGD:732267 | 6480464 | sulforafan results in decreased expression of ENPEP mRNA | CTD | PMID:30529165 | tetrachloromethane | affects expression | EXP | | 6480464 | Carbon Tetrachloride affects the expression of ENPEP mRNA | CTD | PMID:12734012 | tetrachloromethane | decreases expression | ISO | RGD:732267 | 6480464 | Carbon Tetrachloride results in decreased expression of ENPEP mRNA | CTD | PMID:31919559 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of ENPEP mRNA | CTD | PMID:31150632 | thioacetamide | affects expression | EXP | | 6480464 | Thioacetamide affects the expression of ENPEP mRNA | CTD | PMID:19483382 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of ENPEP mRNA | CTD | PMID:23411599 | toluene | increases expression | EXP | | 6480464 | Toluene results in increased expression of ENPEP mRNA | CTD | PMID:22967744 | trichloroethene | increases methylation | EXP | | 6480464 | Trichloroethylene results in increased methylation of ENPEP gene | CTD | PMID:27618143 | trichostatin A | increases expression | ISO | RGD:732266 | 6480464 | trichostatin A results in increased expression of ENPEP mRNA | CTD | PMID:24935251, PMID:26272509 | trichostatin A | multiple interactions | ISO | RGD:732266 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of ENPEP mRNA | CTD | PMID:27188386 | triclosan | increases expression | ISO | RGD:732266 | 6480464 | Triclosan results in increased expression of ENPEP mRNA | CTD | PMID:30510588 | trimellitic anhydride | decreases expression | ISO | RGD:732267 | 6480464 | trimellitic anhydride results in decreased expression of ENPEP mRNA | CTD | PMID:19042947 | Triptolide | affects expression | EXP | | 6480464 | triptolide affects the expression of ENPEP protein | CTD | PMID:32519852 | undecane | increases expression | EXP | | 6480464 | undecane results in increased expression of ENPEP protein | CTD | PMID:17337753 | valdecoxib | decreases expression | EXP | | 6480464 | valdecoxib results in decreased expression of ENPEP mRNA | CTD | PMID:24136188 | valproic acid | increases expression | ISO | RGD:732266 | 6480464 | Valproic Acid results in increased expression of ENPEP mRNA | CTD | PMID:23179753 more ... | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of ENPEP mRNA | CTD | PMID:17381134 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of ENPEP mRNA | CTD | PMID:19015723 | |