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Gene: Enpep (glutamyl aminopeptidase) Rattus norvegicus

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Symbol:

Enpep

Name:

glutamyl aminopeptidase

RGD ID:

621228

Description:

Enables aminopeptidase activity and peptide binding activity. Involved in peptide catabolic process and protein processing. Located in brush border membrane. Orthologous to human ENPEP (glutamyl aminopeptidase); PARTICIPATES IN angiotensin III signaling pathway; renin-angiotensin cascade pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

aminopeptidase A; AP-A; EAP; glutamyl aminopeptidase-like; LOC100910501

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ENPEP (glutamyl aminopeptidase)	HGNC	Ensembl, HomoloGene, Inparanoid, Panther
Mus musculus (house mouse):	Enpep (glutamyl aminopeptidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Enpep (glutamyl aminopeptidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ENPEP (glutamyl aminopeptidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ENPEP (glutamyl aminopeptidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Enpep (glutamyl aminopeptidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ENPEP (glutamyl aminopeptidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ENPEP (glutamyl aminopeptidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Enpep (glutamyl aminopeptidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ENPEP (glutamyl aminopeptidase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Enpep (glutamyl aminopeptidase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	enpep (glutamyl aminopeptidase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG8774	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	anp-1	Alliance	DIOPT (InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG32473	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG8773	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TMA108	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	enpep	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	znhit3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	220,456,258 - 220,526,218 (-)	NCBI		GRCr8
mRatBN7.2	2	217,781,985 - 217,851,947 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	217,782,005 - 217,851,947 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	225,456,243 - 225,526,211 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	223,355,888 - 223,425,871 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	218,213,588 - 218,283,553 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	233,667,253 - 233,743,866 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	233,667,254 - 233,743,866 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	252,991,592 - 253,066,142 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	226,731,079 - 226,732,069 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	226,717,758 - 226,718,749 (-)	NCBI
Celera	2	210,077,457 - 210,147,068 (-)	NCBI		Celera
Cytogenetic Map	2	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Diabetic Nephropathies (ISO)

Experimental Liver Cirrhosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2,4-trimethylbenzene (EXP)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-naphthylamine (EXP,ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3-methylcholanthrene (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-diaminodiphenylmethane (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amiodarone (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

benzbromarone (EXP)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

buspirone (EXP)

carbamazepine (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

clofibrate (EXP,ISO)

clofibric acid (EXP)

cyclosporin A (EXP,ISO)

dextran sulfate (ISO)

diethylstilbestrol (EXP)

dioxygen (ISO)

disodium selenite (ISO)

dorsomorphin (ISO)

entinostat (ISO)

epoxiconazole (ISO)

felbamate (EXP)

flutamide (EXP)

fulvestrant (ISO)

fumonisin B1 (ISO)

glafenine (EXP)

indole-3-methanol (EXP)

inulin (ISO)

L-ethionine (EXP)

methapyrilene (ISO)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N(4)-hydroxycytidine (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

nimesulide (EXP)

omeprazole (EXP)

ozone (ISO)

paracetamol (ISO)

paraquat (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (EXP,ISO)

phenylmercury acetate (ISO)

phenytoin (EXP)

pirinixic acid (EXP,ISO)

progesterone (ISO)

resveratrol (EXP)

rotenone (EXP)

SB 431542 (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sodium fluoride (ISO)

streptozocin (EXP,ISO)

sulforaphane (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

toluene (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

trimellitic anhydride (ISO)

Triptolide (EXP)

undecane (EXP)

valdecoxib (EXP)

valproic acid (EXP,ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

angiogenesis (IEA,ISO)

angiotensin maturation (IEA,ISO)

cell migration (IEA,ISO,ISS)

cell population proliferation (IEA,ISO,ISS)

glomerulus development (IEA,ISO)

peptide catabolic process (IBA,IDA)

protein processing (IDA)

proteolysis (IBA,IEA)

regulation of blood pressure (IBA)

regulation of systemic arterial blood pressure by renin-angiotensin (IEA,ISO,ISS)

Cellular Component

apical part of cell (IEA,ISO)

apical plasma membrane (IEA,ISO)

brush border (IEA,ISO)

brush border membrane (IDA)

cytoplasm (IBA)

cytoplasmic vesicle (IEA,ISO)

external side of plasma membrane (IEA,ISO)

extracellular space (IBA)

membrane (IEA)

plasma membrane (IBA,IEA,ISO,ISS)

Molecular Function

aminopeptidase activity (IDA,IEA,ISO)

glutamyl aminopeptidase activity (IEA)

hydrolase activity (IEA)

metal ion binding (IEA)

metalloaminopeptidase activity (IBA,IEA,ISO,ISS)

metallopeptidase activity (IEA,ISO)

peptidase activity (IEA,ISO)

peptide binding (IBA,IDA)

zinc ion binding (IBA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

angiotensin III signaling pathway (IDA)

renin-angiotensin cascade pathway (IDA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Renin-angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with breast cancer induced by N-methyl-nitrosourea.	Carrera MP, etal., Cancer Invest. 2006 Mar;24(2):149-53.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Targeting the renin-angiotensin system: what's new?	Leckie BJ Curr Med Chem Cardiovasc Hematol Agents. 2005 Jan;3(1):23-32.
5.	Molecular cloning and expression of aminopeptidase A isoforms from rat hippocampus.	Lee HJ, etal., Biochim Biophys Acta 2000 Sep 7;1493(1-2):273-8.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	The luminal membrane of rat thick limb expresses AT1 receptor and aminopeptidase activities.	Poumarat JS, etal., Kidney Int. 2002 Aug;62(2):434-45.
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Rat kidney glutamyl aminopeptidase (aminopeptidase A): molecular identity and cellular localization.	Song L, etal., Am J Physiol 1994 Oct;267(4 Pt 2):F546-57.
14.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15.	Expression of aminopeptidase A, an angiotensinase, in glomerular mesangial cells.	Troyanovskaya M, etal., Hypertension 1996 Mar;27(3 Pt 2):518-22.

Additional References at PubMed

PMID:7795661	PMID:8244382	PMID:8346219	PMID:10692253	PMID:14998491	PMID:15489334	PMID:15682487	PMID:16286663	PMID:16790432	PMID:17519555	PMID:17897319	PMID:19056867
PMID:19608358	PMID:22206666	PMID:23376485	PMID:23533145	PMID:23888046	PMID:25960007	PMID:33161775

Genomics

Comparative Map Data

Enpep
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	220,456,258 - 220,526,218 (-)	NCBI		GRCr8
mRatBN7.2	2	217,781,985 - 217,851,947 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	217,782,005 - 217,851,947 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	225,456,243 - 225,526,211 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	223,355,888 - 223,425,871 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	218,213,588 - 218,283,553 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	233,667,253 - 233,743,866 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	233,667,254 - 233,743,866 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	252,991,592 - 253,066,142 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	226,731,079 - 226,732,069 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	226,717,758 - 226,718,749 (-)	NCBI
Celera	2	210,077,457 - 210,147,068 (-)	NCBI		Celera
Cytogenetic Map	2	q42	NCBI

ENPEP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	110,476,155 - 110,565,285 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	110,365,733 - 110,565,285 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	111,397,311 - 111,486,441 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	111,616,678 - 111,703,942 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	111,754,928 - 111,841,027	NCBI
Celera	4	108,691,011 - 108,778,278 (+)	NCBI		Celera
Cytogenetic Map	4	q25	NCBI
HuRef	4	107,128,917 - 107,216,191 (+)	NCBI		HuRef
CHM1_1	4	111,373,917 - 111,461,184 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	113,778,214 - 113,867,343 (+)	NCBI		T2T-CHM13v2.0

Enpep
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	129,062,826 - 129,126,398 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	129,062,824 - 129,126,369 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	129,269,177 - 129,332,749 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	129,269,175 - 129,332,720 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	128,972,095 - 129,035,667 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	129,261,642 - 129,324,742 (-)	NCBI		MGSCv36	mm8
Celera	3	135,776,158 - 135,839,883 (-)	NCBI		Celera
Cytogenetic Map	3	G3	NCBI
cM Map	3	57.92	NCBI

Enpep
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955457	15,863,881 - 15,943,074 (-)	NCBI	ChiLan1.0	ChiLan1.0

ENPEP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	108,564,622 - 108,650,616 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	108,857,811 - 108,943,716 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	102,969,397 - 103,056,978 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	113,534,565 - 113,620,654 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	113,532,126 - 113,620,654 (+)	Ensembl	panpan1.1		panPan2

ENPEP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	30,553,055 - 30,639,790 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	30,553,182 - 30,638,522 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	11,396,688 - 11,483,396 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	30,773,999 - 30,860,935 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	30,774,117 - 30,859,344 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	30,760,121 - 30,846,715 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	30,511,400 - 30,597,700 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	9,256,791 - 9,343,499 (-)	NCBI		UU_Cfam_GSD_1.0

Enpep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	10,285,323 - 10,365,581 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936563	1,585,471 - 1,665,677 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936563	1,585,450 - 1,665,663 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ENPEP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	111,748,514 - 111,858,510 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	111,765,839 - 111,858,349 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	119,968,866 - 120,060,970 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ENPEP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	58,363,816 - 58,448,231 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	58,364,445 - 58,447,574 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	37,045,128 - 37,128,693 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Enpep
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624838	4,742,794 - 4,828,724 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624838	4,742,841 - 4,826,767 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Enpep
400 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	335
Count of miRNA genes:	186
Interacting mature miRNAs:	205
Transcripts:	ENSRNOT00000074879
Prediction methods:	Microtar, Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	161699179	222436696	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	168358098	223265385	Rat
2301408	Kidm36	Kidney mass QTL 36		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	190613715	226808892	Rat
1598813	Memor9	Memory QTL 9	2.7		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	199341726	234244620	Rat
8693697	Alc36	Alcohol consumption QTL 36	2	0.592	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	2	217139753	236660713	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	141194931	223265385	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	211744537	249053267	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	141194931	223265385	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
2298479	Eau5	Experimental allergic uveoretinitis QTL 5		0.0021	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	2	202446871	237938339	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	214226044	247136170	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	18960362	228801039	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	211744537	249053267	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	215377404	237938339	Rat
738013	Alc15	Alcohol consumption QTL 15	4.1	0.00022	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	2	184165752	229165752	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	189599258	234599258	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	211744537	249053267	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	193452645	245889826	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	211744537	249053267	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	221167075	Rat
2317885	Alcrsp28	Alcohol response QTL 28	2.1	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	212828222	249053267	Rat
1359031	Bp275	Blood pressure QTL 275			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	185876309	219753474	Rat
1581499	Esta2	Estrogen-induced thymic atrophy QTL 2			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	189599258	226936289	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	182171407	227171407	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	182171407	227171407	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	179946951	224946951	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
631203	Gluco14	Glucose level QTL 14		0.0001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	2	206665645	219003804	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	182171407	227171407	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	200990457	245990457	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	211744537	249053267	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
1331745	Bp203	Blood pressure QTL 203	4.377		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	189599258	218414891	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	164073756	227146641	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	182171407	227171407	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	189599258	234599258	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
2299161	Iddm33	Insulin dependent diabetes mellitus QTL 33	2.98		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	206312063	220876787	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	179335906	224335906	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	157142078	226277316	Rat

Markers in Region

D2Wox67

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	217,853,183 - 217,853,423 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	233,984,120 - 233,984,359	NCBI	Rnor6.0
Rnor_6.0	2	233,745,103 - 233,745,342	NCBI	Rnor6.0
Rnor_5.0	2	253,067,379 - 253,067,618	UniSTS	Rnor5.0
Rnor_5.0	2	253,306,223 - 253,306,462	UniSTS	Rnor5.0
RGSC_v3.4	2	226,734,175 - 226,734,414	UniSTS	RGSC3.4
Celera	2	210,148,305 - 210,148,544	UniSTS
Cytogenetic Map	2	q42	UniSTS

RH133895

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	217,782,221 - 217,782,439 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	233,667,471 - 233,667,688	NCBI	Rnor6.0
Rnor_5.0	2	252,991,810 - 252,992,027	UniSTS	Rnor5.0
Celera	2	210,077,694 - 210,077,911	UniSTS
RH 3.4 Map	2	1557.4	UniSTS
Cytogenetic Map	2	q42	UniSTS

BE111146

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	217,819,206 - 217,819,402 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	233,704,485 - 233,704,680	NCBI	Rnor6.0
Rnor_5.0	2	253,028,989 - 253,029,184	UniSTS	Rnor5.0
Celera	2	210,114,297 - 210,114,492	UniSTS
RH 3.4 Map	2	1546.7	UniSTS
Cytogenetic Map	2	q42	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022251	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF146518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF214568	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF214569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC066663	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB747518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK481363	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000087062 ⟹ ENSRNOP00000068728

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	217,782,005 - 217,851,947 (-)	Ensembl
Rnor_6.0 Ensembl	2	233,667,254 - 233,743,866 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000107896 ⟹ ENSRNOP00000085978

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	217,782,005 - 217,851,947 (-)	Ensembl

RefSeq Acc Id:

NM_022251 ⟹ NP_071587

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	220,456,258 - 220,526,218 (-)	NCBI
mRatBN7.2	2	217,781,985 - 217,851,947 (-)	NCBI
Rnor_6.0	2	233,667,253 - 233,743,866 (-)	NCBI
Rnor_5.0	2	252,991,592 - 253,066,142 (-)	NCBI
RGSC_v3.4	2	226,731,079 - 226,732,069 (-)	RGD
Celera	2	210,077,457 - 210,147,068 (-)	RGD

Sequence:

show sequence

TCGAGGCTGACAGAGGTTTGGCAAAATCTCCACCTCTCCCAACCCCCACATCCCTGCCCGCGTT
AGCCGATAGGCTCAAGCCCTGTTTTATATTTAACTCACTCCAGTTCAGGAGGGGCGGGCCTGGG
GAGACGCTGTTTATACAGAGCTGGGCCAACACTCTCATCCGTCCTCCTCCGTCAAGTCAGCCTC
TCTTCTGAGCCTTCATCCCACTGCTTGGTTTCCGCATTCATCCCAGAGTGGCCGGTGAGGACGT
GCAGGACTGGGAAGAGACACCGGACACCAGACAGAGAGGTGTGGGAAAGCGAAGTCAGGCTGCC
AAACTAGGGGACGCCTTCCAATTGAAAAGGGAAGTCAGCTGACGATAGTTAGTTAAATTTAACA
TCCTTTCATGGGTAGTATCTGACTTCAGGGGAGAAAAATGAACTTTGCAGAGGAAGAGCCCTCT
AAGAAATACTGCATTAAAGGCAAACACGTGGCCATCATCTGCGCAACGGTGGTAGCAGTGGGAT
TAATAGTAGGACTTTCTGTGGGCTTGACCAGGTCGTGTGAGCCGGGCACAACCCCCGCTCCTTC
CAACCCTCCTCCCCACACCAGCACTGCCCTGCCTCCCCAGGATCAGAATGTCTGCCCTGACAGT
GACGATGAAAGTGGAGAATGGAAAAACTTCAGGCTGCCGGACTTCATCCAGCCAGTTCACTACG
ACCTGGAGGTGAAGGTCCTAATGGAGGAAGACAGGTACACGGGCATAGTGAGCATCTCTGTCAA
CTTGAGCAAAGACACTCGTGACCTATGGCTGCACATCAGGGAAACCAGGATCACCAAGCTGCCG
GAGCTAAGGAGGCCCTCCGGGGAGCAGGTACCGATTCGACGGTGCTTTGAGTACAAGAAGCAGG
AGTACGTGGTGATTCAGGCTGAAGAAGACCTTGCGGCCACCAGCGGGGACAGTGTCTATCGGCT
GACCATAGAGTTTGAAGGCTGGTTGAACGGCTCCCTTGTGGGTTTTTACAGAACCACCTACACG
GAGGACGGGCAAACCAAGAGCATAGCGGCCACTGACCACGAACCAACAGATGCCAGGAAGTCCT
TCCCTTGTTTCGATGAACCCAACAAGAAGGCGACTTACAACATATCCCTCATTCACCCGAAAGA
ATACTCAGCACTTTCCAATATGCCAGTAGAGAAGGAAGAGACACTGGATAACGACTGGAAGAAA
ACCACTTTCATGAAGTCCGTCCCGATGAGCACTTACCTGGTGTGCTTTGCTGTACATCAGTTCA
CCTCGATACAGAGAACATCCAGGAGTGGCAAACCACTCACTGTTTACGTCCAGCCCAACCAAAA
GCAAACAGCAGAGTATGCGGCAAACATAACCAAAGCTGTGTTTGACTTCTTTGAAGACTACTTC
GCTATGGAGTATTCTCTTCCGAAACTGGATAAAATTGCTATTCCAGATTTTGGCACCGGCGCCA
TGGAAAACTGGGGACTTGTCACTTACCGAGAAACAAACCTGCTTTATGACCCCCTGCTATCGGC
CTCATCCAACCAGCAGAGAGTAGCCAGCGTGGTTGCCCACGAGCTCGTGCACCAGTGGTTTGGA
AATATCGTGACCATGGACTGGTGGGACGACTTGTGGCTAAATGAAGGATTTGCTTCGTTCTTCG
AGTTCTTGGGAGTAAACCACGCAGAAGCAGACTGGCAGATGCTCAGTCAGGTGCTGCTTGAAGA
CGTGCTACCTGTGCAGGAGGATGACTCCCTGATGTCCTCACATCCGGTGGTTGTCACGGTGTCT
ACTCCAGCTGAAATAACGTCTGTGTTCGATGGAATATCATACAGCAAGGGAGCTTCTATCCTGA
GAATGCTTCAAGACTGGATAACACCAGAGAAATTCCAAAAGGGGTGTCAGATTTACTTGGAAAA
CTTCAAGTTCAAGAACGCGAAAACTTCCGACTTTTGGGATTCACTGGAAAAGGCAAGTAATCAA
CCAGTGAAAGAAGTAATGGACACCTGGACTAGCCAGATGGGCTATCCTGTGGTTACTGTGAGTG
GAAAGCAGAACGTCACCCAGAAACGCTTTCTGTTGGACTACAAAGCTGACCCTTCCCAGCCACC
GTCAGCACTTGGTTACACATGGAATATTCCAATCAAATGGACCGAAAATGGCAATTCAAATATC
ACAGTCTACTATAGGTCAAACAGAGAAGGAATCACTTTGAATGCTAATCTTAGCGGAGATGGTT
TTCTTAAAATAAACCCAGATCACATTGGGTTTTATCGTGTAAACTATGAAGCAGAAACTTGGGA
TTGGATAGCTGAGACTCTCTCCTCAAACCACATGAACTTCTCTTCTGCTGACCGGTCAAGTTTT
ATCGATGATGCTTTTGCTCTGGCAAGAGCTCAACTTCTGGATTATGAGAAGGCCCTGAACTTGA
CCAGGTATCTCACATCAGAAAAGGATTTCTTACCATGGGAGAGAGTCATTTCAGCTGTAAGCTA
CATCATTAGCATGTTTGAAGATGACAGAGAGCTGTACCCCCTGATAGAGACATACTTCCGAAGC
CAAGTGAAGCCCATTGCGGATTCTCTGGGATGGCAGGATACCGGAAGCCACATCACAAAGTTAC
TCCGGGCCTCTGTATTAGGATTCGCATGCAAGATGGGAGCCGGAGAAGCCTTGGGCAATGCTTC
CCAGTTATTTGAGGCCTGGCTGAAAGGGAATGAAAGCATTCCTGTGAACCTCAGGCTGCTGGTG
TATCGCTATGGAATGCAGAACTCTGGCAATGAGGCAGCGTGGAACTATACTCTAGAGCAGTACC
AGAAAACATCTCTAGCACAAGAGAAAGAAAAGCTGCTCTATGGGTTAGCTTCGGTGAAGGATGT
TACACTCTTGGCAAGGTATCTGGAAATGCTCAAAGACCCCAATATTATTAAAACTCAGGACGTA
TTTACAGTCATCCGCTACATCTCCTACAACAGCTATGGGAAAAGCATGGCCTGGAACTGGATCC
AACTCAACTGGGACTATCTGGTCAACAGATTTACAATCAACGACAGATACCTTGGCCGGATCGT
CACCATAGCCGAGCCCTTCAACACTGAGCTGCAGCTCTGGCAGATGCAGAGCTTCTTTGCAAAA
TATCCAAATGCTGGCGCTGGAGCAAAACCCAGAGAGCAAGTGCTGGAAACGGTGAAGAACAACA
TCGAGTGGCTAAAACTGAACAGAAAGTCCATCAGCGAGTGGTTCACCAGCATGCCCTAGGAGCG
CTGATGCCTTCCGTTTGTGCCTCCGCTGCACTGTGGAACCTGAGGCGACCTGTTTTACAGACTG
CAGAGGGAGCCTTCAAAACCAGTTCTGCTTTTGCTAAGTACCGTGTTTATGTCTCGCAAAGCTT
TTTAAATTATTCCTCTTTGTCGTTGAAGGAAGATACTAATAGAGTATTTAATATACTCAGGGAT
TTCTGCTAAGTGTACTTTATAGGGATGTCTTTACAAACTGAAGGGTTTAATAGTCACATTAATG
TCTTTAAATATCATTCCTTGTATCTTAAATCTGTGAAAATGGAGCAATTTGGTCCCAGCTTTAC
ATTTTCAGTACCAAAGAAACACCACTTAATCTTCTCTCCTGATTGATTTTTAAAGTTTAAATAC
CAGTACGTGCAGGACGTATTGCCATCTTAATCTTTATTTTATTATTCAGAATTACATAGACCTA
ATATCATTTTATTCACAAACGTCTCACTGCTTTAAATCCTACCAAAGTAACCTTGGCTTAAGTT
TTGCTCAAGGATTGAATGAACGAGCCAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_071587	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF37622	(Get FASTA)	NCBI Sequence Viewer
	AAF66710	(Get FASTA)	NCBI Sequence Viewer
	AAH66663	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000068728
	ENSRNOP00000068728.2
	ENSRNOP00000085978.1
GenBank Protein	P50123	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_071587 ⟸ NM_022251

- UniProtKB:

Q9QV24 (UniProtKB/Swiss-Prot), Q9JLQ9 (UniProtKB/Swiss-Prot), Q9JLQ7 (UniProtKB/Swiss-Prot), Q64200 (UniProtKB/Swiss-Prot), P50123 (UniProtKB/Swiss-Prot), A0A0G2JTI8 (UniProtKB/TrEMBL), A6HVN5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNFAEEEPSKKYCIKGKHVAIICATVVAVGLIVGLSVGLTRSCEPGTTPAPSNPPPHTSTALPP
QDQNVCPDSDDESGEWKNFRLPDFIQPVHYDLEVKVLMEEDRYTGIVSISVNLSKDTRDLWLHI
RETRITKLPELRRPSGEQVPIRRCFEYKKQEYVVIQAEEDLAATSGDSVYRLTIEFEGWLNGSL
VGFYRTTYTEDGQTKSIAATDHEPTDARKSFPCFDEPNKKATYNISLIHPKEYSALSNMPVEKE
ETLDNDWKKTTFMKSVPMSTYLVCFAVHQFTSIQRTSRSGKPLTVYVQPNQKQTAEYAANITKA
VFDFFEDYFAMEYSLPKLDKIAIPDFGTGAMENWGLVTYRETNLLYDPLLSASSNQQRVASVVA
HELVHQWFGNIVTMDWWDDLWLNEGFASFFEFLGVNHAEADWQMLSQVLLEDVLPVQEDDSLMS
SHPVVVTVSTPAEITSVFDGISYSKGASILRMLQDWITPEKFQKGCQIYLENFKFKNAKTSDFW
DSLEKASNQPVKEVMDTWTSQMGYPVVTVSGKQNVTQKRFLLDYKADPSQPPSALGYTWNIPIK
WTENGNSNITVYYRSNREGITLNANLSGDGFLKINPDHIGFYRVNYEAETWDWIAETLSSNHMN
FSSADRSSFIDDAFALARAQLLDYEKALNLTRYLTSEKDFLPWERVISAVSYIISMFEDDRELY
PLIETYFRSQVKPIADSLGWQDTGSHITKLLRASVLGFACKMGAGEALGNASQLFEAWLKGNES
IPVNLRLLVYRYGMQNSGNEAAWNYTLEQYQKTSLAQEKEKLLYGLASVKDVTLLARYLEMLKD
PNIIKTQDVFTVIRYISYNSYGKSMAWNWIQLNWDYLVNRFTINDRYLGRIVTIAEPFNTELQL
WQMQSFFAKYPNAGAGAKPREQVLETVKNNIEWLKLNRKSISEWFTSMP

hide sequence

Ensembl Acc Id:

ENSRNOP00000068728 ⟸ ENSRNOT00000087062

Ensembl Acc Id:

ENSRNOP00000085978 ⟸ ENSRNOT00000107896

Protein Domains

Aminopeptidase N-like N-terminal ERAP1-like C-terminal Peptidase M1 membrane alanine aminopeptidase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P50123-F1-model_v2	AlphaFold	P50123	1-945	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691746

Promoter ID:

EPDNEW_R2271

Type:

multiple initiation site

Name:

Enpep_1

Description:

glutamyl aminopeptidase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	233,743,698 - 233,743,758	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621228	AgrOrtholog
BioCyc Gene	G2FUF-51247	BioCyc
Ensembl Genes	ENSRNOG00000051854	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000087062	ENTREZGENE
	ENSRNOT00000087062.2	UniProtKB/TrEMBL
	ENSRNOT00000107896.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.3480.20	UniProtKB/TrEMBL
	1.10.390.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	1.25.50.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.60.40.1730	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.60.40.1910	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5623429	IMAGE-MGC_LOAD
InterPro	Aminopeptidase_N-like_N	UniProtKB/Swiss-Prot
	Aminopeptidase_N-like_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aminopeptidase_N-like_N	UniProtKB/TrEMBL
	ERAP1-like_C_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	M1_APN-typ	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_M1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_M1_aminopeptidases	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_M1_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_M4/M1_CTD_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:64017	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72453	IMAGE-MGC_LOAD
NCBI Gene	64017	ENTREZGENE
PANTHER	GLUTAMYL AMINOPEPTIDASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEASE M1 ZINC METALLOPROTEASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	ERAP1_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_M1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_M1_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Enpep	PhenoGen
PRINTS	ALADIPTASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ZINC_PROTEASE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000051854	RatGTEx
Superfamily-SCOP	Metalloproteases ('zincins'), catalytic domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF63737	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2JTI8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A4U4_RAT	UniProtKB/TrEMBL
	A6HVN5	ENTREZGENE, UniProtKB/TrEMBL
	AMPE_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q64200	ENTREZGENE
	Q9JLQ7	ENTREZGENE
	Q9JLQ9	ENTREZGENE
	Q9QV24	ENTREZGENE
UniProt Secondary	Q64200	UniProtKB/Swiss-Prot
	Q9JLQ7	UniProtKB/Swiss-Prot
	Q9JLQ9	UniProtKB/Swiss-Prot
	Q9QV24	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Enpep	glutamyl aminopeptidase	LOC100910501	glutamyl aminopeptidase-like	Data merged from RGD:6498411	737654	PROVISIONAL
2012-07-05	LOC100910501	glutamyl aminopeptidase-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-01-20	Enpep	glutamyl aminopeptidase		aminopeptidase A	Name updated	1299863	APPROVED
2002-08-07	Enpep	aminopeptidase A			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in the glomerular mesangial cells	631868
gene_process	may play a role in modulating the activity of intrarenal angiotensin II
gene_process	minimizes the contraction due to angiotensin II in stimulated mesangial cells	631868

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)