Enpep (glutamyl aminopeptidase) - Rat Genome Database

Name: Enpep
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Enpep (glutamyl aminopeptidase) Rattus norvegicus

Analyze

Symbol:

Enpep

Name:

glutamyl aminopeptidase

RGD ID:

621228

Description:

Exhibits aminopeptidase activity and peptide binding activity. Involved in peptide catabolic process and proteolysis. Localizes to brush border membrane. Orthologous to human ENPEP (glutamyl aminopeptidase); PARTICIPATES IN angiotensin III signaling pathway; renin-angiotensin cascade pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

aminopeptidase A; AP-A; EAP

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ENPEP (glutamyl aminopeptidase)	HGNC	Ensembl, HomoloGene, Inparanoid, Panther
Mus musculus (house mouse):	Enpep (glutamyl aminopeptidase)	HGNC	HomoloGene, Inparanoid, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Enpep (glutamyl aminopeptidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ENPEP (glutamyl aminopeptidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ENPEP (glutamyl aminopeptidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Enpep (glutamyl aminopeptidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ENPEP (glutamyl aminopeptidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	LOC103236707 (glutamyl aminopeptidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Enpep (glutamyl aminopeptidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ENPEP (glutamyl aminopeptidase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Enpep (glutamyl aminopeptidase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	enpep (glutamyl aminopeptidase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG8774	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Caenorhabditis elegans (roundworm):	F49B2.6	Alliance	DIOPT (Hieranoid\|OMA\|OrthoInspector)
Caenorhabditis elegans (roundworm):	anp-1	Alliance	DIOPT (InParanoid\|OMA\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG32473	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector)
Drosophila melanogaster (fruit fly):	CG8773	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	217,781,985 - 217,851,947 (-)	NCBI
Rnor_6.0 Ensembl	2	233,667,254 - 233,743,866 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	2	233,667,253 - 233,743,866 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	2	252,991,592 - 253,066,142 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	226,731,079 - 226,732,069 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	2	226,717,758 - 226,718,749 (-)	NCBI
Celera	2	210,077,457 - 210,147,068 (-)	NCBI		Celera
Cytogenetic Map	2	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trimethylbenzene (EXP)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-naphthylamine (EXP,ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3-methylcholanthrene (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-diaminodiphenylmethane (EXP,ISO)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amiodarone (EXP)

antirheumatic drug (ISO)

benzbromarone (EXP)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

buspirone (EXP)

carbamazepine (EXP)

carbon nanotube (ISO)

clofibrate (EXP,ISO)

clofibric acid (EXP)

cyclosporin A (EXP,ISO)

dextran sulfate (ISO)

dioxygen (ISO)

disodium selenite (ISO)

dorsomorphin (ISO)

entinostat (ISO)

felbamate (EXP)

flutamide (EXP)

fumonisin B1 (ISO)

glafenine (EXP)

indole-3-methanol (EXP)

L-ethionine (EXP)

methapyrilene (ISO)

methylmercury chloride (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

nimesulide (EXP)

omeprazole (EXP)

paracetamol (ISO)

phenobarbital (EXP,ISO)

phenylmercury acetate (ISO)

phenytoin (EXP)

pirinixic acid (EXP,ISO)

progesterone (ISO)

resveratrol (EXP)

rotenone (EXP)

SB 431542 (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sodium fluoride (ISO)

streptozocin (EXP)

sulforaphane (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

toluene (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

trimellitic anhydride (ISO)

Triptolide (EXP)

undecane (EXP)

valdecoxib (EXP)

valproic acid (EXP,ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

angiogenesis (IEA,ISO)

cell migration (IEA,ISO,ISS)

cell population proliferation (IEA,ISO,ISS)

glomerulus development (IEA,ISO)

peptide catabolic process (IBA,IDA)

proteolysis (IBA,IDA,IEA)

regulation of blood pressure (IBA)

regulation of systemic arterial blood pressure by renin-angiotensin (IEA,ISO,ISS)

signal transduction (IBA)

Cellular Component

apical part of cell (ISO)

apical plasma membrane (IEA,ISO)

brush border (IEA,ISO)

brush border membrane (IDA)

cytoplasm (IBA)

cytoplasmic vesicle (IEA,ISO)

external side of plasma membrane (IEA,ISO)

integral component of membrane (IEA)

plasma membrane (IBA,ISO,ISS)

Molecular Function

aminopeptidase activity (IDA,ISO)

metalloaminopeptidase activity (IBA,IEA,ISO,ISS)

peptidase activity (ISO)

peptide binding (IBA,IDA)

zinc ion binding (IBA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

angiotensin III signaling pathway (IDA)

renin-angiotensin cascade pathway (IDA,IEA,ISO)

References

References - curated


1.	Carrera MP, etal., Cancer Invest. 2006 Mar;24(2):149-53.
2.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	GOA data from the GO Consortium
4.	Leckie BJ Curr Med Chem Cardiovasc Hematol Agents. 2005 Jan;3(1):23-32.
5.	Lee HJ, etal., Biochim Biophys Acta 2000 Sep 7;1493(1-2):273-8.
6.	MGD data from the GO Consortium
7.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	Pipeline to import KEGG annotations from KEGG into RGD
9.	Poumarat JS, etal., Kidney Int. 2002 Aug;62(2):434-45.
10.	RGD automated data pipeline
11.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	RGD automated import pipeline for gene-chemical interactions
13.	Song L, etal., Am J Physiol 1994 Oct;267(4 Pt 2):F546-57.
14.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15.	Troyanovskaya M, etal., Hypertension 1996 Mar;27(3 Pt 2):518-22.

Additional References at PubMed

PMID:7795661	PMID:8244382	PMID:8346219	PMID:10692253	PMID:14998491	PMID:15489334	PMID:15682487	PMID:16286663	PMID:16790432	PMID:17519555	PMID:17897319	PMID:19056867
PMID:19608358	PMID:22206666	PMID:23376485	PMID:23533145	PMID:23888046	PMID:25960007

Genomics

Comparative Map Data

Enpep
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	217,781,985 - 217,851,947 (-)	NCBI
Rnor_6.0 Ensembl	2	233,667,254 - 233,743,866 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	2	233,667,253 - 233,743,866 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	2	252,991,592 - 253,066,142 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	226,731,079 - 226,732,069 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	2	226,717,758 - 226,718,749 (-)	NCBI
Celera	2	210,077,457 - 210,147,068 (-)	NCBI		Celera
Cytogenetic Map	2	q42	NCBI

ENPEP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	4	110,365,733 - 110,565,285 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	4	110,476,155 - 110,565,285 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	4	111,397,311 - 111,486,441 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	111,616,678 - 111,703,942 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	4	111,754,928 - 111,841,027	NCBI
Celera	4	108,691,011 - 108,778,278 (+)	NCBI
Cytogenetic Map	4	q25	NCBI
HuRef	4	107,128,917 - 107,216,191 (+)	NCBI		HuRef
CHM1_1	4	111,373,917 - 111,461,184 (+)	NCBI		CHM1_1

Enpep
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	129,062,826 - 129,126,398 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	3	129,062,824 - 129,126,369 (-)	Ensembl
GRCm38	3	129,269,177 - 129,332,749 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	129,269,175 - 129,332,720 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	128,972,095 - 129,035,667 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	3	129,261,642 - 129,324,742 (-)	NCBI			mm8
Celera	3	135,776,158 - 135,839,883 (-)	NCBI		Celera
Cytogenetic Map	3	G3	NCBI
cM Map	3	57.92	NCBI

Enpep
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955457	15,863,881 - 15,943,074 (-)	NCBI	ChiLan1.0	ChiLan1.0

ENPEP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	4	113,534,565 - 113,620,654 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	113,532,126 - 113,620,654 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	4	102,969,397 - 103,056,978 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

ENPEP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	32	30,553,182 - 30,638,522 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	32	30,553,055 - 30,639,790 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Enpep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936563	1,585,450 - 1,665,663 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ENPEP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	111,748,514 - 111,858,510 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	111,765,839 - 111,858,349 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	119,968,866 - 120,060,970 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103236707
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	58,363,816 - 58,448,231 (+)	NCBI
ChlSab1.1 Ensembl	7	58,364,445 - 58,447,574 (+)	Ensembl

Enpep
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624838	4,742,841 - 4,826,767 (+)	NCBI

Position Markers

D2Wox67

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	2	233,745,103 - 233,745,342	NCBI	Rnor6.0
Rnor_6.0	2	233,984,120 - 233,984,359	NCBI	Rnor6.0
Rnor_5.0	2	253,306,223 - 253,306,462	UniSTS	Rnor5.0
Rnor_5.0	2	253,067,379 - 253,067,618	UniSTS	Rnor5.0
RGSC_v3.4	2	226,734,175 - 226,734,414	UniSTS	RGSC3.4
Celera	2	210,148,305 - 210,148,544	UniSTS
Cytogenetic Map	2	q42	UniSTS

RH133895

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	2	233,667,471 - 233,667,688	NCBI	Rnor6.0
Rnor_5.0	2	252,991,810 - 252,992,027	UniSTS	Rnor5.0
Celera	2	210,077,694 - 210,077,911	UniSTS
RH 3.4 Map	2	1557.4	UniSTS
Cytogenetic Map	2	q42	UniSTS

BE111146

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	2	233,704,485 - 233,704,680	NCBI	Rnor6.0
Rnor_5.0	2	253,028,989 - 253,029,184	UniSTS	Rnor5.0
Celera	2	210,114,297 - 210,114,492	UniSTS
RH 3.4 Map	2	1546.7	UniSTS
Cytogenetic Map	2	q42	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	228712271	266435125	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	208594330	263179188	Rat
2317885	Alcrsp28	Alcohol response QTL 28	2.1	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	229793522	266435125	Rat
738013	Alc15	Alcohol consumption QTL 15	4.1	0.00022	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	2	199380312	244380312	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	197253963	242253963	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	197253963	242253963	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	197253963	242253963	Rat
631514	Scl8	Serum cholesterol level QTL8	4.4		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	2	231621666	266435125	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	228712271	266435125	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	169852670	243026643	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83754907	237610852	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	228712271	266435125	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	228712271	266435125	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	197253963	242253963	Rat
8693697	Alc36	Alcohol consumption QTL 36	2	0.592	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	2	233013605	253626471	Rat
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	175403337	239166203	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	181990297	240020001	Rat
1331745	Bp203	Blood pressure QTL 203	4.377		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	204585642	235290110	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	147122993	240020001	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	229606682	264899009	Rat
1302789	Stl26	Serum triglyceride level QTL 26	3.1	0.0035	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	218957047	240977220	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83819608	239166203	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66828236	243550655	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83819608	243901375	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	228712271	266435125	Rat
1359031	Bp275	Blood pressure QTL 275			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	200453324	236318668	Rat
1359031	Bp275	Blood pressure QTL 275			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	200453324	236318668	Rat
1581499	Esta2	Estrogen-induced thymic atrophy QTL 2			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	204585642	243689611	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	155965557	254121739	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	155965557	237742948	Rat
1598813	Memor9	Memory QTL 9	2.7		exploratory behavior trait (VT:0010471)	average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	214870793	251212353	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	217743855	262743855	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	204585642	249585642	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	194998627	239998627	Rat
631203	Gluco14	Glucose level QTL 14		0.0001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	2	221880206	235570970	Rat
2298479	Eau5	Experimental allergic uveoretinitis QTL 5		0.0021	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	2	217498545	254132424	Rat
2299161	Iddm33	Insulin dependent diabetes mellitus QTL 33	2.98		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	221488355	254121739	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	177680772	243901375	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	194378622	239378622	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	16679272	245624402	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	147122993	240020001	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	204585642	249585642	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	231224020	254132424	Rat
2301408	Kidm36	Kidney mass QTL 36		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	205583921	243562243	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	335
Count of miRNA genes:	186
Interacting mature miRNAs:	205
Transcripts:	ENSRNOT00000074879
Prediction methods:	Microtar, Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	41	29	19	4	19	2	2		35	22	11	2
Low	1	2	28	22	14	22	6	9	74		16		6
Below cutoff					1						3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022251	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF146518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF214568	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF214569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC066663	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB747518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK481363	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000087062 ⟹ ENSRNOP00000068728

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	2	233,667,254 - 233,743,866 (-)	Ensembl

RefSeq Acc Id:

NM_022251 ⟹ NP_071587

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	217,781,985 - 217,851,947 (-)	NCBI
Rnor_6.0	2	233,667,253 - 233,743,866 (-)	NCBI
Rnor_5.0	2	252,991,592 - 253,066,142 (-)	NCBI
RGSC_v3.4	2	226,731,079 - 226,732,069 (-)	RGD
Celera	2	210,077,457 - 210,147,068 (-)	RGD

Sequence:

show sequence

TCGAGGCTGACAGAGGTTTGGCAAAATCTCCACCTCTCCCAACCCCCACATCCCTGCCCGCGTT
AGCCGATAGGCTCAAGCCCTGTTTTATATTTAACTCACTCCAGTTCAGGAGGGGCGGGCCTGGG
GAGACGCTGTTTATACAGAGCTGGGCCAACACTCTCATCCGTCCTCCTCCGTCAAGTCAGCCTC
TCTTCTGAGCCTTCATCCCACTGCTTGGTTTCCGCATTCATCCCAGAGTGGCCGGTGAGGACGT
GCAGGACTGGGAAGAGACACCGGACACCAGACAGAGAGGTGTGGGAAAGCGAAGTCAGGCTGCC
AAACTAGGGGACGCCTTCCAATTGAAAAGGGAAGTCAGCTGACGATAGTTAGTTAAATTTAACA
TCCTTTCATGGGTAGTATCTGACTTCAGGGGAGAAAAATGAACTTTGCAGAGGAAGAGCCCTCT
AAGAAATACTGCATTAAAGGCAAACACGTGGCCATCATCTGCGCAACGGTGGTAGCAGTGGGAT
TAATAGTAGGACTTTCTGTGGGCTTGACCAGGTCGTGTGAGCCGGGCACAACCCCCGCTCCTTC
CAACCCTCCTCCCCACACCAGCACTGCCCTGCCTCCCCAGGATCAGAATGTCTGCCCTGACAGT
GACGATGAAAGTGGAGAATGGAAAAACTTCAGGCTGCCGGACTTCATCCAGCCAGTTCACTACG
ACCTGGAGGTGAAGGTCCTAATGGAGGAAGACAGGTACACGGGCATAGTGAGCATCTCTGTCAA
CTTGAGCAAAGACACTCGTGACCTATGGCTGCACATCAGGGAAACCAGGATCACCAAGCTGCCG
GAGCTAAGGAGGCCCTCCGGGGAGCAGGTACCGATTCGACGGTGCTTTGAGTACAAGAAGCAGG
AGTACGTGGTGATTCAGGCTGAAGAAGACCTTGCGGCCACCAGCGGGGACAGTGTCTATCGGCT
GACCATAGAGTTTGAAGGCTGGTTGAACGGCTCCCTTGTGGGTTTTTACAGAACCACCTACACG
GAGGACGGGCAAACCAAGAGCATAGCGGCCACTGACCACGAACCAACAGATGCCAGGAAGTCCT
TCCCTTGTTTCGATGAACCCAACAAGAAGGCGACTTACAACATATCCCTCATTCACCCGAAAGA
ATACTCAGCACTTTCCAATATGCCAGTAGAGAAGGAAGAGACACTGGATAACGACTGGAAGAAA
ACCACTTTCATGAAGTCCGTCCCGATGAGCACTTACCTGGTGTGCTTTGCTGTACATCAGTTCA
CCTCGATACAGAGAACATCCAGGAGTGGCAAACCACTCACTGTTTACGTCCAGCCCAACCAAAA
GCAAACAGCAGAGTATGCGGCAAACATAACCAAAGCTGTGTTTGACTTCTTTGAAGACTACTTC
GCTATGGAGTATTCTCTTCCGAAACTGGATAAAATTGCTATTCCAGATTTTGGCACCGGCGCCA
TGGAAAACTGGGGACTTGTCACTTACCGAGAAACAAACCTGCTTTATGACCCCCTGCTATCGGC
CTCATCCAACCAGCAGAGAGTAGCCAGCGTGGTTGCCCACGAGCTCGTGCACCAGTGGTTTGGA
AATATCGTGACCATGGACTGGTGGGACGACTTGTGGCTAAATGAAGGATTTGCTTCGTTCTTCG
AGTTCTTGGGAGTAAACCACGCAGAAGCAGACTGGCAGATGCTCAGTCAGGTGCTGCTTGAAGA
CGTGCTACCTGTGCAGGAGGATGACTCCCTGATGTCCTCACATCCGGTGGTTGTCACGGTGTCT
ACTCCAGCTGAAATAACGTCTGTGTTCGATGGAATATCATACAGCAAGGGAGCTTCTATCCTGA
GAATGCTTCAAGACTGGATAACACCAGAGAAATTCCAAAAGGGGTGTCAGATTTACTTGGAAAA
CTTCAAGTTCAAGAACGCGAAAACTTCCGACTTTTGGGATTCACTGGAAAAGGCAAGTAATCAA
CCAGTGAAAGAAGTAATGGACACCTGGACTAGCCAGATGGGCTATCCTGTGGTTACTGTGAGTG
GAAAGCAGAACGTCACCCAGAAACGCTTTCTGTTGGACTACAAAGCTGACCCTTCCCAGCCACC
GTCAGCACTTGGTTACACATGGAATATTCCAATCAAATGGACCGAAAATGGCAATTCAAATATC
ACAGTCTACTATAGGTCAAACAGAGAAGGAATCACTTTGAATGCTAATCTTAGCGGAGATGGTT
TTCTTAAAATAAACCCAGATCACATTGGGTTTTATCGTGTAAACTATGAAGCAGAAACTTGGGA
TTGGATAGCTGAGACTCTCTCCTCAAACCACATGAACTTCTCTTCTGCTGACCGGTCAAGTTTT
ATCGATGATGCTTTTGCTCTGGCAAGAGCTCAACTTCTGGATTATGAGAAGGCCCTGAACTTGA
CCAGGTATCTCACATCAGAAAAGGATTTCTTACCATGGGAGAGAGTCATTTCAGCTGTAAGCTA
CATCATTAGCATGTTTGAAGATGACAGAGAGCTGTACCCCCTGATAGAGACATACTTCCGAAGC
CAAGTGAAGCCCATTGCGGATTCTCTGGGATGGCAGGATACCGGAAGCCACATCACAAAGTTAC
TCCGGGCCTCTGTATTAGGATTCGCATGCAAGATGGGAGCCGGAGAAGCCTTGGGCAATGCTTC
CCAGTTATTTGAGGCCTGGCTGAAAGGGAATGAAAGCATTCCTGTGAACCTCAGGCTGCTGGTG
TATCGCTATGGAATGCAGAACTCTGGCAATGAGGCAGCGTGGAACTATACTCTAGAGCAGTACC
AGAAAACATCTCTAGCACAAGAGAAAGAAAAGCTGCTCTATGGGTTAGCTTCGGTGAAGGATGT
TACACTCTTGGCAAGGTATCTGGAAATGCTCAAAGACCCCAATATTATTAAAACTCAGGACGTA
TTTACAGTCATCCGCTACATCTCCTACAACAGCTATGGGAAAAGCATGGCCTGGAACTGGATCC
AACTCAACTGGGACTATCTGGTCAACAGATTTACAATCAACGACAGATACCTTGGCCGGATCGT
CACCATAGCCGAGCCCTTCAACACTGAGCTGCAGCTCTGGCAGATGCAGAGCTTCTTTGCAAAA
TATCCAAATGCTGGCGCTGGAGCAAAACCCAGAGAGCAAGTGCTGGAAACGGTGAAGAACAACA
TCGAGTGGCTAAAACTGAACAGAAAGTCCATCAGCGAGTGGTTCACCAGCATGCCCTAGGAGCG
CTGATGCCTTCCGTTTGTGCCTCCGCTGCACTGTGGAACCTGAGGCGACCTGTTTTACAGACTG
CAGAGGGAGCCTTCAAAACCAGTTCTGCTTTTGCTAAGTACCGTGTTTATGTCTCGCAAAGCTT
TTTAAATTATTCCTCTTTGTCGTTGAAGGAAGATACTAATAGAGTATTTAATATACTCAGGGAT
TTCTGCTAAGTGTACTTTATAGGGATGTCTTTACAAACTGAAGGGTTTAATAGTCACATTAATG
TCTTTAAATATCATTCCTTGTATCTTAAATCTGTGAAAATGGAGCAATTTGGTCCCAGCTTTAC
ATTTTCAGTACCAAAGAAACACCACTTAATCTTCTCTCCTGATTGATTTTTAAAGTTTAAATAC
CAGTACGTGCAGGACGTATTGCCATCTTAATCTTTATTTTATTATTCAGAATTACATAGACCTA
ATATCATTTTATTCACAAACGTCTCACTGCTTTAAATCCTACCAAAGTAACCTTGGCTTAAGTT
TTGCTCAAGGATTGAATGAACGAGCCAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_071587	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF37622	(Get FASTA)	NCBI Sequence Viewer
	AAF66710	(Get FASTA)	NCBI Sequence Viewer
	AAH66663	(Get FASTA)	NCBI Sequence Viewer
	P50123	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_071587 ⟸ NM_022251

- UniProtKB:

P50123 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MNFAEEEPSKKYCIKGKHVAIICATVVAVGLIVGLSVGLTRSCEPGTTPAPSNPPPHTSTALPP
QDQNVCPDSDDESGEWKNFRLPDFIQPVHYDLEVKVLMEEDRYTGIVSISVNLSKDTRDLWLHI
RETRITKLPELRRPSGEQVPIRRCFEYKKQEYVVIQAEEDLAATSGDSVYRLTIEFEGWLNGSL
VGFYRTTYTEDGQTKSIAATDHEPTDARKSFPCFDEPNKKATYNISLIHPKEYSALSNMPVEKE
ETLDNDWKKTTFMKSVPMSTYLVCFAVHQFTSIQRTSRSGKPLTVYVQPNQKQTAEYAANITKA
VFDFFEDYFAMEYSLPKLDKIAIPDFGTGAMENWGLVTYRETNLLYDPLLSASSNQQRVASVVA
HELVHQWFGNIVTMDWWDDLWLNEGFASFFEFLGVNHAEADWQMLSQVLLEDVLPVQEDDSLMS
SHPVVVTVSTPAEITSVFDGISYSKGASILRMLQDWITPEKFQKGCQIYLENFKFKNAKTSDFW
DSLEKASNQPVKEVMDTWTSQMGYPVVTVSGKQNVTQKRFLLDYKADPSQPPSALGYTWNIPIK
WTENGNSNITVYYRSNREGITLNANLSGDGFLKINPDHIGFYRVNYEAETWDWIAETLSSNHMN
FSSADRSSFIDDAFALARAQLLDYEKALNLTRYLTSEKDFLPWERVISAVSYIISMFEDDRELY
PLIETYFRSQVKPIADSLGWQDTGSHITKLLRASVLGFACKMGAGEALGNASQLFEAWLKGNES
IPVNLRLLVYRYGMQNSGNEAAWNYTLEQYQKTSLAQEKEKLLYGLASVKDVTLLARYLEMLKD
PNIIKTQDVFTVIRYISYNSYGKSMAWNWIQLNWDYLVNRFTINDRYLGRIVTIAEPFNTELQL
WQMQSFFAKYPNAGAGAKPREQVLETVKNNIEWLKLNRKSISEWFTSMP

hide sequence

RefSeq Acc Id:

ENSRNOP00000068728 ⟸ ENSRNOT00000087062

Protein Domains

ERAP1_C Peptidase_M1

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691746

Promoter ID:

EPDNEW_R2271

Type:

multiple initiation site

Name:

Enpep_1

Description:

glutamyl aminopeptidase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	233,743,698 - 233,743,758	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621228	AgrOrtholog
Ensembl Genes	ENSRNOG00000051854	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000068728	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000087062	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.1730	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5623429	IMAGE-MGC_LOAD
InterPro	Aminopeptidase_A	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aminopeptidase_N-like_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ERAP1-like_C_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	M1_APN-typ	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_M1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_M1_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:64017	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72453	IMAGE-MGC_LOAD
NCBI Gene	64017	ENTREZGENE
PANTHER	PTHR11533:SF242	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	ERAP1_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_M1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Enpep	PhenoGen
PRINTS	ALADIPTASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ZINC_PROTEASE	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF63737	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2JTI8_RAT	UniProtKB/TrEMBL
	AMPE_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	Q64200	UniProtKB/Swiss-Prot
	Q9JLQ7	UniProtKB/Swiss-Prot
	Q9JLQ9	UniProtKB/Swiss-Prot
	Q9QV24	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-01-20	Enpep	glutamyl aminopeptidase		aminopeptidase A	Name updated	1299863	APPROVED
2002-08-07	Enpep	aminopeptidase A			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in the glomerular mesangial cells	631868
gene_process	may play a role in modulating the activity of intrarenal angiotensin II
gene_process	minimizes the contraction due to angiotensin II in stimulated mesangial cells	631868

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)