ENPEP (glutamyl aminopeptidase) - Rat Genome Database

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Gene: ENPEP (glutamyl aminopeptidase) Sus scrofa
Analyze
Symbol: ENPEP
Name: glutamyl aminopeptidase
RGD ID: 13987553
Description: ENCODES a protein that exhibits aminopeptidase activity (ortholog); metalloaminopeptidase activity (ortholog); peptide binding (ortholog); INVOLVED IN angiogenesis (ortholog); cell migration (ortholog); cell population proliferation (ortholog); PARTICIPATES IN angiotensin III signaling pathway; renin-angiotensin cascade pathway; ASSOCIATED WITH Diabetic Nephropathies (ortholog); Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); FOUND IN brush border membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH 1,10-phenanthroline; amastatin; aspartame
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: aminopeptidase A; AP-A; EAP
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8111,748,514 - 111,858,510 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18111,765,839 - 111,858,349 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28119,968,866 - 120,060,970 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:9062131   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ENPEP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8111,748,514 - 111,858,510 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18111,765,839 - 111,858,349 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28119,968,866 - 120,060,970 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ENPEP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384110,476,155 - 110,565,285 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4110,365,733 - 110,565,285 (+)EnsemblGRCh38hg38GRCh38
GRCh374111,397,311 - 111,486,441 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364111,616,678 - 111,703,942 (+)NCBINCBI36Build 36hg18NCBI36
Build 344111,754,928 - 111,841,027NCBI
Celera4108,691,011 - 108,778,278 (+)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4107,128,917 - 107,216,191 (+)NCBIHuRef
CHM1_14111,373,917 - 111,461,184 (+)NCBICHM1_1
T2T-CHM13v2.04113,778,214 - 113,867,343 (+)NCBIT2T-CHM13v2.0
Enpep
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393129,062,826 - 129,126,398 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3129,062,824 - 129,126,369 (-)EnsemblGRCm39 Ensembl
GRCm383129,269,177 - 129,332,749 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,269,175 - 129,332,720 (-)EnsemblGRCm38mm10GRCm38
MGSCv373128,972,095 - 129,035,667 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363129,261,642 - 129,324,742 (-)NCBIMGSCv36mm8
Celera3135,776,158 - 135,839,883 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map357.92NCBI
Enpep
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82220,456,258 - 220,526,218 (-)NCBIGRCr8
mRatBN7.22217,781,985 - 217,851,947 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2217,782,005 - 217,851,947 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2225,456,243 - 225,526,211 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02223,355,888 - 223,425,871 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02218,213,588 - 218,283,553 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02233,667,253 - 233,743,866 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2233,667,254 - 233,743,866 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02252,991,592 - 253,066,142 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42226,731,079 - 226,732,069 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12226,717,758 - 226,718,749 (-)NCBI
Celera2210,077,457 - 210,147,068 (-)NCBICelera
Cytogenetic Map2q42NCBI
Enpep
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545715,863,881 - 15,943,074 (-)NCBIChiLan1.0ChiLan1.0
ENPEP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23108,564,622 - 108,650,616 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14108,857,811 - 108,943,716 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04102,969,397 - 103,056,978 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14113,534,565 - 113,620,654 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4113,532,126 - 113,620,654 (+)Ensemblpanpan1.1panPan2
ENPEP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13230,553,055 - 30,639,790 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3230,553,182 - 30,638,522 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3211,396,688 - 11,483,396 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03230,773,999 - 30,860,935 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3230,774,117 - 30,859,344 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13230,760,121 - 30,846,715 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03230,511,400 - 30,597,700 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,256,791 - 9,343,499 (-)NCBIUU_Cfam_GSD_1.0
Enpep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530110,285,323 - 10,365,581 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365631,585,471 - 1,665,677 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365631,585,450 - 1,665,663 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENPEP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1758,363,816 - 58,448,231 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl758,364,445 - 58,447,574 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603737,045,128 - 37,128,693 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Enpep
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248384,742,794 - 4,828,724 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248384,742,841 - 4,826,767 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ENPEP
2358 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 6 3 3 2 1
Low 4 4 4 2 20 2
Below cutoff 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000010000   ⟹   ENSSSCP00000009739
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8111,748,514 - 111,858,510 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000032793   ⟹   ENSSSCP00000031075
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8111,748,514 - 111,858,510 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000055813   ⟹   ENSSSCP00000044147
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8111,748,514 - 111,858,263 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000072573   ⟹   ENSSSCP00000064005
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8111,766,489 - 111,858,510 (-)Ensembl
RefSeq Acc Id: NM_214017   ⟹   NP_999182
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18111,765,839 - 111,858,349 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_999182   ⟸   NM_214017
- UniProtKB: Q95334 (UniProtKB/Swiss-Prot),   F1S138 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000009739   ⟸   ENSSSCT00000010000
RefSeq Acc Id: ENSSSCP00000044147   ⟸   ENSSSCT00000055813
RefSeq Acc Id: ENSSSCP00000031075   ⟸   ENSSSCT00000032793
RefSeq Acc Id: ENSSSCP00000064005   ⟸   ENSSSCT00000072573
Protein Domains
Aminopeptidase N-like N-terminal   ERAP1-like C-terminal   Peptidase M1 membrane alanine aminopeptidase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000009132 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025068531 UniProtKB/TrEMBL
  ENSSSCG00040007317 UniProtKB/TrEMBL
  ENSSSCG00045005005 UniProtKB/TrEMBL
  ENSSSCG00055016116 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00060041096 UniProtKB/TrEMBL
  ENSSSCG00065067948 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00070020569 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000010000 ENTREZGENE
  ENSSSCT00000010000.4 UniProtKB/TrEMBL
  ENSSSCT00000072573.1 UniProtKB/TrEMBL
  ENSSSCT00025094197.1 UniProtKB/TrEMBL
  ENSSSCT00040009633.1 UniProtKB/TrEMBL
  ENSSSCT00040009648.1 UniProtKB/TrEMBL
  ENSSSCT00040009687.1 UniProtKB/TrEMBL
  ENSSSCT00045008345.1 UniProtKB/TrEMBL
  ENSSSCT00055031803.1 UniProtKB/Swiss-Prot
  ENSSSCT00055031886.1 UniProtKB/TrEMBL
  ENSSSCT00055032022.1 UniProtKB/TrEMBL
  ENSSSCT00060055700.1 UniProtKB/TrEMBL
  ENSSSCT00060055713.1 UniProtKB/TrEMBL
  ENSSSCT00060055731.1 UniProtKB/TrEMBL
  ENSSSCT00065093299.1 UniProtKB/Swiss-Prot
  ENSSSCT00065093307.1 UniProtKB/TrEMBL
  ENSSSCT00065093328.1 UniProtKB/TrEMBL
  ENSSSCT00070040945.1 UniProtKB/TrEMBL
  ENSSSCT00070040950.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.50.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1730 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1910 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aminopeptidase_N-like_N UniProtKB/Swiss-Prot
  Aminopeptidase_N-like_N UniProtKB/Swiss-Prot
  Aminopeptidase_N-like_N UniProtKB/TrEMBL
  Aminopeptidase_N-like_N UniProtKB/TrEMBL
  ERAP1-like_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M1_APN-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M4/M1_CTD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397080 UniProtKB/Swiss-Prot
NCBI Gene ENPEP ENTREZGENE
PANTHER PROTEASE M1 ZINC METALLOPROTEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11533:SF242 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ERAP1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ALADIPTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ZINC_PROTEASE UniProtKB/Swiss-Prot
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63737 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1UZM4_PIG UniProtKB/TrEMBL
  A0A4X1V136_PIG UniProtKB/TrEMBL
  A0A5G2R0G8_PIG UniProtKB/TrEMBL
  A0A8D1D9U3_PIG UniProtKB/TrEMBL
  A0A8D1D9X8_PIG UniProtKB/TrEMBL
  A0A8D1QZU2_PIG UniProtKB/TrEMBL
  A0A8D1VH89_PIG UniProtKB/TrEMBL
  A0A8D1ZQK5_PIG UniProtKB/TrEMBL
  AMPE_PIG UniProtKB/Swiss-Prot
  F1S138 ENTREZGENE, UniProtKB/TrEMBL
  Q95334 ENTREZGENE
VGNC ID VGNC:98923 ENTREZGENE