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Gene: Fgd6 (FYVE, RhoGEF and PH domain containing 6) Rattus norvegicus

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Symbol:

Fgd6

Name:

FYVE, RhoGEF and PH domain containing 6

RGD ID:

1565609

Description:

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human FGD6 (FYVE, RhoGEF and PH domain containing 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; alpha-Zearalanol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

FYVE, RhoGEF and PH domain-containing protein 6; LOC500824; RGD1565609; similar to FYVE, RhoGEF and PH domain containing 6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	30,484,600 - 30,599,898 (+)	NCBI		GRCr8
mRatBN7.2	7	28,597,609 - 28,712,908 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	28,597,609 - 28,712,456 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	30,595,441 - 30,706,847 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	32,757,688 - 32,869,096 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	32,528,179 - 32,639,612 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	34,951,878 - 35,063,006 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	34,952,011 - 35,063,929 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	35,009,998 - 35,135,105 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	31,160,021 - 31,286,379 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	25,690,957 - 25,801,895 (+)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Kuhnt-Junius degeneration (ISO)

malignant mesothelioma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

2-palmitoylglycerol (ISO)

5-fluorouracil (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

atrazine (EXP)

avobenzone (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cadmium dichloride (ISO)

caffeine (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

clofibrate (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

daidzein (ISO)

daidzein 7-O-beta-D-glucoside (ISO)

decabromodiphenyl ether (EXP)

Dibutyl phosphate (ISO)

dimethylarsinous acid (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

fenthion (ISO)

fluoranthene (ISO)

FR900359 (ISO)

furan (EXP)

genistein (ISO)

genistein 7-O-beta-D-glucoside (ISO)

glycitein (ISO)

glycitin (ISO)

inulin (ISO)

lead(0) (ISO)

melphalan (ISO)

methoxychlor (EXP)

okadaic acid (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenylmercury acetate (ISO)

potassium chromate (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

raloxifene (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sulforaphane (ISO)

sunitinib (ISO)

tamoxifen (ISO)

tetrachloromethane (ISO)

tetraphene (ISO)

thimerosal (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

troglitazone (ISO)

urethane (ISO)

vanadyl sulfate (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

cytoplasm (IBA,IEA)

cytoskeleton (IEA)

Molecular Function

guanyl-nucleotide exchange factor activity (IBA,IEA)

metal ion binding (IEA)

protein binding (ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Fgd6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	30,484,600 - 30,599,898 (+)	NCBI		GRCr8
mRatBN7.2	7	28,597,609 - 28,712,908 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	28,597,609 - 28,712,456 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	30,595,441 - 30,706,847 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	32,757,688 - 32,869,096 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	32,528,179 - 32,639,612 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	34,951,878 - 35,063,006 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	34,952,011 - 35,063,929 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	35,009,998 - 35,135,105 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	31,160,021 - 31,286,379 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	25,690,957 - 25,801,895 (+)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

FGD6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	95,076,749 - 95,217,467 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	95,076,749 - 95,217,482 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	95,470,525 - 95,611,243 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	93,994,656 - 94,135,371 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	95,141,807 - 95,282,177 (-)	NCBI		Celera
Cytogenetic Map	12	q22	NCBI
HuRef	12	92,537,521 - 92,679,789 (-)	NCBI		HuRef
CHM1_1	12	95,435,464 - 95,576,763 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	95,057,451 - 95,198,262 (-)	NCBI		T2T-CHM13v2.0

Fgd6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	93,871,862 - 93,981,201 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	93,871,863 - 93,981,201 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	94,035,979 - 94,145,339 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	94,036,001 - 94,145,339 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	93,498,746 - 93,608,084 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	93,465,800 - 93,571,803 (+)	NCBI		MGSCv36	mm8
Celera	10	96,010,198 - 96,120,691 (+)	NCBI		Celera
Cytogenetic Map	10	C2	NCBI
cM Map	10	48.76	NCBI

Fgd6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955405	31,698,963 - 31,801,967 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955405	31,700,706 - 31,801,992 (-)	NCBI	ChiLan1.0	ChiLan1.0

FGD6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	103,150,485 - 103,290,524 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	103,146,876 - 103,286,877 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	92,669,106 - 92,809,002 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	96,065,059 - 96,203,335 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	96,065,059 - 96,203,262 (-)	Ensembl	panpan1.1		panPan2

FGD6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	35,050,993 - 35,162,421 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	35,055,469 - 35,162,224 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	35,437,678 - 35,549,099 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	35,715,346 - 35,826,806 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	35,719,824 - 35,826,617 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	34,988,648 - 35,100,047 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	35,083,820 - 35,194,921 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	35,346,448 - 35,457,712 (-)	NCBI		UU_Cfam_GSD_1.0

Fgd6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	24,796,915 - 24,909,957 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936507	11,326,465 - 11,435,219 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936507	11,325,599 - 11,438,561 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FGD6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	88,104,899 - 88,221,828 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	88,087,032 - 88,229,807 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	92,455,962 - 92,478,709 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FGD6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	90,489,879 - 90,622,251 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	90,490,912 - 90,622,295 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	154,545,328 - 154,681,480 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fgd6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624750	11,868,463 - 11,969,725 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624750	11,869,178 - 11,966,668 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Fgd6
917 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	51
Count of miRNA genes:	40
Interacting mature miRNAs:	45
Transcripts:	ENSRNOT00000059068
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354644	Spl4	Serum phospholipid level QTL 4	4.9		blood phospholipid amount (VT:0006084)	blood phospholipid level (CMO:0001169)	7	19654317	49753746	Rat
7411569	Bw137	Body weight QTL 137		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	21921195	66921195	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	5329019	50329019	Rat
1578652	Bmd15	Bone mineral density QTL 15	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	7	9866467	60460686	Rat
1641885	Alcrsp9	Alcohol response QTL 9			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	7	24099606	69099606	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1	44822433	Rat
1549840	Bss5	Bone structure and strength QTL 5	9.8		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	24751841	69751841	Rat
10755438	Coatc9	Coat color QTL 9		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	3529280	48529280	Rat
2298547	Neuinf5	Neuroinflammation QTL 5	3.7		nervous system integrity trait (VT:0010566)	spinal cord Cd74 protein level (CMO:0002131)	7	9462246	58265113	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	7573985	52573985	Rat
2317047	Wbc4	White blood cell count QTL 4		0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	7	1	35342956	Rat
10755440	Coatc10	Coat color QTL 10		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	7496499	52496499	Rat
1354637	Scl30	Serum cholesterol level QTL 30	3.7		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	7	19654317	49753746	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34000259	Rat
1354639	Spl5	Serum phospholipid level QTL 5	3.9		blood LDL phospholipid amount (VT:0010505)	blood low density lipoprotein phospholipid level (CMO:0001568)	7	19654317	52888450	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	31962314	Rat
10755451	Coatc11	Coat color QTL 11		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	17944357	62944357	Rat
2317059	Aia15	Adjuvant induced arthritis QTL 15	2.46		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	17004598	62004598	Rat
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	44782185	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	9462246	98011544	Rat
2290372	Gluco33	Glucose level QTL 33	2.71		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	20555705	29891047	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	31962314	Rat
1582260	Bw72	Body weight QTL 72	3.2	0.0043	body mass (VT:0001259)	body weight (CMO:0000012)	7	15795565	38073970	Rat
1582261	Bw69	Body weight QTL 69	3.2	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	7	15795565	38073970	Rat
1582262	Bw75	Body weight QTL 75	3	0.0038	body mass (VT:0001259)	body weight (CMO:0000012)	7	15795565	38073970	Rat
70190	Mcs6	Mammary carcinoma susceptibility QTL 6	2.29		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	26737401	63902784	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	19654317	84928080	Rat
61369	Mcs2	Mammary carcinoma susceptibility QTL 2	3.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	19032807	35526300	Rat
738033	Anxrr6	Anxiety related response QTL 6	4.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	7	15573889	60573889	Rat

Markers in Region

D7Got19

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	28,652,529 - 28,652,715 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	35,006,804 - 35,006,989	NCBI	Rnor6.0
Rnor_5.0	7	35,064,533 - 35,064,718	UniSTS	Rnor5.0
RGSC_v3.4	7	31,229,122 - 31,229,307	UniSTS	RGSC3.4
RGSC_v3.4	7	31,229,121 - 31,229,307	RGD	RGSC3.4
RGSC_v3.1	7	31,249,393 - 31,249,578	RGD
Celera	7	25,745,564 - 25,745,749	UniSTS
RH 3.4 Map	7	196.8	UniSTS
RH 3.4 Map	7	196.8	RGD
RH 2.0 Map	7	190.5	RGD
Cytogenetic Map	7	q13	UniSTS

AI231513

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	28,613,951 - 28,614,120 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	34,968,221 - 34,968,389	NCBI	Rnor6.0
Rnor_5.0	7	35,026,246 - 35,026,414	UniSTS	Rnor5.0
RGSC_v3.4	7	31,176,364 - 31,176,532	UniSTS	RGSC3.4
Celera	7	25,707,296 - 25,707,464	UniSTS
RH 3.4 Map	7	193.9	UniSTS
Cytogenetic Map	7	q13	UniSTS

BF388111

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	28,656,488 - 28,656,675 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	35,010,763 - 35,010,949	NCBI	Rnor6.0
Rnor_5.0	7	35,068,492 - 35,068,678	UniSTS	Rnor5.0
RGSC_v3.4	7	31,233,081 - 31,233,267	UniSTS	RGSC3.4
Celera	7	25,749,523 - 25,749,709	UniSTS
RH 3.4 Map	7	195.4	UniSTS
Cytogenetic Map	7	q13	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001137645	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595047	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079738	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063264098	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC105868	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000077666 ⟹ ENSRNOP00000074257

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	28,597,609 - 28,706,927 (+)	Ensembl
Rnor_6.0 Ensembl	7	34,952,011 - 35,063,929 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000101771 ⟹ ENSRNOP00000081090

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	28,597,609 - 28,708,815 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114664 ⟹ ENSRNOP00000097286

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	28,597,609 - 28,712,456 (+)	Ensembl

RefSeq Acc Id:

NM_001137645 ⟹ NP_001131117

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	30,484,600 - 30,595,806 (+)	NCBI
mRatBN7.2	7	28,597,609 - 28,708,815 (+)	NCBI
Rnor_6.0	7	34,951,878 - 35,063,006 (+)	NCBI
Rnor_5.0	7	35,009,998 - 35,135,105 (+)	NCBI
RGSC_v3.4	7	31,160,021 - 31,286,379 (+)	RGD
Celera	7	25,690,957 - 25,801,895 (+)	RGD

Sequence:

show sequence

ACTAGATGAGGAGGGGTGCGCGTCCGCGAAGTCGCGGCTAGCTCCTCTCGTGCGCGCGCCTGGC
GGTCGTCCCGGAGCGCGGCGGAGCGGCGCTCGTGCACGTCCCCCTGTCGCTGGCCGCTAGCGCC
CGGCTCCGCCAGAGGGTCGCGGGAGCCGGCGTCCGTCCTTTGTGAGGCGCTCAGGCGGTTCGGC
TGGGGTGCGGGACGGAATGTGGGCACTGCGGGGACTTTTGTCTCCTGCTCAAACTCTGGGGAGC
GTGGACTGAACTGGAGCCATGGATTGAGGGCGTGTGCTGCGCGGGGCAGTCATGACTTCTGCCG
TGGAGCTGAAGAAGCCACCATTGGCTCCCAAGCCTAAGTTAGTGGGGACCAATAATAAGTCACC
GCCTCCTCCTATTGCCCCTAAACCGGACATTGGAAATGCTAGTGTTCCACGGTTGACGAAGACC
AAACCGGCAATTGCTCCAAAACCGAAAGTCCTGACAAACTCAGATGTTCAAGACGTCAAGGATC
AACCCTCAAAGAAGCTCACTTTGAACCTGGAGGAGCGGGAGCCAGAATTACCCGAGAGCACTGG
CAAGTTTAATTGCAAAGATGTCGGGGATGCACACGGTGATTATATTTTCCCAACATGTTCTTGC
AGTTCTGGGTGTACTCATGAGCCTAGGACTCGCGAAAATCTGTGTGCAGAGCAGCTTGTTTTAG
AGCCTCTGGGAATGAAAGAACATTTAGAGAATGGTAAAAATGGTGAGTCCTCAAAGAGGGGGAG
CAGATGGAATTCAAGCCGTGAAAAGTGCCGGAGCCAAAGTGGAGTTGTTTTAAAGGCAAGCATC
TTCGAAGAGAAGCTTAAAGAGGTTCTCACGCAGCCGAGATCAAGGTCACCTAGTAGTTCCCCAA
GGAAGCACAGATGTCCAAATAAACCAGAAATGAATGGCGACCACAGTTGCGCCAGACAGGTCAG
AATTGAGTTTGCAGACACCTCTTCTTCCCAGTCCAGCTTCGGAAAAGCTCCTCACAGCTGCCAC
ACACAACCTCCCAGGGACAAATCTCAGAATCTCCAGACTTGTCAAGATGGCAGTGCTGAGAGCC
TTGGTCCCTTTCATTCATGTGAGCTGGAGGGCAAAAGAGGGTGTTCCGGCGGAACTAGTCAGAA
GTCGGAGGTCCAAGGTCTCGGTCCTGTAGAAATCCACTTACTACCGTATACCTCAAAGTTTCCA
ACGCCCAAGCCCAGAAGGACACACGCTGCTCGTCTGCGTCGCCAGAAGCATGTAGACACTCCTA
GTGAAAGCACTGAAGAGCCAGAGAGCTCAAACAATGGCTCTTCTTGTCTCCATGAAGATAGTTT
GAAAAACAATAAAGTCAGTGTTCTTCATCAGAATGCTTTGTCTAACCAGGGACCAGTGGATGAG
GTGAGGCCAGGAAACAAGAAGGCATTGACCAGGGAGTCCAACAGTGACAGACAGGACTCAGTCA
GCTCACAGAAAGCTGTGCAGCATGAAACGTCTTCTTTTGAAAAAGTGGCACCTTCTTTAGATAC
AGATTCTAGTTTGACTTCTGACAGCACGGTAGAAGACGGTTCTGATGTGTTACCTGCTGTGGAC
AGAGAGACTGCTTTCATACAATGCAGTCCTCAGCCTTTGAGCTTGCCTAAGCAAGTCAAATTAG
CCTGTGCTGAACAGCAGCCAACTACCTGCAACAGGGAGGTGTCAGTGCCCCAGATACAAAAGGA
ATCTTCCTCGAGAATTGTTCCCAAAAAACCTCAAAGACACAGCTTGCCTGCGGCAGGGGTGCTT
AAAAAGGCTGCATCAGAGGAACTAGTAGAAAAGAACTCTTCAAGTAAGGAAACCAATTCAGAGA
AAGGTCTGCAAAGAAACCACCTTCAACATTTGGGTCCCTCAAACCATGGCATGTCACCGTCATC
CTTTGATATGCCCAACCCAACTTCAGAAAAGCCAGTATGGAAGTTACCTCATCCTATTCTACCT
TTTCCGGGGAGCCCAGAAGCCTTGAAGCGGGTCACTTTATCCTTAAATAATGAGCCTTCCATTT
CCCTAACCAAGCCAAGAGCAAAATCCTTGTCTGCTGTGGATATGGACAGGTGCAGTAAGCCTTG
CAAAGAGCCTCCAAAGAAAACGACTTTTAAAAAGTTGATTAACGTGAAGCTGTCCATTGGTTTC
ATAAAGAGTGATTTTCACAAATTTAAGTCAAAAAACTGCCAACATGGGGATGTCTCTACCGGAC
ATTCGCTCGGTAGAGAGCCAAAAGGGCTTGAAAATAATTGGCAAGGTTTGGCCACAGGAGAAGA
GAAGAAAAGTAAACCCATAAAGGCATATTCTGAAGAAAACTGCAGCCTGGAATCTCAAAAGGTG
AAATCTTGGAGCCAGAGCAGTGCAACTAATGGTCAGAGAGCGGAGTCTTTGGATGACCAGATGC
TCTCCCGGCACGCATCCTGTCAGGCCTCTAGTACAAGTGACTGTGGGCCAGAGTATGAAAATGT
CCGCCATTATGAGGAGATACCAGAGTATGAGAACTTGCCTTTTGTCATGGCTCGAGGGAACCCT
CCAGAATTGGGATGGCAGAATTCCAGCAGTGTGGAGGACACGGATGTAAGTCTGTATGAAGTGG
AAGAGCCCTATGACGCTCCAGATGGCCAGCTGCAACTTGATCCGAGACATCAGCCTTGCAGTTC
TGGAAGATGCCAGGACAGGCAGGATGAGCTCCATCTTGACCTGCCTTCTGATGAGGAAGTCATC
AATAGTTCTGACGAAGATGACGTCAGCTCCGAGTCCAGTAAAGGCGAGCCGGACCCGCTGGAGG
ATAAACAGGATGAAGATGCTGGGATGAAAAGCAAAGTCCATCATATTGCCAAGGAGATCATGAG
CTCGGAGAAAGTGTTTGTCGATGTGTTAAAACTTCTGCATATTGATTTCCGGGGTGCTGTAGCC
CACGCGTCCAGGCAACTCGGGAAGCCCGTGATTGAGGACCGGATCCTTAACCAGATCCTGTACT
ACCTGCCTCAGCTGTATGAGCTCAACCGGGATCTCCTGAAGGAACTGGAGGAAAGAATGCTGAG
CTGGGCTGAACAACAGAGAATTGCTGACATCTTTGTAAAGAAGGGGCCATATTTAAAAATGTAC
TCCATGTACATCAAAGAATTCGACAAGAACATTGCGTTGCTGGATGAACAGTGCAAGAAAAACT
CTGGATTCGCCACGGTCGTCAGGGAATTCGAGATGAGCCCTCGATGTGCCAACCTGGCCCTGAA
GCACTACCTGCTGAAGCCAGTTCAGAGGATCCCTCAGTATAGGCTGCTGCTGACAGATTATTTA
AAGAACCTCCTAGAAGACTCTGTAGACCACAGAGACACCCAAGATGCCCTAGCTGTTGTCATAG
AGGTAGCTAACCATGCCAATGACACCATGAAGCAAGGGGACAACTTTCAGAAGCTCATGCAAAT
TCAGTACAGCTTGAGTGGACACCATGAAATCGTGCAGCCTGGGCGGGTGTTTCTTAAAGAAGGC
ATCCTGATGAAGCTGTCTCGGAAAGTCATGCAGCCGCGAATGATTTTCCTGTTTAATGATGCTC
TACTGTACACCACACCCATGCAGTCTGGGATGTACAAACTGAACAACATGCTCTCCTTGGCTGG
AATGAAGGTCAGAAAACCTACCCAGGAGGCATATCAGAACGAGTTAAAGATTGAAAGTGTAGAG
CGTTCTTTCATCCTCTCAGCAAGTTCTGCCTCAGAAAGAGACGACTGGCTGGAGGCCATATCCA
GGGCTATAGAAGAGTATGCCAAGAAAAGAATCACCTTCTGCCCCAGCAGGAGTCTTGATGAGGA
CTCAGAAAGGAAAGAAGAAGTCAGCCCTCTTGGGGCAAAGGCTCCCATCTGGATTCCTGACACC
AGAGCCACCATGTGTATGATTTGCACAAGTGAATTCACCCTGACCTGGAGAAGACACCACTGCA
GGGCCTGTGGGAAGATCGTGTGCCAAGCTTGCTCGTCCAACAAGTGTGGCTTGGATTACCTGAA
AGGGCAGCCGGCGAGAGTGTGCGAGCTCTGCTTCCAAGAGCTGCAGAAACTAGATCACCAGCTG
TCCCCCAGGATTGGGTCTCCTGGAAATCACAAGTCTCCTTCAAGTGCCTTATCTTCAGTCTTAC
ATAGCATCCCCTCAGGGAGGAAACAGAAGAAAATCCCTGCTGCCCTCAAAGAAGTGTCAGCGAA
CACAGAGGACTCCACCATGAGCGGCTACCTCTACAGATCCAAGGGCAGTAAAAAGCCGTGGAAA
CACCTATGGTTCGTCATCAAGAACAAAGTGCTCTACACATACGCTGCAAGCGAGGATGTGGCAG
CTTTGGAAAGTCAGCCCTTATTGGGATTCACCGTCGCTCAAGTCAAAGACGAGCACTCGGATCC
TAGAGTGTTTCAGCTGCTGCACAAAGGCTTGCTGTTCTACGTGTTCAAGGCAGACGACGCCCAC
TCCACTCAGAGGTGGATAGACGCATTTCAGGAGGGCACAGTATTATAGCCACACTGACTGCACT
GCCTCTGAGGTTCCAACAAGGTGGAGAATGGCATAAAAGCTACTCAAAAGCCGTGTGAAAACGA
ACACTGCCAAGACAAGTCCACCCACCGTCGTTGTGAGATAGAGTGTTTTGTTAGGTATATACAG
TTCCTAAAAATGTCTTTCATGTTTGTTATTTATTAAAATGTTGATGTTTACTCGTTGGTT

hide sequence

RefSeq Acc Id:

XM_039079738 ⟹ XP_038935666

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	30,494,286 - 30,599,898 (+)	NCBI
mRatBN7.2	7	28,610,349 - 28,712,908 (+)	NCBI

RefSeq Acc Id:

XM_063264098 ⟹ XP_063120168

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	30,484,642 - 30,587,465 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001131117	(Get FASTA)	NCBI Sequence Viewer
	XP_038935666	(Get FASTA)	NCBI Sequence Viewer
	XP_063120168	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM16892	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000074257.2
	ENSRNOP00000081090
	ENSRNOP00000081090.1
	ENSRNOP00000097286.1

RefSeq Acc Id:

NP_001131117 ⟸ NM_001137645

- UniProtKB:

A0A0G2K7L6 (UniProtKB/TrEMBL), A0A8I6G5H4 (UniProtKB/TrEMBL), A6IG06 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTSAVELKKPPLAPKPKLVGTNNKSPPPPIAPKPDIGNASVPRLTKTKPAIAPKPKVLTNSDVQ
DVKDQPSKKLTLNLEEREPELPESTGKFNCKDVGDAHGDYIFPTCSCSSGCTHEPRTRENLCAE
QLVLEPLGMKEHLENGKNGESSKRGSRWNSSREKCRSQSGVVLKASIFEEKLKEVLTQPRSRSP
SSSPRKHRCPNKPEMNGDHSCARQVRIEFADTSSSQSSFGKAPHSCHTQPPRDKSQNLQTCQDG
SAESLGPFHSCELEGKRGCSGGTSQKSEVQGLGPVEIHLLPYTSKFPTPKPRRTHAARLRRQKH
VDTPSESTEEPESSNNGSSCLHEDSLKNNKVSVLHQNALSNQGPVDEVRPGNKKALTRESNSDR
QDSVSSQKAVQHETSSFEKVAPSLDTDSSLTSDSTVEDGSDVLPAVDRETAFIQCSPQPLSLPK
QVKLACAEQQPTTCNREVSVPQIQKESSSRIVPKKPQRHSLPAAGVLKKAASEELVEKNSSSKE
TNSEKGLQRNHLQHLGPSNHGMSPSSFDMPNPTSEKPVWKLPHPILPFPGSPEALKRVTLSLNN
EPSISLTKPRAKSLSAVDMDRCSKPCKEPPKKTTFKKLINVKLSIGFIKSDFHKFKSKNCQHGD
VSTGHSLGREPKGLENNWQGLATGEEKKSKPIKAYSEENCSLESQKVKSWSQSSATNGQRAESL
DDQMLSRHASCQASSTSDCGPEYENVRHYEEIPEYENLPFVMARGNPPELGWQNSSSVEDTDVS
LYEVEEPYDAPDGQLQLDPRHQPCSSGRCQDRQDELHLDLPSDEEVINSSDEDDVSSESSKGEP
DPLEDKQDEDAGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRGAVAHASRQLGKPVIEDRILN
QILYYLPQLYELNRDLLKELEERMLSWAEQQRIADIFVKKGPYLKMYSMYIKEFDKNIALLDEQ
CKKNSGFATVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLLEDSVDHRDTQDAL
AVVIEVANHANDTMKQGDNFQKLMQIQYSLSGHHEIVQPGRVFLKEGILMKLSRKVMQPRMIFL
FNDALLYTTPMQSGMYKLNNMLSLAGMKVRKPTQEAYQNELKIESVERSFILSASSASERDDWL
EAISRAIEEYAKKRITFCPSRSLDEDSERKEEVSPLGAKAPIWIPDTRATMCMICTSEFTLTWR
RHHCRACGKIVCQACSSNKCGLDYLKGQPARVCELCFQELQKLDHQLSPRIGSPGNHKSPSSAL
SSVLHSIPSGRKQKKIPAALKEVSANTEDSTMSGYLYRSKGSKKPWKHLWFVIKNKVLYTYAAS
EDVAALESQPLLGFTVAQVKDEHSDPRVFQLLHKGLLFYVFKADDAHSTQRWIDAFQEGTVL

hide sequence

Ensembl Acc Id:

ENSRNOP00000074257 ⟸ ENSRNOT00000077666

RefSeq Acc Id:	XP_038935666 ⟸ XM_039079738
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000097286 ⟸ ENSRNOT00000114664

Ensembl Acc Id:

ENSRNOP00000081090 ⟸ ENSRNOT00000101771

RefSeq Acc Id:	XP_063120168 ⟸ XM_063264098
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AU60 (UniProtKB/TrEMBL)

Protein Domains

DH FYVE-type PH

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K7L6-F1-model_v2	AlphaFold	A0A0G2K7L6	1-1406	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695153

Promoter ID:

EPDNEW_R5677

Type:

multiple initiation site

Name:

Fgd6_1

Description:

FYVE, RhoGEF and PH domain containing 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	34,951,990 - 34,952,050	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1565609	AgrOrtholog
BioCyc Gene	G2FUF-34373	BioCyc
Ensembl Genes	ENSRNOG00000054515	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000077666.2	UniProtKB/TrEMBL
	ENSRNOT00000101771	ENTREZGENE
	ENSRNOT00000101771.1	UniProtKB/TrEMBL
	ENSRNOT00000114664.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.900.10	UniProtKB/TrEMBL
	2.30.29.30	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
InterPro	DBL_dom_sf	UniProtKB/TrEMBL
	DH-domain	UniProtKB/TrEMBL
	FGD6_N_PH	UniProtKB/TrEMBL
	FYVE_RhoGEF_PH	UniProtKB/TrEMBL
	PH_type	UniProtKB/TrEMBL
	Pleckstrin_homology	UniProtKB/TrEMBL
	Znf_FYVE	UniProtKB/TrEMBL
	Znf_FYVE-rel	UniProtKB/TrEMBL
	Znf_FYVE_PHD	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
KEGG Report	rno:500824	UniProtKB/TrEMBL
NCBI Gene	500824	ENTREZGENE
PANTHER	FACIOGENITAL DYSPLASIA PROTEIN	UniProtKB/TrEMBL
	FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 6	UniProtKB/TrEMBL
Pfam	FYVE	UniProtKB/TrEMBL
	PF00169	UniProtKB/TrEMBL
	RhoGEF	UniProtKB/TrEMBL
PhenoGen	Fgd6	PhenoGen
PROSITE	DH_2	UniProtKB/TrEMBL
	PH_DOMAIN	UniProtKB/TrEMBL
	ZF_FYVE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000054515	RatGTEx
SMART	FYVE	UniProtKB/TrEMBL
	RhoGEF	UniProtKB/TrEMBL
	SM00233	UniProtKB/TrEMBL
Superfamily-SCOP	DH-domain	UniProtKB/TrEMBL
	PH domain-like	UniProtKB/TrEMBL
	SSF57903	UniProtKB/TrEMBL
UniProt	A0A0G2K7L6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AU60	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6G5H4	ENTREZGENE, UniProtKB/TrEMBL
	A6IG06	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-07	Fgd6	FYVE, RhoGEF and PH domain containing 6	RGD1565609_predicted	similar to FYVE, RhoGEF and PH domain containing 6 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1565609_predicted	similar to FYVE, RhoGEF and PH domain containing 6 (predicted)	LOC500824	similar to FYVE, RhoGEF and PH domain containing 6	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC500824	similar to FYVE, RhoGEF and PH domain containing 6			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD