Rap1a (RAP1A, member of RAS oncogene family) - Rat Genome Database

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Gene: Rap1a (RAP1A, member of RAS oncogene family) Rattus norvegicus
Analyze
Symbol: Rap1a
Name: RAP1A, member of RAS oncogene family
RGD ID: 1359694
Description: Enables GTP binding activity and guanyl-nucleotide exchange factor activity. Involved in several processes, including cellular response to cAMP; liver regeneration; and positive regulation of signal transduction. Located in cytoplasmic vesicle and perinuclear region of cytoplasm. Orthologous to human RAP1A (RAP1A, member of RAS oncogene family); PARTICIPATES IN adenosine signaling pathway; E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC93785; MGC94873; rap 1A; RAP-1A; RAS-related protein 1a; ras-related protein Krev-1; Ras-related protein RAP-1A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22193,208,631 - 193,286,513 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2193,208,635 - 193,286,501 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2200,803,067 - 200,880,920 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02198,695,421 - 198,773,190 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02193,512,375 - 193,590,151 (-)NCBIRnor_WKY
Rnor_6.02208,193,950 - 208,215,186 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2208,193,954 - 208,215,187 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02227,614,901 - 227,691,823 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42200,980,324 - 201,001,561 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12200,943,077 - 201,020,962 (-)NCBI
Celera2185,670,857 - 185,692,256 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-mevalonic acid  (ISO)
(S)-(-)-perillyl alcohol  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (EXP)
afimoxifene  (ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
cerivastatin  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
cisplatin  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
cortisol  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
doxorubicin  (ISO)
enniatin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fluvastatin  (ISO)
fonofos  (ISO)
formaldehyde  (EXP)
fulvestrant  (ISO)
gentamycin  (EXP)
geranyl diphosphate  (ISO)
geranylgeraniol  (ISO)
GGTI-2133  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (EXP)
hemin  (ISO)
hydralazine  (ISO)
hydroquinone  (ISO)
ivermectin  (ISO)
lovastatin  (ISO)
LY294002  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
myrtenol  (ISO)
N-[3-(aminomethyl)benzyl]acetamidine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nitric oxide  (ISO)
nocodazole  (EXP)
ozone  (EXP)
p-menthan-3-ol  (ISO)
pamidronate  (ISO)
parathion  (ISO)
perillyl alcohol  (ISO)
perillyl aldehyde  (ISO)
Pirarubicin  (EXP)
quercitrin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
Risedronate sodium  (ISO)
rolipram  (EXP)
rutin  (EXP)
simvastatin  (ISO)
sodium arsenite  (ISO)
SU6656  (ISO)
terbufos  (ISO)
thioacetamide  (EXP)
tolcapone  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
wortmannin  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. New targets of urocortin-mediated cardioprotection. Barry SP, etal., J Mol Endocrinol. 2010 Aug;45(2):69-85. doi: 10.1677/JME-09-0148. Epub 2010 May 25.
2. Rap1 activation is required for Fc gamma receptor-dependent phagocytosis. Chung J, etal., J Immunol. 2008 Oct 15;181(8):5501-9.
3. Cell-cycle regulated expression of Rap1 in regenerating liver. Cruise JL, etal., Biochem Biophys Res Commun. 1997 Jan 23;230(3):578-81.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth. Hisata S, etal., J Cell Biol. 2007 Aug 27;178(5):843-60.
6. Rap1-induced p38 mitogen-activated protein kinase activation facilitates AMPA receptor trafficking via the GDI.Rab5 complex. Potential role in (S)-3,5-dihydroxyphenylglycene-induced long term depression. Huang CC, etal., J Biol Chem 2004 Mar 26;279(13):12286-92. Epub 2004 Jan 6.
7. Possible involvement of Rap1 and Ras in glutamatergic synaptic transmission. Imamura Y, etal., Neuroreport 2003 Jul 1;14(9):1203-7.
8. Apocynin-treatment reverses hyperoxaluria induced changes in NADPH oxidase system expression in rat kidneys: a transcriptional study. Joshi S, etal., PLoS One. 2012;7(10):e47738. doi: 10.1371/journal.pone.0047738. Epub 2012 Oct 16.
9. Adrenaline increases glucose transport via a Rap1-p38MAPK pathway in rat vascular smooth muscle cells. Kanda Y and Watanabe Y, Br J Pharmacol. 2007 Jun;151(4):476-82. Epub 2007 Apr 23.
10. Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation. Kelly P, etal., J Biol Chem. 2010 May 21;285(21):15777-85. doi: 10.1074/jbc.M109.069112. Epub 2010 Mar 25.
11. High glucose stimulates synthesis of fibronectin via a novel protein kinase C, Rap1b, and B-Raf signaling pathway. Lin S, etal., J Biol Chem. 2002 Nov 1;277(44):41725-35. Epub 2002 Aug 23.
12. Use of an activation-specific probe to show that Rap1A and Rap1B display different sensitivities to activation by forskolin in rat1 cells. McPhee I, etal., FEBS Lett. 2000 Jul 21;477(3):213-8.
13. Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells. Meng J and Casey PJ, J Biol Chem 2002 Nov 8;277(45):43417-24. Epub 2002 Aug 26.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart. Miller CL, etal., Basic Res Cardiol. 2011 Nov;106(6):1023-39. doi: 10.1007/s00395-011-0228-2. Epub 2011 Oct 20.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells. Schonherr C, etal., Oncogene. 2010 May 13;29(19):2817-30. doi: 10.1038/onc.2010.27. Epub 2010 Mar 1.
22. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
23. Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A. Tsygankova OM, etal., Mol Cell Biol. 2001 Mar;21(6):1921-9.
24. Coincident induction of K rev-1/rap 1A, rap 1B and H-ras mRNAs in the rat spinal cord by noxious stimulation. Urayama O, etal., Brain Res Mol Brain Res 1997 May;45(2):331-4.
25. Rap1GAP impairs cell-matrix adhesion in the absence of effects on cell-cell adhesion. Vuchak LA, etal., Cell Adh Migr. 2011 Jul-Aug;5(4):323-31. Epub 2011 Jul 1.
26. A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathway. Wu C, etal., Traffic. 2007 Nov;8(11):1503-20. Epub 2007 Sep 6.
27. Rap1GAP inhibits tumor growth in oropharyngeal squamous cell carcinoma. Zhang Z, etal., Am J Pathol. 2006 Feb;168(2):585-96.
Additional References at PubMed
PMID:2642744   PMID:9560161   PMID:10854065   PMID:11179219   PMID:11359771   PMID:12202034   PMID:12473665   PMID:15489334   PMID:15894621   PMID:17403904   PMID:17634366   PMID:17916086  
PMID:19635461   PMID:20458337   PMID:21454546   PMID:21840392   PMID:22082260   PMID:22732430   PMID:22797597   PMID:23106098   PMID:23209302   PMID:23376485   PMID:23616533   PMID:24625528  
PMID:25533468   PMID:25931508   PMID:26854595   PMID:30520098   PMID:31173168   PMID:32452765  


Genomics

Comparative Map Data
Rap1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22193,208,631 - 193,286,513 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2193,208,635 - 193,286,501 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2200,803,067 - 200,880,920 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02198,695,421 - 198,773,190 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02193,512,375 - 193,590,151 (-)NCBIRnor_WKY
Rnor_6.02208,193,950 - 208,215,186 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2208,193,954 - 208,215,187 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02227,614,901 - 227,691,823 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42200,980,324 - 201,001,561 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12200,943,077 - 201,020,962 (-)NCBI
Celera2185,670,857 - 185,692,256 (-)NCBICelera
Cytogenetic Map2q34NCBI
RAP1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381111,542,009 - 111,716,691 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1111,542,218 - 111,716,691 (+)EnsemblGRCh38hg38GRCh38
GRCh371112,084,631 - 112,259,313 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361111,963,928 - 112,057,624 (+)NCBINCBI36Build 36hg18NCBI36
Build 341111,874,446 - 111,968,142NCBI
Celera1110,480,558 - 110,502,712 (+)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1110,033,768 - 110,127,466 (+)NCBIHuRef
CHM1_11112,277,395 - 112,371,081 (+)NCBICHM1_1
T2T-CHM13v2.01111,556,699 - 111,731,587 (+)NCBIT2T-CHM13v2.0
Rap1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393105,634,576 - 105,708,740 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3105,634,583 - 105,708,652 (-)EnsemblGRCm39 Ensembl
GRCm383105,727,260 - 105,801,394 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3105,727,267 - 105,801,336 (-)EnsemblGRCm38mm10GRCm38
MGSCv373105,531,200 - 105,604,254 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363105,856,338 - 105,929,392 (-)NCBIMGSCv36mm8
Celera3107,917,236 - 107,990,252 (-)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map346.45NCBI
Rap1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543515,150,827 - 15,171,397 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543515,090,521 - 15,171,397 (+)NCBIChiLan1.0ChiLan1.0
RAP1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11125,971,599 - 126,068,180 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1125,971,598 - 125,994,813 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01114,279,255 - 114,376,977 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
RAP1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11763,725,812 - 63,795,359 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1763,726,248 - 63,746,881 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1763,239,140 - 63,309,862 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01764,898,732 - 64,969,490 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1764,898,198 - 64,969,635 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11763,631,539 - 63,702,422 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01763,690,887 - 63,761,587 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01764,488,459 - 64,559,217 (-)NCBIUU_Cfam_GSD_1.0
Rap1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505817,112,394 - 17,201,855 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936690315,752 - 366,413 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936690275,840 - 363,752 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAP1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4108,676,685 - 108,743,368 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14108,675,537 - 108,750,952 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24118,823,007 - 118,897,253 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAP1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12021,895,829 - 21,989,008 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2021,899,669 - 21,917,350 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603836,490,746 - 36,600,954 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rap1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247727,368,653 - 7,424,938 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247727,340,152 - 7,425,218 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rap1a
269 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:201
Count of miRNA genes:145
Interacting mature miRNAs:166
Transcripts:ENSRNOT00000047836
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat

Markers in Region
RH142625  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22193,245,576 - 193,245,734 (+)MAPPERmRatBN7.2
Rnor_6.02208,230,916 - 208,231,073NCBIRnor6.0
Rnor_5.02227,651,121 - 227,651,278UniSTSRnor5.0
RGSC_v3.42201,017,086 - 201,017,243UniSTSRGSC3.4
Celera2185,707,792 - 185,707,949UniSTS
RH 3.4 Map21369.8UniSTS
Cytogenetic Map2q34UniSTS
RH142722  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22193,267,871 - 193,268,030 (+)MAPPERmRatBN7.2
Rnor_6.02208,253,314 - 208,253,472NCBIRnor6.0
Rnor_5.02227,673,560 - 227,673,718UniSTSRnor5.0
RGSC_v3.42201,039,553 - 201,039,711UniSTSRGSC3.4
Celera2185,729,852 - 185,730,010UniSTS
RH 3.4 Map21366.3UniSTS
Cytogenetic Map2q34UniSTS
RH138422  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22193,245,380 - 193,245,598 (+)MAPPERmRatBN7.2
Rnor_6.02208,230,720 - 208,230,937NCBIRnor6.0
Rnor_5.02227,650,925 - 227,651,142UniSTSRnor5.0
RGSC_v3.42201,016,890 - 201,017,107UniSTSRGSC3.4
Celera2185,707,596 - 185,707,813UniSTS
Cytogenetic Map2q34UniSTS
RH139484  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22193,208,804 - 193,208,995 (+)MAPPERmRatBN7.2
mRatBN7.22193,208,804 - 193,209,041 (+)MAPPERmRatBN7.2
Rnor_6.02208,194,124 - 208,194,360NCBIRnor6.0
Rnor_6.02208,194,124 - 208,194,314NCBIRnor6.0
Rnor_5.02227,615,077 - 227,615,313UniSTSRnor5.0
Rnor_5.02227,615,077 - 227,615,267UniSTSRnor5.0
RGSC_v3.42200,980,498 - 200,980,688UniSTSRGSC3.4
RGSC_v3.42200,980,498 - 200,980,734UniSTSRGSC3.4
Celera2185,671,031 - 185,671,267UniSTS
Celera2185,671,031 - 185,671,221UniSTS
RH 3.4 Map21369.8UniSTS
Cytogenetic Map2q34UniSTS
RH140317  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22193,208,886 - 193,209,124 (+)MAPPERmRatBN7.2
Rnor_6.02208,194,206 - 208,194,443NCBIRnor6.0
Rnor_5.02227,615,159 - 227,615,396UniSTSRnor5.0
RGSC_v3.42200,980,580 - 200,980,817UniSTSRGSC3.4
Celera2185,671,113 - 185,671,350UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 10 74 35 37 11 8
Low 1 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000047836   ⟹   ENSRNOP00000040409
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2193,208,635 - 193,286,473 (-)Ensembl
Rnor_6.0 Ensembl2208,193,954 - 208,215,187 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106875   ⟹   ENSRNOP00000083539
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2193,208,635 - 193,286,473 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110219   ⟹   ENSRNOP00000092463
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2193,217,630 - 193,286,501 (-)Ensembl
RefSeq Acc Id: NM_001005765   ⟹   NP_001005765
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22193,208,631 - 193,286,473 (-)NCBI
Rnor_6.02208,193,950 - 208,215,186 (-)NCBI
Rnor_5.02227,614,901 - 227,691,823 (-)NCBI
RGSC_v3.42200,980,324 - 201,001,561 (-)RGD
Celera2185,670,857 - 185,692,256 (-)RGD
Sequence:
RefSeq Acc Id: XM_039102075   ⟹   XP_038958003
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22193,209,681 - 193,286,513 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001005765 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958003 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83813 (Get FASTA)   NCBI Sequence Viewer  
  BAA20126 (Get FASTA)   NCBI Sequence Viewer  
  EDL85430 (Get FASTA)   NCBI Sequence Viewer  
  P62836 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001005765   ⟸   NM_001005765
- UniProtKB: P62836 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000040409   ⟸   ENSRNOT00000047836
RefSeq Acc Id: XP_038958003   ⟸   XM_039102075
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000092463   ⟸   ENSRNOT00000110219
RefSeq Acc Id: ENSRNOP00000083539   ⟸   ENSRNOT00000106875

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62836-F1-model_v2 AlphaFold P62836 1-184 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359694 AgrOrtholog
BioCyc Gene G2FUF-51726 BioCyc
Ensembl Genes ENSRNOG00000032463 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000040409 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000083539.1 UniProtKB/TrEMBL
  ENSRNOP00000092463.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047836 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000106875.1 UniProtKB/TrEMBL
  ENSRNOT00000110219.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110254 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rap1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_Ras-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:295347 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94873 IMAGE-MGC_LOAD
NCBI Gene 295347 ENTREZGENE
PANTHER PTHR24070 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rap1a PhenoGen
PROSITE RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs small_GTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZX51_RAT UniProtKB/TrEMBL
  A0A8I6AHX7_RAT UniProtKB/TrEMBL
  P62836 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P10113 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-24 Rap1a  RAP1A, member of RAS oncogene family  Rap1a  RAS-related protein 1a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Rap1a  RAS-related protein 1a      Symbol and Name updated 1299863 APPROVED
2005-07-29 RAP-1A  Ras-related protein RAP-1A      Symbol and Name status set to provisional 70820 PROVISIONAL