Mir186 (microRNA 186) - Rat Genome Database

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Gene: Mir186 (microRNA 186) Rattus norvegicus
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Symbol: Mir186
Name: microRNA 186
RGD ID: 2325558
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to act upstream of or within miRNA-mediated gene silencing by inhibition of translation. Orthologous to human MIR186 (microRNA 186); INTERACTS WITH atrazine; bisphenol A; bleomycin A2.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: rno-mir-186
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82249,241,650 - 249,241,735 (+)NCBIGRCr8
mRatBN7.22246,582,806 - 246,582,891 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2246,582,806 - 246,582,891 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2254,293,983 - 254,294,068 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02252,187,801 - 252,187,886 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02247,167,857 - 247,167,942 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02263,873,759 - 263,873,844 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2263,873,759 - 263,873,844 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02282,781,917 - 282,782,002 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2238,390,493 - 238,390,578 (+)NCBICelera
Cytogenetic Map2q45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:16766679   PMID:17604727   PMID:17805466   PMID:20403161   PMID:26710318   PMID:29534107   PMID:30808806   PMID:31805371   PMID:33759271  


Genomics

Comparative Map Data
Mir186
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82249,241,650 - 249,241,735 (+)NCBIGRCr8
mRatBN7.22246,582,806 - 246,582,891 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2246,582,806 - 246,582,891 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2254,293,983 - 254,294,068 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02252,187,801 - 252,187,886 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02247,167,857 - 247,167,942 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02263,873,759 - 263,873,844 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2263,873,759 - 263,873,844 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02282,781,917 - 282,782,002 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2238,390,493 - 238,390,578 (+)NCBICelera
Cytogenetic Map2q45NCBI
MIR186
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38171,067,631 - 71,067,716 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl171,067,631 - 71,067,716 (-)EnsemblGRCh38hg38GRCh38
GRCh37171,533,314 - 71,533,399 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,305,901 - 71,305,986 (-)NCBINCBI36Build 36hg18NCBI36
Celera169,822,549 - 69,822,634 (-)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef169,643,582 - 69,643,667 (-)NCBIHuRef
CHM1_1171,648,663 - 71,648,748 (-)NCBICHM1_1
T2T-CHM13v2.0170,945,632 - 70,945,717 (-)NCBIT2T-CHM13v2.0
Mir186
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393157,249,916 - 157,249,986 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3157,249,916 - 157,249,986 (+)EnsemblGRCm39 Ensembl
GRCm383157,544,279 - 157,544,349 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3157,544,279 - 157,544,349 (+)EnsemblGRCm38mm10GRCm38
MGSCv373157,207,243 - 157,207,313 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera3164,012,289 - 164,012,359 (+)NCBICelera
Cytogenetic Map3H4NCBI
cM Map381.3NCBI
MIR186
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1674,881,615 - 74,881,675 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl674,881,601 - 74,881,686 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha677,556,802 - 77,556,862 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0675,472,184 - 75,472,244 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1675,023,874 - 75,023,934 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0674,921,454 - 74,921,514 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0675,418,358 - 75,418,418 (+)NCBIUU_Cfam_GSD_1.0
MIR186
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6141,943,328 - 141,943,409 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16141,943,328 - 141,943,409 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26131,558,966 - 131,559,047 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:8759
Count of gene targets:4997
Count of transcripts:5430
Interacting mature miRNAs:rno-miR-186-3p, rno-miR-186-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 9 42 82 57 60 41 19 41 156 70 74 34 41 19

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2246,582,806 - 246,582,891 (+)Ensembl
Rnor_6.0 Ensembl2263,873,759 - 263,873,844 (+)Ensembl
RefSeq Acc Id: NR_031904
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82249,241,650 - 249,241,735 (+)NCBI
mRatBN7.22246,582,806 - 246,582,891 (+)NCBI
Rnor_6.02263,873,759 - 263,873,844 (+)NCBI
Rnor_5.02282,781,917 - 282,782,002 (-)NCBI
Celera2238,390,493 - 238,390,578 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325558 AgrOrtholog
BioCyc Gene G2FUF-50716 BioCyc
Ensembl Genes ENSRNOG00000035617 Ensembl
miRBase MI0000931 ENTREZGENE
NCBI Gene 100314043 ENTREZGENE
PhenoGen Mir186 PhenoGen
RatGTEx ENSRNOG00000035617 RatGTEx
RNAcentral URS000040DCFF RNACentral
  URS0000759E4C RNACentral
  URS000075BE1B RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-09 Mir186  microRNA 186  Mir186  microRNA mir-186  Name updated 61478 APPROVED
2010-06-02 Mir186  microRNA mir-186      Symbol and Name status set to provisional 70820 PROVISIONAL