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Gene: Sftpd (surfactant protein D) Rattus norvegicus
Symbol: Sftpd
Name: surfactant protein D
RGD ID: 3667
Description: Exhibits identical protein binding activity; lipopolysaccharide binding activity; and monosaccharide binding activity. Involved in several processes, including negative regulation of interleukin-2 production; opsonization; and regulation of phagocytosis. Localizes to extracellular space; multivesicular body; and rough endoplasmic reticulum. Biomarker of Coronavirus infectious disease; asthma; and lung disease (multiple). Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to human SFTPD (surfactant protein D); PARTICIPATES IN surfactant homeostasis pathway; forkhead class A signaling pathway; phagocytosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
Also known as: CP4; lung surfactant protein D; PSP-D; pulmonary surfactant protein D; pulmonary surfactant-associated protein D; SP-D; SPD; surfactant associated protein D; surfactant pulmonary-associated protein D; surfactant, pulmonary-associated protein D
Homo sapiens (human) : SFTPD (surfactant protein D)  HGNC  Alliance
Mus musculus (house mouse) : Sftpd (surfactant associated protein D)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sftpd (surfactant protein D)
Pan paniscus (bonobo/pygmy chimpanzee) : SFTPD (surfactant protein D)
Canis lupus familiaris (dog) : SFTPD (surfactant protein D)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sftpd (surfactant protein D)
Sus scrofa (pig) : SFTPD (surfactant protein D)
Chlorocebus sabaeus (African green monkey) : SFTPD (surfactant protein D)
Heterocephalus glaber (naked mole-rat) : Sftpd (surfactant protein D)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01618,753,535 - 18,766,100 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1618,745,458 - 18,766,174 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01618,621,441 - 18,633,581 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1617,272,045 - 17,284,082 (-)NCBICelera
Cytogenetic Map16p14NCBI
RH 3.4 Map16167.0RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Sftpd
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3667
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.