Sftpd (surfactant associated protein D) - Rat Genome Database

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Gene: Sftpd (surfactant associated protein D) Mus musculus
Analyze
Symbol: Sftpd
Name: surfactant associated protein D
RGD ID: 11287
MGI Page MGI
Description: Enables identical protein binding activity. Predicted to be involved in several processes, including negative regulation of interleukin-2 production; opsonization; and regulation of phagocytosis. Predicted to act upstream of or within innate immune response and respiratory gaseous exchange by respiratory system. Located in cytoplasm. Is expressed in epidermis spinous layer; lung; lung surfactant; otic capsule; and skeleton. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to human SFTPD (surfactant protein D).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI573415; lung surfactant protein D; PSP-D; pulmonary surfactant-associated protein D; Sf; Sfpd; Sft; Sftp4; SP; SP-D
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391440,894,169 - 40,907,155 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1440,894,171 - 40,907,106 (-)EnsemblGRCm39 Ensembl
GRCm381441,172,212 - 41,185,198 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1441,172,214 - 41,185,149 (-)EnsemblGRCm38mm10GRCm38
MGSCv371441,985,501 - 41,998,487 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361440,080,927 - 40,093,876 (-)NCBIMGSCv36mm8
Celera1437,332,219 - 37,345,205 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1422.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (EXP)
6-propyl-2-thiouracil  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
benzo[a]pyrene  (EXP)
benzo[b]fluoranthene  (EXP)
beryllium sulfate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
cadmium dichloride  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
choline  (EXP)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
dichlorine  (EXP)
Didecyldimethylammonium  (ISO)
dioxygen  (ISO)
epoxiconazole  (EXP)
folic acid  (EXP)
fumonisin B1  (EXP)
furan  (ISO)
genistein  (EXP)
glucose  (ISO)
hydrogen chloride  (ISO)
inulin  (EXP)
L-methionine  (EXP)
lipopolysaccharide  (EXP)
mechlorethamine  (EXP)
methimazole  (ISO)
methylmercury chloride  (ISO)
nitrates  (EXP)
nitrofen  (ISO)
nitrogen dioxide  (ISO)
O-methyleugenol  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pirinixic acid  (ISO)
progesterone  (EXP)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
Sucralfate  (ISO)
sulfadimethoxine  (ISO)
terbutaline  (ISO)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (EXP)
triclosan  (ISO)
vinclozolin  (ISO)
vitamin D  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Pneumocystis carinii pneumonia alters expression and distribution of lung collectins SP-A and SP-D. Atochina EN, etal., J Lab Clin Med. 2001 Jun;137(6):429-39.
2. Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization. Atochina EN, etal., Respir Res. 2003 Dec 8;4:15. Print 2003.
3. Immune reconstitution during Pneumocystis lung infection: disruption of surfactant component expression and function by S-nitrosylation. Atochina-Vasserman EN, etal., J Immunol. 2009 Feb 15;182(4):2277-87.
4. Patterns of neutrophil serine protease-dependent cleavage of surfactant protein D in inflammatory lung disease. Cooley J, etal., J Leukoc Biol. 2008 Apr;83(4):946-55. Epub 2008 Jan 22.
5. Association between single nucleotide polymorphisms of surfactant protein D and allergic rhinitis in Chinese patients. Deng YQ, etal., Tissue Antigens. 2009 Jun;73(6):546-52.
6. Sivelestat sodium hydrate improves septic acute lung injury by reducing alveolar dysfunction. Endo S, etal., Res Commun Mol Pathol Pharmacol. 2006;119(1-6):53-65.
7. Surfactant protein levels in bronchoalveolar lavage after segmental allergen challenge in patients with asthma. Erpenbeck VJ, etal., Allergy. 2006 May;61(5):598-604.
8. Surfactant protein D inhibits early airway response in Aspergillus fumigatus-sensitized mice. Erpenbeck VJ, etal., Clin Exp Allergy. 2006 Jul;36(7):930-40.
9. Pulmonary-specific expression of SP-D corrects pulmonary lipid accumulation in SP-D gene-targeted mice. Fisher JH, etal., Am J Physiol Lung Cell Mol Physiol. 2000 Feb;278(2):L365-73.
10. Polymorphisms in Surfactant Protein D are Associated with COPD. Foreman MG, etal., Am J Respir Cell Mol Biol. 2010 May 6.
11. Serum surfactant protein D is increased in acute and chronic inflammation in mice. Fujita M, etal., Cytokine. 2005 Jul 7;31(1):25-33.
12. Rat respiratory coronavirus infection: replication in airway and alveolar epithelial cells and the innate immune response. Funk CJ, etal., J Gen Virol. 2009 Dec;90(Pt 12):2956-64. Epub 2009 Sep 9.
13. Relationship between pulmonary surfactant protein and lipid peroxidation in lung injury due to paraquat intoxication in rats. Gil HW, etal., Korean J Intern Med. 2007 Jun;22(2):67-72.
14. Serial changes in surfactant-associated proteins in lung and serum before and after onset of ARDS. Greene KE, etal., Am J Respir Crit Care Med. 1999 Dec;160(6):1843-50.
15. Pulmonary surfactant, lung function, and endobronchial inflammation in cystic fibrosis. Griese M, etal., Am J Respir Crit Care Med. 2004 Nov 1;170(9):1000-5. Epub 2004 Jul 21.
16. Children with absent surfactant protein D in bronchoalveolar lavage have more frequently pneumonia. Griese M, etal., Pediatr Allergy Immunol. 2008 Nov;19(7):639-47. Epub 2008 Feb 11.
17. Aspergillus fumigatus-induced allergic airway inflammation alters surfactant homeostasis and lung function in BALB/c mice. Haczku A, etal., Am J Respir Cell Mol Biol. 2001 Jul;25(1):45-50.
18. Surfactant protein D and KL-6 as serum biomarkers of interstitial lung disease in patients with scleroderma. Hant FN, etal., J Rheumatol. 2009 Apr;36(4):773-80. Epub 2009 Mar 13.
19. Circulating surfactant protein D is decreased in systemic lupus erythematosus. Hoegh SV, etal., J Rheumatol. 2009 Nov;36(11):2449-53. Epub 2009 Oct 15.
20. Nihon Kyobu Shikkan Gakkai zasshi Honda Y Nihon Kyobu Shikkan Gakkai Zasshi. 1996 Dec;34 Suppl:181-5.
21. Surfactant protein-D and surfactant inhibit endotoxin-induced pulmonary inflammation. Ikegami M, etal., Chest. 2007 Nov;132(5):1447-54. Epub 2007 Oct 9.
22. SP-D-deficient mice are resistant to hyperoxia. Jain D, etal., Am J Physiol Lung Cell Mol Physiol. 2007 Apr;292(4):L861-71. Epub 2006 Dec 8.
23. Surfactant protein D protects against acute hyperoxic lung injury. Jain D, etal., Am J Respir Crit Care Med. 2008 Oct 15;178(8):805-13. Epub 2008 Jul 17.
24. The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia. Jounblat R, etal., Respir Res. 2005 Oct 28;6:126.
25. Surfactant protein levels in severe respiratory syncytial virus infection. Kerr MH and Paton JY, Am J Respir Crit Care Med. 1999 Apr;159(4 Pt 1):1115-8.
26. Surfactant Protein D Deficiency Increases Lung Injury during Endotoxemia. King BA and Kingma PS, Am J Respir Cell Mol Biol. 2010 Jul 16.
27. Correction of pulmonary abnormalities in Sftpd-/- mice requires the collagenous domain of surfactant protein D. Kingma PS, etal., J Biol Chem. 2006 Aug 25;281(34):24496-505. Epub 2006 Jun 20.
28. Elevation of surfactant protein D, a pulmonary disease biomarker, in the sera of uveitis patients with sarcoidosis. Kitaichi N, etal., Jpn J Ophthalmol. 2010 Jan;54(1):81-4. Epub 2010 Feb 12.
29. Clinical importance of bronchoalveolar lavage fluid and blood cytokines, surfactant protein D, and Kerbs von Lungren 6 antigen in idiopathic pulmonary alveolar proteinosis. Lin FC, etal., Mayo Clin Proc. 2008 Dec;83(12):1344-9.
30. Susceptibility of mice genetically deficient in SP-A or SP-D gene to invasive pulmonary aspergillosis. Madan T, etal., Mol Immunol. 2010 Jun;47(10):1923-30. Epub 2010 Apr 21.
31. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
32. MGDs mouse GO annotations MGD data from the GO Consortium
33. MGD IEA MGD IEA
34. Prognostic value of serum surfactant protein D level prior to transplant for the development of bronchiolitis obliterans syndrome and idiopathic pneumonia syndrome following allogeneic hematopoietic stem cell transplantation. Nakane T, etal., Bone Marrow Transplant. 2008 Jul;42(1):43-9. Epub 2008 Mar 17.
35. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
36. Genetic variants of surfactant proteins A, B, C, and D in bronchopulmonary dysplasia. Pavlovic J, etal., Dis Markers. 2006;22(5-6):277-91.
37. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
38. Mouse MP Annotation Import Pipeline RGD automated import pipeline
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Total extracellular surfactant is increased but abnormal in a rat model of gram-negative bacterial pneumonia. Russo TA, etal., Am J Physiol Lung Cell Mol Physiol. 2002 Sep;283(3):L655-63.
42. Respiratory distress after intratracheal bleomycin: selective deficiency of surfactant proteins B and C. Savani RC, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Sep;281(3):L685-96.
43. Pulmonary surfactant in patients with Pneumocystis pneumonia and acquired immunodeficiency syndrome. Schmidt R, etal., Crit Care Med. 2006 Sep;34(9):2370-6.
44. Increased surfactant protein a and d expression in acute ovalbumin-induced allergic airway inflammation in brown norway rats. Schmiedl A, etal., Int Arch Allergy Immunol. 2009;148(2):118-26. Epub 2008 Sep 19.
45. Serum surfactant protein D during acute exacerbations of chronic obstructive pulmonary disease. Shakoori TA, etal., Dis Markers. 2009;27(6):287-94.
46. The effects of fluticasone with or without salmeterol on systemic biomarkers of inflammation in chronic obstructive pulmonary disease. Sin DD, etal., Am J Respir Crit Care Med. 2008 Jun 1;177(11):1207-14. Epub 2008 Feb 28.
47. Surfactant protein D and bronchial dysplasia in smokers at high risk of lung cancer. Sin DD, etal., Chest. 2008 Sep;134(3):582-8.
48. The association between BMI and plasma cytokine levels in patients with acute lung injury. Stapleton RD, etal., Chest. 2010 Sep;138(3):568-77. Epub 2010 Apr 30.
49. Surfactant protein D regulates airway function and allergic inflammation through modulation of macrophage function. Takeda K, etal., Am J Respir Crit Care Med. 2003 Oct 1;168(7):783-9. Epub 2003 Jul 25.
50. Haplotypes of the surfactant protein genes A and D as susceptibility factors for the development of respiratory distress syndrome. Thomas NJ, etal., Acta Paediatr. 2007 Jul;96(7):985-9. Epub 2007 May 24.
51. Transmission of surfactant protein variants and haplotypes in children hospitalized with respiratory syncytial virus. Thomas NJ, etal., Pediatr Res. 2009 Jul;66(1):70-3.
52. Novel strategy to identify genetic risk factors for COPD severity: a genetic isolate. van Diemen CC, etal., Eur Respir J. 2010 Apr;35(4):768-75. Epub 2009 Sep 24.
53. Elevated expression of surfactant proteins in newborn rats during adaptation to hyperoxia. White CW, etal., Am J Respir Cell Mol Biol. 2001 Jul;25(1):51-9.
54. Sinonasal surfactant protein A1, A2, and D gene expression in cystic fibrosis: a preliminary report. Woodworth BA, etal., Otolaryngol Head Neck Surg. 2007 Jul;137(1):34-8.
55. Serum levels of surfactant protein D predict the anti-tumor activity of gefitinib in patients with advanced non-small cell lung cancer. Yamaguchi H, etal., Cancer Chemother Pharmacol. 2010 Apr 17.
56. Prescreening based on the presence of CT-scan abnormalities and biomarkers (KL-6 and SP-D) may reduce severe radiation pneumonitis after stereotactic radiotherapy. Yamashita H, etal., Radiat Oncol. 2010 May 9;5:32.
57. Reversibility of pulmonary abnormalities by conditional replacement of surfactant protein D (SP-D) in vivo. Zhang L, etal., J Biol Chem 2002 Oct 11;277(41):38709-13.
Additional References at PubMed
PMID:7499852   PMID:7690622   PMID:8725251   PMID:9688929   PMID:9751757   PMID:9774472   PMID:10047533   PMID:10047541   PMID:10226065   PMID:10423401   PMID:10640760   PMID:10675334  
PMID:10725249   PMID:10801980   PMID:10922068   PMID:10956621   PMID:11278637   PMID:11350793   PMID:11390505   PMID:11504698   PMID:11698462   PMID:11850179   PMID:11956209   PMID:12015304  
PMID:12024028   PMID:12053176   PMID:12091242   PMID:12218102   PMID:12244199   PMID:12376353   PMID:12477932   PMID:12595595   PMID:12857753   PMID:12871850   PMID:12884308   PMID:14517255  
PMID:14645847   PMID:15005800   PMID:15016617   PMID:15073692   PMID:15105378   PMID:15145932   PMID:15173172   PMID:15280465   PMID:15310555   PMID:15452354   PMID:15489334   PMID:15579631  
PMID:15580568   PMID:15588319   PMID:15632069   PMID:15663554   PMID:15778712   PMID:15814723   PMID:15905537   PMID:15905582   PMID:15994463   PMID:16141072   PMID:16199436   PMID:16213021  
PMID:16214823   PMID:16387789   PMID:16456184   PMID:16500946   PMID:16514117   PMID:16517724   PMID:16602821   PMID:16861641   PMID:16905545   PMID:16959842   PMID:17000766   PMID:17056703  
PMID:17083619   PMID:17298450   PMID:17464327   PMID:17641300   PMID:17954522   PMID:17967856   PMID:17972221   PMID:17988395   PMID:18056350   PMID:18070924   PMID:18078951   PMID:18287966  
PMID:18302538   PMID:18324732   PMID:18355911   PMID:18358466   PMID:18554706   PMID:18996902   PMID:19007302   PMID:19349424   PMID:19704937   PMID:19968565   PMID:20303366   PMID:20435925  
PMID:20530543   PMID:21199913   PMID:21267068   PMID:21334038   PMID:21408140   PMID:21513708   PMID:21616998   PMID:21677750   PMID:21704616   PMID:21724991   PMID:21865055   PMID:21873635  
PMID:22001906   PMID:22159717   PMID:22405766   PMID:22509382   PMID:22547543   PMID:22878412   PMID:22916088   PMID:23012359   PMID:23183169   PMID:23293024   PMID:23408915   PMID:23435873  
PMID:23451260   PMID:23518578   PMID:23526992   PMID:23590306   PMID:23620511   PMID:23637629   PMID:23762428   PMID:23922714   PMID:23997172   PMID:24111992   PMID:24275123   PMID:24457600  
PMID:24465666   PMID:24478083   PMID:24499815   PMID:24591256   PMID:24785085   PMID:24955853   PMID:25038795   PMID:25079229   PMID:25220458   PMID:25255378   PMID:25472740   PMID:25552309  
PMID:25693975   PMID:26098214   PMID:26252542   PMID:26320150   PMID:26398197   PMID:26421960   PMID:26432866   PMID:26511057   PMID:26603976   PMID:26634656   PMID:26673133   PMID:26849628  
PMID:26874827   PMID:26900854   PMID:26984772   PMID:27150575   PMID:27262512   PMID:27565967   PMID:27578791   PMID:27645581   PMID:27689697   PMID:28185902   PMID:28472244   PMID:28746823  
PMID:28839101   PMID:28878025   PMID:29414772   PMID:29733456   PMID:29950483   PMID:29969487   PMID:30124598   PMID:30337682   PMID:30366943   PMID:30389914   PMID:30619359   PMID:31067462  
PMID:31411060   PMID:31562139   PMID:31616435   PMID:31872075   PMID:31877195   PMID:32410866   PMID:32508527   PMID:33153107   PMID:34484184   PMID:34842360   PMID:35682694   PMID:35874783  
PMID:36464171   PMID:38245585  


Genomics

Comparative Map Data
Sftpd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391440,894,169 - 40,907,155 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1440,894,171 - 40,907,106 (-)EnsemblGRCm39 Ensembl
GRCm381441,172,212 - 41,185,198 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1441,172,214 - 41,185,149 (-)EnsemblGRCm38mm10GRCm38
MGSCv371441,985,501 - 41,998,487 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361440,080,927 - 40,093,876 (-)NCBIMGSCv36mm8
Celera1437,332,219 - 37,345,205 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1422.36NCBI
SFTPD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381079,937,740 - 79,982,383 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1079,937,467 - 79,982,614 (-)EnsemblGRCh38hg38GRCh38
GRCh371081,697,496 - 81,708,861 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361081,687,476 - 81,698,841 (-)NCBINCBI36Build 36hg18NCBI36
Build 341081,687,486 - 81,698,836NCBI
Celera1075,688,432 - 75,699,799 (-)NCBICelera
Cytogenetic Map10q22.3NCBI
HuRef1075,540,246 - 75,551,613 (-)NCBIHuRef
CHM1_11081,980,534 - 81,991,901 (-)NCBICHM1_1
T2T-CHM13v2.01080,806,973 - 80,851,624 (-)NCBIT2T-CHM13v2.0
Sftpd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81617,080,575 - 17,093,047 (-)NCBIGRCr8
mRatBN7.21617,046,491 - 17,058,968 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1617,046,483 - 17,059,927 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1617,110,520 - 17,122,892 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01618,238,920 - 18,251,351 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01617,163,418 - 17,175,790 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01618,753,535 - 18,766,100 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1618,745,458 - 18,766,174 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01618,621,441 - 18,633,581 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1617,272,045 - 17,284,082 (-)NCBICelera
RH 3.4 Map16167.0RGD
Cytogenetic Map16p14NCBI
Sftpd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955510213,438 - 225,896 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955510213,468 - 226,096 (+)NCBIChiLan1.0ChiLan1.0
SFTPD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2891,904,806 - 91,950,749 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11091,910,131 - 91,957,119 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01076,275,147 - 76,318,952 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11078,965,252 - 78,974,181 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1078,965,252 - 78,974,181 (+)Ensemblpanpan1.1panPan2
SFTPD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1429,394,755 - 29,407,499 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl429,394,678 - 29,407,293 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha429,519,118 - 29,533,724 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0429,696,757 - 29,711,366 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl429,696,745 - 29,709,347 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1429,566,382 - 29,580,989 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0429,769,003 - 29,783,612 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0430,123,008 - 30,137,617 (+)NCBIUU_Cfam_GSD_1.0
Sftpd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721351,337,526 - 51,349,920 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493671660,656 - 73,099 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493671660,754 - 73,010 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SFTPD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1482,051,451 - 82,067,976 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11482,051,400 - 82,069,258 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21488,660,094 - 88,675,023 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SFTPD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1951,809,241 - 51,820,974 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl951,811,052 - 51,820,650 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604812,161,420 - 12,172,864 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sftpd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248416,916,849 - 6,936,077 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248416,917,067 - 6,938,594 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sftpd
424 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:49
Interacting mature miRNAs:51
Transcripts:ENSMUST00000077136
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141864Mrdq4_mmodifier of retinal degeneration QTL 4 (mouse)Not determined992324548765082Mouse
1300779Dyscalc4_mdystrophic cardiac calcinosis 4 (mouse)Not determined141221287146213007Mouse
27226748Femd8_mfemur midshaft diameter 8, 10 week (mouse)141376927346737457Mouse
27226752Femd4_mfemur midshaft diameter 4, 5 week (mouse)141376927347237457Mouse
1300544Hypn_mhyperinsulinemia (mouse)Not determined141516061649160765Mouse
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
27226775Tibl7_mtibia length 7, 5 week (mouse)143032195748837457Mouse
27226744Metcl6_mmetatarsal-calcaneal length 6, 5 week (mouse)143032195752937457Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143322195759437449Mouse
27226727Tibl21_mtibia length 21, 16 week (mouse)143412195752937457Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse

Markers in Region
AI573415  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381441,172,406 - 41,172,541UniSTSGRCm38
MGSCv371441,985,695 - 41,985,830UniSTSGRCm37
Celera1437,332,413 - 37,332,548UniSTS
Cytogenetic Map14BUniSTS
cM Map1414.0UniSTS
Whitehead/MRC_RH14374.72UniSTS
UniSTS:237170  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381441,172,343 - 41,172,554UniSTSGRCm38
MGSCv371441,985,632 - 41,985,843UniSTSGRCm37
Celera1437,332,350 - 37,332,561UniSTS
Cytogenetic Map14BUniSTS
cM Map1414.0UniSTS
Sftpd  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381441,176,966 - 41,177,312UniSTSGRCm38
MGSCv371441,990,255 - 41,990,601UniSTSGRCm37
Celera1437,336,973 - 37,337,319UniSTS
Cytogenetic Map14BUniSTS
cM Map1414.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000077136   ⟹   ENSMUSP00000076383
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1440,894,171 - 40,907,106 (-)Ensembl
GRCm38.p6 Ensembl1441,172,214 - 41,185,149 (-)Ensembl
RefSeq Acc Id: ENSMUST00000225892
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1440,896,683 - 40,905,092 (-)Ensembl
GRCm38.p6 Ensembl1441,174,726 - 41,183,135 (-)Ensembl
RefSeq Acc Id: NM_009160   ⟹   NP_033186
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391440,894,169 - 40,907,155 (-)NCBI
GRCm381441,172,212 - 41,185,198 (-)ENTREZGENE
MGSCv371441,985,501 - 41,998,487 (-)RGD
Celera1437,332,219 - 37,345,205 (-)RGD
cM Map14 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_033186 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA92021 (Get FASTA)   NCBI Sequence Viewer  
  AAD31380 (Get FASTA)   NCBI Sequence Viewer  
  AAF15277 (Get FASTA)   NCBI Sequence Viewer  
  AAH03705 (Get FASTA)   NCBI Sequence Viewer  
  EDL24923 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000076383
  ENSMUSP00000076383.4
GenBank Protein P50404 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_033186   ⟸   NM_009160
- Peptide Label: precursor
- UniProtKB: P50404 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000076383   ⟸   ENSMUST00000077136
Protein Domains
C-type lectin   Collagen-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50404-F1-model_v2 AlphaFold P50404 1-374 view protein structure

Promoters
RGD ID:8681994
Promoter ID:EPDNEW_M19028
Type:initiation region
Name:Sftpd_1
Description:Mus musculus surfactant associated protein D , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381441,185,165 - 41,185,225EPDNEW
RGD ID:6825410
Promoter ID:MM_KWN:16277
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:NM_009160
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361441,997,931 - 41,998,431 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109515 AgrOrtholog
Ensembl Genes ENSMUSG00000021795 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000077136 ENTREZGENE
  ENSMUST00000077136.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot
  SFTPD helical domain UniProtKB/Swiss-Prot
InterPro C-type_lectin-like UniProtKB/Swiss-Prot
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot
  C-type_lectin_CS UniProtKB/Swiss-Prot
  Collagen UniProtKB/Swiss-Prot
  Collectin_CTLD UniProtKB/Swiss-Prot
  CTDL_fold UniProtKB/Swiss-Prot
  Surfac_D-trimer UniProtKB/Swiss-Prot
KEGG Report mmu:20390 UniProtKB/Swiss-Prot
MGD MGI:109515 ENTREZGENE
NCBI Gene 20390 ENTREZGENE
PANTHER COLLAGEN ALPHA UniProtKB/Swiss-Prot
  MACROPHAGE RECEPTOR MARCO UniProtKB/Swiss-Prot
Pfam Collagen UniProtKB/Swiss-Prot
  Lectin_C UniProtKB/Swiss-Prot
  Surfac_D-trimer UniProtKB/Swiss-Prot
PhenoGen Sftpd PhenoGen
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot
SMART CLECT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot
  Triple coiled coil domain of C-type lectins UniProtKB/Swiss-Prot
UniProt P50404 ENTREZGENE, UniProtKB/Swiss-Prot