Tcf7 (transcription factor 7) - Rat Genome Database

Name: Tcf7
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Tcf7 (transcription factor 7) Rattus norvegicus

Analyze

Symbol:

Tcf7

Name:

transcription factor 7

RGD ID:

1305894

Description:

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Predicted to be involved in several processes, including canonical Wnt signaling pathway involved in negative regulation of apoptotic process; cellular response to interleukin-4; and regulation of gamma-delta T cell differentiation. Predicted to act upstream of or within several processes, including T cell differentiation; embryonic morphogenesis; and neural tube development. Predicted to be located in nuclear body. Predicted to be part of beta-catenin-TCF complex and euchromatin. Orthologous to human TCF7 (transcription factor 7); PARTICIPATES IN Wnt signaling, canonical pathway; acute myeloid leukemia pathway; arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; cadmium dichloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC363595; transcription factor 7 (T-cell specific, HMG-box); transcription factor 7, T-cell specific

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TCF7 (transcription factor 7)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Tcf7 (transcription factor 7, T cell specific)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tcf7 (transcription factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TCF7 (transcription factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TCF7 (transcription factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tcf7 (transcription factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TCF7 (transcription factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TCF7 (transcription factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tcf7 (transcription factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TCF7 (transcription factor 7)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tcf7 (transcription factor 7, T cell specific)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tcf7 (transcription factor 7)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	pop-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	pan	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	tcf7	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	36,924,363 - 36,954,279 (-)	NCBI		GRCr8
mRatBN7.2	10	36,423,443 - 36,454,350 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	36,423,445 - 36,453,535 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	10	37,616,033 - 37,646,027 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	37,617,279 - 37,645,802 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	37,389,506 - 37,419,457 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	37,686,862 - 37,716,831 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	37,693,621 - 37,723,030 (-)	NCBI
Celera	10	35,778,033 - 35,807,975 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Crohn's disease (ISO)

familial adenomatous polyposis 1 (ISO)

genetic disease (ISO)

Hereditary Neoplastic Syndromes (ISO)

Mycoplasma pneumoniae pneumonia (ISO)

Neurodevelopmental Disorders (ISO)

prostate cancer (ISO)

systemic lupus erythematosus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

acetaldehyde (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

AH23848 (ISO)

alpha-naphthoflavone (ISO)

amiodarone (ISO)

amphetamine (EXP)

aristolochic acid A (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (ISO)

bortezomib (ISO)

buta-1,3-diene (ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

casticin (ISO)

celastrol (ISO)

CGP 52608 (ISO)

choline (ISO)

cisplatin (EXP)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclophosphamide (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

diazinon (EXP,ISO)

dieldrin (EXP)

diethylstilbestrol (ISO)

disodium selenite (ISO)

endosulfan (EXP)

flavonoids (ISO)

flusilazole (ISO)

folic acid (ISO)

FR900359 (ISO)

gentamycin (EXP)

indometacin (ISO)

inulin (ISO)

iron dichloride (ISO)

isoorientin (ISO)

L-methionine (ISO)

lipopolysaccharide (ISO)

methapyrilene (ISO)

methoxychlor (EXP)

naphthalene (ISO)

nickel atom (ISO)

nickel dichloride (EXP)

niclosamide (ISO)

nitrofen (EXP)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

pentanal (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

propanal (ISO)

quercetin (ISO)

quercitrin (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

selenic acid (ISO)

sodium arsenite (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

tibolone (ISO)

topotecan (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

alpha-beta T cell differentiation (ISO)

biological_process (ND)

canonical Wnt signaling pathway (IBA,ISO)

canonical Wnt signaling pathway involved in negative regulation of apoptotic process (ISO)

cellular response to interleukin-4 (ISO)

embryonic digestive tract morphogenesis (ISO)

embryonic genitalia morphogenesis (ISO)

embryonic hindgut morphogenesis (ISO)

gamma-delta T cell differentiation (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

neural tube development (ISO)

regulation of cell population proliferation (ISO)

regulation of DNA-templated transcription (ISO)

regulation of gamma-delta T cell differentiation (ISO)

regulation of transcription by RNA polymerase II (IBA,ISO)

T cell receptor V(D)J recombination (ISO)

Cellular Component

beta-catenin-TCF complex (IBA)

chromatin (IBA)

euchromatin (ISO)

nuclear body (IEA,ISO)

nucleoplasm (ISO)

nucleus (ISO)

Molecular Function

beta-catenin binding (ISO)

DNA binding (ISO)

DNA-binding transcription factor activity (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

DNA-binding transcription repressor activity (ISO)

DNA-binding transcription repressor activity, RNA polymerase II-specific (ISO)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,ISO)

sequence-specific double-stranded DNA binding (ISO)

transcription cis-regulatory region binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acute myeloid leukemia pathway (IEA)

arrhythmogenic right ventricular cardiomyopathy pathway (IEA)

basal cell carcinoma pathway (IEA)

colorectal cancer pathway (IEA)

endometrial cancer pathway (IEA)

prostate cancer pathway (IEA)

thyroid cancer pathway (IEA)

Wnt signaling pathway (IEA)

Wnt signaling, canonical pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation
7.	TCF transcription factors: molecular switches in carcinogenesis.	Roose J and Clevers H, Biochim Biophys Acta. 1999 Oct 29;1424(2-3):M23-37.
8.	TCF7 is suppressed by the androgen receptor via microRNA-1-mediated downregulation and is involved in the development of resistance to androgen deprivation in prostate cancer.	Siu MK, etal., Prostate Cancer Prostatic Dis. 2017 Jun;20(2):172-178. doi: 10.1038/pcan.2017.2. Epub 2017 Feb 21.

Additional References at PubMed

PMID:1827138	PMID:9462507	PMID:9488439	PMID:12235125	PMID:15057272	PMID:17218525	PMID:18158920	PMID:18579517	PMID:20128911	PMID:22723415	PMID:23562159

Genomics

Comparative Map Data

Tcf7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	36,924,363 - 36,954,279 (-)	NCBI		GRCr8
mRatBN7.2	10	36,423,443 - 36,454,350 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	36,423,445 - 36,453,535 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	10	37,616,033 - 37,646,027 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	37,617,279 - 37,645,802 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	37,389,506 - 37,419,457 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	37,686,862 - 37,716,831 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	37,693,621 - 37,723,030 (-)	NCBI
Celera	10	35,778,033 - 35,807,975 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

TCF7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	134,108,218 - 134,148,210 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	134,114,681 - 134,151,865 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	133,450,372 - 133,483,901 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	133,478,301 - 133,511,819 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	5	129,574,095 - 129,607,613 (+)	NCBI		Celera
Cytogenetic Map	5	q31.1	NCBI
HuRef	5	128,635,317 - 128,668,890 (+)	NCBI		HuRef
CHM1_1	5	132,882,980 - 132,916,497 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	134,630,059 - 134,671,840 (+)	NCBI		T2T-CHM13v2.0

Tcf7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	52,137,347 - 52,174,211 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	52,143,198 - 52,174,158 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	52,246,527 - 52,283,383 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	52,252,371 - 52,283,331 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	52,066,106 - 52,096,073 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	52,096,027 - 52,125,994 (-)	NCBI		MGSCv36	mm8
Celera	11	56,821,774 - 56,852,195 (-)	NCBI		Celera
Cytogenetic Map	11	B1.3	NCBI
cM Map	11	31.86	NCBI

Tcf7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	5,362,084 - 5,388,527 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955408	5,362,423 - 5,388,684 (+)	NCBI	ChiLan1.0	ChiLan1.0

TCF7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	129,407,016 - 129,446,603 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	127,546,618 - 127,586,165 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	129,518,134 - 129,549,972 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	135,671,630 - 135,704,417 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	135,671,095 - 135,702,734 (+)	Ensembl	panpan1.1		panPan2

TCF7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	22,313,113 - 22,346,221 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	22,313,105 - 22,344,004 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	21,059,022 - 21,092,131 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	23,113,932 - 23,147,114 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	11	21,814,042 - 21,847,134 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	21,679,173 - 21,712,308 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	22,321,753 - 22,354,875 (+)	NCBI		UU_Cfam_GSD_1.0

Tcf7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	114,092,704 - 114,122,991 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936647	1,097,019 - 1,125,729 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936647	1,096,726 - 1,125,753 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TCF7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	136,422,940 - 136,457,910 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	136,422,740 - 136,456,323 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	142,042,088 - 142,051,487 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TCF7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	36,919,648 - 36,953,088 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	36,919,745 - 36,951,192 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	40,979,669 - 41,016,821 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tcf7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	38,076,410 - 38,104,173 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	38,076,800 - 38,104,265 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tcf7
93 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	190
Count of miRNA genes:	135
Interacting mature miRNAs:	150
Transcripts:	ENSRNOT00000008022, ENSRNOT00000064865
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15028513	60430477	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15275955	60275955	Rat
6893350	Bw99	Body weight QTL 99	0.87	0.16	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
6893352	Bw100	Body weight QTL 100	0.33	0.6	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	17907113	51786432	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18167841	63167841	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	19606483	64606483	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	19606483	64606483	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21329805	61345413	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	26521957	61345413	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	26944628	71944628	Rat
10402859	Bp381	Blood pressure QTL 381		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2292441	Bp308	Blood pressure QTL 308			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28453136	73453136	Rat
1600371	Mcs21	Mammary carcinoma susceptibility QTL 21	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	28875650	52200160	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29299504	64155584	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
631557	Bp136	Blood pressure QTL 136		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	30632053	75632053	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31224026	75632053	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31297439	76297439	Rat
1576319	Cia29	Collagen induced arthritis QTL 29			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	33973921	78973921	Rat
61332	Eau3	Experimental allergic uveoretinitis QTL 3		0.004	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	34490559	45579777	Rat
1354614	Hpcl1	Hepatic cholesterol level QTL 1	3.3		liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	35392267	51793994	Rat
1358897	Stresp6	Stress response QTL 6	4.17	0.022	blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	35392267	64155584	Rat
61441	Btemp1	Thermal response to stress QTL 1	4		body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	10	35392457	63642539	Rat

Markers in Region

BF392792

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	36,430,435 - 36,430,608 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	37,623,024 - 37,623,196	NCBI	Rnor6.0
Rnor_5.0	10	37,396,496 - 37,396,668	UniSTS	Rnor5.0
RGSC_v3.4	10	37,693,864 - 37,694,036	UniSTS	RGSC3.4
Celera	10	35,785,024 - 35,785,196	UniSTS
RH 3.4 Map	10	389.8	UniSTS
Cytogenetic Map	10	q22	UniSTS

PMC126018P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	36,427,772 - 36,428,998 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	37,620,363 - 37,621,586	NCBI	Rnor6.0
Rnor_5.0	10	37,393,836 - 37,395,058	UniSTS	Rnor5.0
RGSC_v3.4	10	37,691,203 - 37,692,426	UniSTS	RGSC3.4
Celera	10	35,782,363 - 35,783,586	UniSTS
Cytogenetic Map	10	q22	UniSTS

UniSTS:498411

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	36,424,434 - 36,425,095 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	37,617,025 - 37,617,685	NCBI	Rnor6.0
Rnor_5.0	10	37,390,498 - 37,391,158	UniSTS	Rnor5.0
RGSC_v3.4	10	37,687,865 - 37,688,525	UniSTS	RGSC3.4
Celera	10	35,779,025 - 35,779,685	UniSTS
Cytogenetic Map	10	q22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	2	12	4	18	4			6	18	27	8
Low	1	41	45	37	1	37	8	11	68	17	14	3	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001427430	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006220666	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006220667	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006220668	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006220669	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597630	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017604056	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017604057	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC130253	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EF519318	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ233211	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000008022 ⟹ ENSRNOP00000008022

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	36,424,888 - 36,453,535 (-)	Ensembl
Rnor_6.0 Ensembl	10	37,617,279 - 37,645,802 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000097186 ⟹ ENSRNOP00000097383

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	36,423,445 - 36,453,535 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000108192 ⟹ ENSRNOP00000088372

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	36,423,445 - 36,453,535 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000116080 ⟹ ENSRNOP00000079588

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	36,425,970 - 36,453,535 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000118654 ⟹ ENSRNOP00000078370

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	36,423,764 - 36,453,535 (-)	Ensembl

RefSeq Acc Id:

NM_001427430 ⟹ NP_001414359

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	36,924,363 - 36,954,279 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001414359	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ABP57803	(Get FASTA)	NCBI Sequence Viewer
	EDM04359	(Get FASTA)	NCBI Sequence Viewer
	EDM04360	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000008022.5
	ENSRNOP00000078370.1
	ENSRNOP00000079588.1
	ENSRNOP00000088372.1
	ENSRNOP00000097383.1

RefSeq Acc Id:

ENSRNOP00000008022 ⟸ ENSRNOT00000008022

RefSeq Acc Id:

ENSRNOP00000088372 ⟸ ENSRNOT00000108192

RefSeq Acc Id:

ENSRNOP00000078370 ⟸ ENSRNOT00000118654

RefSeq Acc Id:

ENSRNOP00000097383 ⟸ ENSRNOT00000097186

RefSeq Acc Id:

ENSRNOP00000079588 ⟸ ENSRNOT00000116080

RefSeq Acc Id:	NP_001414359 ⟸ NM_001427430
- UniProtKB:	A0A8I6ASU6 (UniProtKB/TrEMBL)

Protein Domains

HMG box

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZLD0-F1-model_v2	AlphaFold	D3ZLD0	1-449	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305894	AgrOrtholog
BioCyc Gene	G2FUF-25172	BioCyc
Ensembl Genes	ENSRNOG00000005872	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000008022.8	UniProtKB/TrEMBL
	ENSRNOT00000097186.1	UniProtKB/TrEMBL
	ENSRNOT00000108192.1	UniProtKB/TrEMBL
	ENSRNOT00000116080.1	UniProtKB/TrEMBL
	ENSRNOT00000118654.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.30.10	UniProtKB/TrEMBL
	4.10.900.10	UniProtKB/TrEMBL
InterPro	Catenin_binding_dom	UniProtKB/TrEMBL
	CTNNB1-bd_N	UniProtKB/TrEMBL
	HMG_box_dom_sf	UniProtKB/TrEMBL
	HMG_superfamily	UniProtKB/TrEMBL
	TCF/LEF	UniProtKB/TrEMBL
KEGG Report	rno:363595	UniProtKB/TrEMBL
NCBI Gene	363595	ENTREZGENE
PANTHER	PTHR10373	UniProtKB/TrEMBL
	PTHR10373:SF33	UniProtKB/TrEMBL
Pfam	CTNNB1_binding	UniProtKB/TrEMBL
	HMG_box	UniProtKB/TrEMBL
PhenoGen	Tcf7	PhenoGen
PROSITE	HMG_BOX_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000005872	RatGTEx
SMART	c-clamp	UniProtKB/TrEMBL
	HMG	UniProtKB/TrEMBL
Superfamily-SCOP	HMG-box	UniProtKB/TrEMBL
UniProt	A0A8I5ZLY3_RAT	UniProtKB/TrEMBL
	A0A8I5ZNE8_RAT	UniProtKB/TrEMBL
	A0A8I6A7R1_RAT	UniProtKB/TrEMBL
	A0A8I6ASU6	ENTREZGENE, UniProtKB/TrEMBL
	A6HEA4_RAT	UniProtKB/TrEMBL
	A6HEA5_RAT	UniProtKB/TrEMBL
	D3ZLD0_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-05-18	Tcf7	transcription factor 7	Tcf7	transcription factor 7 (T-cell specific, HMG-box)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-02-02	Tcf7	transcription factor 7 (T-cell specific, HMG-box)	Tcf7	transcription factor 7, T-cell specific	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Tcf7	transcription factor 7, T-cell specific	Tcf7_predicted	transcription factor 7, T-cell specific (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Tcf7_predicted	transcription factor 7, T-cell specific (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)