Fgf22 (fibroblast growth factor 22) - Rat Genome Database

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Gene: Fgf22 (fibroblast growth factor 22) Rattus norvegicus
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Symbol: Fgf22
Name: fibroblast growth factor 22
RGD ID: 620177
Description: Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Predicted to be involved in several processes, including fibroblast growth factor receptor signaling pathway; positive regulation of cell population proliferation; and positive regulation of macromolecule metabolic process. Predicted to be located in Golgi apparatus; cell surface; and nucleolus. Predicted to be active in cytoplasm. Orthologous to human FGF22 (fibroblast growth factor 22); PARTICIPATES IN melanoma pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fgf5d; fibroblast growth factor 5d
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.279,947,632 - 9,956,918 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,948,071 - 9,950,486 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,829,436 - 12,831,324 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0714,707,517 - 14,709,405 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0712,566,846 - 12,568,736 (-)NCBIRnor_WKY
Rnor_6.0712,829,785 - 12,831,675 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,829,785 - 12,831,675 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,999,989 - 13,001,879 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,463,299 - 11,465,189 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,463,298 - 11,465,189 (-)NCBI
Celera78,121,945 - 8,123,835 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain. Umemori H, etal., Cell 2004 Jul 23;118(2):257-70.
Additional References at PubMed
PMID:12837279   PMID:27627962   PMID:28948716  


Genomics

Comparative Map Data
Fgf22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.279,947,632 - 9,956,918 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,948,071 - 9,950,486 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,829,436 - 12,831,324 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0714,707,517 - 14,709,405 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0712,566,846 - 12,568,736 (-)NCBIRnor_WKY
Rnor_6.0712,829,785 - 12,831,675 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,829,785 - 12,831,675 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,999,989 - 13,001,879 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,463,299 - 11,465,189 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,463,298 - 11,465,189 (-)NCBI
Celera78,121,945 - 8,123,835 (-)NCBICelera
Cytogenetic Map7q11NCBI
FGF22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819639,879 - 644,373 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl19639,879 - 644,373 (+)EnsemblGRCh38hg38GRCh38
GRCh3719639,879 - 644,373 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619590,926 - 594,604 (+)NCBINCBI36Build 36hg18NCBI36
Build 3419590,925 - 594,604NCBI
Celera19173,993 - 177,696 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19409,797 - 413,441 (+)NCBIHuRef
CHM1_119639,587 - 643,265 (+)NCBICHM1_1
T2T-CHM13v2.019594,185 - 598,645 (+)NCBIT2T-CHM13v2.0
Fgf22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,590,887 - 79,593,629 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,590,910 - 79,594,430 (+)EnsemblGRCm39 Ensembl
GRCm381079,755,051 - 79,757,795 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,755,076 - 79,758,596 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,217,864 - 79,219,706 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,158,248 - 79,160,090 (+)NCBIMGSCv36mm8
Celera1080,769,712 - 80,771,554 (+)NCBICelera
Cytogenetic Map10C1NCBI
Fgf22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554957,100,309 - 7,102,694 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554957,099,616 - 7,102,749 (-)NCBIChiLan1.0ChiLan1.0
FGF22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.119606,123 - 611,491 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl19606,120 - 611,501 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v019494,172 - 499,003 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FGF22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,899,300 - 57,903,064 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,900,416 - 57,903,061 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,702,234 - 57,705,567 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,642,797 - 58,646,130 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,643,485 - 58,646,130 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,696,924 - 57,700,257 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,176,366 - 58,179,700 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,379,753 - 58,383,087 (-)NCBIUU_Cfam_GSD_1.0
Fgf22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,602,786 - 217,607,156 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588227,685 - 229,925 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936588227,656 - 231,816 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,683,738 - 77,687,282 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,683,252 - 77,687,276 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FGF22
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16385,718 - 393,988 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6385,811 - 388,702 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660818,597,191 - 8,601,000 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf22
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,867,535 - 7,869,937 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,866,886 - 7,870,038 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fgf22
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:57
Count of miRNA genes:52
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000011936
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3
Low 3 10 27 11 19 11 8 11 53 11 20 11 8
Below cutoff 11 12 10 17

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011936   ⟹   ENSRNOP00000011936
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,948,071 - 9,950,486 (-)Ensembl
Rnor_6.0 Ensembl712,829,785 - 12,831,675 (-)Ensembl
RefSeq Acc Id: NM_130751   ⟹   NP_570107
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.279,948,423 - 9,950,313 (-)NCBI
Rnor_6.0712,829,785 - 12,831,675 (-)NCBI
Rnor_5.0712,999,989 - 13,001,879 (-)NCBI
RGSC_v3.4711,463,299 - 11,465,189 (-)RGD
Celera78,121,945 - 8,123,835 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078323   ⟹   XP_038934251
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.279,947,632 - 9,956,918 (-)NCBI
Protein Sequences
Protein RefSeqs NP_570107 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934251 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB84300 (Get FASTA)   NCBI Sequence Viewer  
  EDL89397 (Get FASTA)   NCBI Sequence Viewer  
  EDL89398 (Get FASTA)   NCBI Sequence Viewer  
  VDK10961 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_570107   ⟸   NM_130751
- Peptide Label: precursor
- UniProtKB: Q8VI79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011936   ⟸   ENSRNOT00000011936
RefSeq Acc Id: XP_038934251   ⟸   XM_039078323
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VI79-F1-model_v2 AlphaFold Q8VI79 1-162 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620177 AgrOrtholog
BioCyc Gene G2FUF-34886 BioCyc
Ensembl Genes ENSRNOG00000008960 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000011936 ENTREZGENE
  ENSRNOP00000011936.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011936 ENTREZGENE
  ENSRNOT00000011936.3 UniProtKB/TrEMBL
InterPro Cytokine_IL1-like UniProtKB/TrEMBL
  FGF22 UniProtKB/TrEMBL
  GF_heparin_bd UniProtKB/TrEMBL
KEGG Report rno:170579 UniProtKB/TrEMBL
NCBI Gene 170579 ENTREZGENE
PANTHER IL1_HBGF UniProtKB/TrEMBL
  PTHR11486:SF41 UniProtKB/TrEMBL
Pfam FGF UniProtKB/TrEMBL
PhenoGen Fgf22 PhenoGen
PRINTS HBGFFGF UniProtKB/TrEMBL
PROSITE HBGF_FGF UniProtKB/TrEMBL
SMART FGF UniProtKB/TrEMBL
Superfamily-SCOP Cytok_IL1_like UniProtKB/TrEMBL
UniProt Q8VI79 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Fgf22  fibroblast growth factor 22      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Fgf22  fibroblast growth factor 22      Symbol and Name status set to provisional 70820 PROVISIONAL