Paics (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Paics (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase) Rattus norvegicus
Analyze
Symbol: Paics
Name: phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
RGD ID: 620066
Description: Predicted to enable identical protein binding activity; phosphoribosylaminoimidazole carboxylase activity; and phosphoribosylaminoimidazolesuccinocarboxamide synthase activity. Involved in G1/S transition of mitotic cell cycle. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ade2h1; AIR carboxylase-SAICAR synthetase; Airc; bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase; LOC100910308; MGC93240; multifunctional protein ADE2; multifunctional protein ADE2-like; phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthetase; phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase; phosphoribosylaminoimidazolesuccinocarboxamide synthase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81431,553,355 - 31,586,843 (-)NCBIGRCr8
mRatBN7.21431,199,086 - 31,232,731 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1431,173,541 - 31,232,635 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1431,576,746 - 31,593,097 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01432,885,078 - 32,901,428 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01431,369,751 - 31,386,102 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01433,563,884 - 33,580,944 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,563,886 - 33,580,566 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01433,354,797 - 33,371,784 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41433,492,707 - 33,509,389 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11433,492,708 - 33,509,389 (-)NCBI
Celera1430,512,320 - 30,529,517 (-)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hexadecanoic acid  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
menadione  (ISO)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
nitroglycerin  (EXP)
Nutlin-3  (ISO)
omeprazole  (EXP)
oxaliplatin  (EXP,ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
quinoline  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Nucleotide sequence of a nearly full-length cDNA coding for pepsinogen of rat gastric mucosa. Ichihara Y, etal., Eur J Biochem 1986 Nov 17;161(1):7-12.
3. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. Ikeda M, etal., Biol Psychiatry. 2010 Feb 1;67(3):263-9. Epub 2009 Oct 22.
4. Rat genomic structure of amidophosphoribosyltransferase, cDNA sequence of aminoimidazole ribonucleotide carboxylase, and cell cycle-dependent expression of these two physically linked genes. Iwahana H, etal., Biochim Biophys Acta 1995 Apr 26;1261(3):369-80.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:16169070   PMID:16189514   PMID:19946888   PMID:20458337   PMID:21988832   PMID:23376485   PMID:23533145   PMID:25416956   PMID:25468996  


Genomics

Comparative Map Data
Paics
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81431,553,355 - 31,586,843 (-)NCBIGRCr8
mRatBN7.21431,199,086 - 31,232,731 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1431,173,541 - 31,232,635 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1431,576,746 - 31,593,097 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01432,885,078 - 32,901,428 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01431,369,751 - 31,386,102 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01433,563,884 - 33,580,944 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,563,886 - 33,580,566 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01433,354,797 - 33,371,784 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41433,492,707 - 33,509,389 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11433,492,708 - 33,509,389 (-)NCBI
Celera1430,512,320 - 30,529,517 (-)NCBICelera
Cytogenetic Map14p11NCBI
PAICS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38456,410,507 - 56,464,578 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl456,435,741 - 56,464,578 (+)EnsemblGRCh38hg38GRCh38
GRCh37457,276,673 - 57,330,744 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36456,996,672 - 57,022,291 (+)NCBINCBI36Build 36hg18NCBI36
Build 34457,142,868 - 57,168,453NCBI
Celera454,808,286 - 54,833,908 (+)NCBICelera
Cytogenetic Map4q12NCBI
HuRef453,256,050 - 53,281,675 (+)NCBIHuRef
CHM1_1457,337,028 - 57,362,670 (+)NCBICHM1_1
T2T-CHM13v2.0459,898,501 - 59,952,584 (+)NCBIT2T-CHM13v2.0
Paics
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39577,099,149 - 77,115,356 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl577,099,154 - 77,115,356 (+)EnsemblGRCm39 Ensembl
GRCm38576,951,302 - 76,967,509 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl576,951,307 - 76,967,509 (+)EnsemblGRCm38mm10GRCm38
MGSCv37577,380,436 - 77,396,530 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36578,026,186 - 78,042,280 (+)NCBIMGSCv36mm8
Celera574,219,278 - 74,235,370 (+)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map541.45NCBI
Paics
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544714,558,468 - 14,574,052 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544714,558,468 - 14,571,081 (-)NCBIChiLan1.0ChiLan1.0
LOC100993147
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2373,318,512 - 73,374,750 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1473,524,030 - 73,578,412 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0467,461,799 - 67,491,300 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1474,031,397 - 74,059,868 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl474,031,397 - 74,059,857 (-)Ensemblpanpan1.1panPan2
PAICS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11348,296,232 - 48,682,650 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1348,502,631 - 48,572,598 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01349,226,506 - 49,296,327 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1349,226,501 - 49,298,373 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11348,898,441 - 48,968,392 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01348,427,408 - 48,497,095 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01349,373,530 - 49,443,304 (+)NCBIUU_Cfam_GSD_1.0
LOC101961407
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528527,633,677 - 27,672,235 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648218,626,015 - 18,667,164 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648218,649,093 - 18,664,629 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAICS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl855,700,956 - 55,722,979 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1855,700,700 - 55,722,982 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2857,827,127 - 57,849,464 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Paics
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476112,954,309 - 12,980,381 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476112,954,309 - 12,980,352 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Paics
213 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:57
Count of miRNA genes:53
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000063942
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143076702539153750Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142216796767167967Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat

Markers in Region
RH127888  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21431,199,203 - 31,199,390 (+)MAPPERmRatBN7.2
Rnor_6.01433,564,002 - 33,564,188NCBIRnor6.0
Rnor_6.01433,968,284 - 33,968,470NCBIRnor6.0
Rnor_5.01433,354,915 - 33,355,101UniSTSRnor5.0
Rnor_5.01433,752,801 - 33,752,987UniSTSRnor5.0
RGSC_v3.41433,492,825 - 33,493,011UniSTSRGSC3.4
Celera1430,512,438 - 30,512,624UniSTS
Cytogenetic Map14p11UniSTS
RH129425  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21431,199,203 - 31,199,360 (+)MAPPERmRatBN7.2
Rnor_6.01433,564,002 - 33,564,158NCBIRnor6.0
Rnor_6.01433,968,284 - 33,968,440NCBIRnor6.0
Rnor_5.01433,752,801 - 33,752,957UniSTSRnor5.0
Rnor_5.01433,354,915 - 33,355,071UniSTSRnor5.0
RGSC_v3.41433,492,825 - 33,492,981UniSTSRGSC3.4
Celera1430,512,438 - 30,512,594UniSTS
RH 3.4 Map14427.39UniSTS
Cytogenetic Map14p11UniSTS
RH143742  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01433,360,622 - 33,360,963NCBIRnor5.0
Rnor_5.01433,758,508 - 33,758,849NCBIRnor5.0
Rnor_5.0X5,076,828 - 5,076,944NCBIRnor5.0
RGSC_v3.4X15,625,492 - 15,625,607UniSTSRGSC3.4
RGSC_v3.41433,498,533 - 33,498,873UniSTSRGSC3.4
CeleraX4,574,774 - 4,574,889UniSTS
Celera1430,517,945 - 30,518,285UniSTS
RH 3.4 Map14423.4UniSTS
Cytogenetic Map14p11UniSTS
RH140904  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21431,199,115 - 31,199,335 (+)MAPPERmRatBN7.2
Rnor_6.01433,968,196 - 33,968,415NCBIRnor6.0
Rnor_6.01433,563,914 - 33,564,133NCBIRnor6.0
Rnor_5.01433,752,713 - 33,752,932UniSTSRnor5.0
Rnor_5.01433,354,827 - 33,355,046UniSTSRnor5.0
RGSC_v3.41433,492,737 - 33,492,956UniSTSRGSC3.4
Celera1430,512,350 - 30,512,569UniSTS
RH 3.4 Map14428.59UniSTS
Cytogenetic Map14p11UniSTS
PMC312758P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21431,216,183 - 31,216,360 (+)MAPPERmRatBN7.2
Rnor_6.01433,580,984 - 33,581,160NCBIRnor6.0
Rnor_5.01433,371,897 - 33,372,073UniSTSRnor5.0
RGSC_v3.41433,509,807 - 33,509,983UniSTSRGSC3.4
Celera1430,529,935 - 30,530,111UniSTS
Cytogenetic Map14p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000002890   ⟹   ENSRNOP00000002890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1431,173,541 - 31,232,635 (-)Ensembl
Rnor_6.0 Ensembl1433,968,759 - 33,977,277 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000063942   ⟹   ENSRNOP00000061495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1431,199,086 - 31,216,112 (-)Ensembl
Rnor_6.0 Ensembl1433,563,886 - 33,580,566 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096789   ⟹   ENSRNOP00000089961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1431,173,541 - 31,232,635 (-)Ensembl
RefSeq Acc Id: NM_080910   ⟹   NP_543186
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81431,553,355 - 31,570,035 (-)NCBI
mRatBN7.21431,199,086 - 31,215,766 (-)NCBI
Rnor_6.01433,563,884 - 33,580,566 (-)NCBI
Rnor_5.01433,354,797 - 33,371,784 (-)NCBI
RGSC_v3.41433,492,707 - 33,509,389 (-)RGD
Celera1430,512,320 - 30,529,517 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250852   ⟹   XP_006250914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81431,553,447 - 31,570,386 (-)NCBI
mRatBN7.21431,199,178 - 31,216,117 (-)NCBI
Rnor_6.01433,564,416 - 33,580,893 (-)NCBI
Rnor_5.01433,354,797 - 33,371,784 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250853   ⟹   XP_006250915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81431,553,447 - 31,570,469 (-)NCBI
mRatBN7.21431,199,178 - 31,216,196 (-)NCBI
Rnor_6.01433,563,976 - 33,580,944 (-)NCBI
Rnor_5.01433,354,797 - 33,371,784 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250854   ⟹   XP_006250916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81431,553,447 - 31,570,387 (-)NCBI
mRatBN7.21431,199,178 - 31,216,118 (-)NCBI
Rnor_6.01433,563,976 - 33,580,890 (-)NCBI
Rnor_5.01433,354,797 - 33,371,784 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063272816   ⟹   XP_063128886
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81431,553,447 - 31,586,843 (-)NCBI
RefSeq Acc Id: NP_543186   ⟸   NM_080910
- UniProtKB: P51583 (UniProtKB/Swiss-Prot),   A6JCW8 (UniProtKB/TrEMBL),   A6JCW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250915   ⟸   XM_006250853
- Peptide Label: isoform X2
- UniProtKB: P51583 (UniProtKB/Swiss-Prot),   A6JCW8 (UniProtKB/TrEMBL),   A6JCW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250914   ⟸   XM_006250852
- Peptide Label: isoform X2
- UniProtKB: P51583 (UniProtKB/Swiss-Prot),   A6JCW8 (UniProtKB/TrEMBL),   A6JCW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250916   ⟸   XM_006250854
- Peptide Label: isoform X2
- UniProtKB: P51583 (UniProtKB/Swiss-Prot),   A6JCW8 (UniProtKB/TrEMBL),   A6JCW6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061495   ⟸   ENSRNOT00000063942
Ensembl Acc Id: ENSRNOP00000002890   ⟸   ENSRNOT00000002890
Ensembl Acc Id: ENSRNOP00000089961   ⟸   ENSRNOT00000096789
RefSeq Acc Id: XP_063128886   ⟸   XM_063272816
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A960 (UniProtKB/TrEMBL)
Protein Domains
PurE

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F8WFR8-F1-model_v2 AlphaFold F8WFR8 1-360 view protein structure
AF-P51583-F1-model_v2 AlphaFold P51583 1-425 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699270
Promoter ID:EPDNEW_R9795
Type:initiation region
Name:Paics_1
Description:phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamidesynthase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9797  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01433,580,399 - 33,580,459EPDNEW
RGD ID:13699272
Promoter ID:EPDNEW_R9797
Type:initiation region
Name:Paics_2
Description:phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamidesynthase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9795  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01433,580,598 - 33,580,658EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620066 AgrOrtholog
BioCyc Gene G2FUF-15964 BioCyc
Ensembl Genes ENSRNOG00000002101 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00000046308 Ensembl
  ENSRNOG00055005100 UniProtKB/Swiss-Prot
  ENSRNOG00060017880 UniProtKB/Swiss-Prot
  ENSRNOG00065020233 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002890.7 UniProtKB/TrEMBL
  ENSRNOT00000063942.2 UniProtKB/Swiss-Prot
  ENSRNOT00000096789.1 UniProtKB/TrEMBL
  ENSRNOT00055008192 UniProtKB/Swiss-Prot
  ENSRNOT00060030753 UniProtKB/Swiss-Prot
  ENSRNOT00065034195 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1970 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-grasp fold, B domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7103198 IMAGE-MGC_LOAD
  IMAGE:7192781 IMAGE-MGC_LOAD
InterPro Myb_DNA-bind_4 UniProtKB/TrEMBL
  PurE_classII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PurE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAICAR_synt/ADE2_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAICAR_synthetase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAICAR_synthetase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140946 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91523 IMAGE-MGC_LOAD
  MGC:93240 IMAGE-MGC_LOAD
NCBI Gene 140946 ENTREZGENE
PANTHER MULTIFUNCTIONAL PROTEIN ADE2 UniProtKB/Swiss-Prot
  MULTIFUNCTIONAL PROTEIN ADE2 UniProtKB/Swiss-Prot
  MULTIFUNCTIONAL PROTEIN ADE2 UniProtKB/TrEMBL
  MULTIFUNCTIONAL PROTEIN ADE2 UniProtKB/TrEMBL
Pfam AIRC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myb_DNA-bind_4 UniProtKB/TrEMBL
  SAICAR_synt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Paics PhenoGen
PROSITE SAICAR_SYNTHETASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAICAR_SYNTHETASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002101 RatGTEx
  ENSRNOG00000046308 RatGTEx
  ENSRNOG00055005100 RatGTEx
  ENSRNOG00060017880 RatGTEx
  ENSRNOG00065020233 RatGTEx
SMART AIRC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAICAR synthase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A960 ENTREZGENE, UniProtKB/TrEMBL
  A6JCW6 ENTREZGENE, UniProtKB/TrEMBL
  A6JCW8 ENTREZGENE, UniProtKB/TrEMBL
  F8WFR8_RAT UniProtKB/TrEMBL
  P51583 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Paics  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase  LOC100910308  multifunctional protein ADE2-like  Data merged from RGD:6499293 737654 PROVISIONAL
2017-01-03 Paics  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase  Paics  phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-30 Paics  phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase  Paics  phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910308  multifunctional protein ADE2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-30 Paics  phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase  Paics  phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthetase  Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression induced in G1/S phase of the cell cycle 633691