LOC101961407 (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: LOC101961407 (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase) Ictidomys tridecemlineatus
Analyze
Symbol: LOC101961407 (Ensembl: PAICS)
Name: phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
RGD ID: 12617413
Description: ENCODES a protein that exhibits ATP binding (inferred); carboxy-lyase activity (inferred); identical protein binding (inferred); INVOLVED IN G1/S transition of mitotic cell cycle (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH congenital disorder of glycosylation type IIk (ortholog); gastrointestinal stromal tumor (ortholog); PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE DEFICIENCY (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC110597649; multifunctional protein ADE2; Paics; phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase; uncharacterized LOC110597649; uncharacterized protein LOC110597649
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528527,633,677 - 27,672,235 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648218,626,015 - 18,667,164 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648218,649,093 - 18,664,629 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
LOC101961407
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528527,633,677 - 27,672,235 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648218,626,015 - 18,667,164 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648218,649,093 - 18,664,629 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAICS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38456,410,507 - 56,464,578 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl456,435,741 - 56,464,578 (+)EnsemblGRCh38hg38GRCh38
GRCh37457,276,673 - 57,330,744 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36456,996,672 - 57,022,291 (+)NCBINCBI36Build 36hg18NCBI36
Build 34457,142,868 - 57,168,453NCBI
Celera454,808,286 - 54,833,908 (+)NCBICelera
Cytogenetic Map4q12NCBI
HuRef453,256,050 - 53,281,675 (+)NCBIHuRef
CHM1_1457,337,028 - 57,362,670 (+)NCBICHM1_1
T2T-CHM13v2.0459,898,501 - 59,952,584 (+)NCBIT2T-CHM13v2.0
Paics
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39577,099,149 - 77,115,356 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl577,099,154 - 77,115,356 (+)EnsemblGRCm39 Ensembl
GRCm38576,951,302 - 76,967,509 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl576,951,307 - 76,967,509 (+)EnsemblGRCm38mm10GRCm38
MGSCv37577,380,436 - 77,396,530 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36578,026,186 - 78,042,280 (+)NCBIMGSCv36mm8
Celera574,219,278 - 74,235,370 (+)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map541.45NCBI
Paics
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81431,553,355 - 31,586,843 (-)NCBIGRCr8
mRatBN7.21431,199,086 - 31,232,731 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1431,173,541 - 31,232,635 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1431,576,746 - 31,593,097 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01432,885,078 - 32,901,428 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01431,369,751 - 31,386,102 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01433,563,884 - 33,580,944 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,563,886 - 33,580,566 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01433,354,797 - 33,371,784 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41433,492,707 - 33,509,389 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11433,492,708 - 33,509,389 (-)NCBI
Celera1430,512,320 - 30,529,517 (-)NCBICelera
Cytogenetic Map14p11NCBI
Paics
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544714,558,468 - 14,574,052 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544714,558,468 - 14,571,081 (-)NCBIChiLan1.0ChiLan1.0
LOC100993147
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2373,318,512 - 73,374,750 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1473,524,030 - 73,578,412 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0467,461,799 - 67,491,300 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1474,031,397 - 74,059,868 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl474,031,397 - 74,059,857 (-)Ensemblpanpan1.1panPan2
PAICS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11348,296,232 - 48,682,650 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1348,502,631 - 48,572,598 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01349,226,506 - 49,296,327 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1349,226,501 - 49,298,373 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11348,898,441 - 48,968,392 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01348,427,408 - 48,497,095 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01349,373,530 - 49,443,304 (+)NCBIUU_Cfam_GSD_1.0
PAICS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl855,700,956 - 55,722,979 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1855,700,700 - 55,722,982 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2857,827,127 - 57,849,464 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Paics
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476112,954,309 - 12,980,381 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476112,954,309 - 12,980,352 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000007290   ⟹   ENSSTOP00000006514
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648218,653,757 - 18,664,262 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000039230   ⟹   ENSSTOP00000024077
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648218,626,015 - 18,667,164 (+)Ensembl
RefSeq Acc Id: XM_005320027   ⟹   XP_005320084
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440528527,633,677 - 27,649,201 (-)NCBI
SpeTri2.0NW_00493648218,649,093 - 18,664,379 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040292378   ⟹   XP_040148312
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440528527,633,677 - 27,672,235 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005320084 (Get FASTA)   NCBI Sequence Viewer  
  XP_040148312 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000006514.3
  ENSSTOP00000024077.1
GenBank Protein KAG3276581 (Get FASTA)   NCBI Sequence Viewer  
  KAG3276582 (Get FASTA)   NCBI Sequence Viewer  
  KAG3276584 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005320084   ⟸   XM_005320027
- Peptide Label: isoform X2
- UniProtKB: A0A287CS26 (UniProtKB/TrEMBL),   I3M9F7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040148312   ⟸   XM_040292378
- Peptide Label: isoform X1
Ensembl Acc Id: ENSSTOP00000006514   ⟸   ENSSTOT00000007290
Ensembl Acc Id: ENSSTOP00000024077   ⟸   ENSSTOT00000039230
Protein Domains
PurE


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000007284 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000007290.3 UniProtKB/TrEMBL
  ENSSTOT00000039230.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1970 UniProtKB/TrEMBL
  ATP-grasp fold, B domain UniProtKB/TrEMBL
InterPro PurE_classII UniProtKB/TrEMBL
  PurE_dom UniProtKB/TrEMBL
  SAICAR_synt/ADE2_N UniProtKB/TrEMBL
  SAICAR_synthetase UniProtKB/TrEMBL
  SAICAR_synthetase_CS UniProtKB/TrEMBL
NCBI Gene Paics ENTREZGENE
PANTHER MULTIFUNCTIONAL PROTEIN ADE2 UniProtKB/TrEMBL
  MULTIFUNCTIONAL PROTEIN ADE2 UniProtKB/TrEMBL
Pfam AIRC UniProtKB/TrEMBL
  SAICAR_synt UniProtKB/TrEMBL
PROSITE SAICAR_SYNTHETASE_1 UniProtKB/TrEMBL
  SAICAR_SYNTHETASE_2 UniProtKB/TrEMBL
SMART AIRC UniProtKB/TrEMBL
Superfamily-SCOP N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) UniProtKB/TrEMBL
  SAICAR synthase-like UniProtKB/TrEMBL
UniProt A0A287CS26 ENTREZGENE, UniProtKB/TrEMBL
  I3M9F7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 LOC101961407  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase  Paics  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase  Symbol and/or name change 5135510 APPROVED
2021-03-25 Paics  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase  LOC110597649  uncharacterized LOC110597649  Data merged from RGD:12938817 737654 PROVISIONAL