(R)-adrenaline multiple interactions EXP 6480464 [Corticosterone results in decreased activity of SLC22A3 protein] inhibits the reaction [Epinephrine results in increased abundance of Epinephrine metabolite], [Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased abundance of Epinephrine CTD PMID:19053318 (R)-adrenaline increases uptake ISO RGD:1351828 6480464 SLC22A3 protein results in increased uptake of Epinephrine CTD PMID:20858707 (R)-noradrenaline increases uptake ISO RGD:1351828 6480464 SLC22A3 protein results in increased uptake of Norepinephrine CTD PMID:20858707 (R)-noradrenaline multiple interactions EXP 6480464 Norepinephrine affects the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium] CTD PMID:9830022 1,1'-diethyl-2,2'-cyanine multiple interactions ISO RGD:1351828 6480464 pseudoisocyanine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12110607 , PMID:20858707 1,1'-diethyl-2,2'-cyanine increases uptake ISO RGD:1351828 6480464 SLC22A3 protein results in increased uptake of pseudoisocyanine CTD PMID:28597291 1,1'-diethyl-2,2'-cyanine multiple interactions EXP 6480464 pseudoisocyanine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium], pseudoisocyanine inhibits the reaction [SLC22A3 protein results in increased transport of Histamine] CTD PMID:16928864 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO RGD:735816 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:10966924 1-methylnicotinamide multiple interactions ISO RGD:735816 6480464 N(1)-methylnicotinamide inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium] CTD PMID:10966924 11-deoxycorticosterone multiple interactions EXP 6480464 Desoxycorticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium] CTD PMID:9830022 17beta-estradiol decreases expression ISO RGD:1351828 6480464 Estradiol results in decreased expression of SLC22A3 mRNA CTD PMID:20106945 17beta-estradiol multiple interactions EXP 6480464 Estradiol inhibits the reaction [SLC22A3 protein results in increased transport of Histamine], Estradiol inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium] CTD PMID:16928864 , PMID:9830022 17beta-estradiol decreases activity ISO RGD:1351828 6480464 Estradiol results in decreased activity of SLC22A3 protein CTD PMID:12110607 17beta-estradiol multiple interactions ISO RGD:1351828 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of SLC22A3 mRNA, Estradiol inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12110607 , PMID:30165855 17beta-estradiol decreases activity EXP 6480464 Estradiol results in decreased activity of SLC22A3 protein CTD PMID:12181285 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1351828 6480464 Tetrachlorodibenzodioxin affects the expression of SLC22A3 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:735816 6480464 Tetrachlorodibenzodioxin affects the expression of SLC22A3 mRNA CTD PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SLC22A3 mRNA CTD PMID:21215274 , PMID:26232522 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1351828 6480464 Tetrachlorodibenzodioxin results in decreased expression of SLC22A3 mRNA CTD PMID:20106945 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1351828 6480464 Endosulfan inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC22A3 mRNA] CTD PMID:26159488 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile multiple interactions ISO RGD:1351828 6480464 Verapamil inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium], Verapamil inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin] CTD PMID:21641380 , PMID:21697722 3,3',5,5'-tetrabromobisphenol A increases expression EXP 6480464 tetrabromobisphenol A results in increased expression of SLC22A3 mRNA CTD PMID:28300664 3,7-dihydropurine-6-thione decreases expression EXP 6480464 Mercaptopurine results in decreased expression of SLC22A3 mRNA CTD PMID:23358152 3-[2-(ethylamino)-1-hydroxyethyl]phenol multiple interactions ISO RGD:1351828 6480464 Etilefrine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 3-[2-(ethylamino)-1-hydroxyethyl]phenol increases uptake ISO RGD:1351828 6480464 SLC22A3 protein results in increased uptake of Etilefrine CTD PMID:16263091 3-Amino-1-methyl-5H-pyrido[4,3-b]indole decreases activity ISO RGD:1351828 6480464 3-amino-1-methyl-5H-pyrido(4, 3-b)indole results in decreased activity of SLC22A3 protein CTD PMID:30189235 3-Amino-1-methyl-5H-pyrido[4,3-b]indole multiple interactions ISO RGD:1351828 6480464 3-amino-1-methyl-5H-pyrido(4, 3-b)indole inhibits the reaction [SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide] CTD PMID:30189235 5-aza-2'-deoxycytidine affects expression ISO RGD:1351828 6480464 Decitabine affects the expression of SLC22A3 mRNA CTD PMID:23300844 aflatoxin B1 affects expression ISO RGD:1351828 6480464 Aflatoxin B1 affects the expression of SLC22A3 protein CTD PMID:20106945 aflatoxin B1 decreases expression ISO RGD:1351828 6480464 Aflatoxin B1 results in decreased expression of SLC22A3 mRNA CTD PMID:21632981 more ... all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of SLC22A3 mRNA CTD PMID:20488242 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of SLC22A3 mRNA CTD PMID:16483693 amphetamine multiple interactions EXP 6480464 Amphetamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:9830022 atorvastatin calcium multiple interactions ISO RGD:1351828 6480464 Atorvastatin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 atropine increases uptake ISO RGD:1351828 6480464 SLC22A3 protein results in increased uptake of Atropine CTD PMID:16263091 atropine multiple interactions ISO RGD:1351828 6480464 Atropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 barium(0) multiple interactions ISO RGD:735816 6480464 Barium inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium] CTD PMID:10966924 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of SLC22A3 mRNA CTD PMID:21839799 benzo[a]pyrene decreases expression ISO RGD:1351828 6480464 Benzo(a)pyrene results in decreased expression of SLC22A3 mRNA CTD PMID:16269432 more ... benzo[a]pyrene multiple interactions ISO RGD:1351828 6480464 [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SLC22A3 mRNA CTD PMID:17690111 benzo[b]fluoranthene multiple interactions ISO RGD:1351828 6480464 [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SLC22A3 mRNA CTD PMID:17690111 beta-carboline decreases activity ISO RGD:1351828 6480464 norharman results in decreased activity of SLC22A3 protein CTD PMID:30189235 beta-carboline multiple interactions ISO RGD:1351828 6480464 norharman inhibits the reaction [SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide] CTD PMID:30189235 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SLC22A3 mRNA CTD PMID:18180321 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Genistein] results in increased methylation of SLC22A3 gene CTD PMID:28505145 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of SLC22A3 gene CTD PMID:28505145 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SLC22A3 mRNA CTD PMID:25181051 bisphenol A decreases expression ISO RGD:735816 6480464 bisphenol A results in decreased expression of SLC22A3 mRNA CTD PMID:26063408 budesonide multiple interactions ISO RGD:1351828 6480464 Budesonide inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate], SLC22A3 protein results in increased susceptibility to [Budesonide results in decreased transport of Formoterol Fumarate] CTD PMID:17920670 , PMID:21914487 buta-1,3-diene decreases expression ISO RGD:735816 6480464 1, 3-butadiene results in decreased expression of SLC22A3 mRNA CTD PMID:29038090 butanal decreases expression ISO RGD:1351828 6480464 butyraldehyde results in decreased expression of SLC22A3 mRNA CTD PMID:26079696 carvedilol multiple interactions ISO RGD:1351828 6480464 carvedilol inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium], carvedilol inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin] CTD PMID:21641380 , PMID:21697722 chloroprene decreases expression ISO RGD:735816 6480464 Chloroprene results in decreased expression of SLC22A3 mRNA CTD PMID:23125180 cimetidine multiple interactions ISO RGD:1351828 6480464 Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] more ... CTD PMID:19357179 , PMID:21697722 cimetidine multiple interactions ISO RGD:735816 6480464 Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium] CTD PMID:10966924 cimetidine increases transport ISO RGD:1351828 6480464 SLC22A3 protein results in increased transport of Cimetidine CTD PMID:18253050 cisplatin decreases expression ISO RGD:1351828 6480464 Cisplatin results in decreased expression of SLC22A3, Cisplatin results in decreased expression of SLC22A3 mRNA CTD PMID:21905038 , PMID:27392435 cisplatin multiple interactions ISO RGD:1351828 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of SLC22A3 mRNA CTD PMID:27392435 cisplatin affects expression ISO RGD:1351828 6480464 Cisplatin affects the expression of SLC22A3 mRNA CTD PMID:23300844 cisplatin increases uptake ISO RGD:1351828 6480464 SLC22A3 results in increased uptake of Cisplatin CTD PMID:21905038 cisplatin affects response to substance ISO RGD:1351828 6480464 SLC22A3 affects the susceptibility to Cisplatin CTD PMID:21905038 clobenpropit multiple interactions EXP 6480464 clobenpropit inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12411423 clobenpropit multiple interactions ISO RGD:1351828 6480464 clobenpropit inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12411423 clonidine multiple interactions ISO RGD:1351828 6480464 Clonidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium], Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog] CTD PMID:10966924 , PMID:16263091 clonidine multiple interactions ISO RGD:735816 6480464 Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium] CTD PMID:10966924 clonidine multiple interactions EXP 6480464 Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:9830022 clonidine (amino form) multiple interactions ISO RGD:1351828 6480464 Clonidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium], Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog] CTD PMID:10966924 , PMID:16263091 clonidine (amino form) multiple interactions ISO RGD:735816 6480464 Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium] CTD PMID:10966924 clonidine (amino form) multiple interactions EXP 6480464 Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:9830022 clonidine (imino form) multiple interactions ISO RGD:1351828 6480464 Clonidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium], Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog] CTD PMID:10966924 , PMID:16263091 clonidine (imino form) multiple interactions EXP 6480464 Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:9830022 clonidine (imino form) multiple interactions ISO RGD:735816 6480464 Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium] CTD PMID:10966924 cobalt dichloride decreases expression ISO RGD:1351828 6480464 cobaltous chloride results in decreased expression of SLC22A3 mRNA CTD PMID:19376846 copper(II) sulfate decreases expression ISO RGD:1351828 6480464 Copper Sulfate results in decreased expression of SLC22A3 mRNA CTD PMID:19549813 corticosterone decreases activity EXP 6480464 Corticosterone results in decreased activity of SLC22A3 protein CTD PMID:12181285 corticosterone multiple interactions EXP 6480464 [Corticosterone results in decreased activity of SLC22A3 protein] inhibits the reaction [Epinephrine results in increased abundance of Epinephrine metabolite] more ... CTD PMID:16928864 more ... corticosterone multiple interactions ISO RGD:1351828 6480464 Corticosterone inhibits the reaction [SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide] more ... CTD PMID:12110607 more ... corticosterone decreases activity ISO RGD:1351828 6480464 Corticosterone results in decreased activity of SLC22A3 protein CTD PMID:12110607 cyclosporin A decreases expression ISO RGD:1351828 6480464 Cyclosporine results in decreased expression of SLC22A3 mRNA CTD PMID:20106945 , PMID:25562108 cyclosporin A increases expression ISO RGD:1351828 6480464 Cyclosporine results in increased expression of SLC22A3 mRNA CTD PMID:27989131 decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of SLC22A3 mRNA CTD PMID:23640034 desipramine multiple interactions ISO RGD:1351828 6480464 Desipramine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog] CTD PMID:10966924 desipramine multiple interactions EXP 6480464 Desipramine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:9830022 dextran sulfate multiple interactions ISO RGD:735816 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of SLC22A3 mRNA CTD PMID:29950665 digoxin multiple interactions ISO RGD:1351828 6480464 Digoxin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 dioxygen multiple interactions ISO RGD:735816 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of SLC22A3 mRNA CTD PMID:30529165 diphenhydramine multiple interactions ISO RGD:1351828 6480464 Diphenhydramine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 dopamine increases uptake ISO RGD:1351828 6480464 SLC22A3 protein results in increased uptake of Dopamine CTD PMID:20858707 dopamine multiple interactions EXP 6480464 Dopamine affects the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium] more ... CTD PMID:9830022 dopamine increases uptake EXP 6480464 SLC22A3 protein results in increased uptake of Dopamine CTD PMID:9830022 doxorubicin affects expression ISO RGD:1351828 6480464 Doxorubicin affects the expression of SLC22A3 mRNA CTD PMID:29803840 endosulfan multiple interactions ISO RGD:1351828 6480464 Endosulfan inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC22A3 mRNA] CTD PMID:26159488 ethanol increases expression ISO RGD:735816 6480464 Ethanol results in increased expression of SLC22A3 mRNA CTD PMID:19167417 ethidium increases uptake ISO RGD:1351828 6480464 SLC22A3 protein results in increased uptake of Ethidium CTD PMID:19357179 ethidium multiple interactions ISO RGD:1351828 6480464 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium] more ... CTD PMID:19357179 famotidine multiple interactions ISO RGD:1351828 6480464 Famotidine inhibits the reaction [SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium], Famotidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16141367 famotidine decreases activity ISO RGD:1351828 6480464 Famotidine results in decreased activity of SLC22A3 protein CTD PMID:16141367 flecainide multiple interactions ISO RGD:1351828 6480464 Flecainide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 fluticasone multiple interactions ISO RGD:1351828 6480464 Fluticasone inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate], SLC22A3 protein results in increased susceptibility to [Fluticasone results in decreased transport of Formoterol Fumarate] CTD PMID:17920670 , PMID:21914487 fonofos increases methylation ISO RGD:1351828 6480464 Fonofos results in increased methylation of SLC22A3 promoter CTD PMID:22847954 formaldehyde increases expression ISO RGD:1351828 6480464 Formaldehyde results in increased expression of SLC22A3 mRNA CTD PMID:23649840 formoterol fumarate multiple interactions ISO RGD:1351828 6480464 Budesonide inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate] more ... CTD PMID:17920670 , PMID:21914487 formoterol fumarate increases uptake ISO RGD:1351828 6480464 SLC22A3 protein results in increased uptake of Formoterol Fumarate CTD PMID:17920670 genistein multiple interactions EXP 6480464 [bisphenol A co-treated with Genistein] results in increased methylation of SLC22A3 gene CTD PMID:28505145 Glu-P-1 multiple interactions ISO RGD:1351828 6480464 2-amino-6-methyldipyrido(1 more ... CTD PMID:30189235 Glu-P-1 decreases activity ISO RGD:1351828 6480464 2-amino-6-methyldipyrido(1 more ... CTD PMID:30189235 Glu-P-2 multiple interactions ISO RGD:1351828 6480464 Glu-P-2 inhibits the reaction [SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide] CTD PMID:30189235 Glu-P-2 decreases activity ISO RGD:1351828 6480464 Glu-P-2 results in decreased activity of SLC22A3 protein CTD PMID:30189235 guanidine increases uptake ISO RGD:735816 6480464 SLC22A3 protein results in increased uptake of Guanidine CTD PMID:10966924 guanidine multiple interactions ISO RGD:735816 6480464 Guanidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium] CTD PMID:10966924 guanidine increases uptake ISO RGD:1351828 6480464 SLC22A3 protein results in increased uptake of Guanidine CTD PMID:10966924 guanidine multiple interactions ISO RGD:1351828 6480464 Guanidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog] CTD PMID:10966924 guanidine multiple interactions EXP 6480464 Guanidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:9830022 histamine multiple interactions EXP 6480464 Corticosterone inhibits the reaction [SLC22A3 protein results in increased transport of Histamine] more ... CTD PMID:12411423 , PMID:16928864 histamine increases transport EXP 6480464 SLC22A3 protein results in increased transport of Histamine CTD PMID:16928864 histamine affects uptake ISO RGD:1351828 6480464 SLC22A3 protein polymorphism affects the uptake of Histamine CTD PMID:20562519 histamine increases uptake ISO RGD:1351828 6480464 SLC22A3 protein results in increased uptake of Histamine CTD PMID:20858707 histamine multiple interactions ISO RGD:1351828 6480464 Histamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12411423 hydrogen peroxide affects expression ISO RGD:1351828 6480464 Hydrogen Peroxide affects the expression of SLC22A3 mRNA CTD PMID:23410634 imipramine multiple interactions ISO RGD:1351828 6480464 Imipramine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog] more ... CTD PMID:10966924 , PMID:21697722 Immepip multiple interactions EXP 6480464 4-(1H-imidazol-4-ylmethyl)piperidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12411423 Immepip multiple interactions ISO RGD:1351828 6480464 4-(1H-imidazol-4-ylmethyl)piperidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12411423 iodide salt affects expression EXP 6480464 Iodides deficiency affects the expression of SLC22A3 mRNA CTD PMID:21623536 ipratropium multiple interactions ISO RGD:1351828 6480464 Ipratropium inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 lamivudine increases uptake ISO RGD:1351828 6480464 SLC22A3 protein results in increased uptake of Lamivudine CTD PMID:19141712 lead diacetate multiple interactions ISO RGD:1351828 6480464 [lead acetate co-treated with zinc protoporphyrin] results in increased expression of SLC22A3 mRNA CTD PMID:22839698 lidocaine multiple interactions ISO RGD:1351828 6480464 Lidocaine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 MeIQ decreases activity ISO RGD:1351828 6480464 2-amino-3 more ... CTD PMID:30189235 MeIQ multiple interactions ISO RGD:1351828 6480464 2-amino-3 more ... CTD PMID:30189235 MeIQx multiple interactions ISO RGD:1351828 6480464 2-amino-3 more ... CTD PMID:30189235 MeIQx decreases activity ISO RGD:1351828 6480464 2-amino-3 more ... CTD PMID:30189235 menadione affects expression ISO RGD:1351828 6480464 Vitamin K 3 affects the expression of SLC22A3 mRNA CTD PMID:23410634 mercaptopurine decreases expression EXP 6480464 Mercaptopurine results in decreased expression of SLC22A3 mRNA CTD PMID:23358152 mercury dichloride increases expression EXP 6480464 Mercuric Chloride results in increased expression of SLC22A3 mRNA CTD PMID:28536007 metformin multiple interactions ISO RGD:1351828 6480464 carvedilol inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin] more ... CTD PMID:16141367 , PMID:21697722 metformin multiple interactions EXP 6480464 [1-Methyl-4-phenylpyridinium results in decreased activity of [SLC22A3 protein co-treated with SLC47A1 protein]] which results in decreased transport of Metformin CTD PMID:23562376 metformin increases uptake EXP 6480464 SLC22A3 protein results in increased uptake of Metformin CTD PMID:23562376 metformin increases uptake ISO RGD:1351828 6480464 SLC22A3 protein results in increased uptake of Metformin CTD PMID:21697722 methamphetamine multiple interactions EXP 6480464 Methamphetamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:9830022 mifepristone decreases expression ISO RGD:1351828 6480464 Mifepristone results in decreased expression of SLC22A3 mRNA CTD PMID:17584828 Molsidomine multiple interactions ISO RGD:1351828 6480464 Molsidomine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 N-methyl-4-phenylpyridinium multiple interactions ISO RGD:1351828 6480464 1-Methyl-4-phenylpyridinium analog inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog] more ... CTD PMID:10966924 more ... N-methyl-4-phenylpyridinium increases uptake ISO RGD:735816 6480464 SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog CTD PMID:10966924 N-methyl-4-phenylpyridinium affects abundance ISO RGD:735816 6480464 SLC22A3 protein affects the abundance of 1-Methyl-4-phenylpyridinium CTD PMID:11390648 N-methyl-4-phenylpyridinium multiple interactions ISO RGD:735816 6480464 1-Methyl-4-phenylpyridinium analog inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium] CTD PMID:10966924 N-methyl-4-phenylpyridinium increases transport ISO RGD:1351828 6480464 SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium CTD PMID:16263091 N-methyl-4-phenylpyridinium increases transport EXP 6480464 SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium CTD PMID:16928864 , PMID:22543277 N-methyl-4-phenylpyridinium affects uptake ISO RGD:1351828 6480464 SLC22A3 protein polymorphism affects the uptake of 1-Methyl-4-phenylpyridinium CTD PMID:20562519 N-methyl-4-phenylpyridinium increases uptake ISO RGD:1351828 6480464 SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium, SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog CTD PMID:10966924 more ... N-methyl-4-phenylpyridinium increases uptake EXP 6480464 SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium CTD PMID:12411423 , PMID:9830022 N-methyl-4-phenylpyridinium multiple interactions EXP 6480464 4-(1H-imidazol-4-ylmethyl)piperidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] more ... CTD PMID:12411423 more ... N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine multiple interactions ISO RGD:1351828 6480464 Ranitidine inhibits the reaction [SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium] more ... CTD PMID:16141367 , PMID:16263091 nifedipine multiple interactions ISO RGD:1351828 6480464 Nifedipine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 paclitaxel increases expression EXP 6480464 Paclitaxel results in increased expression of SLC22A3 mRNA CTD PMID:15585946 paclitaxel affects response to substance ISO RGD:1351828 6480464 SLC22A3 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 papaverine multiple interactions ISO RGD:1351828 6480464 Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12411423 papaverine multiple interactions EXP 6480464 Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium], Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium] CTD PMID:12411423 , PMID:9830022 paracetamol affects expression ISO RGD:735816 6480464 Acetaminophen affects the expression of SLC22A3 mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:1351828 6480464 Acetaminophen results in decreased expression of SLC22A3 mRNA CTD PMID:22230336 parathion increases methylation ISO RGD:1351828 6480464 Parathion results in increased methylation of SLC22A3 promoter CTD PMID:22847954 pentanal decreases expression ISO RGD:1351828 6480464 pentanal results in decreased expression of SLC22A3 mRNA CTD PMID:26079696 perchlorate affects expression EXP 6480464 perchlorate affects the expression of SLC22A3 mRNA CTD PMID:21623536 phenobarbital multiple interactions ISO RGD:735816 6480464 NR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLC22A3 mRNA] CTD PMID:19482888 phenobarbital affects expression ISO RGD:735816 6480464 Phenobarbital affects the expression of SLC22A3 mRNA CTD PMID:23091169 phenobarbital affects expression ISO RGD:1351828 6480464 Phenobarbital affects the expression of SLC22A3 mRNA CTD PMID:19159669 phenobarbital increases expression ISO RGD:735816 6480464 Phenobarbital results in increased expression of SLC22A3 mRNA CTD PMID:19482888 Phenoxybenzamine decreases activity ISO RGD:1351828 6480464 Phenoxybenzamine results in decreased activity of SLC22A3 protein CTD PMID:12110607 Phenoxybenzamine multiple interactions ISO RGD:1351828 6480464 Phenoxybenzamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12110607 phentolamine multiple interactions EXP 6480464 Phentolamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12411423 phentolamine multiple interactions ISO RGD:1351828 6480464 Phentolamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12411423 phenylephrine multiple interactions EXP 6480464 [Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased import of Phenylephrine CTD PMID:21140131 PhIP decreases activity ISO RGD:1351828 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in decreased activity of SLC22A3 protein CTD PMID:30189235 PhIP multiple interactions ISO RGD:1351828 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine inhibits the reaction [SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide] CTD PMID:30189235 pirinixic acid multiple interactions ISO RGD:735816 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SLC22A3 mRNA CTD PMID:18489776 pirinixic acid increases expression ISO RGD:735816 6480464 pirinixic acid results in increased expression of SLC22A3 mRNA CTD PMID:17426115 , PMID:20813756 potassium atom multiple interactions ISO RGD:735816 6480464 Potassium inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium] CTD PMID:10966924 prazosin multiple interactions ISO RGD:1351828 6480464 Prazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12110607 prazosin decreases activity ISO RGD:1351828 6480464 Prazosin results in decreased activity of SLC22A3 protein CTD PMID:12110607 procainamide multiple interactions ISO RGD:1351828 6480464 Procainamide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog] CTD PMID:10966924 progesterone multiple interactions ISO RGD:1351828 6480464 Progesterone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12110607 progesterone multiple interactions EXP 6480464 Progesterone inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium] CTD PMID:9830022 progesterone decreases activity ISO RGD:1351828 6480464 Progesterone results in decreased activity of SLC22A3 protein CTD PMID:12110607 propafenone multiple interactions ISO RGD:1351828 6480464 Propafenone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 propanal decreases expression ISO RGD:1351828 6480464 propionaldehyde results in decreased expression of SLC22A3 mRNA CTD PMID:26079696 propranolol multiple interactions ISO RGD:1351828 6480464 Propranolol inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 purine-6-thiol decreases expression EXP 6480464 Mercaptopurine results in decreased expression of SLC22A3 mRNA CTD PMID:23358152 quercetin increases expression EXP 6480464 Quercetin results in increased expression of SLC22A3 mRNA CTD PMID:18095365 quercetin decreases expression ISO RGD:1351828 6480464 Quercetin results in decreased expression of SLC22A3 mRNA CTD PMID:21632981 quinidine multiple interactions ISO RGD:1351828 6480464 Quinidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16141367 quinine multiple interactions ISO RGD:1351828 6480464 Quinine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium], Quinine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium] CTD PMID:16263091 , PMID:19357179 quinolin-8-ol decreases expression ISO RGD:1351828 6480464 Oxyquinoline results in decreased expression of SLC22A3 mRNA CTD PMID:21632981 ranitidine multiple interactions ISO RGD:1351828 6480464 Ranitidine inhibits the reaction [SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium] more ... CTD PMID:16141367 , PMID:16263091 Salmeterol xinafoate increases uptake ISO RGD:1351828 6480464 SLC22A3 protein results in increased uptake of Salmeterol Xinafoate CTD PMID:17920670 serotonin multiple interactions EXP 6480464 Serotonin inhibits the reaction [SLC22A3 protein results in increased transport of Histamine], Serotonin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16928864 , PMID:9830022 serotonin increases uptake ISO RGD:1351828 6480464 SLC22A3 protein results in increased uptake of Serotonin CTD PMID:20858707 silicon dioxide decreases expression ISO RGD:1351828 6480464 Silicon Dioxide analog results in decreased expression of SLC22A3 mRNA CTD PMID:25895662 silicon dioxide increases expression ISO RGD:1351828 6480464 Silicon Dioxide analog results in increased expression of SLC22A3 mRNA CTD PMID:23806026 sodium dodecyl sulfate decreases expression ISO RGD:1351828 6480464 Sodium Dodecyl Sulfate results in decreased expression of SLC22A3 mRNA CTD PMID:31734321 spironolactone multiple interactions ISO RGD:1351828 6480464 Spironolactone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 sulpiride increases uptake ISO RGD:1351828 6480464 SLC22A3 protein results in increased uptake of Sulpiride CTD PMID:28597291 synephrine multiple interactions EXP 6480464 [Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased import of Synephrine CTD PMID:21140131 terbufos increases methylation ISO RGD:1351828 6480464 terbufos results in increased methylation of SLC22A3 promoter CTD PMID:22847954 tert-butyl hydroperoxide affects expression ISO RGD:1351828 6480464 tert-Butylhydroperoxide affects the expression of SLC22A3 mRNA CTD PMID:23410634 testosterone multiple interactions EXP 6480464 Testosterone inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium] CTD PMID:9830022 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of SLC22A3 mRNA CTD PMID:31150632 tetraethylammonium multiple interactions ISO RGD:1351828 6480464 Tetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog] more ... CTD PMID:10966924 more ... tetraethylammonium multiple interactions EXP 6480464 Corticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium] more ... CTD PMID:9830022 tetraethylammonium increases uptake EXP 6480464 SLC22A3 protein results in increased uptake of Tetraethylammonium CTD PMID:9830022 tetraethylammonium multiple interactions ISO RGD:735816 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:10966924 tetraethylammonium increases uptake ISO RGD:735816 6480464 SLC22A3 protein results in increased uptake of Tetraethylammonium CTD PMID:10966924 tetraethylammonium increases uptake ISO RGD:1351828 6480464 SLC22A3 protein results in increased uptake of Tetraethylammonium CTD PMID:10966924 , PMID:21256917 Thioperamide multiple interactions ISO RGD:1351828 6480464 thioperamide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12411423 Thioperamide multiple interactions EXP 6480464 thioperamide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12411423 titanium dioxide multiple interactions ISO RGD:735816 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of SLC22A3 mRNA CTD PMID:29950665 triclosan decreases expression ISO RGD:1351828 6480464 Triclosan results in decreased expression of SLC22A3 mRNA CTD PMID:30510588 trimazosin multiple interactions EXP 6480464 trimazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12411423 trimazosin multiple interactions ISO RGD:1351828 6480464 trimazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12411423 trimethoprim increases transport ISO RGD:1351828 6480464 SLC22A3 protein results in increased transport of Trimethoprim CTD PMID:18253050 tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate increases uptake ISO RGD:1351828 6480464 SLC22A3 protein results in increased uptake of Atropine CTD PMID:16263091 tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate multiple interactions ISO RGD:1351828 6480464 Atropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 tunicamycin increases expression ISO RGD:735816 6480464 Tunicamycin results in increased expression of SLC22A3 mRNA CTD PMID:17127020 valproic acid affects expression ISO RGD:735816 6480464 Valproic Acid affects the expression of SLC22A3 mRNA CTD PMID:17292431 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of SLC22A3 mRNA CTD PMID:29427782 valproic acid affects expression ISO RGD:1351828 6480464 Valproic Acid affects the expression of SLC22A3 mRNA CTD PMID:25979313 verapamil multiple interactions ISO RGD:1351828 6480464 Verapamil inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium], Verapamil inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin] CTD PMID:21641380 , PMID:21697722 vincaleukoblastine affects response to substance ISO RGD:1351828 6480464 SLC22A3 protein affects the susceptibility to Vinblastine CTD PMID:16217747 zinc protoporphyrin multiple interactions ISO RGD:1351828 6480464 [lead acetate co-treated with zinc protoporphyrin] results in increased expression of SLC22A3 mRNA CTD PMID:22839698
Gene-Chemical Interaction Annotations
