Hnrnpu (heterogeneous nuclear ribonucleoprotein U) - Rat Genome Database
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Gene: Hnrnpu (heterogeneous nuclear ribonucleoprotein U) Rattus norvegicus
Analyze
Symbol: Hnrnpu
Name: heterogeneous nuclear ribonucleoprotein U
RGD ID: 620372
Description: Exhibits poly(G) binding activity; promoter-specific chromatin binding activity; and ribonucleoprotein complex binding activity. Involved in cellular response to dexamethasone stimulus; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity; and positive regulation of gene expression. Localizes to nucleus and ribonucleoprotein complex. Predicted to colocalize with RNA polymerase II transcription regulator complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 54. Orthologous to human HNRNPU (heterogeneous nuclear ribonucleoprotein U); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: hnRNP U; Hnrpu; SAF-A; scaffold-attachment factor A; SN1; SP120; system N1 Na+ and H+-coupled glutamine transporter; transporter protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21390,069,058 - 90,086,905 (-)NCBI
Rnor_6.0 Ensembl1396,225,912 - 96,238,572 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01396,222,093 - 96,238,845 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013100,663,218 - 100,679,960 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41393,978,865 - 93,987,654 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11394,168,061 - 94,176,568 (-)NCBI
Celera1389,636,544 - 89,645,333 (-)NCBICelera
Cytogenetic Map13q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP)
Brodifacoum  (EXP)
butanal  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbamazepine  (ISO)
chloroprene  (ISO)
chromium(6+)  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
enniatin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
PCB138  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tamoxifen  (EXP,ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive thermogenesis  (ISO,ISS)
cardiac muscle cell development  (ISO)
cell division  (IEA)
cellular response to dexamethasone stimulus  (IDA)
cellular response to glucocorticoid stimulus  (IEA,ISO)
cellular response to leukemia inhibitory factor  (ISO,ISS)
chromatin organization  (IEA)
circadian regulation of gene expression  (ISO)
CRD-mediated mRNA stabilization  (IBA,IEA,ISO)
dendritic transport of messenger ribonucleoprotein complex  (ISO)
dosage compensation by inactivation of X chromosome  (ISO)
maintenance of protein location in nucleus  (IEA,ISO)
mRNA metabolic process  (ISO)
mRNA processing  (IEA)
mRNA stabilization  (ISO)
negative regulation of kinase activity  (IEA,ISO)
negative regulation of stem cell differentiation  (IEA,ISO,ISS)
negative regulation of telomere maintenance via telomerase  (IBA,IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
negative regulation of transcription elongation from RNA polymerase II promoter  (IEA,ISO)
positive regulation of attachment of mitotic spindle microtubules to kinetochore  (IBA,IEA,ISO,ISS)
positive regulation of brown fat cell differentiation  (ISO,ISS)
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity  (IDA)
positive regulation of gene expression  (IMP)
positive regulation of stem cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,ISO,ISS)
protein localization to spindle microtubule  (IEA,ISO,ISS)
regulation of alternative mRNA splicing, via spliceosome  (IBA,IEA,ISO)
regulation of chromatin organization  (IBA,IEA,ISO,ISS)
regulation of mitotic cell cycle  (IEA,ISO,ISS)
regulation of mitotic spindle assembly  (IBA,IEA,ISO,ISS)
RNA localization to chromatin  (IBA,ISO)
RNA splicing  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1628625   PMID:7993898   PMID:8068679   PMID:8174554   PMID:9105675   PMID:9204873   PMID:9353307   PMID:9405365   PMID:10490622   PMID:11003645   PMID:11909954   PMID:11991638  
PMID:14608463   PMID:15121898   PMID:15312650   PMID:15711563   PMID:16210410   PMID:17174306   PMID:17289661   PMID:18082603   PMID:18332112   PMID:19029303   PMID:19617346   PMID:19946888  
PMID:20833368   PMID:21235343   PMID:21242313   PMID:22082260   PMID:22162999   PMID:22325991   PMID:22658674   PMID:22681889   PMID:22720776   PMID:23811339   PMID:23979707   PMID:24625528  
PMID:25921091   PMID:25931508   PMID:25986610   PMID:26039991   PMID:26244333   PMID:28221134   PMID:28622508   PMID:28784777  


Genomics

Comparative Map Data
Hnrnpu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21390,069,058 - 90,086,905 (-)NCBI
Rnor_6.0 Ensembl1396,225,912 - 96,238,572 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01396,222,093 - 96,238,845 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013100,663,218 - 100,679,960 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41393,978,865 - 93,987,654 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11394,168,061 - 94,176,568 (-)NCBI
Celera1389,636,544 - 89,645,333 (-)NCBICelera
Cytogenetic Map13q25NCBI
HNRNPU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1244,840,638 - 244,864,560 (-)EnsemblGRCh38hg38GRCh38
GRCh381244,850,297 - 244,864,543 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371245,013,599 - 245,027,845 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361243,080,225 - 243,094,450 (-)NCBINCBI36hg18NCBI36
Build 341241,343,003 - 241,353,868NCBI
Celera1218,303,553 - 218,317,021 (-)NCBI
Cytogenetic Map1q44NCBI
HuRef1215,396,765 - 215,410,903 (-)NCBIHuRef
CHM1_11246,285,948 - 246,300,167 (-)NCBICHM1_1
Hnrnpu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,148,673 - 178,170,063 (-)NCBIGRCm39mm39
GRCm39 Ensembl1178,148,673 - 178,165,362 (-)Ensembl
GRCm381178,321,108 - 178,338,891 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,321,108 - 178,337,797 (-)EnsemblGRCm38mm10GRCm38
MGSCv371180,258,431 - 180,267,915 (-)NCBIGRCm37mm9NCBIm37
MGSCv361180,165,990 - 180,174,387 (-)NCBImm8
Celera1185,387,923 - 185,397,431 (-)NCBICelera
Cytogenetic Map1H4NCBI
Hnrnpu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554068,000,269 - 8,021,554 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554068,000,269 - 8,021,554 (-)NCBIChiLan1.0ChiLan1.0
HNRNPU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11225,830,663 - 225,842,031 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1225,817,899 - 225,842,031 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01220,450,218 - 220,461,412 (-)NCBIMhudiblu_PPA_v0panPan3
HNRNPU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl735,833,988 - 35,843,754 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1735,832,956 - 35,842,898 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Hnrnpu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365266,014,745 - 6,022,213 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNRNPU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1017,475,270 - 17,497,130 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11017,475,266 - 17,497,060 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21019,942,586 - 19,951,287 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HNRNPU
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12581,879,532 - 81,890,684 (-)NCBI
ChlSab1.1 Ensembl2581,878,111 - 81,890,701 (-)Ensembl
Hnrnpu
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477114,756,088 - 14,766,106 (+)NCBI

Position Markers
RH125798  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01396,229,759 - 96,230,002NCBIRnor6.0
Rnor_5.013100,670,884 - 100,671,127UniSTSRnor5.0
RGSC_v3.41393,978,939 - 93,979,182UniSTSRGSC3.4
Celera1389,636,618 - 89,636,861UniSTS
Cytogenetic Map13q26UniSTS
WI-7584  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01396,229,789 - 96,230,125NCBIRnor6.0
Rnor_5.013100,670,914 - 100,671,250UniSTSRnor5.0
RGSC_v3.41393,978,969 - 93,979,305UniSTSRGSC3.4
Celera1389,636,648 - 89,636,984UniSTS
Cytogenetic Map13q26UniSTS
WI-8450  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01396,229,789 - 96,230,102NCBIRnor6.0
Rnor_5.013100,670,914 - 100,671,227UniSTSRnor5.0
RGSC_v3.41393,978,969 - 93,979,282UniSTSRGSC3.4
Celera1389,636,648 - 89,636,961UniSTS
Cytogenetic Map13q26UniSTS
RH135335  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01396,229,884 - 96,230,074NCBIRnor6.0
Rnor_5.013100,671,009 - 100,671,199UniSTSRnor5.0
RGSC_v3.41393,979,064 - 93,979,254UniSTSRGSC3.4
Celera1389,636,743 - 89,636,933UniSTS
RH 3.4 Map13608.5UniSTS
Cytogenetic Map13q26UniSTS
C86794  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01396,231,306 - 96,231,788NCBIRnor6.0
Rnor_5.013100,672,431 - 100,672,913UniSTSRnor5.0
RGSC_v3.41393,980,486 - 93,980,968UniSTSRGSC3.4
Celera1389,638,165 - 89,638,647UniSTS
Cytogenetic Map13q26UniSTS
MARC_20677-20678:1024509130:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01396,230,358 - 96,231,022NCBIRnor6.0
Rnor_5.013100,671,483 - 100,672,147UniSTSRnor5.0
RGSC_v3.41393,979,538 - 93,980,202UniSTSRGSC3.4
Celera1389,637,217 - 89,637,881UniSTS
Cytogenetic Map13q26UniSTS
MARC_26419-26420:1036768776:5  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01396,229,783 - 96,230,272NCBIRnor6.0
Rnor_5.013100,670,908 - 100,671,397UniSTSRnor5.0
RGSC_v3.41393,978,963 - 93,979,452UniSTSRGSC3.4
Celera1389,636,642 - 89,637,131UniSTS
Cytogenetic Map13q26UniSTS
ksks277  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01396,230,510 - 96,230,982NCBIRnor6.0
Rnor_5.013100,671,635 - 100,672,107UniSTSRnor5.0
RGSC_v3.41393,979,690 - 93,980,162UniSTSRGSC3.4
Celera1389,637,369 - 89,637,841UniSTS
Cytogenetic Map13q26UniSTS
A007A33  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01396,230,397 - 96,231,014NCBIRnor6.0
Rnor_5.013100,671,522 - 100,672,139UniSTSRnor5.0
RGSC_v3.41393,979,577 - 93,980,194UniSTSRGSC3.4
Celera1389,637,256 - 89,637,873UniSTS
Cytogenetic Map13q26UniSTS
HNRPU_1518  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01396,229,586 - 96,230,447NCBIRnor6.0
Rnor_5.013100,670,711 - 100,671,572UniSTSRnor5.0
RGSC_v3.41393,978,766 - 93,979,627UniSTSRGSC3.4
Celera1389,636,445 - 89,637,306UniSTS
Cytogenetic Map13q26UniSTS
UniSTS:546820  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01396,230,503 - 96,231,029NCBIRnor6.0
Rnor_5.013100,671,628 - 100,672,154UniSTSRnor5.0
Celera1389,637,362 - 89,637,888UniSTS
Cytogenetic Map13q26UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131107975663Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1312193394108478121Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1324502279108770533Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1335301263107975663Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133614753399968921Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135156924896569248Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1357903612102903612Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1362975663107975663Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1366971778111971778Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1371230858114033958Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1371230858114033958Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1372583716114033958Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)777694986114033958Rat
8655959Pur32Proteinuria QTL 328.4total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1379567081103613733Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1380403559108770687Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1386833393114033958Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:380
Count of miRNA genes:216
Interacting mature miRNAs:251
Transcripts:ENSRNOT00000044477
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 4
Medium 3 43 57 41 19 41 8 11 70 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000044477   ⟹   ENSRNOP00000046783
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1396,229,688 - 96,238,474 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078061   ⟹   ENSRNOP00000070912
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1396,225,912 - 96,238,572 (-)Ensembl
RefSeq Acc Id: NM_057139   ⟹   NP_476480
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21390,077,755 - 90,086,544 (-)NCBI
Rnor_6.01396,229,685 - 96,238,474 (-)NCBI
Rnor_5.013100,663,218 - 100,679,960 (-)NCBI
RGSC_v3.41393,978,865 - 93,987,654 (-)RGD
Celera1389,636,544 - 89,645,333 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250311   ⟹   XP_006250373
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01396,222,093 - 96,238,845 (-)NCBI
Rnor_5.013100,663,218 - 100,679,960 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090285   ⟹   XP_038946213
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21390,069,058 - 90,086,905 (-)NCBI
RefSeq Acc Id: XR_005492193
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21390,069,058 - 90,086,905 (-)NCBI
RefSeq Acc Id: XR_359126
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01396,222,093 - 96,238,845 (-)NCBI
Rnor_5.013100,663,218 - 100,679,960 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_476480   ⟸   NM_057139
- UniProtKB: Q6IMY8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250373   ⟸   XM_006250311
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000070912   ⟸   ENSRNOT00000078061
RefSeq Acc Id: ENSRNOP00000046783   ⟸   ENSRNOT00000044477
RefSeq Acc Id: XP_038946213   ⟸   XM_039090285
- Peptide Label: isoform X1
Protein Domains
B30.2/SPRY   SAP

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699050
Promoter ID:EPDNEW_R9574
Type:initiation region
Name:Hnrnpu_1
Description:heterogeneous nuclear ribonucleoprotein U
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01396,238,515 - 96,238,575EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620372 AgrOrtholog
Ensembl Genes ENSRNOG00000033790 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000046783 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000070912 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044477 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000078061 UniProtKB/TrEMBL
Gene3D-CATH 1.10.720.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7096906 IMAGE-MGC_LOAD
InterPro B30.2/SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hnRNP_U UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY_hnRNP_U UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117280 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91534 IMAGE-MGC_LOAD
NCBI Gene 117280 ENTREZGENE
PANTHER PTHR12381:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hnrnpu PhenoGen
PROSITE B302_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF68906 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JZ52_RAT UniProtKB/TrEMBL
  HNRPU_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Hnrnpu  heterogeneous nuclear ribonucleoprotein U  Hnrpu  heterogeneous nuclear ribonucleoprotein U  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Hnrpu  heterogeneous nuclear ribonucleoprotein U    transporter protein; system N1 Na+ and H+-coupled glutamine transporter  Name updated 1299863 APPROVED
2002-08-07 Hnrpu  transporter protein; system N1 Na+ and H+-coupled glutamine transporter      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in astroglia, Bergmann glia, and vascular endothelium 632946
gene_expression expressed at high levels in the postnatal period 632946