Hnrnpu (heterogeneous nuclear ribonucleoprotein U) - Rat Genome Database

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Gene: Hnrnpu (heterogeneous nuclear ribonucleoprotein U) Rattus norvegicus
Analyze
Symbol: Hnrnpu
Name: heterogeneous nuclear ribonucleoprotein U
RGD ID: 620372
Description: Enables poly(G) binding activity; promoter-specific chromatin binding activity; and ribonucleoprotein complex binding activity. Involved in cellular response to dexamethasone stimulus; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity; and positive regulation of gene expression. Part of ribonucleoprotein complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 54. Orthologous to human HNRNPU (heterogeneous nuclear ribonucleoprotein U); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hnRNP U; Hnrpu; SAF-A; scaffold-attachment factor A; SN1; SP120; system N1 Na+ and H+-coupled glutamine transporter; transporter protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21390,069,058 - 90,086,905 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1390,074,181 - 90,086,588 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1392,582,994 - 92,591,782 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01393,983,136 - 93,991,924 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01391,164,719 - 91,173,509 (-)NCBIRnor_WKY
Rnor_6.01396,222,093 - 96,238,845 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1396,225,912 - 96,238,572 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013100,663,218 - 100,679,960 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41393,978,865 - 93,987,654 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11394,168,061 - 94,176,568 (-)NCBI
Celera1389,636,544 - 89,645,333 (-)NCBICelera
Cytogenetic Map13q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3',5'-cyclic UMP  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetylsalicylic acid  (ISO)
aconitine  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
butanal  (ISO)
caffeine  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbamazepine  (ISO)
chloroprene  (ISO)
chromium(6+)  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
enniatin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
ivermectin  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tamoxifen  (EXP,ISO)
thapsigargin  (EXP)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive thermogenesis  (ISO,ISS)
cardiac muscle cell development  (ISO)
cell division  (IEA)
cellular response to dexamethasone stimulus  (IDA)
cellular response to glucocorticoid stimulus  (IEA,ISO)
cellular response to leukemia inhibitory factor  (ISO,ISS)
circadian regulation of gene expression  (ISO)
CRD-mediated mRNA stabilization  (IBA,IEA,ISO)
dendritic transport of messenger ribonucleoprotein complex  (ISO)
dosage compensation by inactivation of X chromosome  (ISO)
maintenance of protein location in nucleus  (IEA,ISO)
mRNA metabolic process  (ISO)
mRNA processing  (IEA)
mRNA stabilization  (ISO)
negative regulation of kinase activity  (IEA,ISO)
negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (IEA,ISO)
negative regulation of stem cell differentiation  (IEA,ISO,ISS)
negative regulation of telomere maintenance via telomerase  (IBA,IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
negative regulation of transcription elongation by RNA polymerase II  (IEA,ISO)
positive regulation of attachment of mitotic spindle microtubules to kinetochore  (IBA,IEA,ISO,ISS)
positive regulation of brown fat cell differentiation  (ISO,ISS)
positive regulation of cytoplasmic translation  (IEA,ISO)
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity  (IDA)
positive regulation of gene expression  (IMP)
positive regulation of stem cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,ISO,ISS)
protein localization to spindle microtubule  (IEA,ISO,ISS)
regulation of alternative mRNA splicing, via spliceosome  (IBA,IEA,ISO)
regulation of chromatin organization  (IBA,IEA,ISO,ISS)
regulation of mitotic cell cycle  (IEA,ISO,ISS)
regulation of mitotic spindle assembly  (IBA,IEA,ISO,ISS)
RNA localization to chromatin  (IBA,ISO)
RNA splicing  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Highly differential expression of SN1, a bidirectional glutamine transporter, in astroglia and endothelium in the developing rat brain. Boulland JL, etal., Glia 2003 Feb;41(3):260-75.
2. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
3. The proximal region of the 3'-untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U. Cok SJ, etal., J Biol Chem. 2003 Sep 19;278(38):36157-62. Epub 2003 Jul 9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The expression profile of RNA-binding proteins in primary and metastatic colorectal cancer: relationship of heterogeneous nuclear ribonucleoproteins with prognosis. Hope NR and Murray GI, Hum Pathol. 2011 Mar;42(3):393-402. doi: 10.1016/j.humpath.2010.08.006. Epub 2010 Dec 30.
7. Interactions between the nuclear matrix and an enhancer of the tryptophan oxygenase gene. Kaneoka H, etal., Biochem Biophys Res Commun. 2009 Oct 2;387(4):717-22. doi: 10.1016/j.bbrc.2009.07.095. Epub 2009 Jul 24.
8. Regulation of DNA Topoisomerase IIbeta through RNA-dependent association with heterogeneous nuclear ribonucleoprotein U (hnRNP U). Kawano S, etal., J Biol Chem. 2010 Aug 20;285(34):26451-60. doi: 10.1074/jbc.M110.112979. Epub 2010 Jun 16.
9. Myosin VI in the nucleus of neurosecretory PC12 cells: Stimulation-dependent nuclear translocation and interaction with nuclear proteins. Majewski L, etal., Nucleus. 2018 Jan 1;9(1):125-141. doi: 10.1080/19491034.2017.1421881.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. The spliceosome: design principles of a dynamic RNP machine. Wahl MC, etal., Cell. 2009 Feb 20;136(4):701-18. doi: 10.1016/j.cell.2009.02.009.
Additional References at PubMed
PMID:1628625   PMID:7993898   PMID:8068679   PMID:8174554   PMID:9105675   PMID:9204873   PMID:9353307   PMID:9405365   PMID:10490622   PMID:11003645   PMID:11909954   PMID:11991638  
PMID:14608463   PMID:15121898   PMID:15312650   PMID:15711563   PMID:16210410   PMID:17174306   PMID:17289661   PMID:18082603   PMID:18332112   PMID:19029303   PMID:19617346   PMID:19946888  
PMID:20833368   PMID:21235343   PMID:21242313   PMID:22082260   PMID:22162999   PMID:22325991   PMID:22658674   PMID:22681889   PMID:22720776   PMID:23811339   PMID:23979707   PMID:24625528  
PMID:25921091   PMID:25931508   PMID:25986610   PMID:26039991   PMID:26244333   PMID:28221134   PMID:28622508   PMID:28784777   PMID:34585626   PMID:35659652  


Genomics

Comparative Map Data
Hnrnpu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21390,069,058 - 90,086,905 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1390,074,181 - 90,086,588 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1392,582,994 - 92,591,782 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01393,983,136 - 93,991,924 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01391,164,719 - 91,173,509 (-)NCBIRnor_WKY
Rnor_6.01396,222,093 - 96,238,845 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1396,225,912 - 96,238,572 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013100,663,218 - 100,679,960 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41393,978,865 - 93,987,654 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11394,168,061 - 94,176,568 (-)NCBI
Celera1389,636,544 - 89,645,333 (-)NCBICelera
Cytogenetic Map13q25NCBI
HNRNPU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381244,850,297 - 244,864,543 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1244,840,638 - 244,864,560 (-)EnsemblGRCh38hg38GRCh38
GRCh371245,013,599 - 245,027,845 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361243,080,225 - 243,094,450 (-)NCBINCBI36Build 36hg18NCBI36
Build 341241,343,003 - 241,353,868NCBI
Celera1218,303,553 - 218,317,021 (-)NCBICelera
Cytogenetic Map1q44NCBI
HuRef1215,396,765 - 215,410,903 (-)NCBIHuRef
CHM1_11246,285,948 - 246,300,167 (-)NCBICHM1_1
T2T-CHM13v2.01244,266,602 - 244,280,849 (-)NCBIT2T-CHM13v2.0
Hnrnpu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,148,673 - 178,170,063 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,148,673 - 178,165,362 (-)EnsemblGRCm39 Ensembl
GRCm381178,321,108 - 178,338,891 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,321,108 - 178,337,797 (-)EnsemblGRCm38mm10GRCm38
MGSCv371180,258,431 - 180,267,915 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361180,165,990 - 180,174,387 (-)NCBIMGSCv36mm8
Celera1185,387,923 - 185,397,431 (-)NCBICelera
Cytogenetic Map1H4NCBI
Hnrnpu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554068,000,269 - 8,021,554 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554068,000,269 - 8,021,554 (-)NCBIChiLan1.0ChiLan1.0
HNRNPU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan114,511,584 - 4,522,898 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01220,450,218 - 220,461,412 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11225,830,663 - 225,842,031 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1225,817,899 - 225,842,031 (-)Ensemblpanpan1.1panPan2
HNRNPU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1735,832,956 - 35,842,898 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl735,833,988 - 35,843,754 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha735,302,229 - 35,316,897 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0735,653,977 - 35,672,359 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl735,655,401 - 35,672,356 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1735,493,577 - 35,507,810 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0735,509,582 - 35,522,877 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0735,777,999 - 35,788,402 (-)NCBIUU_Cfam_GSD_1.0
Hnrnpu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934448,725,125 - 48,767,809 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365266,014,745 - 6,022,213 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNRNPU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1017,477,902 - 17,497,030 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11017,475,266 - 17,497,060 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21019,942,586 - 19,951,287 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HNRNPU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12581,879,532 - 81,890,684 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2581,878,111 - 81,890,701 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605584,093,092 - 84,115,743 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hnrnpu
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477114,756,100 - 14,765,832 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477114,756,088 - 14,766,106 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hnrnpu
49 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:380
Count of miRNA genes:216
Interacting mature miRNAs:251
Transcripts:ENSRNOT00000044477
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
RH125798  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21390,077,828 - 90,078,072 (+)MAPPERmRatBN7.2
Rnor_6.01396,229,759 - 96,230,002NCBIRnor6.0
Rnor_5.013100,670,884 - 100,671,127UniSTSRnor5.0
RGSC_v3.41393,978,939 - 93,979,182UniSTSRGSC3.4
Celera1389,636,618 - 89,636,861UniSTS
Cytogenetic Map13q26UniSTS
WI-7584  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21390,077,858 - 90,078,195 (+)MAPPERmRatBN7.2
Rnor_6.01396,229,789 - 96,230,125NCBIRnor6.0
Rnor_5.013100,670,914 - 100,671,250UniSTSRnor5.0
RGSC_v3.41393,978,969 - 93,979,305UniSTSRGSC3.4
Celera1389,636,648 - 89,636,984UniSTS
Cytogenetic Map13q26UniSTS
WI-8450  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21390,077,858 - 90,078,172 (+)MAPPERmRatBN7.2
Rnor_6.01396,229,789 - 96,230,102NCBIRnor6.0
Rnor_5.013100,670,914 - 100,671,227UniSTSRnor5.0
RGSC_v3.41393,978,969 - 93,979,282UniSTSRGSC3.4
Celera1389,636,648 - 89,636,961UniSTS
Cytogenetic Map13q26UniSTS
RH135335  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21390,077,953 - 90,078,144 (+)MAPPERmRatBN7.2
Rnor_6.01396,229,884 - 96,230,074NCBIRnor6.0
Rnor_5.013100,671,009 - 100,671,199UniSTSRnor5.0
RGSC_v3.41393,979,064 - 93,979,254UniSTSRGSC3.4
Celera1389,636,743 - 89,636,933UniSTS
RH 3.4 Map13608.5UniSTS
Cytogenetic Map13q26UniSTS
C86794  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21390,079,375 - 90,079,858 (+)MAPPERmRatBN7.2
Rnor_6.01396,231,306 - 96,231,788NCBIRnor6.0
Rnor_5.013100,672,431 - 100,672,913UniSTSRnor5.0
RGSC_v3.41393,980,486 - 93,980,968UniSTSRGSC3.4
Celera1389,638,165 - 89,638,647UniSTS
Cytogenetic Map13q26UniSTS
MARC_20677-20678:1024509130:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21390,078,427 - 90,079,092 (+)MAPPERmRatBN7.2
Rnor_6.01396,230,358 - 96,231,022NCBIRnor6.0
Rnor_5.013100,671,483 - 100,672,147UniSTSRnor5.0
RGSC_v3.41393,979,538 - 93,980,202UniSTSRGSC3.4
Celera1389,637,217 - 89,637,881UniSTS
Cytogenetic Map13q26UniSTS
MARC_26419-26420:1036768776:5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21390,077,852 - 90,078,342 (+)MAPPERmRatBN7.2
Rnor_6.01396,229,783 - 96,230,272NCBIRnor6.0
Rnor_5.013100,670,908 - 100,671,397UniSTSRnor5.0
RGSC_v3.41393,978,963 - 93,979,452UniSTSRGSC3.4
Celera1389,636,642 - 89,637,131UniSTS
Cytogenetic Map13q26UniSTS
ksks277  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21390,078,579 - 90,079,052 (+)MAPPERmRatBN7.2
Rnor_6.01396,230,510 - 96,230,982NCBIRnor6.0
Rnor_5.013100,671,635 - 100,672,107UniSTSRnor5.0
RGSC_v3.41393,979,690 - 93,980,162UniSTSRGSC3.4
Celera1389,637,369 - 89,637,841UniSTS
Cytogenetic Map13q26UniSTS
A007A33  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21390,078,466 - 90,079,084 (+)MAPPERmRatBN7.2
Rnor_6.01396,230,397 - 96,231,014NCBIRnor6.0
Rnor_5.013100,671,522 - 100,672,139UniSTSRnor5.0
RGSC_v3.41393,979,577 - 93,980,194UniSTSRGSC3.4
Celera1389,637,256 - 89,637,873UniSTS
Cytogenetic Map13q26UniSTS
HNRPU_1518  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21390,077,655 - 90,078,517 (+)MAPPERmRatBN7.2
Rnor_6.01396,229,586 - 96,230,447NCBIRnor6.0
Rnor_5.013100,670,711 - 100,671,572UniSTSRnor5.0
RGSC_v3.41393,978,766 - 93,979,627UniSTSRGSC3.4
Celera1389,636,445 - 89,637,306UniSTS
Cytogenetic Map13q26UniSTS
UniSTS:546820  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21390,078,572 - 90,079,099 (+)MAPPERmRatBN7.2
Rnor_6.01396,230,503 - 96,231,029NCBIRnor6.0
Rnor_5.013100,671,628 - 100,672,154UniSTSRnor5.0
Celera1389,637,362 - 89,637,888UniSTS
Cytogenetic Map13q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 4
Medium 3 43 57 41 19 41 8 11 70 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000044477   ⟹   ENSRNOP00000046783
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1390,077,755 - 90,086,588 (-)Ensembl
Rnor_6.0 Ensembl1396,229,688 - 96,238,474 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078061   ⟹   ENSRNOP00000070912
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1390,074,181 - 90,086,586 (-)Ensembl
Rnor_6.0 Ensembl1396,225,912 - 96,238,572 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095557   ⟹   ENSRNOP00000093222
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1390,077,755 - 90,086,588 (-)Ensembl
RefSeq Acc Id: NM_057139   ⟹   NP_476480
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21390,077,755 - 90,086,544 (-)NCBI
Rnor_6.01396,229,685 - 96,238,474 (-)NCBI
Rnor_5.013100,663,218 - 100,679,960 (-)NCBI
RGSC_v3.41393,978,865 - 93,987,654 (-)RGD
Celera1389,636,544 - 89,645,333 (-)RGD
Sequence:
RefSeq Acc Id: XM_039090285   ⟹   XP_038946213
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21390,069,058 - 90,086,905 (-)NCBI
RefSeq Acc Id: XR_005492193
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21390,069,058 - 90,086,905 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_476480   ⟸   NM_057139
- UniProtKB: Q6IMY8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070912   ⟸   ENSRNOT00000078061
RefSeq Acc Id: ENSRNOP00000046783   ⟸   ENSRNOT00000044477
RefSeq Acc Id: XP_038946213   ⟸   XM_039090285
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JZ52 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000093222   ⟸   ENSRNOT00000095557
Protein Domains
B30.2/SPRY   SAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IMY8-F1-model_v2 AlphaFold Q6IMY8 1-798 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699050
Promoter ID:EPDNEW_R9574
Type:initiation region
Name:Hnrnpu_1
Description:heterogeneous nuclear ribonucleoprotein U
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01396,238,515 - 96,238,575EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620372 AgrOrtholog
BioCyc Gene G2FUF-17173 BioCyc
Ensembl Genes ENSRNOG00000033790 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000046783 ENTREZGENE
  ENSRNOP00000046783.3 UniProtKB/Swiss-Prot
  ENSRNOP00000070912 ENTREZGENE
  ENSRNOP00000070912.1 UniProtKB/TrEMBL
  ENSRNOP00000093222.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044477 ENTREZGENE
  ENSRNOT00000044477.4 UniProtKB/Swiss-Prot
  ENSRNOT00000078061 ENTREZGENE
  ENSRNOT00000078061.2 UniProtKB/TrEMBL
  ENSRNOT00000095557.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.720.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7096906 IMAGE-MGC_LOAD
InterPro B30.2/SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY_hnRNP_U UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117280 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91534 IMAGE-MGC_LOAD
NCBI Gene 117280 ENTREZGENE
PANTHER HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12381:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AAA_33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hnrnpu PhenoGen
PROSITE B302_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF68906 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JZ52 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AI90_RAT UniProtKB/TrEMBL
  HNRPU_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Hnrnpu  heterogeneous nuclear ribonucleoprotein U  Hnrpu  heterogeneous nuclear ribonucleoprotein U  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Hnrpu  heterogeneous nuclear ribonucleoprotein U    transporter protein; system N1 Na+ and H+-coupled glutamine transporter  Name updated 1299863 APPROVED
2002-08-07 Hnrpu  transporter protein; system N1 Na+ and H+-coupled glutamine transporter      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in astroglia, Bergmann glia, and vascular endothelium 632946
gene_expression expressed at high levels in the postnatal period 632946