Adcyap1 (adenylate cyclase activating polypeptide 1) - Rat Genome Database

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Gene: Adcyap1 (adenylate cyclase activating polypeptide 1) Rattus norvegicus
Analyze
Symbol: Adcyap1
Name: adenylate cyclase activating polypeptide 1
RGD ID: 2037
Description: Enables neuropeptide hormone activity; pituitary adenylate cyclase activating polypeptide activity; and pituitary adenylate cyclase-activating polypeptide receptor binding activity. Involved in several processes, including negative regulation of acute inflammatory response; positive regulation of cell communication; and positive regulation of macromolecule metabolic process. Located in extracellular space and terminal bouton. Is active in neuronal dense core vesicle lumen. Used to study Parkinsonism and acute necrotizing pancreatitis. Biomarker of cystitis. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human ADCYAP1 (adenylate cyclase activating polypeptide 1); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; alendronic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adenylate cyclase activating polypeptide 1 (pituitary); Pacap; pituitary adenylate cyclase activating polypeptide 1; pituitary adenylate cyclase-activating polypeptide; pituitary adenylate cyclase-activating polypeptide precursor (Pacap); rat pituitary adenylate cyclase activating polypeptide 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89120,550,236 - 120,569,096 (-)NCBIGRCr8
mRatBN7.29113,102,632 - 113,122,500 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9113,103,718 - 113,109,773 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9121,581,877 - 121,587,073 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09126,711,026 - 126,716,222 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09125,056,936 - 125,062,132 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09121,705,897 - 121,725,736 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9121,706,979 - 121,725,716 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09121,155,213 - 121,175,023 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera9110,207,950 - 110,213,150 (-)NCBICelera
Cytogenetic Map9q38NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-palmitoylglycerol  (ISO)
3',5'-cyclic AMP  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alendronic acid  (EXP)
ammonium chloride  (EXP)
Ampullosporin  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
ATP  (EXP)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carmustine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
clofibrate  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
diepoxybutane  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
famotidine  (ISO)
folic acid  (ISO)
furan  (EXP)
Galanin  (EXP)
histamine  (EXP)
hydrazine  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
methotrexate  (ISO)
misoprostol  (EXP)
Muscarine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel dichloride  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
prostaglandin E2  (EXP)
pyridaben  (ISO)
raloxifene  (EXP)
rolipram  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
Testosterone propionate  (EXP)
titanium dioxide  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA,IDA,IEA,ISO)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IMP,ISO)
behavioral fear response  (IDA)
cellular response to glucocorticoid stimulus  (IEP)
histamine secretion  (IDA)
insulin secretion  (IEA,ISO,ISS)
negative regulation of acute inflammatory response to antigenic stimulus  (IDA)
negative regulation of acute inflammatory response to non-antigenic stimulus  (IDA)
negative regulation of cell cycle  (IEA,ISO)
negative regulation of glial cell proliferation  (IDA)
negative regulation of GTPase activity  (IDA)
negative regulation of muscle cell apoptotic process  (IDA)
negative regulation of potassium ion transport  (IDA)
neuron projection development  (IBA,IDA,ISO)
neuropeptide signaling pathway  (IBA,IDA,ISO,NAS)
ovarian follicle development  (IDA)
pituitary gland development  (IEP)
positive regulation of cAMP/PKA signal transduction  (IDA)
positive regulation of cell population proliferation  (IDA)
positive regulation of chemokine (C-C motif) ligand 5 production  (ISO)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of ERK1 and ERK2 cascade  (IBA,IDA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of growth hormone secretion  (IDA)
positive regulation of GTPase activity  (IDA,ISO)
positive regulation of interleukin-6 production  (IDA)
positive regulation of neuron projection development  (IDA,IGI)
positive regulation of protein kinase activity  (IDA,ISO)
positive regulation of somatostatin secretion  (IDA)
positive regulation of synaptic transmission, glutamatergic  (IDA)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
regulation of G protein-coupled receptor signaling pathway  (ISO,ISS)
regulation of oligodendrocyte progenitor proliferation  (IDA)
regulation of postsynaptic membrane potential  (IDA)
regulation of protein localization  (IBA,IDA,IEA,ISO)
regulation of protein phosphorylation  (IGI)
response to ethanol  (IEP)
response to starvation  (IEP)
vasodilation  (IDA)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Pituitary adenylate-cyclase-activating polypeptide expression in the immune system. Abad C, etal., Neuroimmunomodulation 2002-2003;10(3):177-86.
2. Identification of PAC1 receptor isoform mRNAs by real-time PCR in rat suprachiasmatic nucleus. Ajpru S, etal., Brain Res Mol Brain Res 2002 Sep 30;105(1-2):29-37.
3. Tachyphylaxis of the ECL-cell response to PACAP: receptor desensitization and/or depletion of secretory products. Bernsand M, etal., Br J Pharmacol. 2007 Sep;152(2):240-8. Epub 2007 Jul 30.
4. The in vivo effect of VIP, PACAP-38 and PACAP-27 and mRNA expression of their receptors in rat middle meningeal artery. Boni LJ, etal., Cephalalgia. 2009 Aug;29(8):837-47. Epub 2009 Feb 12.
5. Pituitary adenylate cyclase-activating polypeptide prevents cell death in the spinal cord with traumatic injury. Chen WH and Tzeng SF, Neurosci Lett. 2005 Aug 12-19;384(1-2):117-21.
6. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Chen YD, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 Jan;36(1):64-8.
7. Modulation of AMPA receptor-mediated ion current by pituitary adenylate cyclase-activating polypeptide (PACAP) in CA1 pyramidal neurons from rat hippocampus. Costa L, etal., Hippocampus. 2009 Jan;19(1):99-109.
8. Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells. Emery AC, etal., Sci Signal. 2013 Jun 25;6(281):ra51. doi: 10.1126/scisignal.2003993.
9. PACAP inhibits oxidative stress-induced activation of MAP kinase-dependent apoptotic pathway in cultured cardiomyocytes. Gasz B, etal., Ann N Y Acad Sci. 2006 Jul;1070:293-7.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. PACAP-mediated ATP release from rat urothelium and regulation of PACAP/VIP and receptor mRNA in micturition pathways after cyclophosphamide (CYP)-induced cystitis. Girard BM, etal., J Mol Neurosci. 2008 Nov;36(1-3):310-20. Epub 2008 Jun 19.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Temperature-sensitive phenotype in mice lacking pituitary adenylate cyclase-activating polypeptide. Gray SL, etal., Endocrinology. 2002 Oct;143(10):3946-54. doi: 10.1210/en.2002-220401.
14. Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion. Grumolato L, etal., FASEB J. 2008 Jun;22(6):1756-68. Epub 2008 Jan 15.
15. Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP). Hashimoto H, etal., Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13355-60. Epub 2001 Oct 30.
16. PACAP is transiently expressed in anterior pituitary gland of rats: in situ hybridization and cell immunoblot assay studies. Heinzlmann A, etal., Peptides. 2008 Apr;29(4):571-7. Epub 2008 Feb 19.
17. Inhibitory effect of PACAP-38 on acute neurogenic and non-neurogenic inflammatory processes in the rat. Helyes Z, etal., Peptides. 2007 Sep;28(9):1847-55. Epub 2007 Jul 7.
18. Effects of PACAP on Mitochondrial Apoptotic Pathways and Cytokine Expression in Rats Subjected to Renal Ischemia/Reperfusion. Horvath G, etal., J Mol Neurosci. 2010 Mar 16.
19. Short-term fasting differentially alters PACAP and VIP levels in the brains of rat and chicken. Jozsa R, etal., Ann N Y Acad Sci. 2006 Jul;1070:354-8.
20. Effects of PACAP, VIP and related peptides on cyclic AMP formation in rat neuronal and astrocyte cultures and cerebral cortical slices. Jozwiak-Bebenista M, etal., Pharmacol Rep. 2007 Jul-Aug;59(4):414-20.
21. Regulation of pituitary adenylate cyclase-activating polypeptide gene transcription by TTF-1, a homeodomain-containing transcription factor. Kim MS, etal., J Biol Chem 2002 Sep 27;277(39):36863-71.
22. Ethanol decreases the expression of pituitary adenylate cyclase activating polypeptide in rat testes. Koh PO, etal., J Vet Med Sci. 2006 Jun;68(6):635-7.
23. Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. Kovanen L, etal., Alcohol Alcohol. 2010 Jul-Aug;45(4):303-11. doi: 10.1093/alcalc/agq035. Epub 2010 Jun 16.
24. Inhibitory effect of pituitary adenylate cyclase activating polypeptide on the initial stages of rat follicle development. Latini S, etal., Mol Cell Endocrinol. 2010 May 14;320(1-2):34-44. Epub 2010 Feb 6.
25. Microinfusion of pituitary adenylate cyclase-activating polypeptide into the central nucleus of amygdala of the rat produces a shift from an active to passive mode of coping in the shock-probe fear/defensive burying test. Legradi G, etal., Neural Plast. 2007;2007:79102.
26. Pituitary adenylate cyclase-activating polypeptide-nerve terminals densely innervate corticotropin-releasing hormone-neurons in the hypothalamic paraventricular nucleus of the rat. Legradi G, etal., Neurosci Lett. 1998 May 1;246(3):145-8.
27. Growth factor-dependent actions of PACAP on oligodendrocyte progenitor proliferation. Lelievre V, etal., Regul Pept. 2006 Nov 15;137(1-2):58-66. Epub 2006 Sep 20.
28. Pituitary adenylyl cyclase-activating polypeptide 38 reduces astroglial proliferation by inhibiting the GTPase RhoA. Meyer DK, etal., J Biol Chem. 2005 Jul 1;280(26):25258-66. Epub 2005 May 3.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. Expression of pituitary adenylate cyclase-activating polypeptide and PACAP type 1 receptor in the rat gastric and colonic myenteric neurons. Miampamba M, etal., Regul Pept 2002 May 30;105(3):145-54.
31. Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus. Michel S, etal., BMC Neurosci. 2006 Feb 16;7:15.
32. Weaning and the developmental changes in follicle-stimulating hormone, pituitary adenylate cyclase-activating polypeptide, and inhibin B in the male rat. Moore JP Jr and Winters SJ, Biol Reprod. 2008 Apr;78(4):752-60. Epub 2007 Dec 26.
33. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. Structural characterization of PACAP receptors on rat liver plasma membranes. Nguyen TD, etal., Am J Physiol. 1993 Nov;265(5 Pt 1):G811-8.
35. Pituitary adenylate cyclase-activating polypeptide and sonic hedgehog interact to control cerebellar granule precursor cell proliferation. Nicot A, etal., J Neurosci 2002 Nov 1;22(21):9244-54.
36. PACAP regulation of secretion and proliferation of pure populations of gastric ECL cells. Oh DS, etal., J Mol Neurosci. 2005;26(1):85-97.
37. Comparative study of the effects of PACAP in young, aging, and castrated males in a rat model of Parkinson's disease. Reglodi D, etal., Ann N Y Acad Sci. 2006 Jul;1070:518-24.
38. GOA pipeline RGD automated data pipeline
39. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
40. Differential regulation of CXCL12 and PACAP mRNA expression after focal and global ischemia. Riek-Burchardt M, etal., Neuropharmacology. 2010 Jan;58(1):199-207. Epub 2009 Jul 30.
41. Divergent peripheral effects of pituitary adenylate cyclase-activating polypeptide-38 on nociception in rats and mice. Sandor K, etal., Pain. 2009 Jan;141(1-2):143-50. Epub 2008 Dec 16.
42. PACAP stimulates the release of interleukin-6 in cultured rat Muller cells. Seki T, etal., Ann N Y Acad Sci. 2006 Jul;1070:535-9.
43. Electrical stimulation and testosterone differentially enhance expression of regeneration-associated genes. Sharma N, etal., Exp Neurol. 2010 May;223(1):183-91. Epub 2009 May 7.
44. Pituitary adenylate cyclase-activating polypeptide 38-mediated Rin activation requires Src and contributes to the regulation of HSP27 signaling during neuronal differentiation. Shi GX, etal., Mol Cell Biol. 2008 Aug;28(16):4940-51. Epub 2008 Jun 9.
45. The augmentation of pituitary adenylate cyclase-activating polypeptide (PACAP) in streptozotocin-induced diabetic rats. Tamakawa H, etal., Peptides. 1998;19(9):1497-502.
46. Postinjury administration of pituitary adenylate cyclase activating polypeptide (PACAP) attenuates traumatically induced axonal injury in rats. Tamas A, etal., J Neurotrauma. 2006 May;23(5):686-95.
47. Overexpression of pituitary adenylate cyclase-activating polypeptide in islets inhibits hyperinsulinemia and islet hyperplasia in agouti yellow mice. Tomimoto S, etal., J Pharmacol Exp Ther. 2004 May;309(2):796-803. Epub 2004 Jan 23.
48. Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates the oxygen sensing type I (glomus) cells of rat carotid bodies via reduction of a background TASK-like K+ current. Xu F, etal., J Neurochem. 2007 Jun;101(5):1284-93.
49. VIP induces the translocation and degradation of the alpha subunit of Gs protein in rat pituitary GH4C1 cells. Yajima Y, etal., J Biochem. 1998 Jun;123(6):1024-30.
50. Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1. Yaka R, etal., J Biol Chem 2003 Mar 14;278(11):9630-8.
51. Changes of dopamine content and cell proliferation by dexamethsone via pituitary adenylate cyclase-activating polypeptide in PC12 cell. Yang TT, etal., Neurosci Lett. 2007 Oct 9;426(1):45-8. Epub 2007 Aug 24.
52. Changes in pituitary adenylate cyclase activating polypeptide expression in urinary bladder pathways after spinal cord injury. Zvarova K, etal., Exp Neurol. 2005 Mar;192(1):46-59.
Additional References at PubMed
PMID:2268329   PMID:2803320   PMID:7680413   PMID:7835287   PMID:10698199   PMID:11175907   PMID:11784714   PMID:11972030   PMID:12031689   PMID:12060780   PMID:12409216   PMID:12409218  
PMID:12409220   PMID:12409221   PMID:12438166   PMID:12438169   PMID:12473665   PMID:12646491   PMID:12761277   PMID:12867270   PMID:12932850   PMID:14593074   PMID:14983478   PMID:15093701  
PMID:15176082   PMID:15181370   PMID:15355970   PMID:15380005   PMID:15641142   PMID:15721490   PMID:15917345   PMID:15935492   PMID:15976009   PMID:16004991   PMID:16095757   PMID:16181705  
PMID:16407775   PMID:16427158   PMID:16626868   PMID:16687279   PMID:16806497   PMID:16876955   PMID:16888155   PMID:16888157   PMID:16888211   PMID:16888234   PMID:16905223   PMID:17026529  
PMID:17154257   PMID:17181550   PMID:17213203   PMID:17286974   PMID:17464199   PMID:17470806   PMID:17680996   PMID:18001699   PMID:18272663   PMID:18313848   PMID:18331476   PMID:18353507  
PMID:18626793   PMID:18707003   PMID:18717811   PMID:18835258   PMID:18959742   PMID:18983912   PMID:19181454   PMID:19342443   PMID:19346254   PMID:19474768   PMID:19574403   PMID:20339872  
PMID:20422475   PMID:20559421   PMID:20569302   PMID:20646049   PMID:20974701   PMID:21038678   PMID:21291921   PMID:21620115   PMID:21674129   PMID:21919910   PMID:21975601   PMID:22001490  
PMID:22108610   PMID:22245521   PMID:22328515   PMID:22418790   PMID:22454142   PMID:22944728   PMID:23080176   PMID:23099490   PMID:23564451   PMID:23594614   PMID:23690336   PMID:23798575  
PMID:23801193   PMID:23913443   PMID:24696163   PMID:24823390   PMID:24928446   PMID:24968020   PMID:24998751   PMID:25490058   PMID:25712659   PMID:25964356   PMID:26880766   PMID:27181029  
PMID:27383213   PMID:28057459   PMID:28106040   PMID:28125843   PMID:28751044   PMID:28776455   PMID:28902127   PMID:30359769   PMID:30513524   PMID:30579677   PMID:32186931   PMID:32439415  
PMID:33191400   PMID:34639032   PMID:35460713   PMID:36604785   PMID:36801394   PMID:36842389   PMID:37511603   PMID:37646964   PMID:37775045   PMID:37880634  


Genomics

Comparative Map Data
Adcyap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89120,550,236 - 120,569,096 (-)NCBIGRCr8
mRatBN7.29113,102,632 - 113,122,500 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9113,103,718 - 113,109,773 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9121,581,877 - 121,587,073 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09126,711,026 - 126,716,222 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09125,056,936 - 125,062,132 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09121,705,897 - 121,725,736 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9121,706,979 - 121,725,716 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09121,155,213 - 121,175,023 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera9110,207,950 - 110,213,150 (-)NCBICelera
Cytogenetic Map9q38NCBI
ADCYAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3818904,411 - 912,172 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl18904,871 - 912,172 (+)EnsemblGRCh38hg38GRCh38
GRCh3718904,872 - 912,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3618894,944 - 902,173 (+)NCBINCBI36Build 36hg18NCBI36
Build 3418895,386 - 901,050NCBI
Celera18779,552 - 786,777 (+)NCBICelera
Cytogenetic Map18p11.32NCBI
HuRef18865,131 - 872,354 (+)NCBIHuRef
CHM1_118904,574 - 911,803 (+)NCBICHM1_1
T2T-CHM13v2.0181,058,628 - 1,066,467 (+)NCBIT2T-CHM13v2.0
Adcyap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391793,506,448 - 93,513,967 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1793,506,445 - 93,513,965 (+)EnsemblGRCm39 Ensembl
GRCm381793,198,245 - 93,206,541 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1793,199,017 - 93,206,537 (+)EnsemblGRCm38mm10GRCm38
MGSCv371793,598,762 - 93,604,831 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361793,503,713 - 93,509,782 (+)NCBIMGSCv36mm8
Celera1797,603,693 - 97,609,773 (+)NCBICelera
Cytogenetic Map17E5NCBI
cM Map1760.67NCBI
Adcyap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554029,091,725 - 9,099,803 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554029,091,927 - 9,099,803 (-)NCBIChiLan1.0ChiLan1.0
ADCYAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21737,590,265 - 37,598,057 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11823,283,967 - 23,290,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01813,414,618 - 13,421,668 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11815,712,078 - 15,718,693 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1815,713,479 - 15,717,749 (-)Ensemblpanpan1.1panPan2
ADCYAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1767,682,421 - 67,691,035 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha767,135,853 - 67,143,650 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0767,748,641 - 67,756,430 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl767,749,208 - 67,822,788 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1767,424,965 - 67,432,752 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0767,436,457 - 67,444,234 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0767,738,672 - 67,746,464 (+)NCBIUU_Cfam_GSD_1.0
Adcyap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494464,074,352 - 64,081,544 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366723,460,383 - 3,468,255 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366723,461,387 - 3,468,053 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCYAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6105,414,631 - 105,422,294 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16105,414,628 - 105,422,294 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2698,531,534 - 98,539,159 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADCYAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11860,259,479 - 60,267,302 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605035,058,453 - 35,066,176 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adcyap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477011,358,286 - 11,375,813 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477011,359,606 - 11,375,833 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adcyap1
16 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:161
Count of miRNA genes:121
Interacting mature miRNAs:140
Transcripts:ENSRNOT00000073432
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat

Markers in Region
RH143645  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29113,106,880 - 113,106,983 (+)MAPPERmRatBN7.2
Rnor_6.09121,710,142 - 121,710,244NCBIRnor6.0
Rnor_5.09121,159,458 - 121,159,560UniSTSRnor5.0
Celera9110,210,168 - 110,210,270UniSTS
RH 3.4 Map9857.8UniSTS
Cytogenetic Map9q37UniSTS
RH139550  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29113,105,011 - 113,105,231 (+)MAPPERmRatBN7.2
Rnor_6.09121,708,273 - 121,708,492NCBIRnor6.0
Rnor_5.09121,157,589 - 121,157,808UniSTSRnor5.0
Celera9110,208,299 - 110,208,518UniSTS
RH 3.4 Map9859.7UniSTS
Cytogenetic Map9q37UniSTS
BE118210  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29113,103,442 - 113,103,592 (+)MAPPERmRatBN7.2
Rnor_6.09121,706,704 - 121,706,853NCBIRnor6.0
Rnor_5.09121,156,020 - 121,156,169UniSTSRnor5.0
Celera9110,206,730 - 110,206,879UniSTS
RH 3.4 Map9858.9UniSTS
Cytogenetic Map9q37UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 5 30 111 61 58 32 24 32 6 156 73 93 38 58 26

Sequence


Ensembl Acc Id: ENSRNOT00000073432   ⟹   ENSRNOP00000063920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9113,103,718 - 113,109,773 (-)Ensembl
Rnor_6.0 Ensembl9121,706,979 - 121,713,091 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087405   ⟹   ENSRNOP00000070007
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl9121,707,482 - 121,725,716 (-)Ensembl
RefSeq Acc Id: NM_016989   ⟹   NP_058685
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89120,551,273 - 120,556,473 (-)NCBI
mRatBN7.29113,104,663 - 113,109,863 (-)NCBI
Rnor_6.09121,707,924 - 121,713,124 (-)NCBI
Rnor_5.09121,155,213 - 121,175,023 (-)NCBI
Celera9110,207,950 - 110,213,150 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245672   ⟹   XP_006245734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89120,550,236 - 120,569,095 (-)NCBI
mRatBN7.29113,102,632 - 113,122,497 (-)NCBI
Rnor_6.09121,705,897 - 121,725,735 (-)NCBI
Rnor_5.09121,155,213 - 121,175,023 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245673   ⟹   XP_006245735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89120,550,236 - 120,562,004 (-)NCBI
mRatBN7.29113,102,632 - 113,111,377 (-)NCBI
Rnor_6.09121,705,897 - 121,714,431 (-)NCBI
Rnor_5.09121,155,213 - 121,175,023 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245674   ⟹   XP_006245736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89120,550,236 - 120,562,008 (-)NCBI
mRatBN7.29113,102,632 - 113,111,402 (-)NCBI
Rnor_6.09121,705,897 - 121,714,432 (-)NCBI
Rnor_5.09121,155,213 - 121,175,023 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767418   ⟹   XP_008765640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89120,550,236 - 120,569,096 (-)NCBI
mRatBN7.29113,102,632 - 113,122,500 (-)NCBI
Rnor_6.09121,705,897 - 121,725,736 (-)NCBI
Sequence:
RefSeq Acc Id: NP_058685   ⟸   NM_016989
- Peptide Label: precursor
- UniProtKB: P13589 (UniProtKB/Swiss-Prot),   A6KFB2 (UniProtKB/TrEMBL),   A0A0H2UI25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245734   ⟸   XM_006245672
- Peptide Label: isoform X1
- UniProtKB: P13589 (UniProtKB/Swiss-Prot),   A6KFB2 (UniProtKB/TrEMBL),   A0A0H2UI25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245736   ⟸   XM_006245674
- Peptide Label: isoform X1
- UniProtKB: P13589 (UniProtKB/Swiss-Prot),   A6KFB2 (UniProtKB/TrEMBL),   A0A0H2UI25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245735   ⟸   XM_006245673
- Peptide Label: isoform X1
- UniProtKB: P13589 (UniProtKB/Swiss-Prot),   A6KFB2 (UniProtKB/TrEMBL),   A0A0H2UI25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765640   ⟸   XM_008767418
- Peptide Label: isoform X1
- UniProtKB: P13589 (UniProtKB/Swiss-Prot),   A6KFB2 (UniProtKB/TrEMBL),   A0A0H2UI25 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063920   ⟸   ENSRNOT00000073432
Ensembl Acc Id: ENSRNOP00000070007   ⟸   ENSRNOT00000087405
Protein Domains
Glucagon / GIP / secretin / VIP family

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13589-F1-model_v2 AlphaFold P13589 1-175 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696916
Promoter ID:EPDNEW_R7441
Type:initiation region
Name:Adcyap1_1
Description:adenylate cyclase activating polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.09121,725,700 - 121,725,760EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2037 AgrOrtholog
BioCyc Gene G2FUF-26307 BioCyc
Ensembl Genes ENSRNOG00000049882 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055007690 UniProtKB/Swiss-Prot
  ENSRNOG00060004749 UniProtKB/Swiss-Prot
  ENSRNOG00065009286 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073432 UniProtKB/TrEMBL
  ENSRNOT00000073432.3 UniProtKB/Swiss-Prot
  ENSRNOT00055012866 UniProtKB/Swiss-Prot
  ENSRNOT00060007935 UniProtKB/Swiss-Prot
  ENSRNOT00065014840 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.250.590 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Glucagon_GIP_secretin_VIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VIP/GHRH-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24166 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24166 ENTREZGENE
PANTHER PTHR11213 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11213:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adcyap1 PhenoGen
PRINTS GLUCAGON UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLUCAGON UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049882 RatGTEx
  ENSRNOG00055007690 RatGTEx
  ENSRNOG00060004749 RatGTEx
  ENSRNOG00065009286 RatGTEx
SMART GLUCA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UI25 ENTREZGENE, UniProtKB/TrEMBL
  A6KFB2 ENTREZGENE, UniProtKB/TrEMBL
  P13589 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Adcyap1  adenylate cyclase activating polypeptide 1  Adcyap1  adenylate cyclase activating polypeptide 1 (pituitary)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Adcyap1  adenylate cyclase activating polypeptide 1 (pituitary)  Adcyap1  adenylate cyclase activating polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-28 Adcyap1  adenylate cyclase activating polypeptide 1  Adcyap1  adenylate cyclase activating polypeptide 1 (pituitary)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Adcyap1  adenylate cyclase activating polypeptide 1 (pituitary)  Adcyap1  adenylate cyclase activating polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Adcyap1  adenylate cyclase activating polypeptide 1      Symbol and Name status set to approved 70586 APPROVED
2001-06-18 Adcyap1  Rat pituitary adenylate cyclase activating polypeptide 1      Name withdrawn 67952 WITHDRAWN
2001-06-18 Adcyap1  adenylate cyclase activating enzyme polypeptide 1      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization colocalizes with glutamate within the retinohypothalmic tract (RHT) 734509
gene_expression expressed in the hypothalamus 631803
gene_expression expressed in neurons in the gastrointestinal tract 631752
gene_function prevents Shh mitogenic action and can block Shh-induced proliferation  
gene_pathway involved in the glutamate-mediated light entrainment pathway 734509
gene_process may play a role in neuropeptide signaling 631801
gene_process may regulate circadian rhythm 631802
gene_process may regulate gastric acid secretion and intestinal motility 631752
gene_process regulates the daytime biological clock by a PACAP-cAMP-dependent mechanism 734507
gene_process regulates the daytime biological clock by a PACAP-cAMP-dependent mechanism 734508
gene_process regulates the daytime biological clock by a PACAP-cAMP-dependent mechanism 734509
gene_process blocks the circadian rhythm of neuronal firing in the slices of rat suprachiasmatic nucleus of the hypothalamus which is induced by glutamate during late night 734509
gene_process activates Pac1 receptor and the cAMP-signaling cascade 734509
gene_process involved in cerebellar neurogenesis 628387
gene_process regulates prenatal and postnatal granule cell production 628387
gene_process prevents Shh mitogenic action and can block Shh-induced proliferation 628387
gene_process regulates proliferation by the action of the polypeptide on GNPs 628387
gene_product member of the vasoactive intestinal peptide/secretin/glucagon family which exists in two forms and stimulates the adenylate cyclase 734508
gene_product member of the peptide family that includes secretin, glucagon, growth hormone-releasing factors amd vasoactive intestinal peptide 628387