Adcyap1 (adenylate cyclase activating polypeptide 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Adcyap1 (adenylate cyclase activating polypeptide 1) Rattus norvegicus
Analyze
Symbol: Adcyap1
Name: adenylate cyclase activating polypeptide 1
RGD ID: 2037
Description: Exhibits neuropeptide hormone activity; pituitary adenylate cyclase activating polypeptide activity; and pituitary adenylate cyclase-activating polypeptide receptor binding activity. Involved in several processes, including negative regulation of acute inflammatory response; positive regulation of cell communication; and regulation of GTPase activity. Localizes to extracellular space and terminal bouton. Biomarker of cystitis. Orthologous to human ADCYAP1 (adenylate cyclase activating polypeptide 1); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; alendronic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: adenylate cyclase activating polypeptide 1 (pituitary); Pacap; pituitary adenylate cyclase activating polypeptide 1; pituitary adenylate cyclase-activating polypeptide; pituitary adenylate cyclase-activating polypeptide precursor (Pacap); rat pituitary adenylate cyclase activating polypeptide 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.29113,102,632 - 113,122,500 (-)NCBI
Rnor_6.0 Ensembl9121,706,979 - 121,725,716 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.09121,705,897 - 121,725,736 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.09121,155,213 - 121,175,023 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera9110,207,950 - 110,213,150 (-)NCBICelera
Cytogenetic Map9q38NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
3',5'-cyclic AMP  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alendronic acid  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
ATP  (EXP)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
cadmium dichloride  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carmustine  (ISO)
chlorpyrifos  (EXP)
clofibrate  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
diepoxybutane  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
famotidine  (ISO)
folic acid  (ISO)
furan  (EXP)
Galanin  (EXP)
histamine  (EXP)
hydrazine  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
methotrexate  (ISO)
misoprostol  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel dichloride  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
prostaglandin E2  (EXP)
pyridaben  (ISO)
raloxifene  (EXP)
rolipram  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
Testosterone propionate  (EXP)
titanium dioxide  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA,IDA,ISO)
ATP metabolic process  (IDA)
behavioral fear response  (IDA)
cAMP-mediated signaling  (IMP,ISO)
cellular response to glucocorticoid stimulus  (IEP)
G protein-coupled receptor signaling pathway  (IEA)
histamine secretion  (IDA)
insulin secretion  (IEA,ISO,ISS)
negative regulation of acute inflammatory response to antigenic stimulus  (IDA)
negative regulation of acute inflammatory response to non-antigenic stimulus  (IDA)
negative regulation of cell cycle  (ISO)
negative regulation of glial cell proliferation  (IDA)
negative regulation of GTPase activity  (IDA)
negative regulation of muscle cell apoptotic process  (IDA)
negative regulation of potassium ion transport  (IDA)
neuron projection development  (IBA,IDA,ISO)
neuropeptide signaling pathway  (IBA,IDA,ISO,NAS)
ovarian follicle development  (IDA)
pituitary gland development  (IEP)
positive regulation of cAMP-mediated signaling  (IDA)
positive regulation of cell population proliferation  (IDA)
positive regulation of chemokine (C-C motif) ligand 5 production  (ISO)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of ERK1 and ERK2 cascade  (IBA,IDA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of growth hormone secretion  (IDA)
positive regulation of GTPase activity  (IBA,IDA,ISO)
positive regulation of interleukin-6 production  (IDA)
positive regulation of neuron projection development  (IDA,IGI)
positive regulation of protein kinase activity  (IBA,IDA,ISO)
positive regulation of somatostatin secretion  (IDA)
positive regulation of synaptic transmission, glutamatergic  (IDA)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,ISO)
regulation of G protein-coupled receptor signaling pathway  (ISO,ISS)
regulation of oligodendrocyte progenitor proliferation  (IDA)
regulation of postsynaptic membrane potential  (IDA)
regulation of protein localization  (IBA,IDA,ISO)
regulation of protein phosphorylation  (IGI)
response to ethanol  (IEP)
response to starvation  (IEP)
sensory perception of pain  (IDA)
vasodilation  (IDA)

Cellular Component

References

References - curated
1. Abad C, etal., Neuroimmunomodulation 2002-2003;10(3):177-86.
2. Ajpru S, etal., Brain Res Mol Brain Res 2002 Sep 30;105(1-2):29-37.
3. Bernsand M, etal., Br J Pharmacol. 2007 Sep;152(2):240-8. Epub 2007 Jul 30.
4. Boni LJ, etal., Cephalalgia. 2009 Aug;29(8):837-47. Epub 2009 Feb 12.
5. Chen WH and Tzeng SF, Neurosci Lett. 2005 Aug 12-19;384(1-2):117-21.
6. Chen YD, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 Jan;36(1):64-8.
7. Costa L, etal., Hippocampus. 2009 Jan;19(1):99-109.
8. Emery AC, etal., Sci Signal. 2013 Jun 25;6(281):ra51. doi: 10.1126/scisignal.2003993.
9. Gasz B, etal., Ann N Y Acad Sci. 2006 Jul;1070:293-7.
10. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Girard BM, etal., J Mol Neurosci. 2008 Nov;36(1-3):310-20. Epub 2008 Jun 19.
12. GOA data from the GO Consortium
13. Gray SL, etal., Endocrinology. 2002 Oct;143(10):3946-54. doi: 10.1210/en.2002-220401.
14. Grumolato L, etal., FASEB J. 2008 Jun;22(6):1756-68. Epub 2008 Jan 15.
15. Hashimoto H, etal., Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13355-60. Epub 2001 Oct 30.
16. Heinzlmann A, etal., Peptides. 2008 Apr;29(4):571-7. Epub 2008 Feb 19.
17. Helyes Z, etal., Peptides. 2007 Sep;28(9):1847-55. Epub 2007 Jul 7.
18. Horvath G, etal., J Mol Neurosci. 2010 Mar 16.
19. Jozsa R, etal., Ann N Y Acad Sci. 2006 Jul;1070:354-8.
20. Jozwiak-Bebenista M, etal., Pharmacol Rep. 2007 Jul-Aug;59(4):414-20.
21. Kim MS, etal., J Biol Chem 2002 Sep 27;277(39):36863-71.
22. Koh PO, etal., J Vet Med Sci. 2006 Jun;68(6):635-7.
23. Latini S, etal., Mol Cell Endocrinol. 2010 May 14;320(1-2):34-44. Epub 2010 Feb 6.
24. Legradi G, etal., Neural Plast. 2007;2007:79102.
25. Legradi G, etal., Neurosci Lett. 1998 May 1;246(3):145-8.
26. Lelievre V, etal., Regul Pept. 2006 Nov 15;137(1-2):58-66. Epub 2006 Sep 20.
27. Meyer DK, etal., J Biol Chem. 2005 Jul 1;280(26):25258-66. Epub 2005 May 3.
28. MGD data from the GO Consortium
29. Miampamba M, etal., Regul Pept 2002 May 30;105(3):145-54.
30. Michel S, etal., BMC Neurosci. 2006 Feb 16;7:15.
31. Moore JP Jr and Winters SJ, Biol Reprod. 2008 Apr;78(4):752-60. Epub 2007 Dec 26.
32. NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. Nguyen TD, etal., Am J Physiol. 1993 Nov;265(5 Pt 1):G811-8.
34. Nicot A, etal., J Neurosci 2002 Nov 1;22(21):9244-54.
35. Oh DS, etal., J Mol Neurosci. 2005;26(1):85-97.
36. Reglodi D, etal., Ann N Y Acad Sci. 2006 Jul;1070:518-24.
37. RGD automated data pipeline
38. RGD automated import pipeline for gene-chemical interactions
39. Riek-Burchardt M, etal., Neuropharmacology. 2010 Jan;58(1):199-207. Epub 2009 Jul 30.
40. Sandor K, etal., Pain. 2009 Jan;141(1-2):143-50. Epub 2008 Dec 16.
41. Seki T, etal., Ann N Y Acad Sci. 2006 Jul;1070:535-9.
42. Sharma N, etal., Exp Neurol. 2010 May;223(1):183-91. Epub 2009 May 7.
43. Shi GX, etal., Mol Cell Biol. 2008 Aug;28(16):4940-51. Epub 2008 Jun 9.
44. Tamakawa H, etal., Peptides. 1998;19(9):1497-502.
45. Tamas A, etal., J Neurotrauma. 2006 May;23(5):686-95.
46. Tomimoto S, etal., J Pharmacol Exp Ther. 2004 May;309(2):796-803. Epub 2004 Jan 23.
47. Xu F, etal., J Neurochem. 2007 Jun;101(5):1284-93.
48. Yajima Y, etal., J Biochem. 1998 Jun;123(6):1024-30.
49. Yaka R, etal., J Biol Chem 2003 Mar 14;278(11):9630-8.
50. Yang TT, etal., Neurosci Lett. 2007 Oct 9;426(1):45-8. Epub 2007 Aug 24.
51. Zvarova K, etal., Exp Neurol. 2005 Mar;192(1):46-59.
Additional References at PubMed
PMID:2268329   PMID:2803320   PMID:7680413   PMID:7835287   PMID:10698199   PMID:11175907   PMID:11784714   PMID:11972030   PMID:12031689   PMID:12060780   PMID:12409216   PMID:12409218  
PMID:12409220   PMID:12409221   PMID:12438166   PMID:12438169   PMID:12473665   PMID:12646491   PMID:12761277   PMID:12867270   PMID:12932850   PMID:14593074   PMID:14983478   PMID:15093701  
PMID:15176082   PMID:15181370   PMID:15355970   PMID:15380005   PMID:15641142   PMID:15721490   PMID:15917345   PMID:15935492   PMID:15976009   PMID:16004991   PMID:16095757   PMID:16181705  
PMID:16407775   PMID:16427158   PMID:16626868   PMID:16687279   PMID:16806497   PMID:16876955   PMID:16888155   PMID:16888157   PMID:16888211   PMID:16888234   PMID:16905223   PMID:17026529  
PMID:17154257   PMID:17181550   PMID:17213203   PMID:17286974   PMID:17464199   PMID:17470806   PMID:17680996   PMID:18001699   PMID:18272663   PMID:18313848   PMID:18331476   PMID:18353507  
PMID:18626793   PMID:18707003   PMID:18717811   PMID:18835258   PMID:18959742   PMID:18983912   PMID:19181454   PMID:19342443   PMID:19346254   PMID:19474768   PMID:19574403   PMID:20339872  
PMID:20422475   PMID:20559421   PMID:20569302   PMID:20646049   PMID:20974701   PMID:21038678   PMID:21291921   PMID:21620115   PMID:21674129   PMID:21919910   PMID:21975601   PMID:22001490  
PMID:22108610   PMID:22245521   PMID:22328515   PMID:22418790   PMID:22454142   PMID:22944728   PMID:23080176   PMID:23099490   PMID:23564451   PMID:23594614   PMID:23690336   PMID:23798575  
PMID:23801193   PMID:23913443   PMID:24696163   PMID:24823390   PMID:24928446   PMID:24968020   PMID:24998751   PMID:25490058   PMID:25712659   PMID:25964356   PMID:26880766   PMID:27181029  
PMID:27383213   PMID:28057459   PMID:28106040   PMID:28125843   PMID:28751044   PMID:28776455   PMID:28902127   PMID:30359769   PMID:30513524   PMID:30579677   PMID:32186931  


Genomics

Comparative Map Data
Adcyap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.29113,102,632 - 113,122,500 (-)NCBI
Rnor_6.0 Ensembl9121,706,979 - 121,725,716 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.09121,705,897 - 121,725,736 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.09121,155,213 - 121,175,023 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera9110,207,950 - 110,213,150 (-)NCBICelera
Cytogenetic Map9q38NCBI
ADCYAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl18904,871 - 912,172 (+)EnsemblGRCh38hg38GRCh38
GRCh3818904,384 - 912,172 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3718904,872 - 912,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3618894,944 - 902,173 (+)NCBINCBI36hg18NCBI36
Build 3418895,386 - 901,050NCBI
Celera18779,552 - 786,777 (+)NCBI
Cytogenetic Map18p11.32NCBI
HuRef18865,131 - 872,354 (+)NCBIHuRef
CHM1_118904,574 - 911,803 (+)NCBICHM1_1
Adcyap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391793,505,673 - 93,513,969 (+)NCBIGRCm39mm39
GRCm39 Ensembl1793,506,445 - 93,513,965 (+)Ensembl
GRCm381793,198,245 - 93,206,541 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1793,199,017 - 93,206,537 (+)EnsemblGRCm38mm10GRCm38
MGSCv371793,598,762 - 93,604,831 (+)NCBIGRCm37mm9NCBIm37
MGSCv361793,503,713 - 93,509,782 (+)NCBImm8
Celera1797,603,693 - 97,609,773 (+)NCBICelera
Cytogenetic Map17E5NCBI
Adcyap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554029,091,725 - 9,099,803 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554029,091,927 - 9,099,803 (-)NCBIChiLan1.0ChiLan1.0
ADCYAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11815,712,078 - 15,718,693 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1815,713,479 - 15,717,749 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01813,414,618 - 13,421,668 (-)NCBIMhudiblu_PPA_v0panPan3
ADCYAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1767,682,421 - 67,691,035 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha767,135,853 - 67,143,650 (+)NCBI
ROS_Cfam_1.0767,748,641 - 67,756,430 (+)NCBI
UMICH_Zoey_3.1767,424,965 - 67,432,752 (+)NCBI
UNSW_CanFamBas_1.0767,436,457 - 67,444,234 (+)NCBI
UU_Cfam_GSD_1.0767,738,672 - 67,746,464 (+)NCBI
Adcyap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494464,074,352 - 64,081,544 (+)NCBI
SpeTri2.0NW_0049366723,461,387 - 3,468,053 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCYAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6105,414,630 - 105,422,295 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16105,414,628 - 105,422,294 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2698,531,534 - 98,539,159 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADCYAP1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11860,259,479 - 60,267,302 (+)NCBI
Adcyap1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477011,359,606 - 11,375,833 (+)NCBI

Position Markers
RH143645  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29113,106,880 - 113,106,983 (+)MAPPER
Rnor_6.09121,710,142 - 121,710,244NCBIRnor6.0
Rnor_5.09121,159,458 - 121,159,560UniSTSRnor5.0
Celera9110,210,168 - 110,210,270UniSTS
RH 3.4 Map9857.8UniSTS
Cytogenetic Map9q37UniSTS
RH139550  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29113,105,011 - 113,105,231 (+)MAPPER
Rnor_6.09121,708,273 - 121,708,492NCBIRnor6.0
Rnor_5.09121,157,589 - 121,157,808UniSTSRnor5.0
Celera9110,208,299 - 110,208,518UniSTS
RH 3.4 Map9859.7UniSTS
Cytogenetic Map9q37UniSTS
BE118210  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29113,103,442 - 113,103,592 (+)MAPPER
Rnor_6.09121,706,704 - 121,706,853NCBIRnor6.0
Rnor_5.09121,156,020 - 121,156,169UniSTSRnor5.0
Celera9110,206,730 - 110,206,879UniSTS
RH 3.4 Map9858.9UniSTS
Cytogenetic Map9q37UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)929075079122095297Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:161
Count of miRNA genes:121
Interacting mature miRNAs:140
Transcripts:ENSRNOT00000073432
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 50 7
Low 7 24 13
Below cutoff 3 24 27 14 7 14 4 5 28 19 7 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000073432   ⟹   ENSRNOP00000063920
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl9121,706,979 - 121,713,091 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087405   ⟹   ENSRNOP00000070007
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl9121,707,482 - 121,725,716 (-)Ensembl
RefSeq Acc Id: NM_016989   ⟹   NP_058685
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29113,104,663 - 113,109,863 (-)NCBI
Rnor_6.09121,707,924 - 121,713,124 (-)NCBI
Rnor_5.09121,155,213 - 121,175,023 (-)NCBI
Celera9110,207,950 - 110,213,150 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245672   ⟹   XP_006245734
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29113,102,632 - 113,122,497 (-)NCBI
Rnor_6.09121,705,897 - 121,725,735 (-)NCBI
Rnor_5.09121,155,213 - 121,175,023 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245673   ⟹   XP_006245735
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29113,102,632 - 113,111,377 (-)NCBI
Rnor_6.09121,705,897 - 121,714,431 (-)NCBI
Rnor_5.09121,155,213 - 121,175,023 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245674   ⟹   XP_006245736
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29113,102,632 - 113,111,402 (-)NCBI
Rnor_6.09121,705,897 - 121,714,432 (-)NCBI
Rnor_5.09121,155,213 - 121,175,023 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767418   ⟹   XP_008765640
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.29113,102,632 - 113,122,500 (-)NCBI
Rnor_6.09121,705,897 - 121,725,736 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058685   ⟸   NM_016989
- Peptide Label: precursor
- UniProtKB: P13589 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006245734   ⟸   XM_006245672
- Peptide Label: isoform X1
- UniProtKB: P13589 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006245736   ⟸   XM_006245674
- Peptide Label: isoform X1
- UniProtKB: P13589 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006245735   ⟸   XM_006245673
- Peptide Label: isoform X1
- UniProtKB: P13589 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008765640   ⟸   XM_008767418
- Peptide Label: isoform X1
- UniProtKB: P13589 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000063920   ⟸   ENSRNOT00000073432
RefSeq Acc Id: ENSRNOP00000070007   ⟸   ENSRNOT00000087405
Protein Domains
GLUCAGON

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696916
Promoter ID:EPDNEW_R7441
Type:initiation region
Name:Adcyap1_1
Description:adenylate cyclase activating polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.09121,725,700 - 121,725,760EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2037 AgrOrtholog
Ensembl Genes ENSRNOG00000049882 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000063920 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000070007 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073432 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000087405 UniProtKB/Swiss-Prot
InterPro Glucagon_GIP_secretin_VIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PACAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24166 UniProtKB/Swiss-Prot
NCBI Gene 24166 ENTREZGENE
PANTHER PTHR11213:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adcyap1 PhenoGen
PRINTS GLUCAGON UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLUCAGON UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GLUCA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UI25_RAT UniProtKB/TrEMBL
  P13589 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Adcyap1  adenylate cyclase activating polypeptide 1  Adcyap1  adenylate cyclase activating polypeptide 1 (pituitary)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Adcyap1  adenylate cyclase activating polypeptide 1 (pituitary)  Adcyap1  adenylate cyclase activating polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-28 Adcyap1  adenylate cyclase activating polypeptide 1  Adcyap1  adenylate cyclase activating polypeptide 1 (pituitary)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Adcyap1  adenylate cyclase activating polypeptide 1 (pituitary)  Adcyap1  adenylate cyclase activating polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Adcyap1  adenylate cyclase activating polypeptide 1      Symbol and Name status set to approved 70586 APPROVED
2001-06-18 Adcyap1  adenylate cyclase activating enzyme polypeptide 1      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-06-18 Adcyap1  Rat pituitary adenylate cyclase activating polypeptide 1      Name withdrawn 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization colocalizes with glutamate within the retinohypothalmic tract (RHT) 734509
gene_expression expressed in the hypothalamus 631803
gene_expression expressed in neurons in the gastrointestinal tract 631752
gene_function prevents Shh mitogenic action and can block Shh-induced proliferation  
gene_pathway involved in the glutamate-mediated light entrainment pathway 734509
gene_process may play a role in neuropeptide signaling 631801
gene_process may regulate circadian rhythm 631802
gene_process may regulate gastric acid secretion and intestinal motility 631752
gene_process regulates the daytime biological clock by a PACAP-cAMP-dependent mechanism 734507
gene_process regulates the daytime biological clock by a PACAP-cAMP-dependent mechanism 734508
gene_process regulates the daytime biological clock by a PACAP-cAMP-dependent mechanism 734509
gene_process blocks the circadian rhythm of neuronal firing in the slices of rat suprachiasmatic nucleus of the hypothalamus which is induced by glutamate during late night 734509
gene_process activates Pac1 receptor and the cAMP-signaling cascade 734509
gene_process involved in cerebellar neurogenesis 628387
gene_process regulates prenatal and postnatal granule cell production 628387
gene_process prevents Shh mitogenic action and can block Shh-induced proliferation 628387
gene_process regulates proliferation by the action of the polypeptide on GNPs 628387
gene_product member of the vasoactive intestinal peptide/secretin/glucagon family which exists in two forms and stimulates the adenylate cyclase 734508
gene_product member of the peptide family that includes secretin, glucagon, growth hormone-releasing factors amd vasoactive intestinal peptide 628387