RGD Reference Report - Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. - Rat Genome Database

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Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption.

Authors: Kovanen, Leena  Saarikoski, Sirkku T  Haukka, Jari  Pirkola, Sami  Aromaa, Arpo  Lönnqvist, Jouko  Partonen, Timo 
Citation: Kovanen L, etal., Alcohol Alcohol. 2010 Jul-Aug;45(4):303-11. doi: 10.1093/alcalc/agq035. Epub 2010 Jun 16.
RGD ID: 401976551
Pubmed: PMID:20554694   (View Abstract at PubMed)
DOI: DOI:10.1093/alcalc/agq035   (Journal Full-text)


AIMS: Circadian clock genes are involved in the development of drug-induced behaviors and regulate neurotransmission pathways in addiction. Our aim was to study whether circadian clock gene polymorphisms predispose to alcohol dependence or abuse or other alcohol-related characteristics.
METHODS: The study sample comprised of 512 individuals having alcohol dependence or alcohol abuse (according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)) and their 511 age- and sex-matched controls. This population-based sample was drawn from a cohort (n = 7415), representative of the Finnish general population aged 30 and over. Altogether 42 single-nucleotide polymorphisms of 19 genes related to the circadian pacemaker system were genotyped.
RESULTS: ARNTL rs6486120 T(+) allelic status (P = 0.0007, q = 0.17), ADCYAP1 rs2856966 GG genotype (P = 0.0006, q = 0.17) and VIP CC haplotype (rs3823082-rs688136) (P = 0.0006) were suggestively associated with alcohol consumption in socially drinking controls. ARNTL2 GT haplotype (rs7958822-rs4964057) associated suggestively with alcohol abuse diagnosis (P = 0.0013). Earlier findings on the associations of DRD2 and NPY with alcohol dependence were supported: DRD2/ANKK1 Taq1A(1) increased (P = 0.04) and NPY Pro7 decreased (P = 0.01) the risk of alcohol dependence.
CONCLUSIONS: ARNTL, ARNTL2, VIP and ADCYAP1 were indicated as having influence on alcohol use or abuse. The role of DRD2 and NPY on alcohol dependence was also supported.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ADCYAP1Humanalcohol dependence susceptibilityIAGP DNA:SNP:: (rs2856966) (human)RGD 
Adcyap1Ratalcohol dependence susceptibilityISOADCYAP1 (Homo sapiens)DNA:SNP:: (rs2856966) (human)RGD 
Adcyap1Mousealcohol dependence susceptibilityISOADCYAP1 (Homo sapiens)DNA:SNP:: (rs2856966) (human)RGD 
BMAL1Humanalcohol dependence susceptibilityIAGP DNA:SNP::(rs6486120) (human)RGD 
BMAL2Humanalcohol dependence susceptibilityIAGP DNA:SNPs more ...RGD 
Bmal1Ratalcohol dependence susceptibilityISOBMAL1 (Homo sapiens)DNA:SNP::(rs6486120) (human)RGD 
Bmal1Mousealcohol dependence susceptibilityISOBMAL1 (Homo sapiens)DNA:SNP::(rs6486120) (human)RGD 
Bmal2Ratalcohol dependence susceptibilityISOBMAL2 (Homo sapiens)DNA:SNPs more ...RGD 
Bmal2Mousealcohol dependence susceptibilityISOBMAL2 (Homo sapiens)DNA:SNPs more ...RGD 
NPYHumanalcohol dependence susceptibilityIAGP DNA:SNP:cd: p.L7P (rs16139) (human)RGD 
NpyRatalcohol dependence susceptibilityISONPY (Homo sapiens)DNA:SNP:cd: p.L7P (rs16139) (human)RGD 
NpyMousealcohol dependence susceptibilityISONPY (Homo sapiens)DNA:SNP:cd: p.L7P (rs16139) (human)RGD 
ACADSHumanalcohol use disorder susceptibilityIAGP DNA:SNP:: (rs1799958) (human)RGD 
AcadsRatalcohol use disorder susceptibilityISOACADS (Homo sapiens)DNA:SNP:: (rs1799958) (human)RGD 
AcadsMousealcohol use disorder susceptibilityISOACADS (Homo sapiens)DNA:SNP:: (rs1799958) (human)RGD 
CLOCKHumanalcohol use disorder susceptibilityIAGP DNA:SNP:: (rs2412648) (human)RGD 
TIMELESSHumanalcohol use disorder susceptibilityIAGP DNA:SNP:: (rs2291738) (human)RGD 
TimelessRatalcohol use disorder susceptibilityISOTIMELESS (Homo sapiens)DNA:SNP:: (rs2291738) (human)RGD 
TimelessMousealcohol use disorder susceptibilityISOTIMELESS (Homo sapiens)DNA:SNP:: (rs2291738) (human)RGD 
VIPHumanalcohol use disorder susceptibilityIAGP DNA:SNPs more ...RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ACADSHumanAddictive alcohol use susceptibilityIAGP DNA:SNP:: (rs1799958) (human)RGD 
ADCYAP1HumanAddictive alcohol use susceptibilityIAGP DNA:SNP:: (rs2856966) (human)RGD 
BMAL1HumanAddictive alcohol use susceptibilityIAGP DNA:SNP::(rs6486120) (human)RGD 
BMAL2HumanAddictive alcohol use susceptibilityIAGP DNA:SNPs more ...RGD 
CLOCKHumanAddictive alcohol use susceptibilityIAGP DNA:SNP:: (rs2412648) (human)RGD 
NPYHumanAddictive alcohol use susceptibilityIAGP DNA:SNP:cd: p.L7P (rs16139) (human)RGD 
TIMELESSHumanAddictive alcohol use susceptibilityIAGP DNA:SNP:: (rs2291738) (human)RGD 
VIPHumanAddictive alcohol use susceptibilityIAGP DNA:SNPs more ...RGD 
Objects Annotated

Genes (Rattus norvegicus)
Acads  (acyl-CoA dehydrogenase short chain)
Adcyap1  (adenylate cyclase activating polypeptide 1)
Bmal1  (basic helix-loop-helix ARNT like 1)
Bmal2  (basic helix-loop-helix ARNT like 2)
Npy  (neuropeptide Y)
Timeless  (timeless circadian regulator)

Genes (Mus musculus)
Acads  (acyl-Coenzyme A dehydrogenase, short chain)
Adcyap1  (adenylate cyclase activating polypeptide 1)
Bmal1  (basic helix-loop-helix ARNT like 1)
Bmal2  (basic helix-loop-helix ARNT like 2)
Npy  (neuropeptide Y)
Timeless  (timeless circadian clock 1)

Genes (Homo sapiens)
ACADS  (acyl-CoA dehydrogenase short chain)
ADCYAP1  (adenylate cyclase activating polypeptide 1)
BMAL1  (basic helix-loop-helix ARNT like 1)
BMAL2  (basic helix-loop-helix ARNT like 2)
CLOCK  (clock circadian regulator)
NPY  (neuropeptide Y)
TIMELESS  (timeless circadian regulator)
VIP  (vasoactive intestinal peptide)


Additional Information