NPY (neuropeptide Y) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: NPY (neuropeptide Y) Homo sapiens
Analyze
Symbol: NPY
Name: neuropeptide Y
RGD ID: 730830
HGNC Page HGNC:7955
Description: Predicted to enable neuropeptide Y receptor binding activity and neuropeptide hormone activity. Involved in defense response to symbiont and nervous system development. Located in Golgi apparatus. Implicated in several diseases, including Huntington's disease; alcohol dependence; alcohol use disorder; artery disease (multiple); and epilepsy (multiple). Biomarker of Alzheimer's disease; dementia; and peripheral artery disease.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: prepro-neuropeptide Y; pro-neuropeptide Y; PYY4
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Candidate Gene For: BW292_H BW391_H BW297_H
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38724,284,190 - 24,291,862 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl724,284,188 - 24,291,862 (+)EnsemblGRCh38hg38GRCh38
GRCh37724,323,809 - 24,331,481 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36724,290,334 - 24,298,002 (+)NCBINCBI36Build 36hg18NCBI36
Build 34724,097,048 - 24,104,717NCBI
Celera724,312,617 - 24,320,302 (+)NCBICelera
Cytogenetic Map7p15.3NCBI
HuRef724,208,802 - 24,216,490 (+)NCBIHuRef
CHM1_1724,325,406 - 24,333,092 (+)NCBICHM1_1
T2T-CHM13v2.0724,422,184 - 24,429,876 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2724,375,683 - 24,383,371 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(R)-noradrenaline  (EXP)
(S)-amphetamine  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-deoxy-D-glucose  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
acarbose  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
alpha-Zearalanol  (ISO)
AM-251  (ISO)
amitriptyline  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
aspartame  (ISO)
ATP  (EXP)
Aurothioglucose  (ISO)
belinostat  (EXP)
benzo[a]pyrene  (EXP,ISO)
bexarotene  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cannabidiol  (ISO)
cannabigerol  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbachol  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorisondamine  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
clofibrate  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clozapine  (ISO)
cocaine  (ISO)
corticosterone  (ISO)
cortisol  (EXP)
cyanocob(III)alamin  (ISO)
cytarabine  (EXP)
D-glucose  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dieldrin  (ISO)
diprotium oxide  (ISO)
dorsomorphin  (EXP,ISO)
entinostat  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
fructose  (ISO)
furan  (ISO)
gentamycin  (ISO)
glucose  (ISO)
Glutathione ethyl ester  (ISO)
glycidol  (ISO)
guanethidine  (EXP,ISO)
haloperidol  (ISO)
Hexamethonium  (ISO)
kainic acid  (ISO)
ketamine  (ISO)
L-methionine  (ISO)
limonene  (EXP,ISO)
linalool  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
masoprocol  (ISO)
mercury dibromide  (EXP)
metformin  (ISO)
methamphetamine  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
morphine  (ISO)
Muraglitazar  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
nitroglycerin  (ISO)
olanzapine  (ISO)
orlistat  (EXP)
orphenadrine  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
Oxotremorine  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (EXP)
paracetamol  (ISO)
paricalcitol  (ISO)
pentobarbital  (ISO)
perfluorooctanoic acid  (ISO)
phenacetin  (ISO)
phenformin  (ISO)
phenylephrine  (ISO)
phenylhydrazine  (ISO)
phenylmercury acetate  (EXP)
phenylpropanolamine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium atom  (ISO)
potassium chloride  (ISO)
prazosin  (ISO)
progesterone  (EXP,ISO)
propofol  (ISO)
quinpirole  (ISO)
RES-701-1  (ISO)
reserpine  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
ruthenium red  (ISO)
SB 431542  (EXP)
SCH 23390  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
SKF 38393  (ISO)
Soman  (ISO)
streptozocin  (ISO)
succimer  (ISO)
tauroursodeoxycholic acid  (ISO)
terbutaline  (ISO)
Tesaglitazar  (ISO)
tetrachloromethane  (ISO)
tetrodotoxin  (ISO)
thioacetamide  (ISO)
thiopental  (ISO)
titanium dioxide  (ISO)
topiramate  (ISO)
topotecan  (ISO)
tribromoethanol  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP,ISO)
triclosan  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
undecane  (ISO)
valproic acid  (EXP,ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
veratridine  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vorinostat  (EXP)
water  (ISO)
XL147  (ISO)
yohimbine  (ISO)
zalcitabine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Chronic quinolinic acid lesions in rats closely resemble Huntington's disease. Beal MF, etal., J Neurosci. 1991 Jun;11(6):1649-59.
2. Somatostatin and neuropeptide Y immunoreactivity in Parkinson's disease dementia with Alzheimer's changes. Beal MF, etal., Synapse. 1988;2(4):463-7.
3. The antidepressant effects of running and escitalopram are associated with levels of hippocampal NPY and Y1 receptor but not cell proliferation in a rat model of depression. Bjornebekk A, etal., Hippocampus. 2010 Jul;20(7):820-8. doi: 10.1002/hipo.20683.
4. Nerve stimulation induced overflow of neuropeptide Y and modulation by angiotensin II in spontaneously hypertensive rats. Byku M, etal., Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2188-97. doi: 10.1152/ajpheart.00384.2008. Epub 2008 Oct 3.
5. Renal and cardiac neuropeptide Y and NPY receptors in a rat model of congestive heart failure. Callanan EY, etal., Am J Physiol Renal Physiol. 2007 Dec;293(6):F1811-7. Epub 2007 Sep 5.
6. Hypothyroidism Induces Hypophagia Associated with Alterations in Protein Expression of Neuropeptide Y and Proopiomelanocortin in the Arcuate Nucleus, Independently of Hypothalamic Nuclei-Specific Changes in Leptin Signaling. Calvino C, etal., Thyroid. 2016 Jan;26(1):134-43. doi: 10.1089/thy.2015.0384. Epub 2015 Dec 1.
7. Alteration of NPY and Y1 receptor in dorsomedial and ventromedial areas of hypothalamus in anorectic tumor-bearing rats. Chance WT, etal., Peptides. 2007 Feb;28(2):295-301. Epub 2007 Jan 17.
8. Support for involvement of glutamate decarboxylase 1 and neuropeptide y in anxiety susceptibility. Donner J, etal., Am J Med Genet B Neuropsychiatr Genet. 2012 Apr;159B(3):316-27. doi: 10.1002/ajmg.b.32029. Epub 2012 Feb 10.
9. The role of neuropeptide Y and aquaporin 4 in the pathogenesis of intestinal dysfunction caused by traumatic brain injury. Duan H, etal., J Surg Res. 2013 Oct;184(2):1006-12. doi: 10.1016/j.jss.2013.03.096. Epub 2013 Apr 18.
10. Endogenous neuropeptide Y prevents recurrence of experimental febrile seizures by increasing seizure threshold. Dube C, etal., J Mol Neurosci. 2005;25(3):275-84.
11. Long-term valproate treatment increases brain neuropeptide Y expression and decreases seizure expression in a genetic rat model of absence epilepsy. Elms J, etal., PLoS One. 2013 Sep 9;8(9):e73505. doi: 10.1371/journal.pone.0073505. eCollection 2013.
12. Neuropeptide Y level in paraventricular nucleus of experimental diabetic rats: correlation with sympathetic activity and body weight. Ganguly PK Int J Gen Med. 2010 Oct 5;3:321-5. doi: 10.2147/IJGM.S7749.
13. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
14. Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism. Heilig M, etal., J Psychiatr Res 2004 Mar-Apr;38(2):113-21.
15. Neuropeptide Y is expressed by rat mononuclear blood leukocytes and strongly down-regulated during inflammation. Holler J, etal., J Immunol. 2008 Nov 15;181(10):6906-12.
16. Hypothalamic expression of mutant huntingtin contributes to the development of depressive-like behavior in the BAC transgenic mouse model of Huntington's disease. Hult Lundh S, etal., Hum Mol Genet. 2013 Sep 1;22(17):3485-97. doi: 10.1093/hmg/ddt203. Epub 2013 May 22.
17. Neuropeptide y and neuropeptide y y5 receptor interaction restores impaired growth potential of aging bone marrow stromal cells. Igura K, etal., Rejuvenation Res. 2011 Aug;14(4):393-403. doi: 10.1089/rej.2010.1129. Epub 2011 May 19.
18. Leucine7 to proline7 polymorphism in the preproneuropeptide Y is associated with the progression of carotid atherosclerosis, blood pressure and serum lipids in Finnish men. Karvonen MK, etal., Atherosclerosis. 2001 Nov;159(1):145-51.
19. Changes in neuropeptide Y protein expression following photothrombotic brain infarction and epileptogenesis. Kharlamov EA, etal., Brain Res. 2007 Jan 5;1127(1):151-62. Epub 2006 Nov 22.
20. Association of age at onset in Huntington disease with functional promoter variations in NPY and NPY2R. Kloster E, etal., J Mol Med (Berl). 2014 Feb;92(2):177-84.
21. Changes in hypothalamic corticotropin-releasing hormone, neuropeptide Y, and proopiomelanocortin gene expression during chronic rapid eye movement sleep deprivation of rats. Koban M, etal., Endocrinology. 2006 Jan;147(1):421-31. doi: 10.1210/en.2005-0695. Epub 2005 Oct 6.
22. Plasma neuropeptide Y is reduced in patients with Alzheimer's disease. Koide S, etal., Neurosci Lett. 1995 Sep 29;198(2):149-51.
23. Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. Kovanen L, etal., Alcohol Alcohol. 2010 Jul-Aug;45(4):303-11. doi: 10.1093/alcalc/agq035. Epub 2010 Jun 16.
24. Differential susceptibility of interneurons expressing neuropeptide Y or parvalbumin in the aged hippocampus to acute seizure activity. Kuruba R, etal., PLoS One. 2011;6(9):e24493. doi: 10.1371/journal.pone.0024493. Epub 2011 Sep 6.
25. A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States. Lappalainen J, etal., Arch Gen Psychiatry. 2002 Sep;59(9):825-31.
26. Of mice and men: neuropeptide Y and its receptors are associated with atherosclerotic lesion burden and vulnerability. Li L, etal., J Cardiovasc Transl Res. 2011 Jun;4(3):351-62. doi: 10.1007/s12265-011-9271-5. Epub 2011 Apr 6.
27. Increased neuropeptide Y-like immunoreactivity in cerebrospinal fluid and plasma of human immunodeficiency virus-infected patients: relationship to HIV encephalopathy. Malessa R, etal., J Neurol Sci. 1996 Mar;136(1-2):154-8.
28. Neuropeptide Y: identification of a novel rat mRNA splice-variant that is downregulated in the hippocampus and the prefrontal cortex of a depression-like model. Melas PA, etal., Peptides. 2012 May;35(1):49-55. doi: 10.1016/j.peptides.2012.02.020. Epub 2012 Mar 3.
29. Central neuropeptide Y signaling ameliorates N(omega)-nitro-L-arginine methyl ester hypertension in the rat through a Y1 receptor mechanism. Michalkiewicz M, etal., Hypertension 2005 Apr;45(4):780-5. Epub 2005 Feb 7.
30. Neuropeptide Y suppresses absence seizures in a genetic rat model primarily through effects on Y receptors. Morris MJ, etal., Eur J Neurosci. 2007 Feb;25(4):1136-43.
31. Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling. Morrison CD, etal., Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E1051-7. Epub 2005 Jul 26.
32. Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y2 receptor activation. Nave H, etal., J Neuroimmunol. 2004 Oct;155(1-2):1-12.
33. Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy. Noe F, etal., Brain. 2008 Jun;131(Pt 6):1506-15. doi: 10.1093/brain/awn079. Epub 2008 May 13.
34. Leu7Pro polymorphism in the neuropeptide Y (NPY) gene is associated with impaired glucose tolerance and type 2 diabetes in Swedish men. Nordman S, etal., Exp Clin Endocrinol Diabetes. 2005 May;113(5):282-7.
35. Amelioration of dextran sulfate sodium-induced colitis by neuropeptide Y antisense oligodeoxynucleotide. Pang XH, etal., Int J Colorectal Dis. 2010 Sep;25(9):1047-53. doi: 10.1007/s00384-010-0964-z. Epub 2010 Jun 5.
36. Nicotine evoked improvement in learning and memory is mediated through NPY Y1 receptors in rat model of Alzheimer's disease. Rangani RJ, etal., Peptides. 2012 Feb;33(2):317-28. doi: 10.1016/j.peptides.2012.01.004. Epub 2012 Jan 16.
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Hippocampal NPY gene transfer attenuates seizures without affecting epilepsy-induced impairment of LTP. Sorensen AT, etal., Exp Neurol. 2009 Feb;215(2):328-33. doi: 10.1016/j.expneurol.2008.10.015. Epub 2008 Nov 10.
39. Effect of polymorphism on expression of the neuropeptide Y gene in inbred alcohol-preferring and -nonpreferring rats. Spence JP, etal., Neuroscience 2005;131(4):871-6.
40. Neuropeptide Y receptor Y2 gene polymorphism interacts with plasma neuropeptide Y levels in predicting left ventricular hypertrophy in dialysis patients. Testa A, etal., J Hypertens. 2010 Aug;28(8):1745-51.
41. Epistatic interaction between beta2-adrenergic receptor and neuropeptide Y genes influences LDL-cholesterol in hypertension. Tomaszewski M, etal., Hypertension. 2004 Nov;44(5):689-94. Epub 2004 Sep 13.
42. Neuropeptide Y modulates c-Fos protein expression in the cuneate nucleus and contributes to mechanical hypersensitivity following rat median nerve injury. Tsai YJ, etal., J Neurotrauma. 2009 Sep;26(9):1609-21. doi: 10.1089/neu.2008.0642.
43. Overpressure blast-wave induced brain injury elevates oxidative stress in the hypothalamus and catecholamine biosynthesis in the rat adrenal medulla. Tumer N, etal., Neurosci Lett. 2013 Jun 7;544:62-7. doi: 10.1016/j.neulet.2013.03.042. Epub 2013 Apr 6.
44. Involvement of neuropeptide Y in the acute, chronic and withdrawal responses of morphine in nociception in neuropathic rats: behavioral and neuroanatomical correlates. Upadhya MA, etal., Neuropeptides. 2009 Aug;43(4):303-14. doi: 10.1016/j.npep.2009.05.003. Epub 2009 Jun 24.
45. Difference of NPY and its receptor gene expressions between obesity and obesity-resistant rats in response to high-fat diet. Wang C, etal., Horm Metab Res. 2007 Apr;39(4):262-7.
46. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue Xu ZQ, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2004 Apr;16(4):218-20.
47. [Number changes and axonal sprouting of neuropeptide Y interneurons in the hippocampus of pilocarpine-induced rats]. Zhiguo W, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009 Feb;34(2):93-8.
Additional References at PubMed
PMID:1321422   PMID:1425680   PMID:2427515   PMID:2444979   PMID:3753985   PMID:3839058   PMID:6589611   PMID:7493937   PMID:7559383   PMID:7782078   PMID:8132547   PMID:8421707  
PMID:9001438   PMID:9008359   PMID:9067840   PMID:9756788   PMID:9845072   PMID:10488139   PMID:10557353   PMID:10561544   PMID:10698177   PMID:10770181   PMID:11196643   PMID:11278902  
PMID:11325787   PMID:11410744   PMID:11422604   PMID:11696660   PMID:11814620   PMID:11884208   PMID:11914038   PMID:11932939   PMID:12007534   PMID:12015205   PMID:12034130   PMID:12081635  
PMID:12106685   PMID:12187394   PMID:12187924   PMID:12209475   PMID:12454738   PMID:12477932   PMID:12479530   PMID:12544000   PMID:12609745   PMID:12646110   PMID:12663466   PMID:12689610  
PMID:12690205   PMID:12759898   PMID:12782203   PMID:12818415   PMID:12843176   PMID:12853948   PMID:12875921   PMID:12878188   PMID:12932169   PMID:14628185   PMID:14747236   PMID:14751436  
PMID:15126561   PMID:15165988   PMID:15201542   PMID:15336593   PMID:15485137   PMID:15489334   PMID:15597110   PMID:15604093   PMID:15625769   PMID:15680469   PMID:15736042   PMID:15759545  
PMID:15797951   PMID:15847953   PMID:15850450   PMID:15894681   PMID:15897713   PMID:15959845   PMID:16135994   PMID:16136022   PMID:16339211   PMID:16382997   PMID:16382999   PMID:16383000  
PMID:16383001   PMID:16383009   PMID:16383010   PMID:16390370   PMID:16459651   PMID:16500360   PMID:16568137   PMID:16785149   PMID:16912140   PMID:17066479   PMID:17154253   PMID:17187020  
PMID:17268419   PMID:17305733   PMID:17325259   PMID:17366345   PMID:17516289   PMID:17525122   PMID:17554476   PMID:17695723   PMID:17702963   PMID:17948870   PMID:17984244   PMID:18031993  
PMID:18037100   PMID:18043699   PMID:18054939   PMID:18055304   PMID:18211417   PMID:18241322   PMID:18257117   PMID:18279562   PMID:18385673   PMID:18420205   PMID:18423883   PMID:18461271  
PMID:18499283   PMID:18577758   PMID:18603306   PMID:18636124   PMID:18641693   PMID:18715275   PMID:18815063   PMID:18828811   PMID:18974842   PMID:18996102   PMID:19056482   PMID:19058789  
PMID:19086053   PMID:19119412   PMID:19150389   PMID:19240061   PMID:19245788   PMID:19264362   PMID:19289742   PMID:19309436   PMID:19367093   PMID:19404163   PMID:19423065   PMID:19491387  
PMID:19566775   PMID:19587357   PMID:19619519   PMID:19620246   PMID:19699258   PMID:19804960   PMID:19846279   PMID:19854625   PMID:19865784   PMID:19874574   PMID:19913121   PMID:19913525  
PMID:19942238   PMID:20033074   PMID:20037921   PMID:20138117   PMID:20164781   PMID:20173430   PMID:20180986   PMID:20308990   PMID:20351714   PMID:20435026   PMID:20452482   PMID:20453000  
PMID:20459474   PMID:20468064   PMID:20531438   PMID:20602615   PMID:20628086   PMID:20648632   PMID:20673868   PMID:20675276   PMID:20676138   PMID:20691708   PMID:20734064   PMID:20823688  
PMID:20832114   PMID:20846339   PMID:20945961   PMID:21041608   PMID:21047193   PMID:21145602   PMID:21190576   PMID:21273004   PMID:21303710   PMID:21346312   PMID:21396710   PMID:21426768  
PMID:21626172   PMID:21640760   PMID:21746772   PMID:21796371   PMID:21849543   PMID:21873635   PMID:21898706   PMID:21917383   PMID:21937627   PMID:21988832   PMID:22143932   PMID:22289186  
PMID:22308535   PMID:22393040   PMID:22492775   PMID:22584873   PMID:22632858   PMID:22808091   PMID:22849656   PMID:22941950   PMID:22966009   PMID:22979996   PMID:22985695   PMID:23021333  
PMID:23074243   PMID:23083763   PMID:23107365   PMID:23110814   PMID:23116540   PMID:23122776   PMID:23277265   PMID:23390522   PMID:23403409   PMID:23407263   PMID:23457218   PMID:23459936  
PMID:23468908   PMID:23482625   PMID:23599389   PMID:23624317   PMID:23652383   PMID:23831408   PMID:23838112   PMID:23864142   PMID:23994577   PMID:24012636   PMID:24077326   PMID:24184719  
PMID:24213859   PMID:24289328   PMID:24699455   PMID:24709369   PMID:24757681   PMID:24779394   PMID:24858338   PMID:24897239   PMID:24965867   PMID:25026432   PMID:25081719   PMID:25208829  
PMID:25221996   PMID:25256105   PMID:25258030   PMID:25387699   PMID:25427865   PMID:25453484   PMID:25714031   PMID:25798605   PMID:25871004   PMID:25920420   PMID:25924821   PMID:26002416  
PMID:26021463   PMID:26111352   PMID:26156739   PMID:26220979   PMID:26240981   PMID:26291814   PMID:26431933   PMID:26621486   PMID:26683132   PMID:26988064   PMID:27251038   PMID:27469060  
PMID:27527739   PMID:27559040   PMID:27599771   PMID:27720230   PMID:27749914   PMID:27788523   PMID:27837667   PMID:28361739   PMID:28787737   PMID:28857123   PMID:28890052   PMID:28927333  
PMID:28954935   PMID:29099554   PMID:29197114   PMID:29381655   PMID:29494882   PMID:29650257   PMID:30337638   PMID:30691985   PMID:30984535   PMID:31164324   PMID:31263154   PMID:31291230  
PMID:31569168   PMID:31834357   PMID:31852985   PMID:31887359   PMID:31999643   PMID:32296183   PMID:32561647   PMID:32593562   PMID:32686440   PMID:32902020   PMID:33022812   PMID:33242785  
PMID:33491492   PMID:33652060   PMID:34422139   PMID:34488599   PMID:34627187   PMID:34684394   PMID:34716471   PMID:34847673   PMID:35165283   PMID:35170267   PMID:35180645   PMID:35728621  
PMID:36429093   PMID:36525977   PMID:36768369   PMID:37013432   PMID:37070394   PMID:37544294   PMID:37653540   PMID:37889542   PMID:37918268   PMID:37931511   PMID:37937329   PMID:38087221  
PMID:38387703   PMID:39090596   PMID:39216475  


Genomics

Comparative Map Data
NPY
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38724,284,190 - 24,291,862 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl724,284,188 - 24,291,862 (+)EnsemblGRCh38hg38GRCh38
GRCh37724,323,809 - 24,331,481 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36724,290,334 - 24,298,002 (+)NCBINCBI36Build 36hg18NCBI36
Build 34724,097,048 - 24,104,717NCBI
Celera724,312,617 - 24,320,302 (+)NCBICelera
Cytogenetic Map7p15.3NCBI
HuRef724,208,802 - 24,216,490 (+)NCBIHuRef
CHM1_1724,325,406 - 24,333,092 (+)NCBICHM1_1
T2T-CHM13v2.0724,422,184 - 24,429,876 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2724,375,683 - 24,383,371 (+)NCBI
Npy
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39649,799,690 - 49,806,487 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl649,799,690 - 49,806,487 (+)EnsemblGRCm39 Ensembl
GRCm38649,822,710 - 49,829,507 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl649,822,710 - 49,829,507 (+)EnsemblGRCm38mm10GRCm38
MGSCv37649,772,728 - 49,779,506 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36649,752,315 - 49,759,093 (+)NCBIMGSCv36mm8
Celera650,334,213 - 50,340,981 (+)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map624.04NCBI
Npy
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8480,212,111 - 80,219,310 (+)NCBIGRCr8
mRatBN7.2478,881,294 - 78,888,495 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl478,881,264 - 78,888,495 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx484,098,422 - 84,105,619 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0479,873,911 - 79,881,112 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0478,314,242 - 78,321,437 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0479,557,856 - 79,565,059 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl479,573,998 - 79,581,208 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl479,557,854 - 79,565,097 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04144,233,753 - 144,240,956 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4478,038,013 - 78,045,187 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1478,314,142 - 78,321,317 (+)NCBI
Celera473,795,148 - 73,802,371 (+)NCBICelera
RH 3.4 Map4508.6RGD
RH 3.4 Map4507.8RGD
Cytogenetic Map4q24NCBI
Npy
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541026,348,504 - 26,355,297 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541026,348,388 - 26,355,232 (+)NCBIChiLan1.0ChiLan1.0
NPY
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2629,145,106 - 29,152,854 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1777,469,833 - 77,477,581 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0724,963,056 - 24,970,803 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1724,566,963 - 24,574,657 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl724,568,041 - 24,574,657 (+)Ensemblpanpan1.1panPan2
NPY
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11437,824,579 - 37,831,289 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1437,823,861 - 37,831,443 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1437,373,133 - 37,380,851 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01437,758,052 - 37,765,788 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1437,758,938 - 37,765,943 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11437,872,113 - 37,879,841 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01437,564,477 - 37,572,202 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01437,908,665 - 37,916,390 (+)NCBIUU_Cfam_GSD_1.0
Npy
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511882,077,623 - 82,085,085 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364781,290,505 - 1,296,874 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364781,289,437 - 1,296,819 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPY
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1847,985,725 - 47,992,667 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11847,985,796 - 47,993,726 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21852,929,745 - 52,937,666 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPY
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12134,068,533 - 34,076,205 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2134,068,530 - 34,075,127 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604270,564,869 - 70,572,551 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npy
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247396,277,612 - 6,285,397 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247396,277,704 - 6,285,454 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NPY
16 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000905.4(NPY):c.20T>C (p.Leu7Pro) single nucleotide variant NEUROPEPTIDE Y POLYMORPHISM [RCV000015068]|not provided [RCV002054440] Chr7:24285260 [GRCh38]
Chr7:24324879 [GRCh37]
Chr7:7p15.3		 benign
GRCh38/hg38 7p22.3-14.1(chr7:54185-41875885)x3 copy number gain See cases [RCV000051159] Chr7:54185..41875885 [GRCh38]
Chr7:54185..41915483 [GRCh37]
Chr7:149268..41882008 [NCBI36]
Chr7:7p22.3-14.1		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7p22.3-15.3(chr7:53985-24361531)x3 copy number gain See cases [RCV000053528] Chr7:53985..24361531 [GRCh38]
Chr7:53985..24401150 [GRCh37]
Chr7:149068..24367675 [NCBI36]
Chr7:7p22.3-15.3		 pathogenic
GRCh38/hg38 7p22.3-14.2(chr7:54185-37089712)x3 copy number gain See cases [RCV000053530] Chr7:54185..37089712 [GRCh38]
Chr7:54185..37129317 [GRCh37]
Chr7:149268..37095842 [NCBI36]
Chr7:7p22.3-14.2		 pathogenic
GRCh38/hg38 7p21.2-15.2(chr7:16234212-26167278)x3 copy number gain See cases [RCV000053531] Chr7:16234212..26167278 [GRCh38]
Chr7:16273837..26206898 [GRCh37]
Chr7:16240362..26173423 [NCBI36]
Chr7:7p21.2-15.2		 pathogenic
GRCh38/hg38 7p21.1-15.2(chr7:20210912-27849400)x1 copy number loss See cases [RCV000134333] Chr7:20210912..27849400 [GRCh38]
Chr7:20250535..27889019 [GRCh37]
Chr7:20217060..27855544 [NCBI36]
Chr7:7p21.1-15.2		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7p22.3-15.2(chr7:54185-26827634)x3 copy number gain See cases [RCV000136557] Chr7:54185..26827634 [GRCh38]
Chr7:54185..26867253 [GRCh37]
Chr7:149268..26833778 [NCBI36]
Chr7:7p22.3-15.2		 pathogenic
GRCh38/hg38 7p21.1-14.3(chr7:20561456-32005143)x1 copy number loss See cases [RCV000136775] Chr7:20561456..32005143 [GRCh38]
Chr7:20601079..32044755 [GRCh37]
Chr7:20567604..32011280 [NCBI36]
Chr7:7p21.1-14.3		 pathogenic
GRCh38/hg38 7p22.1-15.2(chr7:5682209-27230311)x3 copy number gain See cases [RCV000136649] Chr7:5682209..27230311 [GRCh38]
Chr7:5721840..27269930 [GRCh37]
Chr7:5688366..27236455 [NCBI36]
Chr7:7p22.1-15.2		 pathogenic
GRCh38/hg38 7p22.3-15.3(chr7:45130-25221165)x3 copy number gain See cases [RCV000137824] Chr7:45130..25221165 [GRCh38]
Chr7:45130..25260784 [GRCh37]
Chr7:140213..25227309 [NCBI36]
Chr7:7p22.3-15.3		 pathogenic
GRCh38/hg38 7p21.2-15.3(chr7:15533812-24851432)x1 copy number loss See cases [RCV000137924] Chr7:15533812..24851432 [GRCh38]
Chr7:15573437..24891051 [GRCh37]
Chr7:15539962..24857576 [NCBI36]
Chr7:7p21.2-15.3		 pathogenic
GRCh38/hg38 7p15.3-15.2(chr7:23765383-26136158)x1 copy number loss See cases [RCV000138258] Chr7:23765383..26136158 [GRCh38]
Chr7:23805002..26175778 [GRCh37]
Chr7:23771527..26142303 [NCBI36]
Chr7:7p15.3-15.2		 likely pathogenic|uncertain significance
GRCh38/hg38 7p22.3-15.2(chr7:1698124-27207295)x3 copy number gain See cases [RCV000143060] Chr7:1698124..27207295 [GRCh38]
Chr7:1737760..27246914 [GRCh37]
Chr7:1704286..27213439 [NCBI36]
Chr7:7p22.3-15.2		 pathogenic
GRCh38/hg38 7p21.3-15.2(chr7:10610069-25760560)x1 copy number loss See cases [RCV000142708] Chr7:10610069..25760560 [GRCh38]
Chr7:10649696..25800180 [GRCh37]
Chr7:10616221..25766705 [NCBI36]
Chr7:7p21.3-15.2		 pathogenic
GRCh38/hg38 7p15.3(chr7:24103873-24632089)x3 copy number gain See cases [RCV000143733] Chr7:24103873..24632089 [GRCh38]
Chr7:24143492..24671708 [GRCh37]
Chr7:24110017..24638233 [NCBI36]
Chr7:7p15.3		 likely benign
GRCh38/hg38 7p22.3-15.2(chr7:43360-27196404)x3 copy number gain See cases [RCV000143586] Chr7:43360..27196404 [GRCh38]
Chr7:43360..27236023 [GRCh37]
Chr7:138443..27202548 [NCBI36]
Chr7:7p22.3-15.2		 pathogenic
GRCh37/hg19 7p15.3-14.3(chr7:22935369-32621975)x1 copy number loss See cases [RCV000240125] Chr7:22935369..32621975 [GRCh37]
Chr7:7p15.3-14.3		 pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34		 pathogenic
GRCh37/hg19 7p21.3-14.2(chr7:11562624-36395416)x3 copy number gain See cases [RCV000446478] Chr7:11562624..36395416 [GRCh37]
Chr7:7p21.3-14.2		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p21.3-12.1(chr7:11048840-52863626)x3 copy number gain See cases [RCV000512091] Chr7:11048840..52863626 [GRCh37]
Chr7:7p21.3-12.1		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-14.3(chr7:704573-29257946)x3 copy number gain See cases [RCV000510275] Chr7:704573..29257946 [GRCh37]
Chr7:7p22.3-14.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
NM_000905.4(NPY):c.17G>C (p.Arg6Pro) single nucleotide variant not specified [RCV004306814] Chr7:24285257 [GRCh38]
Chr7:24324876 [GRCh37]
Chr7:7p15.3		 uncertain significance
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Childhood apraxia of speech [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
NC_000007.13:g.23236782_30690453del7453672 deletion Silver Russell Syndrome-related disorder [RCV000785664] Chr7:23236782..30690453 [GRCh37]
Chr7:7p15.3-14.3		 pathogenic
GRCh37/hg19 7p15.3-14.3(chr7:23877135-33139446)x1 copy number loss not provided [RCV001005924] Chr7:23877135..33139446 [GRCh37]
Chr7:7p15.3-14.3		 pathogenic
NM_000905.4(NPY):c.84G>A (p.Ala28=) single nucleotide variant not provided [RCV000956468] Chr7:24285324 [GRCh38]
Chr7:24324943 [GRCh37]
Chr7:7p15.3		 benign
Single allele complex Ring chromosome 7 [RCV002280646] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p21.3-14.2(chr7:10745750-35305167) copy number gain not specified [RCV002053668] Chr7:10745750..35305167 [GRCh37]
Chr7:7p21.3-14.2		 likely pathogenic
NM_000905.4(NPY):c.204C>T (p.Ser68=) single nucleotide variant not provided [RCV002125047] Chr7:24289514 [GRCh38]
Chr7:24329133 [GRCh37]
Chr7:7p15.3		 benign
NM_000905.4(NPY):c.189-5dup duplication not provided [RCV002193810] Chr7:24289484..24289485 [GRCh38]
Chr7:24329103..24329104 [GRCh37]
Chr7:7p15.3		 benign
NM_000905.4(NPY):c.150G>A (p.Ser50=) single nucleotide variant not provided [RCV002182350] Chr7:24285390 [GRCh38]
Chr7:24325009 [GRCh37]
Chr7:7p15.3		 benign
GRCh37/hg19 7p22.3-q36.3(chr7:56604613-96692931)x1 copy number loss See cases [RCV002287832] Chr7:56604613..96692931 [GRCh37]
Chr7:7p22.3-q36.3		 uncertain significance
NM_000905.4(NPY):c.152C>A (p.Ala51Glu) single nucleotide variant not specified [RCV004242205] Chr7:24285392 [GRCh38]
Chr7:24325011 [GRCh37]
Chr7:7p15.3		 uncertain significance
NM_000905.4(NPY):c.188+15G>A single nucleotide variant not provided [RCV002618765] Chr7:24285443 [GRCh38]
Chr7:24325062 [GRCh37]
Chr7:7p15.3		 likely benign
NM_000905.4(NPY):c.293G>A (p.Ter98=) single nucleotide variant not provided [RCV002976338] Chr7:24291686 [GRCh38]
Chr7:24331305 [GRCh37]
Chr7:7p15.3		 likely benign
NM_000905.4(NPY):c.133A>C (p.Met45Leu) single nucleotide variant not specified [RCV004206088] Chr7:24285373 [GRCh38]
Chr7:24324992 [GRCh37]
Chr7:7p15.3		 likely benign
NM_000905.4(NPY):c.31G>A (p.Gly11Arg) single nucleotide variant not provided [RCV002585809] Chr7:24285271 [GRCh38]
Chr7:24324890 [GRCh37]
Chr7:7p15.3		 uncertain significance
NM_000905.4(NPY):c.34C>A (p.Leu12Met) single nucleotide variant not specified [RCV004323321] Chr7:24285274 [GRCh38]
Chr7:24324893 [GRCh37]
Chr7:7p15.3		 uncertain significance
NM_000905.4(NPY):c.234G>A (p.Leu78=) single nucleotide variant not provided [RCV003833727] Chr7:24289544 [GRCh38]
Chr7:24329163 [GRCh37]
Chr7:7p15.3		 likely benign
NM_000905.4(NPY):c.270-12T>C single nucleotide variant not provided [RCV003819242] Chr7:24291651 [GRCh38]
Chr7:24331270 [GRCh37]
Chr7:7p15.3		 likely benign
GRCh37/hg19 7p21.1-14.3(chr7:17736012-30663423)x1 copy number loss not specified [RCV003986712] Chr7:17736012..30663423 [GRCh37]
Chr7:7p21.1-14.3		 pathogenic
GRCh37/hg19 7p21.3-15.2(chr7:13107394-27514163)x1 copy number loss not specified [RCV003986690] Chr7:13107394..27514163 [GRCh37]
Chr7:7p21.3-15.2		 pathogenic
NM_000905.4(NPY):c.175A>T (p.Ile59Phe) single nucleotide variant not specified [RCV004491175] Chr7:24285415 [GRCh38]
Chr7:24325034 [GRCh37]
Chr7:7p15.3		 uncertain significance
NM_000905.4(NPY):c.287T>C (p.Met96Thr) single nucleotide variant not specified [RCV004491176] Chr7:24291680 [GRCh38]
Chr7:24331299 [GRCh37]
Chr7:7p15.3		 uncertain significance
NC_000007.13:g.(?_24323410)_(25163738_?)dup duplication not provided [RCV004578564] Chr7:24323410..25163738 [GRCh37]
Chr7:7p15.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:370
Count of miRNA genes:153
Interacting mature miRNAs:155
Transcripts:ENST00000242152, ENST00000405982, ENST00000407573
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2289453BW297_HBody weight QTL 297 (human)3.83Body weightbody mass index72334946449349464Human
407331464GWAS980440_Hadiponectin measurement QTL GWAS980440 (human)0.000007adiponectin measurementblood adiponectin level (CMO:0000485)72429021824290219Human

Markers in Region
NPY  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37724,324,872 - 24,325,021UniSTSGRCh37
GRCh37724,331,376 - 24,331,435UniSTSGRCh37
Build 36724,297,901 - 24,297,960RGDNCBI36
Celera724,320,194 - 24,320,253RGD
Celera724,313,682 - 24,313,831UniSTS
Cytogenetic Map7p15.1UniSTS
HuRef724,216,382 - 24,216,441UniSTS
HuRef724,209,867 - 24,210,016UniSTS
CRA_TCAGchr7v2724,383,263 - 24,383,322UniSTS
CRA_TCAGchr7v2724,376,748 - 24,376,897UniSTS
STS-M14298  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37724,331,309 - 24,331,495UniSTSGRCh37
Build 36724,297,834 - 24,298,020RGDNCBI36
Celera724,320,127 - 24,320,313RGD
Cytogenetic Map7p15.1UniSTS
HuRef724,216,315 - 24,216,501UniSTS
CRA_TCAGchr7v2724,383,196 - 24,383,382UniSTS
GeneMap99-GB4 RH Map7103.44UniSTS
NCBI RH Map7415.5UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
627 2284 1832 1571 4116 1328 1589 268 729 150 1171 4471 3946 32 3623 1 662 1570 1173 123 1

Sequence


Ensembl Acc Id: ENST00000242152   ⟹   ENSP00000242152
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl724,284,190 - 24,291,862 (+)Ensembl
Ensembl Acc Id: ENST00000405982   ⟹   ENSP00000385282
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl724,285,107 - 24,291,824 (+)Ensembl
Ensembl Acc Id: ENST00000407573   ⟹   ENSP00000384364
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl724,284,188 - 24,291,808 (+)Ensembl
RefSeq Acc Id: NM_000905   ⟹   NP_000896
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38724,284,190 - 24,291,862 (+)NCBI
GRCh37724,323,807 - 24,331,484 (+)ENTREZGENE
Build 36724,290,334 - 24,298,002 (+)NCBI Archive
HuRef724,208,802 - 24,216,490 (+)ENTREZGENE
CHM1_1724,325,406 - 24,333,092 (+)NCBI
T2T-CHM13v2.0724,422,184 - 24,429,876 (+)NCBI
CRA_TCAGchr7v2724,375,683 - 24,383,371 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: NP_000896   ⟸   NM_000905
- Peptide Label: preproprotein
- UniProtKB: P01303 (UniProtKB/Swiss-Prot),   A4D158 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000242152   ⟸   ENST00000242152
Ensembl Acc Id: ENSP00000385282   ⟸   ENST00000405982
Ensembl Acc Id: ENSP00000384364   ⟸   ENST00000407573

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01303-F1-model_v2 AlphaFold P01303 1-97 view protein structure

Promoters
RGD ID:7210113
Promoter ID:EPDNEW_H10802
Type:multiple initiation site
Name:NPY_1
Description:neuropeptide Y
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38724,284,190 - 24,284,250EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7955 AgrOrtholog
COSMIC NPY COSMIC
Ensembl Genes ENSG00000122585 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000242152 ENTREZGENE
  ENST00000242152.7 UniProtKB/Swiss-Prot
  ENST00000405982.1 UniProtKB/Swiss-Prot
  ENST00000407573.5 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.250.900 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000122585 GTEx
HGNC ID HGNC:7955 ENTREZGENE
Human Proteome Map NPY Human Proteome Map
InterPro Pancreatic_hormone-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pancreatic_hormone-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4852 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 4852 ENTREZGENE
OMIM 162640 OMIM
PANTHER PRO-NEUROPEPTIDE Y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10533 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NPY RGD, PharmGKB
PRINTS PANCHORMONE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PANCREATIC_HORMONE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PANCREATIC_HORMONE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A4D158 ENTREZGENE, UniProtKB/TrEMBL
  NPY_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE