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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730830
Species: Homo sapiens
RGD Object: Gene
Symbol: NPY
Name: neuropeptide Y
Acc ID: CHEBI:28487
Term: reserpine
Definition: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Chemical ID: MESH:D012110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NPYdecreases expressionISONpy (Rattus norvegicus)6480464CTDReserpine results in decreased expression of NPY mRNA; Reserpine results in decreased expression of NPY proteinPMID:2233698 PMID:3805164 PMID:7911764
NPYincreases expressionISONpy (Rattus norvegicus)6480464CTDReserpine results in increased expression of NPY mRNA; Reserpine results in increased expression of NPY proteinPMID:1671012 PMID:1676830 PMID:1687976 PMID:1698642 PMID:1713314 PMID:1714554 PMID:1878751 PMID:1907749 PMID:20504635 PMID:2233698 PMID:2897091 PMID:2903502 PMID:3215285 PMID:7644023 PMID:7911764 PMID:8189248
NPYmultiple interactionsISONpy (Rattus norvegicus)6480464CTDChlorisondamine inhibits the reaction [Reserpine results in increased expression of NPY mRNA]; Chlorisondamine promotes the reaction [Reserpine results in increased expression of NPY mRNA]; Dexamethasone inhibits the reaction [Reserpine results in increased expression of NPY mRNA]PMID:1714554 PMID:20504635
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