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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730830
Species: Homo sapiens
RGD Object: Gene
Symbol: NPY
Name: neuropeptide Y
Acc ID: CHEBI:2679
Term: amphetamine
Definition: A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.
Chemical ID: MESH:D000661
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NPYaffects expressionISONpy (Rattus norvegicus)6480464CTDAmphetamine affects the expression of NPY proteinPMID:16896163
NPYaffects response to substanceISONpy (Rattus norvegicus)6480464CTDNPY protein affects the susceptibility to AmphetaminePMID:16101753
NPYdecreases expressionISONpy (Rattus norvegicus)6480464CTDAmphetamine results in decreased expression of NPY mRNA; Amphetamine results in decreased expression of NPY proteinPMID:12005258 PMID:15680483 PMID:15985714 PMID:16084549 PMID:16101753 PMID:16896163 PMID:25825358
NPYdecreases response to substanceISONpy (Mus musculus)6480464CTDNPY protein results in decreased susceptibility to AmphetaminePMID:12183048
NPYincreases expressionISONpy (Rattus norvegicus)6480464CTDAmphetamine results in increased expression of NPY mRNAPMID:15183010
NPYincreases response to substanceISONpy (Rattus norvegicus)6480464CTDNPY protein results in increased susceptibility to AmphetaminePMID:12005258
NPYmultiple interactionsISONpy (Rattus norvegicus)6480464CTDFOS protein promotes the reaction [Amphetamine results in decreased expression of NPY mRNA]; Haloperidol promotes the reaction [Amphetamine results in decreased expression of NPY protein]; JUN protein promotes the reaction [Amphetamine results in decreased expression of NPY mRNA]; NPY mutant form promotes the reaction [Amphetamine results in increased expression of CARTPT mRNA]; PRKCA protein promotes the reaction [Amphetamine results in decreased expression of NPY mRNA]; S-ethyl glutathione inhibits the reaction [Amphetamine results in decreased expression of NPY mRNA]; S-ethyl glutathione inhibits the reaction [Amphetamine results in decreased expression of NPY protein]PMID:15985714 PMID:16084549 PMID:16101753 PMID:25825358
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