Timeless (timeless circadian clock 1) - Rat Genome Database

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Gene: Timeless (timeless circadian clock 1) Mus musculus
Analyze
Symbol: Timeless
Name: timeless circadian clock 1
RGD ID: 731568
MGI Page MGI
Description: Enables identical protein binding activity. Involved in several processes, including DNA damage response; circadian rhythm; and regulation of circadian rhythm. Acts upstream of or within branching morphogenesis of an epithelial tube and lung development. Located in nucleus. Is expressed in several structures, including future brain; genitourinary system; gut; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome and alcohol use disorder. Orthologous to human TIMELESS (timeless circadian regulator).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C77407; Debt69; mTim; ti; tim; timeless homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,067,932 - 128,088,810 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,067,934 - 128,088,810 (+)EnsemblGRCm39 Ensembl
GRCm3810128,232,063 - 128,252,941 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,232,065 - 128,252,941 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710127,669,119 - 127,689,997 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,641,015 - 127,655,888 (+)NCBIMGSCv36mm8
Celera10133,268,115 - 133,283,209 (+)NCBICelera
Celera10130,632,719 - 130,638,534 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,6-dinitrotoluene  (ISO)
2-palmitoylglycerol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
amphetamine  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (EXP)
folic acid  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (ISO)
geraniol  (ISO)
L-methionine  (EXP)
menadione  (ISO)
methimazole  (ISO)
microcystin-LR  (ISO)
Monobutylphthalate  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP)
tungsten  (EXP)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
2. Identification of the mammalian homologues of the Drosophila timeless gene, Timeless1. Koike N, etal., FEBS Lett 1998 Dec 28;441(3):427-31.
3. Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. Kovanen L, etal., Alcohol Alcohol. 2010 Jul-Aug;45(4):303-11. doi: 10.1093/alcalc/agq035. Epub 2010 Jun 16.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9856465   PMID:9856466   PMID:9988221   PMID:9989497   PMID:10231394   PMID:10349636   PMID:10428031   PMID:10903565   PMID:10922068   PMID:10963667   PMID:11042159   PMID:11076861  
PMID:11217851   PMID:11544199   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12875843   PMID:12904583   PMID:12950082   PMID:14564007   PMID:14610273   PMID:15489334   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:16602821   PMID:17141802   PMID:18799693   PMID:19805627   PMID:20211142   PMID:20360068   PMID:21359199   PMID:21873635   PMID:23266470   PMID:23418588  
PMID:24489120   PMID:25448545   PMID:26365490   PMID:26496610   PMID:30973865   PMID:31138685   PMID:32325033   PMID:33473114   PMID:33590678   PMID:34321999   PMID:37043347   PMID:38355793  


Genomics

Comparative Map Data
Timeless
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,067,932 - 128,088,810 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,067,934 - 128,088,810 (+)EnsemblGRCm39 Ensembl
GRCm3810128,232,063 - 128,252,941 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,232,065 - 128,252,941 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710127,669,119 - 127,689,997 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,641,015 - 127,655,888 (+)NCBIMGSCv36mm8
Celera10133,268,115 - 133,283,209 (+)NCBICelera
Celera10130,632,719 - 130,638,534 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.49NCBI
TIMELESS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,416,363 - 56,449,426 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,416,363 - 56,449,426 (-)EnsemblGRCh38hg38GRCh38
GRCh371256,810,147 - 56,843,210 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,097,174 - 55,129,433 (-)NCBINCBI36Build 36hg18NCBI36
Build 341255,097,174 - 55,129,433NCBI
Celera1256,463,518 - 56,496,570 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1253,849,203 - 53,882,241 (-)NCBIHuRef
CHM1_11256,777,536 - 56,810,809 (-)NCBICHM1_1
T2T-CHM13v2.01256,384,058 - 56,417,137 (-)NCBIT2T-CHM13v2.0
Timeless
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,239,388 - 1,263,344 (+)NCBIGRCr8
mRatBN7.27654,804 - 678,769 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7654,822 - 678,738 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,413,239 - 3,434,822 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,289,244 - 5,310,791 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,591,124 - 5,613,782 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,643,288 - 2,667,329 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,643,288 - 2,667,628 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,622,164 - 2,646,205 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,516,568 - 1,540,512 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,516,569 - 1,540,504 (+)NCBI
Celera7533,427 - 554,888 (+)NCBICelera
Cytogenetic Map7q11NCBI
Timeless
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,997,725 - 4,029,766 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,999,143 - 4,029,523 (-)NCBIChiLan1.0ChiLan1.0
TIMELESS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,882,182 - 37,914,254 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,878,947 - 37,911,019 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,465,529 - 32,497,581 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,718,649 - 32,750,728 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,718,649 - 32,750,728 (+)Ensemblpanpan1.1panPan2
TIMELESS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110671,829 - 701,152 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10671,269 - 687,016 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10735,035 - 764,351 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010680,644 - 710,114 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10680,997 - 710,061 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110657,877 - 687,187 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010901,025 - 930,299 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,025,061 - 1,054,020 (-)NCBIUU_Cfam_GSD_1.0
Timeless
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,077,412 - 58,090,044 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646780,087 - 792,837 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646780,021 - 792,856 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMELESS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,371,781 - 52,408,923 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,372,375 - 52,389,284 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,573,940 - 193,611,044 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Timeless
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480211,605,116 - 11,629,911 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Timeless
508 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2134
Count of miRNA genes:667
Interacting mature miRNAs:855
Transcripts:ENSMUST00000055539, ENSMUST00000105240, ENSMUST00000105242, ENSMUST00000105243, ENSMUST00000105244, ENSMUST00000105245, ENSMUST00000125289, ENSMUST00000129147, ENSMUST00000135376, ENSMUST00000135538, ENSMUST00000136854, ENSMUST00000142149, ENSMUST00000142484, ENSMUST00000145710, ENSMUST00000146945
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097217101130530862Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10100986516130530862Mouse
12904000Opfaq7_mopen field activity QTL 7 (mouse)10127746318129466375Mouse
12904001Opfaq10_mopen field activity QTL 10 (mouse)10125633671129466375Mouse
12879490Frct3_mfear conditioning traits 3 (mouse)10122785970129466996Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108575094130530862Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097217101130530862Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101497164130530862Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104110021130530862Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10102847852130530862Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105041304130530862Mouse
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102506908130530862Mouse
14746996Manh69_mmandible shape 69 (mouse)10104763638130530862Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097535905130530862Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101497164130530862Mouse
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108515907130530862Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108575094130530862Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10100986516130530862Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97758644130530862Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108575094130530862Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105041304130530862Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397217101130530862Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103243727130530862Mouse
12911221Frct3d_mfear conditioning traits 3d (mouse)10127675574129466996Mouse
12911220Frct3c_mfear conditioning traits 3c (mouse)10122785970129466996Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108575094130530862Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108515907130530862Mouse
12911219Frct3b_mfear conditioning traits 3b (mouse)10127675574129466996Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10102902508130530862Mouse
12911218Frct3a_mfear conditioning traits 3a (mouse)10122785970129466996Mouse
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099220635130530862Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105179713130530862Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099220635130530862Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097217101130530862Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105179713130530862Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099220635130530862Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105041304130530862Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105179713130530862Mouse

Markers in Region
AI323353  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810128,231,614 - 128,231,759UniSTSGRCm38
MGSCv3710127,668,670 - 127,668,815UniSTSGRCm37
Celera10133,267,672 - 133,267,817UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map10D1UniSTS
cM Map1018.0UniSTS
cM Map1074.0UniSTS
Whitehead/MRC_RH101376.83UniSTS
U27502  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810128,230,506 - 128,230,604UniSTSGRCm38
MGSCv3710127,667,562 - 127,667,660UniSTSGRCm37
Celera10133,266,562 - 133,266,660UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map10D1UniSTS
cM Map1018.0UniSTS
cM Map1074.0UniSTS
Whitehead/MRC_RH101376.51UniSTS
UniSTS:236486  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810128,231,643 - 128,231,772UniSTSGRCm38
MGSCv3710127,668,699 - 127,668,828UniSTSGRCm37
Celera10133,267,701 - 133,267,830UniSTS
Cytogenetic Map10D1UniSTS
Cytogenetic Map10D3UniSTS
cM Map1018.0UniSTS
cM Map1074.0UniSTS
RH126161  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810128,252,676 - 128,252,907UniSTSGRCm38
MGSCv3710127,689,732 - 127,689,963UniSTSGRCm37
Celera10130,638,269 - 130,638,500UniSTS
Cytogenetic Map10D3UniSTS
cM Map1018.0UniSTS
cM Map1076.0UniSTS
Whitehead/MRC_RH101378.73UniSTS
AB019001  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810128,252,477 - 128,252,577UniSTSGRCm38
MGSCv3710127,689,533 - 127,689,633UniSTSGRCm37
Celera10130,638,070 - 130,638,170UniSTS
Cytogenetic Map10D3UniSTS
cM Map1018.0UniSTS
cM Map1076.0UniSTS
Whitehead/MRC_RH101376.51UniSTS
Mip  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810128,230,512 - 128,230,658UniSTSGRCm38
MGSCv3710127,667,568 - 127,667,714UniSTSGRCm37
Celera10133,266,568 - 133,266,714UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map10D1UniSTS
cM Map1074.0UniSTS
Timeless  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810128,244,506 - 128,244,717UniSTSGRCm38
MGSCv3710127,681,562 - 127,681,773UniSTSGRCm37
Cytogenetic Map10D3UniSTS
cM Map1018.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001136082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001164080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001164081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB015598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB019001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC135859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF071506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF098161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF106800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF126480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK087033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC064788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC082770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ088470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000055539   ⟹   ENSMUSP00000058021
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,067,934 - 128,088,810 (+)Ensembl
GRCm38.p6 Ensembl10128,232,065 - 128,252,941 (+)Ensembl
Ensembl Acc Id: ENSMUST00000105240
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,083,209 - 128,088,808 (+)Ensembl
GRCm38.p6 Ensembl10128,247,340 - 128,252,939 (+)Ensembl
Ensembl Acc Id: ENSMUST00000105242   ⟹   ENSMUSP00000100876
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,068,003 - 128,088,810 (+)Ensembl
GRCm38.p6 Ensembl10128,232,134 - 128,252,941 (+)Ensembl
Ensembl Acc Id: ENSMUST00000105243   ⟹   ENSMUSP00000100877
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,067,960 - 128,081,978 (+)Ensembl
GRCm38.p6 Ensembl10128,232,091 - 128,246,109 (+)Ensembl
Ensembl Acc Id: ENSMUST00000105244   ⟹   ENSMUSP00000100878
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,067,958 - 128,088,721 (+)Ensembl
GRCm38.p6 Ensembl10128,232,089 - 128,252,852 (+)Ensembl
Ensembl Acc Id: ENSMUST00000105245   ⟹   ENSMUSP00000100879
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,073,935 - 128,088,810 (+)Ensembl
GRCm38.p6 Ensembl10128,238,066 - 128,252,941 (+)Ensembl
Ensembl Acc Id: ENSMUST00000125289   ⟹   ENSMUSP00000132079
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,067,984 - 128,077,544 (+)Ensembl
GRCm38.p6 Ensembl10128,232,115 - 128,241,675 (+)Ensembl
Ensembl Acc Id: ENSMUST00000129147
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,085,488 - 128,086,241 (+)Ensembl
GRCm38.p6 Ensembl10128,249,619 - 128,250,372 (+)Ensembl
Ensembl Acc Id: ENSMUST00000135376
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,078,208 - 128,078,879 (+)Ensembl
GRCm38.p6 Ensembl10128,242,339 - 128,243,010 (+)Ensembl
Ensembl Acc Id: ENSMUST00000135538
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,076,270 - 128,077,484 (+)Ensembl
GRCm38.p6 Ensembl10128,240,401 - 128,241,615 (+)Ensembl
Ensembl Acc Id: ENSMUST00000136854
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,085,082 - 128,085,729 (+)Ensembl
GRCm38.p6 Ensembl10128,249,213 - 128,249,860 (+)Ensembl
Ensembl Acc Id: ENSMUST00000142149
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,078,498 - 128,079,564 (+)Ensembl
GRCm38.p6 Ensembl10128,242,629 - 128,243,695 (+)Ensembl
Ensembl Acc Id: ENSMUST00000142484
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,083,154 - 128,083,915 (+)Ensembl
GRCm38.p6 Ensembl10128,247,285 - 128,248,046 (+)Ensembl
Ensembl Acc Id: ENSMUST00000145710
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,067,949 - 128,088,801 (+)Ensembl
GRCm38.p6 Ensembl10128,232,080 - 128,252,932 (+)Ensembl
Ensembl Acc Id: ENSMUST00000146945
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,078,277 - 128,079,799 (+)Ensembl
GRCm38.p6 Ensembl10128,242,408 - 128,243,930 (+)Ensembl
RefSeq Acc Id: NM_001136082   ⟹   NP_001129554
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,067,932 - 128,088,810 (+)NCBI
GRCm3810128,232,063 - 128,252,941 (+)ENTREZGENE
MGSCv3710127,669,119 - 127,689,997 (+)RGD
Celera10133,268,115 - 133,283,209 (+)ENTREZGENE
Celera10130,632,719 - 130,638,534 (+)NCBI
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001164080   ⟹   NP_001157552
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,067,932 - 128,088,810 (+)NCBI
GRCm3810128,232,063 - 128,252,941 (+)ENTREZGENE
MGSCv3710127,669,119 - 127,689,997 (+)RGD
Celera10133,268,115 - 133,283,209 (+)ENTREZGENE
Celera10130,632,719 - 130,638,534 (+)NCBI
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001164081   ⟹   NP_001157553
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,067,932 - 128,088,810 (+)NCBI
GRCm3810128,232,063 - 128,252,941 (+)ENTREZGENE
MGSCv3710127,669,119 - 127,689,997 (+)RGD
Celera10133,268,115 - 133,283,209 (+)ENTREZGENE
Celera10130,632,719 - 130,638,534 (+)NCBI
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_011589   ⟹   NP_035719
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,073,935 - 128,088,810 (+)NCBI
GRCm3810128,238,066 - 128,252,941 (+)NCBI
MGSCv3710127,669,119 - 127,689,997 (+)RGD
Celera10130,632,719 - 130,638,534 (+)NCBI
Celera10133,268,115 - 133,283,209 (+)ENTREZGENE
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006513580   ⟹   XP_006513643
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,071,352 - 128,088,810 (+)NCBI
GRCm3810128,235,479 - 128,252,941 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006513581   ⟹   XP_006513644
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,071,351 - 128,088,808 (+)NCBI
GRCm3810128,235,478 - 128,252,939 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006513582   ⟹   XP_006513645
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,071,351 - 128,088,808 (+)NCBI
GRCm3810128,235,478 - 128,252,939 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006513583   ⟹   XP_006513646
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,073,467 - 128,088,810 (+)NCBI
GRCm3810128,237,598 - 128,252,941 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030245049   ⟹   XP_030100909
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,071,349 - 128,088,808 (+)NCBI
GRCm3810128,235,477 - 128,252,939 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030245050   ⟹   XP_030100910
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,067,938 - 128,088,810 (+)NCBI
GRCm3810128,232,069 - 128,252,941 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001129554 (Get FASTA)   NCBI Sequence Viewer  
  NP_001157552 (Get FASTA)   NCBI Sequence Viewer  
  NP_001157553 (Get FASTA)   NCBI Sequence Viewer  
  NP_035719 (Get FASTA)   NCBI Sequence Viewer  
  XP_006513643 (Get FASTA)   NCBI Sequence Viewer  
  XP_006513644 (Get FASTA)   NCBI Sequence Viewer  
  XP_006513645 (Get FASTA)   NCBI Sequence Viewer  
  XP_006513646 (Get FASTA)   NCBI Sequence Viewer  
  XP_030100909 (Get FASTA)   NCBI Sequence Viewer  
  XP_030100910 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC79687 (Get FASTA)   NCBI Sequence Viewer  
  AAC80010 (Get FASTA)   NCBI Sequence Viewer  
  AAD24467 (Get FASTA)   NCBI Sequence Viewer  
  AAH26526 (Get FASTA)   NCBI Sequence Viewer  
  AAH52884 (Get FASTA)   NCBI Sequence Viewer  
  AAH58641 (Get FASTA)   NCBI Sequence Viewer  
  AAH64788 (Get FASTA)   NCBI Sequence Viewer  
  AAH82770 (Get FASTA)   NCBI Sequence Viewer  
  AAO23021 (Get FASTA)   NCBI Sequence Viewer  
  BAA36500 (Get FASTA)   NCBI Sequence Viewer  
  BAA76390 (Get FASTA)   NCBI Sequence Viewer  
  BAE32206 (Get FASTA)   NCBI Sequence Viewer  
  EDL24548 (Get FASTA)   NCBI Sequence Viewer  
  EDL24549 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000058021
  ENSMUSP00000058021.5
  ENSMUSP00000100876
  ENSMUSP00000100876.2
  ENSMUSP00000100877.3
  ENSMUSP00000100878
  ENSMUSP00000100878.2
  ENSMUSP00000100879
  ENSMUSP00000100879.3
  ENSMUSP00000132079.3
GenBank Protein Q9R1X4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_035719   ⟸   NM_011589
- Peptide Label: isoform 2
- UniProtKB: Q9R1X4 (UniProtKB/Swiss-Prot),   Q9R268 (UniProtKB/Swiss-Prot),   Q8R0Q2 (UniProtKB/Swiss-Prot),   Q7TPV8 (UniProtKB/Swiss-Prot),   Q6PDL4 (UniProtKB/Swiss-Prot),   Q6P204 (UniProtKB/Swiss-Prot),   Q63ZX9 (UniProtKB/Swiss-Prot),   Q9Z0E7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001129554   ⟸   NM_001136082
- Peptide Label: isoform 1
- UniProtKB: Q9R1X4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001157552   ⟸   NM_001164080
- Peptide Label: isoform 3
- UniProtKB: Q3U574 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157553   ⟸   NM_001164081
- Peptide Label: isoform 2
- UniProtKB: Q9R1X4 (UniProtKB/Swiss-Prot),   Q9R268 (UniProtKB/Swiss-Prot),   Q8R0Q2 (UniProtKB/Swiss-Prot),   Q7TPV8 (UniProtKB/Swiss-Prot),   Q6PDL4 (UniProtKB/Swiss-Prot),   Q6P204 (UniProtKB/Swiss-Prot),   Q63ZX9 (UniProtKB/Swiss-Prot),   Q9Z0E7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006513643   ⟸   XM_006513580
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006513645   ⟸   XM_006513582
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006513644   ⟸   XM_006513581
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006513646   ⟸   XM_006513583
- Peptide Label: isoform X5
- UniProtKB: Q9R1X4 (UniProtKB/Swiss-Prot),   Q9R268 (UniProtKB/Swiss-Prot),   Q8R0Q2 (UniProtKB/Swiss-Prot),   Q7TPV8 (UniProtKB/Swiss-Prot),   Q6PDL4 (UniProtKB/Swiss-Prot),   Q6P204 (UniProtKB/Swiss-Prot),   Q63ZX9 (UniProtKB/Swiss-Prot),   Q9Z0E7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030100910   ⟸   XM_030245050
- Peptide Label: isoform X6
RefSeq Acc Id: XP_030100909   ⟸   XM_030245049
- Peptide Label: isoform X4
Ensembl Acc Id: ENSMUSP00000132079   ⟸   ENSMUST00000125289
Ensembl Acc Id: ENSMUSP00000100876   ⟸   ENSMUST00000105242
Ensembl Acc Id: ENSMUSP00000100877   ⟸   ENSMUST00000105243
Ensembl Acc Id: ENSMUSP00000100878   ⟸   ENSMUST00000105244
Ensembl Acc Id: ENSMUSP00000100879   ⟸   ENSMUST00000105245
Ensembl Acc Id: ENSMUSP00000058021   ⟸   ENSMUST00000055539
Protein Domains
Timeless C-terminal   Timeless N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R1X4-F1-model_v2 AlphaFold Q9R1X4 1-1197 view protein structure

Promoters
RGD ID:6820007
Promoter ID:MM_KWN:5970
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   MEF_B6
Transcripts:ENSMUST00000105242,   ENSMUST00000105243,   ENSMUST00000105246,   NM_001164080,   OTTMUST00000059534,   OTTMUST00000059537,   OTTMUST00000059595,   OTTMUST00000059596,   UC007HLT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610127,668,776 - 127,669,437 (+)MPROMDB
RGD ID:6820010
Promoter ID:MM_KWN:5972
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000059539
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610127,675,024 - 127,675,524 (+)MPROMDB
RGD ID:6820009
Promoter ID:MM_KWN:5976
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Kidney,   Liver,   Lung
Transcripts:ENSMUST00000105240,   OTTMUST00000059601
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610127,683,981 - 127,684,481 (+)MPROMDB
RGD ID:8673584
Promoter ID:EPDNEW_M14823
Type:multiple initiation site
Name:Timeless_1
Description:Mus musculus timeless circadian clock 1 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14825  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810128,232,080 - 128,232,140EPDNEW
RGD ID:8673588
Promoter ID:EPDNEW_M14825
Type:multiple initiation site
Name:Timeless_2
Description:Mus musculus timeless circadian clock 1 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14823  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810128,238,037 - 128,238,097EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1321393 AgrOrtholog
Ensembl Genes ENSMUSG00000039994 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000055539 ENTREZGENE
  ENSMUST00000055539.11 UniProtKB/Swiss-Prot
  ENSMUST00000105242 ENTREZGENE
  ENSMUST00000105242.8 UniProtKB/Swiss-Prot
  ENSMUST00000105243.9 UniProtKB/TrEMBL
  ENSMUST00000105244 ENTREZGENE
  ENSMUST00000105244.8 UniProtKB/Swiss-Prot
  ENSMUST00000105245 ENTREZGENE
  ENSMUST00000105245.3 UniProtKB/Swiss-Prot
  ENSMUST00000125289.8 UniProtKB/TrEMBL
InterPro Timeless UniProtKB/Swiss-Prot
  Timeless UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Timeless UniProtKB/TrEMBL
  TIMELESS_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21853 UniProtKB/Swiss-Prot
MGD MGI:1321393 ENTREZGENE
NCBI Gene 21853 ENTREZGENE
PANTHER PROTEIN TIMELESS HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR22940 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TIMELESS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMELESS_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Timeless PhenoGen
UniProt E9Q302_MOUSE UniProtKB/TrEMBL
  H7BX89_MOUSE UniProtKB/TrEMBL
  Q3U574 ENTREZGENE, UniProtKB/TrEMBL
  Q63ZX9 ENTREZGENE
  Q6P204 ENTREZGENE
  Q6PDL4 ENTREZGENE
  Q7TPV8 ENTREZGENE
  Q812D7_MOUSE UniProtKB/TrEMBL
  Q8R0Q2 ENTREZGENE
  Q9R1X4 ENTREZGENE
  Q9R268 ENTREZGENE
  Q9Z0E7 ENTREZGENE
  TIM_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q63ZX9 UniProtKB/Swiss-Prot
  Q6P204 UniProtKB/Swiss-Prot
  Q6PDL4 UniProtKB/Swiss-Prot
  Q7TPV8 UniProtKB/Swiss-Prot
  Q8R0Q2 UniProtKB/Swiss-Prot
  Q9R268 UniProtKB/Swiss-Prot
  Q9Z0E7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-08 Timeless  timeless circadian clock 1    timeless homolog (Drosophila)  Symbol and/or name change 5135510 APPROVED