RGD Reference Report - Requirement of mammalian Timeless for circadian rhythmicity. - Rat Genome Database

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Requirement of mammalian Timeless for circadian rhythmicity.

Authors: Barnes, JW  Tischkau, SA  Barnes, JA  Mitchell, JW  Burgoon, PW  Hickok, JR  Gillette, MU 
Citation: Barnes JW, etal., Science 2003 Oct 17;302(5644):439-42.
RGD ID: 734503
Pubmed: (View Article at PubMed) PMID:14564007
DOI: Full-text: DOI:10.1126/science.1086593

Despite a central circadian role in Drosophila for the transcriptional regulator Timeless (dTim), the relevance of mammalian Timeless (mTim) remains equivocal. Conditional knockdown of mTim protein expression in the rat suprachiasmatic nucleus (SCN) disrupted SCN neuronal activity rhythms, and altered levels of known core clock elements. Full-length mTim protein (mTIM-fl) exhibited a 24-hour oscillation, where as a truncated isoform (mTIM-s) was constitutively expressed. mTIM-fl associated with the mammalian clock Period proteins (mPERs) in oscillating SCN cells. These data suggest that mTim is required for rhythmicity and is a functional homolog of dTim on the negative-feedback arm of the mammalian molecular clockwork.

Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Timeless  (timeless circadian regulator)

Objects referenced in this article
Strain LE/BluGill null Rattus norvegicus
Gene Per2 period circadian regulator 2 Rattus norvegicus

Additional Information