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Gene: CLOCK (clock circadian regulator) Homo sapiens
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Symbol: CLOCK
Name: clock circadian regulator
Description: Exhibits E-box binding activity and histone acetyltransferase activity. Involved in several processes, including DNA damage checkpoint; cellular response to ionizing radiation; and regulation of gene expression. Localizes to several cellular components, including the cytosol; nucleoplasm; and transcription factor complex. Implicated in Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bHLHe8; circadian locomoter output cycles kaput protein; circadian locomoter output cycles protein kaput; class E basic helix-loop-helix protein 8; clock homolog; KAT13D; KIAA0334
Orthologs:
Mus musculus (house mouse) : Clock (circadian locomotor output cycles kaput)  MGI  Alliance
Rattus norvegicus (Norway rat) : Clock (clock circadian regulator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Clock (clock circadian regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : CLOCK (clock circadian regulator)
Canis lupus familiaris (dog) : CLOCK (clock circadian regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Clock (clock circadian regulator)
Sus scrofa (pig) : CLOCK (clock circadian regulator)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38455,427,901 - 55,547,138 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37456,294,068 - 56,413,076 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36455,993,417 - 56,107,754 (-)NCBINCBI36hg18NCBI36
Build 34456,139,587 - 56,253,925NCBI
Celera453,800,517 - 53,915,033 (-)NCBI
Cytogenetic Map4q12NCBI
HuRef452,243,062 - 52,362,368 (-)NCBIHuRef
CHM1_1456,329,197 - 56,448,202 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CLOCK
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1348034
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.