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Gene: CLOCK (clock circadian regulator) Homo sapiens
Symbol: CLOCK
Name: clock circadian regulator
Description: Exhibits E-box binding activity and histone acetyltransferase activity. Involved in several processes, including DNA damage checkpoint; cellular response to ionizing radiation; and regulation of gene expression. Localizes to several cellular components, including the cytosol; nucleoplasm; and transcription factor complex. Implicated in Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bHLHe8; circadian locomoter output cycles kaput protein; circadian locomoter output cycles protein kaput; class E basic helix-loop-helix protein 8; clock homolog; KAT13D; KIAA0334
Mus musculus (house mouse) : Clock (circadian locomotor output cycles kaput)  MGI  Alliance
Rattus norvegicus (Norway rat) : Clock (clock circadian regulator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Clock (clock circadian regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : CLOCK (clock circadian regulator)
Canis lupus familiaris (dog) : CLOCK (clock circadian regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Clock (clock circadian regulator)
Sus scrofa (pig) : CLOCK (clock circadian regulator)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38455,427,901 - 55,547,138 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37456,294,068 - 56,413,076 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36455,993,417 - 56,107,754 (-)NCBINCBI36hg18NCBI36
Build 34456,139,587 - 56,253,925NCBI
Celera453,800,517 - 53,915,033 (-)NCBI
Cytogenetic Map4q12NCBI
HuRef452,243,062 - 52,362,368 (-)NCBIHuRef
CHM1_1456,329,197 - 56,448,202 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CLOCK
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1348034
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.